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George A. Kuchel, M.D., FRCP, AGSFTravelers Chair in Geriatrics and GerontologyProfessor of Medicine Director, UConn Center on Aging Chief of Geriatric Medicine
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- Education & Training
- Committees & Organizations
- Research
- Research Opportunities
- Lab Rotations
- Publications
- Presentations
Degree | Institution | Major |
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Other | Vanier College | Health Sciences |
Other | McGill Medical School | Medicine |
Post-Graduate Training
Training | Institution | Specialty |
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Internship | Montreal General Hospital | Internal Medicine |
Residency | Montreal General Hospital | Internal Medicine |
Postdoctoral | Harvard Medical School | Kaiser, Faculty Development Program in General Internal Medicine |
Fellowship | Harvard Medical School, Division on Aging and Beth Israel Hospital | Geriatrics and Gerontology |
Postdoctoral | Harvard Medical School | Biological Chemistry and Molecular Pharmacology |
Postdoctoral | Mount Sinai Medical Center | Neurobiology and Gerontology |
Awards
Name of Award/Honor | Awarding Organization |
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Brookdale Senior Fellow, New York | Brookdale Foundation |
John A. Hartford Leadership Award | |
Travelers/Citicorp Chair in Geriatrics and Gerontology | University of Connecticut |
Montreal General Hospital 175th Anniversary Award | Montreal General Hospital |
Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec | |
Fellowship | Medical Research Council of Canada |
Brookdale National Fellow | Brookdale Foundation |
Royal Canadian Legion Fellowship in Geriatric Medicine | |
Mona Bronfman Scheckman Prize in Psychiatry | McGill |
University Scholar | McGill |
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
---|---|---|---|---|---|---|
Aging Systems and Geriatrics Study Section, NIH/CSR | Study Section | Chair | External | National | 2008 | 2011 |
Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR | Study Section | Member | External | National | 2007 | 2011 |
Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut | Advisory Committee | Advisory Board | External | University | 2002 | |
Older Americans Independence Center, University of Connecticut | Professional/Scientific Organization | Director | External | University | 2001 | 2004 |
MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill | Education Committee | Committee Member | External | University | 1998 | 2001 |
Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ | Professional/Scientific Organization | Director | External | University | 1998 | 2001 |
Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ | Professional/Scientific Organization | Co-PI | External | University | 1996 | 1999 |
Research fellow, Neurobiology, Mount Sinai School of Medicine, New York | Professional/Scientific Organization | Fellow | External | University | 1989 | 1992 |
Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School | Professional/Scientific Organization | Fellow | External | University | 1987 | 1989 |
Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School | Education Committee | Member | External | University | 1985 | 1986 |
RESEARCH INTERESTS:
- Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense
- Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging
- Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”
Current Research Support
NIH/NIA R33 AG061456 Kirkland, Kritchevsky, Kuchel (MPIs) 02/01/2019-11/30/2023
Translational Geroscience Network
The role of the NIA Translational Geroscience Network (TGN) is to develop a consortium of academic programs in geriatrics focused on overcoming barriers to the translation of new geroscience-guided therapies from bench research to human studies and ultimately clinical care.
Role: Multiple PI (MPI)
NIH/NIA R21 AG063528 Kuchel, Xu, Smith (MPIs) 04/15/2019-12/31/2020
Role of Senolytics in Lower Urinary Tract Aging and Voiding Disorders
Our goal is to test senolytic drugs that target senescent cells throughout the body including the bladder and nervous system for their ability to prevent or slow the onset of bladder dysfunction in mouse models of aging.
Role: Multiple PI
NIH/NIA R56 AG060746 Oh, Robison, Kuchel (MPIs) 09/01/2019-08/31/2020
Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing Care
We will examine differences in microbiomes between older adults residing in different long-term care facilities and follow their return to the community, assessing baseline differences and microbiome “plasticity” on transition.
Role: Multiple PI
IHS-1502-27171 (PCORI) Fortinsky (PI) 05/01/2016-09/30/2023
3D Team Care for Cognitively Vulnerable Older Adults
Achieving better outcomes for cognitively vulnerable community-dwelling older adults living with dementia, depression, and/or delirium via home-based clinical care teams guided by APRNs with geriatrics expertise.
Role: Co-Investigator
NIH/NIA R01 AG051647 Binder (PI; Washington U) 09/15/2017-05/31/2022
Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture
Dr. Fortinsky and Dr. Kuchel (site Co-PIs) will work with others to perform a multicenter randomized clinical trial of testosterone therapy and exercise training on functional capacity in frail older women post hip fracture.
Role: Co-investigator
NIH/NIGMS R35 GM124922 Ucar (PI; Jackson Lab) 08/01/2017-07/31/2022
Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells
The goal of these studies is to define chromatin changes associated with aging in human immune cells.
Role: Co-Investigator
NIH/NIAID R01 AG052608 Banchereau (PI; Jackson Lab) 09/01/2016-04/30/2020
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
We are evaluating the impact of aging on genomic and epigenomic responses within peripheral white blood cells upon administration of pneumococcal vaccines, PPSV23 (Pneumovax®) and PCV13 (Prevnar®).
Role: Co-Investigator
NIH/NIAID U01 AI124297 Banchereau (PI; Jackson Lab) 04/15/2016-03/31/2021
Combination Adjuvants to Activate Human Dendritic Cell Subsets and B Cells
We are studying human dendritic cell (DC) subsets exposed to adjuvants ex vivo and in vivo, assessing capacity of adjuvant-activated human DC subsets to skew differentiation of naïve CD4+ T cells into Tfh cells.
Role: Co-Investigator
NIH/NIA K76 AG054777 Smith (PI) 09/15/2016-05/31/2020
Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding Problems and Incontinence
Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)
Role: Primary Mentor; Eric Levine, PhD; Laura Haynes, PhD, and Lori Birder, PhD (co-mentors)
NIH/NIA R21 AG060018 Kuo (PI) 09/01/2018-06/30/2020
Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions using 500,000 UK Biobank Participants
We will use UK Biobank data, which features a very large sample size (500,000 participants) and rich genetic and phenotypic data, to characterize associations between ApoE2 and age-related health outcomes.
Role: Co-Investigator
NIH/NIA R01 AG058814 Smith (PI) 05/15/2019-01/31/2024
Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
The main goal of this project is to investigate the role of a “pacemaker” ion channel in the age evolution of a control mechanism critical to neural regulation of bladder volume sensitivity.
Role: Co-Investigator
NIH/NIA 75N95019P00538 Kuchel (PI) 08/19/2019-08/18/2020
Precision Geroscience: Heterogeneity in the Genetics of Inflammatory Variants and Immunogenic Responses to Exercise and Dietary Restriction with Aging
We will establish the roles of inflammatory cytokines in chronic diseases of aging, healthspan, and lifespan by examining GWAS variants in UK Biobank and gene expression data in human PBMCs after clinical interventions.
Role: PI
NIH/NIAID R01 AI142086 Banchereau (PI; Jackson Lab) 02/14/2020-01/31/2024
High-Resolution Single Cell Profiling of Vaccine Responsiveness in the Elderly
Drs. Kuchel and McElhaney will provide cryopreserved PBMC samples from earlier study of high-dose (HD) vs. standard dose (SD) flu vaccine to define key determinants of cell-mediated vaccine protection in frail older subjects. They will also assist with data analysis and manuscript preparation.
Role: Co-Investigator
NIH/NIA UH3AG056925-S1 Colon-Emeric, Whitson (PIs; Duke) 10/01/2019-09/30/2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative-Administrative Supplement
Drs. Kuchel and Banchereau will oversee study design, execution and data analysis of study of genome-wide signatures of poor and high resiliency using baseline samples of subjects with PCR-proven flu infection.
Role: Consortium Co-Investigator
NIH/NIA UH3AG056925-03 Colon-Emeric, Whitson (PIs; Duke) 10/01/2019-09/30/2022
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
Dr. Kuchel will advise on proposed analyses regarding stimulation of PBMCs as part of the PRIME-KNEE study. He will also join the study steering committee.
Role: Consultant
NIH/NIA U24AG065204 Van der Willik, Gill, Walston, Yaffe (PIs) 09/30/2019-04/30/2024
Clin-STAR Coordinating Center
Role: Member, External Advisory Committee
Accepting Lab Rotation Students: Summer '20, Fall '20, Spring '21
Research Rotation Projects
Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases training in the translational T1 (bench to bedside) sciences.
Journal Articles
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Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team.
Drugs & aging 2020 Dec;
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Incontinence in frail elderly persons: Report of the 6th International Consultation on Incontinence.
Neurourology and urodynamics 2020 Oct;
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Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.
Journal of the American Geriatrics Society 2020 Oct;
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A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin.
GeroScience 2020 Sep;
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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jul;
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Role of Sarcopenia Definition and Diagnosis in Clinical Care: Moving from Risk Assessment to Mechanism-Guided Interventions.
Journal of the American Geriatrics Society 2020 Jul;68(7):1406-1409
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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.
Aging 2020 Jun;12
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Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jun;
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Sestrins induce natural killer function in senescent-like CD8+ T cells.
Nature immunology 2020 Mar;
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International drive to illuminate delirium: A developing public health blueprint for action.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Mar;
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Clinical trial testing in-home multidisciplinary care management for older adults with cognitive vulnerability: Rationale and study design.
Contemporary clinical trials 2020 Mar;92105992
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Sexual-dimorphism in human immune system aging.
Nature communications 2020 Feb;11(1):751
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Transplanting cells from old but not young donors causes physical dysfunction in older recipients.
Aging cell 2020 Jan;e13106
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Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jan;75(1):77-86
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Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults.
Interdisciplinary topics in gerontology and geriatrics 2020 Jan;4398-112
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The lethal sex gap: COVID-19.
Immunity & ageing : I & A 2020 Jan;1713
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Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
Aging cell 2019 Aug;e13017
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The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Aug;
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Creating the Next Generation of Translational Geroscientists.
Journal of the American Geriatrics Society 2019 Jul;
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Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Jul;
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Sarcopenia and variation in the Human Leukocyte Antigen complex.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;
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Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;74(3):337-342
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Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;74(3):350-357
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Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.
Neurology 2019 Feb;
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Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.
Age and ageing 2019 Feb;
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Inclusion of Older Adults in Research: Ensuring Relevance, Feasibility, and Rigor.
Journal of the American Geriatrics Society 2019 Feb;67(2):203-204
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Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
Journal of the American Geriatrics Society 2019 Jan;
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Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.
BMJ (Clinical research ed.) 2019 Jan;364k5222
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Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Jan;74(2):261-268
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Risk Factors for Falls Among Older Adults Following Transition From Nursing Home to the Community.
Medical care research and review : MCRR 2019 Jan;1077558717697012
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Reply to: Hands-free but Nonwearable Technology Needed for Outpatient Clinical Gait-speed Assessment.
Journal of the American Geriatrics Society 2018 Oct;67184-185
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Implementing "Patient-Centered Care": A Revolutionary Change in Health Care Delivery.
Journal of the American Geriatrics Society 2018 Oct;66(10):1863-1865
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HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation.
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Aug;
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Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 May;73995
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A Relationship Between Blood Levels of Otolin-1 and Vitamin D.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2018 Apr;39(4):e269-e273
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Design and Validation of a Radio-Frequency Identification-Based Device for Routinely Assessing Gait Speed in a Geriatrics Clinic.
Journal of the American Geriatrics Society 2018 Feb;66982-986
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Blood Pressure Trajectories in the 20 Years Before Death.
JAMA internal medicine 2018 Jan;178(1):93-99
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Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years.
PloS one 2018 Jan;13(9):e0203504
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Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging 2017 Dec;9(12):2504-2520
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Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.
Journal of the American Geriatrics Society 2017 Dec;66773-782
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Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.
Experimental gerontology 2017 Sep;107116-125
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The chromatin accessibility signature of human immune aging stems from CD8(+) T cells.
The Journal of experimental medicine 2017 Sep;2143123-3144
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Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants.
The American journal of clinical nutrition 2017 Jul;106(1):130-135
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Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium.
BMC medical research methodology 2017 Jun;17(1):88
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Age-related Increase in Blood Levels of Otolin-1 in Humans.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2017 May;38865-869
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Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2017 May;72980-990
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Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.
Journal of the American Geriatrics Society 2017 May;65(5):995-1003
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MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.
Scientific reports 2017 Mar;744620
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Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study.
Biological psychiatry 2017 Jan;81(2):145-153
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Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses.
Frontiers in immunology 2017 Jan;81164
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
PloS one 2017 Jan;12(9):e0185083
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Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.
Journal of the American Geriatrics Society 2016 Nov;64e238-e247
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Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients.
The journals of gerontology. Series A, Biological sciences and medical sciences 2016 Aug;72203-209
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Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.
Aging cell 2016 Jun;15903-13
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IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.
Oncotarget 2016 Jun;739171-39183
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Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span.
Journal of women's health (2002) 2016 Jun;251086-1096
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Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.
Aging 2016 Mar;8(3):547-60
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Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.
Aging 2016 Feb;8620-35
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A Geriatric Perspective on Benign Paroxysmal Positional Vertigo.
Journal of the American Geriatrics Society 2016 Jan;64378-85
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Geriatric perspective on benign paroxysmal positional vertigo.
Journal of the American Geriatrics Society. 2016 Jan;
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Functional Brain Imaging and the Neural Basis for Voiding Dysfunction in Older Adults.
Clinics in geriatric medicine 2015 Nov;31(4):549-65
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Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice.
International journal of obesity (2005) 2015 Jul;40129-37
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Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery.
The journals of gerontology. Series A, Biological sciences and medical sciences 2015 Jul;70(10):1289-95
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Urinary incontinence in frail elderly persons: Report from the 5th International Consultation on Incontinence.
Neurourology and urodynamics 2015 Jun;34(5):398-406
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Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12.
BMC geriatrics 2015 Jan;15146
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Advanced therapeutic directions to treat the underactive bladder.
International urology and nephrology 2014 Sep;46 Suppl 1S35-44
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Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston study.
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2014 Sep;56(9):e73-7
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Vitamin D insufficiency and abnormal hemoglobin a1c in black and white older persons.
The journals of gerontology. Series A, Biological sciences and medical sciences 2014 Aug;70(4):525-31
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HIV and aging: a clinical journey from Koch's postulate to the chronic disease model and the contribution of geriatric syndromes.
Current opinion in HIV and AIDS 2014 Jul;9(4):405-11
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Overactive bladder in the vulnerable elderly.
Research and reports in urology 2014 Jan;6131-8
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C-reactive protein, vitamin D deficiency, and slow gait speed.
Journal of the American Geriatrics Society 2013 Aug;61(9):1574-9
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Editorial comment.
The Journal of urology 2013 May;189(5):1810
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Stroke severity and outcomes for octogenarians receiving statins.
Archives of gerontology and geriatrics 2013 Jan;57(3):377-82
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Gender differences in anthropometric predictors of physical performance in older adults.
Gender medicine 2012 Dec;9(6):445-56
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Interventional stroke therapies in the elderly: are we helping?
AJNR. American journal of neuroradiology 2012 Apr;33(4):638-42
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Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse.
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Mar;302(5):R577-86
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Evidence of central modulation of bladder compliance during filling phase.
Neurourology and urodynamics 2012 Jan;31(1):30-5
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Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons.
Hippocampus 2011 Jun;21(6):661-77
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The blood-brain barrier: geriatric relevance of a critical brain-body interface.
Journal of the American Geriatrics Society 2010 Sep;58(9):1749-57
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Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women.
Bone 2010 Aug;47(2):424-9
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White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults.
Journal of the American Geriatrics Society 2010 Feb;58(2):275-81
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Macrophage migration inhibitory factor inhibits osteoclastogenesis.
Bone 2009 Oct;45(4):640-9
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Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009 Aug;64(8):902-9
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Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice.
Prostaglandins & other lipid mediators 2009 Jan;88(1-2):36-41
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Chemokines are associated with delirium after cardiac surgery.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008 Feb;63(2):184-9
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Measurement of muscle disease by quantitative second-harmonic generation imaging.
Journal of biomedical optics 2008 Jan;13(4):044018
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Functional impact of relative versus absolute sarcopenia in healthy older women.
Journal of the American Geriatrics Society 2007 Nov;55(11):1712-9
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The effect of 3-year treatment with 0.25 mg/day of micronized 17beta-estradiol on cognitive function in older postmenopausal women.
Journal of the American Geriatrics Society 2007 Mar;55(3):426-31
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Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction.
American journal of physiology. Renal physiology 2006 Dec;291(6):F1343-53
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Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder.
Cell and tissue research 2005 Apr;320(1):115-25
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Estrogen replacement raises rat CRP without evidence of complement activation.
Endocrine research 2005 Jan;31(2):121-32
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Pelvic floor muscle training with biofeedback and bladder training in elderly women: a feasibility study.
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society / WOCN 2005 Jan;32(3):186-99
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Estrogen and postnatal maturation increase caveolar number and caveolin-1 protein in bladder smooth muscle cells.
The Journal of urology 2004 Jan;171(1):467-71
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Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents.
The Journal of urology 2001 Sep;166(3):1136-41
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Ovariectomy up-regulates neuronal neurofilament light chain mRNA expression with regional and temporal specificity.
Neuroscience 2001 Jan;103(3):629-37
Book Chapters
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Aging of the Urinary Tract
Brocklehurst's Textbook of Geriatrics and Clinical Gerontology 2010 Jan;
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Aging, Animal Model
Encyclopedia of Endocrine Diseases 2004 Jan;126-130
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Influenza Vaccination: Accelerating the process for new vaccine development in older adults
Vaccines for the older population
Abstracts
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Upside-Down Stomach in a 92-year-old Woman
J Am Geriatr Soc 2007 Jan;55(8):1307-9
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Macrophage migration inhibitory factor mediates smooth muscle death in bladder outlet obstruction.
J Urol 2005 Jan;17338
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Null mutation in macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
J Am Geriatr Soc. 2005 Jan;538
Conference Papers
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Mice with a null mutation for macrophage migration inhibitory factor have lower stage tumors in a model of bladder cancer.
Taylor won New Investigator Award.
2006 Jan;
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Locomotion in vitamin D receptor gene knockout mice.
2005 Jan;
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Macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
2005 Jan;
Editorials
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Editorial Comment.
The Journal of urology 2019 Aug;10109701JU00005803687322725
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Frailty and Resilience as Outcome Measures in Clinical Trials and Geriatric Care: Are We Getting Any Closer?
Journal of the American Geriatrics Society 2018 Aug;661451-1454
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Reduce the burden of dementia now.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Jul;14(7):845-847
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Physical Resilience: Not Simply the Opposite of Frailty.
Journal of the American Geriatrics Society 2018 Mar;661459-1461
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Function Begets Function and Resilience in Old Age: Is Precision Gerontology Possible?
Journal of the American Geriatrics Society 2017 May;651141-1144
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Clinical Meaning of a High Postvoid Residual: When the Value of a Result Is Less and More than One Would Expect.
Journal of the American Geriatrics Society 2015 Jul;63(7):1432-4
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Moving beyond static body composition paradigms to assessments of change, plasticity, and function.
Journal of the American Geriatrics Society 2010 Feb;58(2):377-9
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Frailty, allostatic load, and the future of predictive gerontology.
Journal of the American Geriatrics Society 2009 Sep;57(9):1704-6
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Nutrition and inflammation: the missing link between periodontal disease and systemic health in the frail elderly?
Journal of clinical periodontology 2006 May;33(5):309-11
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Burn brightly
Connecticut Medicine 2003 Jan;67(8):453
Erratums
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Erratum: Estrogen replacement raises rat CRP without evidence of complement activation (Endocrine Research (2005) 32 (121-132))
Endocrine Research 2005 Jan;31(4):407
Letters
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ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jul;
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APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 May;
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Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers.
Translational stroke research 2018 Oct;
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Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up In 186,000 U.K. Biobank Participants.
Journal of the American College of Cardiology 2016 Aug;68(8):874-5
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Re: Lai HH, Boone TB, Thompson TC, et al: Using caveolin-1 knockout mouse to study impaired detrusor contractility and disrupted muscarinic activity in the aging bladder. Urology 69: 407-411, 2007.
Urology 2008 Jun;71(6):1227-8; author reply 1228-9
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A physiological explanation for an unexpected benefit of carotid endarterectomy.
Journal of the American Geriatrics Society 2007 Aug;55(8):1310-1
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Response letter to Drs. Rockwood and Mitnitski [3]
Journal of the American Geriatrics Society 2007 Jan;55(12):2092-2093
Reviews
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The Prevention of Infections in Older Adults: Vaccination.
Journal of the American Geriatrics Society 2019 Oct;
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Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.
Drugs & aging 2018 Nov;3629-37
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Sex differences in lower urinary tract biology and physiology.
Biology of sex differences 2018 Oct;9(1):45
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A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.
GeroScience 2018 Aug;40419-436
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Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.
Frontiers in immunology 2017 Jan;8784
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T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines.
Frontiers in immunology 2016 Jan;741
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Incontinence in the frail elderly: report from the 4th International Consultation on Incontinence.
Neurourology and urodynamics 2010 Jan;29(1):165-78
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Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction.
Nature clinical practice. Urology 2009 Mar;6(3):135-44
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ELISA and multiplex technologies for cytokine measurement in inflammation and aging research.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008 Aug;63(8):879-84
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Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.
Journal of the American Geriatrics Society 2007 May;55(5):780-91
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Detrusor underactivity: Clinical features and pathogenesis of an underdiagnosed geriatric condition.
Journal of the American Geriatrics Society 2006 Dec;54(12):1920-32
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Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk.
Molecular aspects of medicine 2005 Jun;26(3):181-201
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Evaluation and management of urinary incontinence in elderly women.
Connecticut medicine 2003 Sep;67(8):491-5
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Promoting healthy and successful aging in everyday clinical practice.
Connecticut medicine 2003 Sep;67(8):455-60
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Can variability in the hormonal status of elderly women assist in the decision to administer estrogens?
Journal of women's health & gender-based medicine 2001 Mar;10(2):109-16
Short Surveys
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Pharmacological approaches to cognitive deficits and incontinence (1899-2002): progress in geriatric care.
Trends in pharmacological sciences 2002 Apr;23(4):192-3
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective. | Plenary Lecture | 2019 SUFU Annual Meeting | 2019 | Miami, FL |
Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience. | Talk | Robert and Arlene Kogod Aging Center, Mayo Clinic | 2018 | Mayo Clinic, Rochester, MN |
Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights. | Talk | Department of Medicine, Montefiore Medical Center | 2018 | New York, NY |
Biomarkers for geroscience-guided clinical trials | Talk | NIA P30 Claude D. Pepper Older Americans Independence Center | 2018 | Arlington, VA |
Role of Biomarkers in Aging and Vitality | Talk | WHO Clinical Consortium on Healthy Aging meeting on Vitality | 2018 | New York, NY |
Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME. | Talk | 9th Annual Alliance for Healthy Aging Research, Mayo Clinic | 2018 | Rochester, MN |
New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms. | Talk | NIA Workshop on the Epidemiology of Aging. NIA Intramural Program | 2018 | Baltimore, MD |
Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience. | Plenary Lecture | 31st Annual Meeting of the Canadian Society for Immunology | 2018 | London, Ont. Canada |