Photo of George A. Kuchel, M.D., FRCP, AGSF

George A. Kuchel, M.D., FRCP, AGSF

Director, UConn Center on Aging
Travelers Chair in Geriatrics and Gerontology
Academic Office Location:
UConn Center on Aging
UConn Health
263 Farmington Avenue
Farmington, CT 06030-5215
Phone: 860-679-3956
860-679-6796
Fax: 860-679-1307
Website(s):

Genetics & Developmental Biology Graduate Program

UConn AgingNet

UConn Center on Aging

Education
DegreeInstitutionMajor
OtherVanier CollegeHealth Sciences
OtherMcGill Medical SchoolMedicine

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipMontreal General HospitalInternal Medicine
ResidencyMontreal General HospitalInternal Medicine
PostdoctoralHarvard Medical SchoolKaiser, Faculty Development Program in General Internal Medicine
FellowshipHarvard Medical School, Division on Aging and Beth Israel HospitalGeriatrics and Gerontology
PostdoctoralHarvard Medical SchoolBiological Chemistry and Molecular Pharmacology
PostdoctoralMount Sinai Medical CenterNeurobiology and Gerontology

Awards
Name of Award/HonorAwarding Organization
Brookdale Senior Fellow, New York Brookdale Foundation
John A. Hartford Leadership Award
Travelers/Citicorp Chair in Geriatrics and GerontologyUniversity of Connecticut
Montreal General Hospital 175th Anniversary Award Montreal General Hospital
Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec
FellowshipMedical Research Council of Canada
Brookdale National FellowBrookdale Foundation
Royal Canadian Legion Fellowship in Geriatric Medicine
Mona Bronfman Scheckman Prize in PsychiatryMcGill
University ScholarMcGill
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Aging Systems and Geriatrics Study Section, NIH/CSR Study SectionChairExternalNational20082011
Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR Study SectionMemberExternalNational20072011
Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut Advisory CommitteeAdvisory BoardExternalUniversity2002
Older Americans Independence Center, University of Connecticut Professional/Scientific OrganizationDirectorExternalUniversity20012004
MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill Education CommitteeCommittee MemberExternalUniversity19982001
Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ Professional/Scientific OrganizationDirectorExternalUniversity19982001
Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ Professional/Scientific OrganizationCo-PIExternalUniversity19961999
Research fellow, Neurobiology, Mount Sinai School of Medicine, New York Professional/Scientific OrganizationFellowExternalUniversity19891992
Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School Professional/Scientific OrganizationFellowExternalUniversity19871989
Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School Education CommitteeMemberExternalUniversity19851986

RESEARCH INTERESTS:


 


1.      Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense


2.      Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging


3.      Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”

Current Grant Support:  


NIA/NIH; Immune Response to High-Dose vs. Standard Dose Influenza Vaccine


R01 AG048023; George Kuchel, MD (communicating PI) and Janet McElhaney (PI)


Total Budget: $ 1,934,901; 7/15/2014-5/31/2019


 


NIAID/NIH; Combination Adjuvants to Activate Human Dendritic Cell Subsets & B Cells


U01 AI124297; Jacques Banchereau (PI) Jackson Lab for Genomic Medicine, Farmington, CT


George Kuchel, MD (co-investigator)


Budget: $ 3,296,716; Award to UCHC: $104,460; 4/15/2016-3/31/2021 


 


NIA/NIH; Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines.


R01 AG052608; Jacques Banchereau (PI) Jackson Laboratory for Genomic Medicine, Farmington, CT


Budget: $ 1,580,481(total), $ 572,170 (UCH total direct); 9/15/2016-9/15/2021


 


PCORI (Patient-Centered Outcomes Research Institute); 3D Team Care for Cognitively Vulnerable Older Adults


PCORI-PFA-2015-Spring;                   


IHS-1502-27171; Fortinsky (PI)                                                                       


Total Budget: $6,219,556; 04/01/2016-03/31/2021                    


Role: Co-Investigator 


 


NIGMS/NIH; Chromatin Changes Associated with Aging of Human Immune Cells


R35 GM124922; Maximizing Investigators Research Award for New & Early-Stage Investigators


Duygu Ucar (PI), Jackson Lab for Genomic Medicine


07/01/2017-06/30/2022


Role: Co-Investigator 


 


NIA/NIH; Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME Collaborative)


UH2 AG056925; Predictors and Determinants of Age-Related Changes in Resiliencies to Physical Stressors in Humans (UH2/UH3)


Cathleen Colon-Emeric and Heather Whitson (Multiple PIs); Duke University Medical Center


09/30/2017-05/31/2019


Role: Immunology Group Lead; Consortium Co-Investigator 


 


NIA/NIH; Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture


R01 AG051647


Multiple PI Plan: Binder, E. (communicating PI/Wash U), Schechtman, K. (Wash U), Volpi, E. (UTMB), Kuchel, G.(UCONN), Orwig, D. (U Maryland), Schwartz, R. (U Colorado), Magaziner, J. (U Maryland), Kiel, D. (Harvard)


UCHC Budget: $272,235/yr; 09/15/2017 – 05/31/2022


Role: Co-Investigator


 


CMMS/DHHS; Transforming Clinical Practices: Practice Transformation Network          


1L1 CMS331467-01


PI: Dr Bruce Liang (UConn) and Dr David Polakoff (UMass)


Annual Budget: $ 1,305,264; 9/29/2015-9/28/2019                                          


Role: co-investigator 


 


NIA/NIH; R21 AG060018. Understanding the role of ApoE2 in longevity and age-related diseases and conditions using 500,000 UK Biobank participants


PI: Chia-Ling Kuo (UConn Biostatistics), David Melzer (UConn Center on Aging & U Exeter), George Kuchel (UConn Center on Aging).


Budget: $357,374; 7/1/2018-6/30/2020


Role: Co-Investigator 


 


NIA/NIH; NIA Translational Geroscience Network (TGN)


R33 AG061456; Multiple PI Plan: Kirkland JL (Mayo), Kritchevsky S (Wake Forest), Kuchel G (UConn) and Tchkonia T (Mayo)


UCHC Budget (Direct): $ 174,394; 02/01/2019-11/30/2023


Roles: Multiple PI; Chair of Biobanking and Repository Committee 


 


NIAID/NIH; High-resolution single cell profiling of vaccine responsiveness in the elderly


R01 AI142086; PI: J Banchereau (Jackson Lab for Genomic Medicine)


UCHC Budget (Direct): $19,232; 10/01/2018-9/30/2023


Role: Co-Investigator 


 


Current Grant Support(Roles without a funded effort):   


NIA/NIH; Cytoskeletal functions in cell aging and disease


K02 AG050774; Ken Campellone – PI (Mol Cell Bio; UConn, Storrs); Co-Mentors: G Kuchel and Laura Haynes (UConn); Ron Korstanje (JAX BH)


09/15/2016-04/30/2021


Role: Co-Mentor (No Funded Effort)


 


NIA/NIH; Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding and Incontinence


K76 AG054777; Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)


Phillip P Smith, MD (PI)


George A Kuchel, MD (Primary Mentor)


Eric Levine, PhD (Neuroscience); Laura Haynes, PhD (Aging/Immunology), and Lori Birder, PhD (Cell Biology/U Pittsburgh) co-mentors


Total Budget: $646,773; 9/1/2016-10/30/2019.


Role: Primary Mentor (No funded effort)


 


AFAR; Effect of Metformin on Influenza Vaccine Responses and T cell Function in the Elderly


2018 Irene Diamond Fund/AFAR Postdoctoral Transition Award in Aging


Jenna Bartley, PhD (PI)


George A Kuchel, MD (Primary Mentor)


Laura Haynes, PhD (Aging/Immunology) co-mentor


7/1/2018-6/31/2020


 


CICATS (Connecticut Institute for Clinical and Translational Sciences)


Effect of Metformin on Influenza Vaccine Responses and T cell Function in the Elderly


2018 Irene Diamond Fund/AFAR Postdoctoral Transition Award in Aging


Jenna Bartley, PhD (PI)


George A Kuchel, MD (Primary Mentor)


Laura Haynes, PhD (Aging/Immunology) co-mentor


7/1/2018-6/31/2020


 


UConn Microbiome Research Seed Grant; Microbiome Plasticity and Pathogenicity in Older Adults: Baselines of Community Dwelling Adults


George Kuchel (PI); Julia Oh, Jackson Lab (MPI), Julie Robison, Center on Aging (MPI),                


Jamie Grady, Biostatistics (co-investigator), Ock K Chun, Nutritional Sciences (co-investigator)


Budget: $ 50,000; 01/01/19-12/31/19


NIA/NIH; Delirium, Dementia and the Vulnerable Brain: An Integrative Approach


P01 AG031720


Sharon K. Inouye, MD, MPH, Principal Investigator (Harvard/Beth Israel).


9/15/19-5/31/2023


Role: Chair, Scientific Advisory Board (No Funded Effort).


 


 

Accepting Lab Rotation Students: Summer '19, Fall '19, Spring '20


Research Rotation Projects


Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases  training in the translational T1 (bench to bedside) sciences.

Journal Articles

Book Chapters

  • Aging of the Urinary Tract
    Smith PP, Kuchel G Brocklehurst's Textbook of Geriatrics and Clinical Gerontology 2010 Jan;
  • Aging, Animal Model
    Kuchel, G.A., Zhu, Q., Rogina, B. and Clark, S.H. Encyclopedia of Endocrine Diseases 2004 Jan;126-130
  • Influenza Vaccination: Accelerating the process for new vaccine development in older adults
    McElhaney J.E., Andrew M.K., Haynes L., Kuchel G.A., McNeill S.A. and Pawelec G. Vaccines for the older population

Abstracts

  • Upside-Down Stomach in a 92-year-old Woman
    Maghaydah YS, Kuchel GA. J Am Geriatr Soc 2007 Jan;55(8):1307-9
  • Macrophage migration inhibitory factor mediates smooth muscle death in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. J Urol 2005 Jan;17338
  • Null mutation in macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. J Am Geriatr Soc. 2005 Jan;538

Conference Papers

  • Mice with a null mutation for macrophage migration inhibitory factor have lower stage tumors in a model of bladder cancer. Taylor won New Investigator Award.
    Taylor JA, Kuchel GA, Hegde H, Voznesensky OS, Claffey K, Tsmikas J, Bucala R and Pilbeam C. 2006 Jan;
  • Locomotion in vitamin D receptor gene knockout mice.
    DuBose M, Sasso D, Kenny A, Pilbeam C, Demay M and Kuchel GA. 2005 Jan;
  • Macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Pilbeam C, Leng L, Bucala R and Kuchel GA. 2005 Jan;

Editorials

Erratums

Letters

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective.Plenary LectureSUFU Annual Meeting2019Miami, FL
Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience.TalkRobert and Arlene Kogod Aging Center, Mayo Clinic2018Mayo Clinic, Rochester, MN
Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights.TalkDepartment of Medicine, Montefiore Medical Center2018New York, NY
Biomarkers for geroscience-guided clinical trialsTalkNIA P30 Claude D. Pepper Older Americans Independence Center2018Arlington, VA
Role of Biomarkers in Aging and VitalityTalkWHO Clinical Consortium on Healthy Aging meeting on Vitality2018New York, NY
Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME.Talk9th Annual Alliance for Healthy Aging Research, Mayo Clinic2018Rochester, MN
New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms.TalkNIA Workshop on the Epidemiology of Aging. NIA Intramural Program2018Baltimore, MD
Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience.Plenary Lecture31st Annual Meeting of the Canadian Society for Immunology2018London, Ont. Canada