Education

Degree	Institution	Major
Other	Vanier College	Health Sciences
Other	McGill Medical School	Medicine

Post-Graduate Training

Training	Institution	Specialty
Internship	Montreal General Hospital	Internal Medicine
Residency	Montreal General Hospital	Internal Medicine
Postdoctoral	Harvard Medical School	Kaiser, Faculty Development Program in General Internal Medicine
Fellowship	Harvard Medical School, Division on Aging and Beth Israel Hospital	Geriatrics and Gerontology
Postdoctoral	Harvard Medical School	Biological Chemistry and Molecular Pharmacology
Postdoctoral	Mount Sinai Medical Center	Neurobiology and Gerontology

Awards

Name of Award/Honor	Awarding Organization
Brookdale Senior Fellow, New York	Brookdale Foundation
John A. Hartford Leadership Award
Travelers/Citicorp Chair in Geriatrics and Gerontology	University of Connecticut
Montreal General Hospital 175th Anniversary Award	Montreal General Hospital
Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec
Fellowship	Medical Research Council of Canada
Brookdale National Fellow	Brookdale Foundation
Royal Canadian Legion Fellowship in Geriatric Medicine
Mona Bronfman Scheckman Prize in Psychiatry	McGill
University Scholar	McGill

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Aging Systems and Geriatrics Study Section, NIH/CSR	Study Section	Chair	External	National	2008	2011
Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR	Study Section	Member	External	National	2007	2011
Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut	Advisory Committee	Advisory Board	External	University	2002
Older Americans Independence Center, University of Connecticut	Professional/Scientific Organization	Director	External	University	2001	2004
MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill	Education Committee	Committee Member	External	University	1998	2001
Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ	Professional/Scientific Organization	Director	External	University	1998	2001
Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ	Professional/Scientific Organization	Co-PI	External	University	1996	1999
Research fellow, Neurobiology, Mount Sinai School of Medicine, New York	Professional/Scientific Organization	Fellow	External	University	1989	1992
Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School	Professional/Scientific Organization	Fellow	External	University	1987	1989
Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School	Education Committee	Member	External	University	1985	1986

RESEARCH INTERESTS:

1. Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense


2. Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging


3. Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”

Current Research Support

NIH/NIA R33 AG061456       Kirkland, Kritchevsky, Kuchel (MPIs)       02/01/2019-11/30/2023
Translational Geroscience Network
The role of the NIA Translational Geroscience Network (TGN) is to develop a consortium of academic programs in geriatrics focused on overcoming barriers to the translation of new geroscience-guided therapies from bench research to human studies and ultimately clinical care.
Role: Multiple PI (MPI)

NIH/NIA R21 AG063528       Kuchel, Xu, Smith (MPIs)       04/15/2019-12/31/2020
Role of Senolytics in Lower Urinary Tract Aging and Voiding Disorders
Our goal is to test senolytic drugs that target senescent cells throughout the body including the bladder and nervous system for their ability to prevent or slow the onset of bladder dysfunction in mouse models of aging.
Role: Multiple PI

NIH/NIA R56 AG060746       Oh, Robison, Kuchel (MPIs)       09/01/2019-08/31/2020
Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing Care
We will examine differences in microbiomes between older adults residing in different long-term care facilities and follow their return to the community, assessing baseline differences and microbiome “plasticity” on transition.
Role: Multiple PI

IHS-1502-27171 (PCORI)       Fortinsky (PI)       05/01/2016-09/30/2023
3D Team Care for Cognitively Vulnerable Older Adults
Achieving better outcomes for cognitively vulnerable community-dwelling older adults living with dementia, depression, and/or delirium via home-based clinical care teams guided by APRNs with geriatrics expertise.
Role: Co-Investigator

NIH/NIA R01 AG051647       Binder (PI; Washington U)       09/15/2017-05/31/2022
Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture
Dr. Fortinsky and Dr. Kuchel (site Co-PIs) will work with others to perform a multicenter randomized clinical trial of testosterone therapy and exercise training on functional capacity in frail older women post hip fracture.
Role: Co-investigator

NIH/NIGMS R35 GM124922       Ucar (PI; Jackson Lab)       08/01/2017-07/31/2022
Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells
The goal of these studies is to define chromatin changes associated with aging in human immune cells.
Role: Co-Investigator

NIH/NIAID R01 AG052608       Banchereau (PI; Jackson Lab)       09/01/2016-04/30/2020
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
We are evaluating the impact of aging on genomic and epigenomic responses within peripheral white blood cells upon administration of pneumococcal vaccines, PPSV23 (Pneumovax®) and PCV13 (Prevnar®).
Role: Co-Investigator

NIH/NIAID U01 AI124297       Banchereau (PI; Jackson Lab)       04/15/2016-03/31/2021
Combination Adjuvants to Activate Human Dendritic Cell Subsets and B Cells
We are studying human dendritic cell (DC) subsets exposed to adjuvants ex vivo and in vivo, assessing capacity of adjuvant-activated human DC subsets to skew differentiation of naïve CD4+ T cells into Tfh cells.
Role: Co-Investigator

NIH/NIA K76 AG054777       Smith (PI)       09/15/2016-05/31/2020
Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding Problems and Incontinence
Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)
Role: Primary Mentor; Eric Levine, PhD; Laura Haynes, PhD, and Lori Birder, PhD (co-mentors)

NIH/NIA R21 AG060018       Kuo (PI)        09/01/2018-06/30/2020
Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions using 500,000 UK Biobank Participants
We will use UK Biobank data, which features a very large sample size (500,000 participants) and rich genetic and phenotypic data, to characterize associations between ApoE2 and age-related health outcomes.
Role: Co-Investigator

NIH/NIA R01 AG058814       Smith (PI)       05/15/2019-01/31/2024
Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
The main goal of this project is to investigate the role of a “pacemaker” ion channel in the age evolution of a control mechanism critical to neural regulation of bladder volume sensitivity.
Role: Co-Investigator

NIH/NIA 75N95019P00538       Kuchel (PI)       08/19/2019-08/18/2020
Precision Geroscience: Heterogeneity in the Genetics of Inflammatory Variants and Immunogenic Responses to Exercise and Dietary Restriction with Aging
We will establish the roles of inflammatory cytokines in chronic diseases of aging, healthspan, and lifespan by examining GWAS variants in UK Biobank and gene expression data in human PBMCs after clinical interventions.
Role: PI

NIH/NIAID R01 AI142086       Banchereau (PI; Jackson Lab)       02/14/2020-01/31/2024
High-Resolution Single Cell Profiling of Vaccine Responsiveness in the Elderly
Drs. Kuchel and McElhaney will provide cryopreserved PBMC samples from earlier study of high-dose (HD) vs. standard dose (SD) flu vaccine to define key determinants of cell-mediated vaccine protection in frail older subjects. They will also assist with data analysis and manuscript preparation.
Role: Co-Investigator

NIH/NIA UH3AG056925-S1       Colon-Emeric, Whitson (PIs; Duke)       10/01/2019-09/30/2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative-Administrative Supplement
Drs. Kuchel and Banchereau will oversee study design, execution and data analysis of study of genome-wide signatures of poor and high resiliency using baseline samples of subjects with PCR-proven flu infection. 
Role: Consortium Co-Investigator

NIH/NIA UH3AG056925-03       Colon-Emeric, Whitson (PIs; Duke)       10/01/2019-09/30/2022
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
Dr. Kuchel will advise on proposed analyses regarding stimulation of PBMCs as part of the PRIME-KNEE study. He will also join the study steering committee.
Role: Consultant

NIH/NIA U24AG065204       Van der Willik, Gill, Walston, Yaffe (PIs)        09/30/2019-04/30/2024
Clin-STAR Coordinating Center
Role: Member, External Advisory Committee

Accepting Lab Rotation Students: Summer '20, Fall '20, Spring '21

Research Rotation Projects

Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases  training in the translational T1 (bench to bedside) sciences.

Journal Articles

Book Chapters

Abstracts

Conference Papers

Editorials

Erratums

Letters

Reviews

Short Surveys

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective.	Plenary Lecture	2019 SUFU Annual Meeting	2019	Miami, FL
Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience.	Talk	Robert and Arlene Kogod Aging Center, Mayo Clinic	2018	Mayo Clinic, Rochester, MN
Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights.	Talk	Department of Medicine, Montefiore Medical Center	2018	New York, NY
Biomarkers for geroscience-guided clinical trials	Talk	NIA P30 Claude D. Pepper Older Americans Independence Center	2018	Arlington, VA
Role of Biomarkers in Aging and Vitality	Talk	WHO Clinical Consortium on Healthy Aging meeting on Vitality	2018	New York, NY
Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME.	Talk	9th Annual Alliance for Healthy Aging Research, Mayo Clinic	2018	Rochester, MN
New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms.	Talk	NIA Workshop on the Epidemiology of Aging. NIA Intramural Program	2018	Baltimore, MD
Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience.	Plenary Lecture	31st Annual Meeting of the Canadian Society for Immunology	2018	London, Ont. Canada