Faculty Directory > Kuchel, George
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George A. Kuchel, MD CM, FRCP, AGSF, FAAASProfessor of Medicine, Travelers Chair in Geriatrics and GerontologyDirector, UConn Center on Aging, University of Connecticut Director, UConn Pepper Center (P30AG067988) Director, Geroscience Education and Training Network (R25AG073119) Director, KAPP-Sen Tissue Mapping Center (U54AG075941)
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- Education & Training
- Clinical Interests
- Teaching
- Committees & Organizations
- Research
- Research Opportunities
- Lab Rotations
- Publications
- Presentations
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| Other | Vanier College | Health Sciences |
| Other | McGill Medical School | Medicine |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Internship | Montreal General Hospital | Internal Medicine |
| Residency | Montreal General Hospital | Internal Medicine |
| Postdoctoral | Harvard Medical School | Kaiser, Faculty Development Program in General Internal Medicine |
| Fellowship | Harvard Medical School, Division on Aging and Beth Israel Hospital | Geriatrics and Gerontology |
| Postdoctoral | Harvard Medical School | Biological Chemistry and Molecular Pharmacology |
| Postdoctoral | Mount Sinai Medical Center | Neurobiology and Gerontology |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Fellow AAAS | AAAS - American Association for the Advancement of Science |
| Fellow, American College of Physicians | American College of Physicians |
| UConn Institute for Collaboration on Health, Intervention and Policy (InCHIP) Excellence in Faculty Mentoring Award, 2023 | Excellence in Faculty Mentoring Award |
| Elected Member | Academy for Health and Lifespan Research |
| Carole and Ray Neag Medal of Honor | University of Connecticut |
| Fellow | Gerontological Society of America |
| Brookdale Senior Fellow, New York | Brookdale Foundation |
| Fellow | American Geriatrics Society |
| John A. Hartford Leadership Award | John A. Hartford Foundation, New York |
| Travelers Chair in Geriatrics and Gerontology | University of Connecticut |
| Montreal General Hospital 175th Anniversary Award | Montreal General Hospital, McGill University |
| Chercheur-Boursier Award | Fonds de la Recherche en Santé du Québec |
| Fellowship | Medical Research Council of Canada |
| Brookdale National Fellow | Brookdale Foundation |
| Royal Canadian Legion Fellowship in Geriatric Medicine | Royal College of Physicians and Surgeons of Canada |
| McGill - Mona Bronfman Scheckman Prize in Psychiatry | McGill University |
| McGill University Scholar | McGill University |
Individualized Approaches to Geroscience-Guided Interventions for the Promotion of Healthy and Independent Aging
Geriatric Assessment
R25AG073119 NIA/NIH. Kuchel (contact MPI) Espinoza, Justice, Newman, Pignolo (MPIs) 07/2021-06/2024
NIA Geroscience Education and Training (GET) Network
Geroscience-guided therapies seeking to alleviate chronic conditions of aging as a group by targeting basic aging processes are now entering clinical trials. The discovery, validation and translation into routine clinical care of such transformational therapies will require a robust and diverse geroscience workforce and training pipeline. We are proposing the creation of a network model designed to integrate expertise, knowledge, and resources across multiple institutions and organizations in addressing the following Aims. Aim 1: Develop shared geroscience curricula and educational materials initially targeting medical, PhD students and geriatric medicine fellows. Aim 2: Develop a Certificate in Geroscience Research Program to train the next generation of geroscience researchers by offering multidisciplinary training in geroscience. Aim 3: Ensure optimal dissemination of the educational materials developed through this award.
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| ADGAP - Association of Directors of Geriatrics Academic Programs. | President | National | 2024 | |||
| Aging Cell. | Editorial Board | Editorial Board Member | External | International | 2023 | |
| Immunity and Ageing. | Editorial Board | Member, Editorial Board | International | 2023 | ||
| Special Issue. 50th Anniversary National Institute on Aging. Journal of the American Geriatrics Society. | Other | International | 2023 | 2024 | ||
| Special Issue on Lower Urinary Tract Aging and Incontinence. Journal of Gerontology Medical Sciences. | Other | International | 2023 | 2024 | ||
| External Advisory Board, University of Michigan Pepper Center | Advisory Committee | Member, External Advisory Board | National | 2023 | ||
| External Advisory Board, Wake Forest Pepper Center | Member, External Advisory Board | National | 2023 | |||
| External Advisory Board, University of Texas Health Sciences Center San Antonio Pepper Center | Member, External Advisory Board | State | 2023 | |||
| Scientific Advisory Board, Buck Institute for Research on Aging | Member, External Advisory Board | International | 2023 | |||
| Member, Scientific Advisory Board, XPRIZE Foundation, Culver City, CA | Member, External Advisory Board | International | 2023 | |||
| National Institute on Aging (NIA), National Advisory Council on Aging (NACA), Review of the Division of Aging Biology (DAB), 2021-2022 | Advisory Committee | Member | External | National | 2021 | 2022 |
| Member, External Advisory Board, UCSF Bakar Aging Research Institute, University of California at San Francisco, | Advisory Committee | Member | External | National | 2021 | |
| Member, External Scientific Advisory Board (NIA P30AG028740) Claude D Pepper Older Americans Independence Center at the University of Florida, | Advisory Committee | Member | External | National | 2021 | |
| Member, External Advisory Committee, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN. | Advisory Committee | Member | External | National | 2021 | 2022 |
| Member, Delirium Expert Task Force, Global Council on Brain Health, AARP | Advisory Committee | Advisory Board | External | International | 2019 | 2019 |
| Member, Advisory Board, resTORbio, Cambridge, MA | Advisory Committee | Advisory Board | International | 2019 | 2020 | |
| NIA Access Panel of the Caenorhabditis Intervention Testing Program (CITP) | Advisory Committee | Member | External | National | 2019 | 2024 |
| Board of Directors, Association of Directors of Geriatric Academic Programs (ADGAP) | Professional/Scientific Organization | Member | External | National | 2019 | |
| External Scientific Advisory Board, PAWEL Trial (Patient safety, cost effectiveness & quality of life): Reduction of delirium risk and post-operative decline in elective surgery in the elderly. Universities of Tübingen, Freiburg and Ulm, Germany; PI: Dr Christine Thomas, 2017- | Advisory Committee | Advisory Board | External | International | 2017 | |
| Member, External Scientific Advisory Board (NIA P30AG02482), The University of Pittsburgh Claude D Pepper Older Americans Independence Center | Advisory Committee | Advisory Board | External | National | 2016 | 2020 |
| Deputy Editor, Journal of the American Geriatrics Society | Editorial Board | Deputy Editor | External | International | 2016 | 2024 |
| NIA Clinical Trials Advisory Panel (CTAP) | Advisory Committee | Member | External | National | 2016 | 2020 |
| Journal of the American Geriatrics Society (JAGS) | Editorial Board | Deputy Editor | External | International | 2016 | 2024 |
| Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut | Other | External | University | 2002 | ||
| MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill | Education Committee | Committee Member | External | University | 1998 | 2001 |
| Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ | Professional/Scientific Organization | Director | External | University | 1998 | 2001 |
| Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ | Professional/Scientific Organization | Co-PI | External | University | 1996 | 1999 |
| Research fellow, Neurobiology, Mount Sinai School of Medicine, New York | Professional/Scientific Organization | Fellow | External | University | 1989 | 1992 |
| Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School | Professional/Scientific Organization | Fellow | External | University | 1987 | 1989 |
| Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School | Education Committee | Member | External | University | 1985 | 1986 |
| Member, AFAR-American Federation for Aging Research, National Scientific Advisory Council | Advisory Committee | reviewer | External | International | ||
| Member, Scientific Advisory Board, Jackson Laboratory NCI Cancer Center, | Advisory Committee | Member | External | National |
RESEARCH INTERESTS:
- Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense
- Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging
- Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”
CURRENT RESEARCH FUNDING:
NIH/NIA P30 AG067988 Kuchel and Fortinsky (MPIs) 8/15/2021-06/30/2026. UConn Claude D. Pepper Older Americans Independence Center. The Claude D Pepper Older Americans Independence Center at UConn (UConn OAIC) seeks to develop clinical strategies for enhancing function and independence in older adults that are more precise, personalized, and effective accomplished through a multidisciplinary emphasis on Precision Gerontology. Role: MPI (Contact)
NIAID/NIH U01 AI165452 A deep longitudinal analysis of next generation influenza vaccines in older adults. MPIs: Duygu Ucar (Jackson Lab), Adolfo Garcia-Sastre (Mount Sinai), George Kuchel (UConn). 1/1/2022 – 2/28/2027. - Multiple PI
NIH/NIA R33 AG061456 Kirkland, Kritchevsky, Kuchel, Tchkonia (MPIs) 2/01/2019-11/30/2023. Translational Geroscience Network. The role of the NIA Translational Geroscience Network (TGN) is to overcome barriers to the translation of new geroscience-guided therapies from bench research to human studies and ultimately clinical care. Role: Multiple PI (MPI). See link for more information on the TGN network (https://www.gerosciencenetwork.org/).
NIH/NIA U54AG075941. Kuchel, Garovic, Musi, Robson (MPIs). 9/30/21-8/31/22. The KAPP-Sen Tissue Mapping Center Collaborative. As part of the Cellular Senescence Network: Tissue Mapping Centers initiative (RFA-RM-21-008), KAPP-Sen brings together skills, resources, and perspectives needed to address SenNet goals across 6 sites (UConn Health, Jackson Laboratory for Genomic Medicine, Brigham and Womens Hospital, Joslin Clinic, Mayo Clinic and University of Texas Health Sciences Center at San Antonio) in the framework of the healthy human Kidney, Adipose tissues, Pancreas, and Placenta. Role: MPI (Contact) and Leader Administrative Core
R25AG073119 NIA/NIH. Kuchel (contact MPI UConn) Espinoza (UT San Antonio), Justice (Wake Forest), Newman (UCSF/Buck Institute), Pignolo (Mayo) -MPIs; 07/2021-06/2026. NIA Geroscience Education and Training (GET) Network. Geroscience-guided therapies seeking to alleviate chronic conditions of aging as a group by targeting basic aging processes are now entering clinical trials. The discovery, validation and translation into routine clinical care of such transformational therapies will require a robust and diverse geroscience workforce and training pipeline. We are proposing the creation of a network model designed to integrate expertise, knowledge, and resources across multiple institutions and organizations in addressing the following Aims. Aim 1: Develop shared geroscience curricula and educational materials initially targeting medical, PhD students and geriatric medicine fellows. Aim 2: Develop a Certificate in Geroscience Research Program to train the next generation of geroscience researchers by offering multidisciplinary training in geroscience. Aim 3: Ensure optimal dissemination of the educational materials developed through this award.
NIH/NIA R01 AG051647 Binder (PI, Washington U) 9/15/2017-05/31/2022. Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture. Dr. Richard Fortinsky and Dr. Kuchel (site Co-PIs) are site leaders of a multicenter randomized clinical trial of testosterone therapy and exercise training on functional capacity in frail older women following hip fracture. Role: Co-Investigator
NIH/NIAID R01 AI142086 Banchereau(PI; Jackson Lab)02/14/2020-01/31/2024. High-Resolution Single Cell Profiling of Vaccine Responsiveness in the Elderly. Cell-mediated vaccine protection will be studied in samples from earlier flu vaccine study. Role: Co-Investigator
IHS-1502-27171 (PCORI) Fortinsky (PI) 05/01/2016-10/31/2023. 3D Team Care for Cognitively Vulnerable Older Adults. Achieving better outcomes for cognitively vulnerable community-dwelling older adults living with dementia, depression, and/or delirium via home-based clinical care teams guided by APRNs with geriatrics expertise. Role: Co-Investigator
NIH/NIA R01 AG058814 Kuchel and Levine (MPIs) 05/15/2019-01/31/2024. Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging. The main goal of this project is to investigate the role of a “pacemaker” ion channel in the age evolution of a control mechanism critical to neural regulation of bladder volume sensitivity. Role: Contact MPI
NIH/NIA R21 AG060018-02S1 Kuo (PI) 09/01/2020-06/30/2021.Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions Using 500,000 UK Biobank Participants-Administrative Supplement. We hypothesize that patients with ApoE e3e4 or e4e4 genotypes are more likely than e3e3 to experience delirium during COVID-19 related hospitalizations and be diagnosed with cognitive impairment and dementia. Role: Co-Investigator
NIH/NIGMS R35 GM124922 Ucar (PI; Jackson Lab) 08/01/2017-07/31/2022. Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells. The goal of these studies is to define chromatin changes associated with aging in human immune cells. Role: Co-Investigator
NIH/NIA UH3AG056925-S1 Colon-Emeric, Whitson (PIs; Duke) 09/30/2019-08/31/2021. Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative-Administrative Supplement. Immunogenomic signatures of resilience in baseline samples of subjects with PCR-proven flu infection. Role: Consortium Co-Investigator
NIH/NIA UH3AG056925-03 Colon-Emeric, Whitson (PIs; Duke)10/01/2019-09/30/2022. Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative Role: Consultant
NIH/NINR R21 NR018963 Kuo (PI) 09/02/2020-07/31/2022. Identifying Potentially Modifiable Exposures to Improve Telomere Health and Disease Outcomes. We will use UK Biobank data to delineate modifiable exposures that directly influence or moderate telomere length, and how these influence health and risk of disease. Role: Co-Investigator
NIH/NIA R01 AG072301 Kirkland (PI; Mayo) 09/15/2020-05/31/2023. COVID-FIS: A phase 2 placebo-controlled pilot study in covid-19 of fisetin to alleviate dysfunction and excessive inflammatory response in older adults in nursing homes. RCT to test if senolytic drug fisetin prevents nursing home residents with COVID-19 from adverse outcomes Role: Co-Investigator/Site PI UConn
NIH/NIA R56 AG060746 Oh, Robison, Kuchel (MPIs) 9/01/2019-08/31/2021. Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing Care. We will examine differences in microbiomes between older adults residing in different long-term care facilities and follow their return to the community, assessing baseline differences and microbiome “plasticity” on transition. Role: Multiple PI
Accepting Lab Rotation Students: Spring 1 and 2 Block 2025
Research Rotation Projects
Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases training in the translational T1 (bench to bedside) sciences.
Journal Articles
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Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.
Kuchel, George A; Hevener, Andrea L; Ruby, J Graham; Sebastiani, Paola; Kumar, Vivek The Journals of Gerontology. Series A, Biological sciences and medical sciences 2025 Mar;80(4):
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Expanding Geroscience to Vulnerable Populations in mid-late life: Medicaid home- and community-based service users and formerly incarcerated individuals.
Fortinsky, Richard H; Al-Naggar, Iman M; Barry, Lisa C; Dillon, Ellis C; Kuchel, George A; Robison, Julie The Journals of Gerontology. Series A, Biological sciences and medical sciences 2025 Feb;
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Real-World Insights Into Dementia Diagnosis Trajectory and Clinical Practice Patterns Unveiled by Natural Language Processing: Development and Usability Study.
Paek, Hunki; Fortinsky, Richard H; Lee, Kyeryoung; Huang, Liang-Chin; Maghaydah, Yazeed S; Kuchel, George A; Wang, Xiaoyan JMIR Aging. 2025 Feb;8e65221
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SenSkin™: a human skin-specific cellular senescence gene set.
Wyles, Saranya P; Yu, Grace T; Ganier, Clarisse; Tchkonia, Tamar; Lynch, Magnus D; Kuchel, George A; Kirkland, James L GeroScience. 2025 Feb;
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Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.
Kritchevsky, Stephen; Zamora, Ezequiel; Bhasin, Shalender; Cohen, Alan; Chandler, Allison; Covinsky, Kevin; Crane, Heidi; Cummings, Steven; Erlandson, Kristine; Espeland, Mark; Espinoza, Sara; Ferrucci, Luigi; Fleming, Alexander; Forman, Daniel; LaCroix-Fralish, Michael; Gonzales, Mitzi; Justice, Jamie; Kiel, Douglas; Kuchel, George; Mannick, Joan; Menetski, Joseph; Miller, Michael; Musi, Nicolas; Newman, Anne; Newman, John; Owens, Sarah Simpson; Pandey, Ambarish; Reilly, Kandice; Sedrak, Mina; Wagner, John; Whitson, Heather; Williamson, Jeff Research square 2025 Feb;
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Expanded Recommendations for Use of Pneumococcal Conjugate Vaccines Among Adults Aged ≥50 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024.
Kobayashi, Miwako; Leidner, Andrew J; Gierke, Ryan; Xing, Wei; Accorsi, Emma; Moro, Pedro; Kamboj, Mini; Kuchel, George A; Schechter, Robert; Loehr, Jamie; Cohen, Adam L MMWR. Morbidity and Mortality Weekly Report. 2025 Jan;74(1):1-8
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Interactions between vitamin D deficiency and inflammation on diabetes risk: data from 336,500 UK Biobank adults: Short title Vitamin D Deficiency, Inflammation, and Diabetes.
Kositsawat, Jatupol; Zhao, Shangshu; Kuchel, George A; Barry, Lisa C; Fortinsky, Richard H; Kirk, Ben; Duque, Gustavo; Kuo, Chia-Ling The Journal of Nutrition, Health & Aging. 2024 Dec;29(2):100446
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Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics.
Al-Naggar, Iman M; Antony, Maria; Baker, Dylan; Wang, Lichao; Godoy, Lucas Da Cunha; Kuo, Chia-Ling; Fraser, Matthew O; Smith, Phillip P; Xu, Ming; Kuchel, George A Aging Cell. 2024 Dec;e14399
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Diagnostic power of serum creatinine/cystatin C ratio for identifying low MRI-muscle volume and low grip strength: Data from 9,731 to 149,707 UK Biobank older adults.
Kirk, Ben; Kuo, Chia-Ling; Liu, Peiran; Xiang, Meiruo; Zanker, Jesse; Prokopidis, Konstantinos; Sim, Marc; Fortinsky, Richard H; Kuchel, George A; Duque, Gustavo The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Nov;
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Vaccinations in older adults: Optimization, strategies, and latest guidelines.
Pangilinan, Aileen R; Brangman, Sharon A; Gravenstein, Stefan; Schmader, Kenneth; Kuchel, George A Journal of the American Geriatrics Society. 2024 Oct;
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Emergency Department Boarding Time Is Associated with Functional Decline in Older Adults Six Months Post Discharge.
Duquette, Caroline L; Andrew, Melissa K; Kuchel, George A; Clarke, Jo-Anne; Ohle, Robert; Verschoor, Chris P Canadian Journal on Aging. 2024 Sep;1-9
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Challenges and recommendations for the translation of biomarkers of aging.
Biomarkers of Aging Consortium; Herzog, Chiara M S; Goeminne, Ludger J E; Poganik, Jesse R; Barzilai, Nir; Belsky, Daniel W; Betts-LaCroix, Joe; Chen, Brian H; Chen, Michelle; Cohen, Alan A; Cummings, Steven R; Fedichev, Peter O; Ferrucci, Luigi; Fleming, Alexander; Fortney, Kristen; Furman, David; Gorbunova, Vera; Higgins-Chen, Albert; Hood, Lee; Horvath, Steve; Justice, Jamie N; Kiel, Douglas P; Kuchel, George A; Lasky-Su, Jessica; LeBrasseur, Nathan K; Maier, Andrea B; Schilling, Birgit; Sebastiano, Vittorio; Slagboom, P Eline; Snyder, Michael P; Verdin, Eric; Widschwendter, Martin; Zhavoronkov, Alex; Moqri, Mahdi; Gladyshev, Vadim N Nature Aging. 2024 Sep;
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Bringing Geroscience into the Mainstream: From Education to Clinical Practice, What Will It Take?
Al-Naggar, Iman M; Campellone, Kenneth G; Espinoza, Sara E; Justice, Jamie N; Orr, Miranda E; Kozikowski, Chester; van der Willik, Odette; Thatcher, Christine; Schmader, Kenneth; Pignolo, Robert J; Newman, John C; Kuchel, George A. The Journals of Gerontology. Series A, Biological sciences and medical sciences. 2024 Sep;79(9):
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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
Wang, Binsheng; Wang, Lichao; Gasek, Nathan S; Kuo, Chia-Ling; Nie, Jia; Kim, Taewan; Yan, Pengyi; Zhu, Junyu; Torrance, Blake L; Zhou, Yueying; Flores, Lisa C; Allen, Colton; Andrade, Allison M; Guo, Chun; Cohn, Rachel L; Jellison, Evan R; Bartley, Jenna M; Kuchel, George A; Li, Sheng; Pirtskhalava, Tamar; Tchkonia, Tamar; Yadav, Sumit; Haynes, Laura; Kirkland, James L; Ikeno, Yuji; Xu, Ming Cell Metabolism. 2024 Aug;36(8):1795-1805.e6
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Role of the National Institute on Aging in Transforming Aging Research Through Geroscience and Gerotherapeutics-50 Years of Innovation.
Newman, John C; Al-Naggar, Iman M; Kuchel, George A JAMA Internal Medicine. 2024 Aug;
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A proteomic signature of healthspan.
Kuo, Chia-Ling; Liu, Peiran; Chen, Zhiduo; Pilling, Luke C; Atkins, Janice L; Fortinsky, Richard H; Kuchel, George A; Diniz, Breno S. MedRxiv : the preprint server for health sciences. 2024 Jun;
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Aging precisely: Precision medicine through the lens of an older adult.
Austin, C Adrian; Seligman, Benjamin; Shan-Bala, Sangeetha; Kuchel, George A; Loh, Kah Poh; Kistler, Chrissy E; Batsis, John A Journal of the American Geriatrics Society. 2024 Jun;
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SenNet recommendations for detecting senescent cells in different tissues.
Suryadevara, Vidyani; Hudgins, Adam D; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M; Aguayo-Mazzucato, Cristina; Baker, Darren J; Bernlohr, David A; Jurk, Diana; Mangarova, Dilyana B; Quardokus, Ellen M; Enninga, Elizabeth Ann L; Schmidt, Elizabeth L; Chen, Feng; Duncan, Francesca E; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A; Lee, Gung; Daldrup-Link, Heike E; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M; Rahman, Irfan; Nie, Jia; Passos, João F; Silverstein, Jonathan C; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J; Ding, Li; Wang, Lichao; Adams, Lisa C; Ruiyang, Liu; Doolittle, Madison L; Teneche, Marcos G; Schafer, Marissa J; Xu, Ming; Hajipour, Mohammadjavad; Boroumand, Mozhgan; Basisty, Nathan; Sloan, Nicholas; Slavov, Nikolai; Kuksenko, Olena; Robson, Paul; Gomez, Paul T; Vasilikos, Periklis; Adams, Peter D; Carapeto, Priscila; Zhu, Quan; Ramasamy, Ramalakshmi; Perez-Lorenzo, Rolando; Fan, Rong; Dong, Runze; Montgomery, Ruth R; Shaikh, Sadiya; Vickovic, Sanja; Yin, Shanshan; Kang, Shoukai; Suvakov, Sonja; Khosla, Sundeep; Garovic, Vesna D; Menon, Vilas; Xu, Yanxin; Song, Yizhe; Suh, Yousin; Dou, Zhixun; Neretti, Nicola. Nature Reviews Molecular Cell Biology. 2024 Jun;
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Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.
Kuo, Chia-Ling; Chen, Zhiduo; Liu, Peiran; Pilling, Luke C; Atkins, Janice L; Fortinsky, Richard H; Kuchel, George A; Diniz, Breno S Aging Cell. 2024 May;e14195
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Happy 50th birthday to the National Institute on Aging: Where would geriatric medicine and care of older adults be without you?
Kuchel, George A; Smith, Alexander K Journal of the American Geriatrics Society 2024 Apr;
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NIA Translational Geroscience Network: An infrastructure to facilitate geroscience-guided clinical trials.
Tchkonia, Tamara; Kritchevsky, Stephen B; Kuchel, George A; Kirkland, James L Journal of the American Geriatrics Society 2024 Apr;
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Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications: JACC Family Series.
Kumar, Manish; Yan, Pengyi; Kuchel, George A; Xu, Ming. JACC. Basic to translational science. 2024 Apr;9(4):522-534
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Leukocyte telomere length is associated with MRI-thigh fat-free muscle volume: data from 16 356 UK Biobank adults.
Kirk, Ben; Kuo, Chia-Ling; Liu, Peiran; Xiang, Meiruo; Earp, Jacob E; Kositsawat, Jatupol; Kuchel, George A; Duque, Gustavo Journal of Cachexia, Sarcopenia and Muscle 2024 Mar;
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Frailty as an upstream target for intervention: A unifying approach to intervening in the trajectories of health, function, and disease in late life.
Callahan, Kathryn E; Kuchel, George A Journal of the American Geriatrics Society 2024 Mar;
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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions.
Hajj-Boutros, Guy; Faust, Andréa; Muscedere, John; Kim, Perry; Abumrad, Naji; Chevalier, Stéphanie; Aubertin-Leheudre, Mylene; Bergman, Howard; Bowdish, Dawn; Burford, Jessica; Carrington-Lawrence, Stacy; Côté, Hélène; Dawe, David E; Barreto, Philipe de Souto; Farrelly, Colin; Fowler, Robert; Gouspillou, Gilles; Harrington, Lea; Lautrup, Sofie; Howlett, Susan; Imani, Mahdi; Kirkland, James; Kuchel, George; Mallette, Frédérick A; Morais, José A; Newman, John C; Pullman, Daryl; Sierra, Felipe; Van Raamsdonk, Jeremy; Watt, Jennifer; Rylett, R Jane; Duque, Gustavo The Journals of Gerontology. Series A, Biological sciences and medical sciences 2024 Mar;
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AGS/NIA Conference Series on delirium, sleep disorders, and urinary incontinence.
Kuchel, George A Journal of the American Geriatrics Society 2024 Mar;
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Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.
Ravichandran, Sathyabaarathi; Erra-Diaz, Fernando; Karakaslar, Onur E; Marches, Radu; Kenyon-Pesce, Lisa; Rossi, Robert; Chaussabel, Damien; Nehar-Belaid, Djamel; LaFon, David C; Pascual, Virginia; Palucka, Karolina; Paust, Silke; Nahm, Moon H; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu. Nature Immunology. 2024 Jan;
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Persistent elevation of plasma markers of cellular senescence after hip fracture: a pilot longitudinal study.
Lenze, Eric J; Nicol, Ginger E; Kuchel, George A; Avidan, Michael S; Diniz, Breno S Frontiers in Aging - Cellular Senescence. 2024 Jan;51477528
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CRISPR-Powered Aptasensor for Diagnostics of Alzheimer's Disease.
Jia, Zhengyang; Maghaydah, Yazeed; Zdanys, Kristina; Kuchel, George A; Diniz, Breno Satler; Liu, Changchun ACS Sensors. 2023 Dec;
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Dysfunctional Bladder Morphology and Functional Impairments Are Identified in the Alzheimer's Disease APPNL-G-F/NL-G-F Murine Model.
Ge, Yingying; AlObaidi, Alya S; Kuchel, George A; Bartley, Jenna M; Smith, Phillip P; He, Wanxia; Hu, Xiangyou Journal of Alzheimer's Disease : JAD. 2023 Dec;
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Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.
Kuo, Chia-Ling; Chen, Zhiduo; Liu, Peiran; Pilling, Luke C; Atkins, Janice L; Fortinsky, Richard H; Kuchel, George A; Diniz, Breno S MedRxiv : the preprint server for health sciences 2023 Dec;
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Life's Essential 8: Optimizing Health in Older Adults.
Kumar, Manish; Orkaby, Ariela; Tighe, Caitlan; Villareal, Dennis T; Billingsley, Hayley; Nanna, Michael G; Kwak, Min Ji; Rohant, Namit; Patel, Shreya; Goyal, Parag; Hummel, Scott; Al-Malouf, Christina; Kolimas, Amie; Krishnaswami, Ashok; Rich, Mike W; Kirkpatrick, James; Damluji, Abdulla A; Kuchel, George A; Forman, Daniel E; Alexander, Karen P. JACC. Journal of the American College of Cardiology Advances. 2023 Sep;2(7):
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Antibody-mediated NK cell activation as a correlate of immunity against influenza infection.
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Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants.
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Association of a blood-based aging biomarker index with death and chronic disease: Cardiovascular Health Study.
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Hypoxanthine Induces Signs of Bladder Aging with Voiding dysfunction and Lower Urinary Tract Remodeling.
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Metformin for Treatment of Acute COVID-19: Systematic Review of Clinical Trial Data Against SARS-CoV-2.
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Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.
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Dietary Docosahexaenoic Acid and Glucose Systemic Metabolic Changes in the Mouse.
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Dynamic model assuming mutually inhibitory biomarkers of frailty suggests bistability with contrasting mobility phenotypes.
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The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial.
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Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.
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Challenges and opportunities for modeling aging and cancer.
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Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants.
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Parsing chronological and biological age effects on vaccine responses.
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NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults.
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Loss of resilience contributes to detrusor underactivity in advanced age.
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Healthy Eating Patterns: A Stealthy Geroscience-Guided Approach to Enhancing the Human Healthspan.
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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
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Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop.
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Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes.
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Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons.
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Resilience in older adults with cancer: A scoping literature review.
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Examining the Role of Nonsurgical Therapy in the Treatment of Geriatric Urinary Incontinence.
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Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.
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Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank.
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Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.
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Alzheimer's disease amyloidogenesis is linked to altered lower urinary tract physiology.
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Improving the Approach to Defining, Classifying, Reporting and Monitoring Adverse Events in Seriously Ill Older Adults: Recommendations from a Multi-stakeholder Convening.
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The Hyperpolarization Activated, Cyclic Nucleotide Gated Channel Resides on Myocytes in Mouse Bladders and Contributes to Adrenergic-Induced Detrusor Relaxation.
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Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization.
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Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.
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Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.
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Demand Ischemia as a Predictor of Mortality in Older Patients With Delirium.
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Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging.
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Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study.
Pilling, Luke C; Türkmen, Deniz; Fullalove, Hannah; Atkins, Janice L; Delgado, Joao; Kuo, Chia-Ling; Kuchel, George A; Ferrucci, Luigi; Bowden, Jack; Masoli, Jane A H; Melzer, David BMJ open 2021 Dec;11(12):e053905
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Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging.
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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
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Antidiabetic Effects of the Senolytic Agent Dasatinib.
Salaami, Omid; Kuo, Chia-Ling; Drake, Matthew T; Kuchel, George A; Kirkland, James L; Pignolo, Robert J. Mayo Clinic Proceedings 2021 Oct;96(12):3021-3029
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An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
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An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
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Accelerated aging in older cancer survivors.
Sedrak, Mina S; Kirkland, James L; Tchkonia, Tamar; Kuchel, George A. Journal of the American Geriatrics Society. 2021 Sep;
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The geriatric incontinence syndrome: Characterizing geriatric incontinence in older women.
Parker-Autry, Candace; Neiberg, Rebecca H; Leng, Iris; Colombo, Lisa; Kuchel, George A; Kritchevsky, Stephen B Journal of the American Geriatrics Society 2021 Sep;
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Extending human healthspan and longevity: a symposium report.
DeVito, Loren M; Barzilai, Nir; Cuervo, Ana Maria; Niedernhofer, Laura J; Milman, Sofiya; Levine, Morgan; Promislow, Daniel; Ferrucci, Luigi; Kuchel, George A; Mannick, Joan; Justice, Jamie; Gonzales, Mitzi M; Kirkland, James L; Cohen, Pinchas; Campisi, Judith. Annals of the New York Academy of Sciences. 2021 Sep;
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AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data.
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Urinary Incontinence in Older Women: A Syndrome-Based Approach to Addressing Late Life Heterogeneity.
Parker-Autry, Candace; Kuchel, George A Obstetrics and gynecology clinics of North America 2021 Sep;48(3):665-675
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Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.
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Increased Levels of Circulating Cell-Free mtDNA in the Plasma of Subjects With Late-Life Depression and Frailty: A Preliminary Study.
Ampo, Emi; Mendes-Silva, Ana Paula; Goncalves, Vanessa; Bartley, Jenna M; Kuchel, George A; Diniz, Breno S The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2021 Jul;
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Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19
Landay, Alan; Bartley, Jenna; Banerjee, Dishary; Hargis, Geneva; Haynes, Laura; Keshavarzian, Ali; Kuo, Chia-Ling; Kwon, Oh Sung; Li, Sheng; Li, Shuzhao; Oh, Julia; Ozbolat, Ibrahim Tarik; Ucar, Duygu; Xu, Ming; Yao, Xudong; Unutmaz, Derya; Kuchel, George A. Front Aging 2021 Jul;
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APOE e4 genotypes increase risk of delirium during COVID-19 related hospitalizations: evidence from a large United Kingdom cohort.
Kuo, Chia-Ling; Pilling, Luke C; Atkins, Janice L; Fortinsky, Richard H; Kuchel, George A; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Jun;
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Moving geroscience from the bench to clinical care and health policy.
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Senolytics alleviate the degenerative disorders of temporomandibular joint in old age.
Zhou, Yueying; Al-Naggar, Iman M A; Chen, Po-Jung; Gasek, Nathan S; Wang, Ke; Mehta, Shivam; Kuchel, George A; Yadav, Sumit; Xu, Ming Aging Cell. 2021 Jun;e13394
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A multi-center trial of exercise and testosterone therapy in women after hip fracture: Design, methods and impact of the COVID-19 pandemic.
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Aging changes in bladder HCN are associated with increasing heterogeneity of adrenergic/mucosal influence on detrusor control in the mouse.
Hardy, Cara C; Al-Naggar, Iman M; Kuo, Chia-Ling; Kuchel, George A; Smith, Phillip P The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Mar;
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Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants.
Kuo, Chia-Ling; Pilling, Luke C; Atkins, Janice L; Masoli, Jane A H; Delgado, João; Tignanelli, Christopher; Kuchel, George A; Melzer, David; Beckman, Kenneth B; Levine, Morgan E The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Mar;
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Heterogeneity of Aging: Individual Risk Factors, Mechanisms, Patient Priorities, and Outcomes.
Ferrucci, Luigi; Kuchel, George A Journal of the American Geriatrics Society 2021 Mar;69(3):610-612
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
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Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults.
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Corrigendum: Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults.
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Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults.
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Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
Atkins, Janice L; Pilling, Luke C; Heales, Christine J; Savage, Sharon; Kuo, Chia-Ling; Kuchel, George A; Steffens, David C; Melzer, David Journal of Alzheimer's disease : JAD 2021 Jan;79(3):1203-1211
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Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team.
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Incontinence in frail elderly persons: Report of the 6th International Consultation on Incontinence.
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Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.
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A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin.
Justice, Jamie N; Gubbi, Sriram; Kulkarni, Ameya S; Bartley, Jenna M; Kuchel, George A; Barzilai, Nir GeroScience 2020 Sep;
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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
Atkins, Janice L; Masoli, Jane A H; Delgado, Joao; Pilling, Luke C; Kuo, Chia-Ling; Kuchel, George A; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jul;
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Role of Sarcopenia Definition and Diagnosis in Clinical Care: Moving from Risk Assessment to Mechanism-Guided Interventions.
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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.
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Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.
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Sestrins induce natural killer function in senescent-like CD8+ T cells.
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International drive to illuminate delirium: A developing public health blueprint for action.
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Clinical trial testing in-home multidisciplinary care management for older adults with cognitive vulnerability: Rationale and study design.
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Sexual-dimorphism in human immune system aging.
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Transplanting cells from old but not young donors causes physical dysfunction in older recipients.
Wang, Binsheng; Liu, Zukai; Chen, Vicky P; Wang, Lichao; Inman, Christina L; Zhou, Yueying; Guo, Chun; Tchkonia, Tamar; Rowe, David W; Kuchel, George A; Robson, Paul; Kirkland, James L; Xu, Ming Aging Cell. 2020 Jan;e13106
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Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.
Newman, Anne B; Kritchevsky, Stephen B; Guralnik, Jack M; Cummings, Steven R; Salive, Marcel; Kuchel, George A; Schrack, Jennifer; Morris, Martha Clare; Weir, David; Baccarelli, Andrea; Murabito, Joanne M; Ben-Shlomo, Yoav; Espeland, Mark A; Kirkland, James; Melzer, David; Ferrucci, Luigi The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jan;75(1):77-86
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Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults.
McElhaney, Janet E; Andrew, Melissa K; Haynes, Laura; Kuchel, George A; McNeil, Shelly A; Pawelec, Graham Interdisciplinary topics in gerontology and geriatrics 2020 Jan;4398-112
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The lethal sex gap: COVID-19.
Márquez, Eladio J; Trowbridge, Jennifer; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu Immunity & ageing : I & A 2020 Jan;1713
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Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
Kuo, Chia-Ling; Pilling, Luke C; Kuchel, George A; Ferrucci, Luigi; Melzer, David Aging Cell. 2019 Aug;e13017
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The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.
Kuo, Chia-Ling; Joaquim, Micaella; Kuchel, George A; Ferrucci, Luigi; Harries, Lorna; Pilling, Luke C; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Aug;
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Creating the Next Generation of Translational Geroscientists.
Newman, John C; Sokoloski, Julie L; Robbins, Paul D; Niedernhofer, Laura J; Reed, May J; Wei, Jeanne; Austad, Steven N; Barzilai, Nir; Cohen, Harvey Jay; Kuchel, George A; Kirkland, James L; Pignolo, Robert J Journal of the American Geriatrics Society 2019 Jul;
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Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.
Kositsawat, Jatupol; Kuo, Chia-Ling; Barry, Lisa; Melzer, David; Bandinelli, Stefania; Ferrucci, Luigi; Wu, Rong; Kuchel, George A The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Jul;
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Sarcopenia and variation in the Human Leukocyte Antigen complex.
Jones, Garan; Pilling, Luke C; Kuo, Chia-Ling; Kuchel, George; Ferrucci, Luigi; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;
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Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.
Tamosauskaite, Jone; Atkins, Janice L; Pilling, Luke C; Kuo, Chia-Ling; Kuchel, George A; Ferrucci, Luigi; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;74(3):337-342
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Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts.
Atkins, Janice L; Delgado, João; Pilling, Luke C; Bowman, Kirsty; Masoli, Jane A H; Kuchel, George A; Ferrucci, Luigi; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;74(3):350-357
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Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.
Bowman, Kirsty; Jones, Lindsay; Pilling, Luke C; Delgado, João; Kuchel, George A; Ferrucci, Luigi; Fortinsky, Richard H; Melzer, David Neurology 2019 Feb;
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Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.
Bowman, Kirsty; Thambisetty, Madhav; Kuchel, George A; Ferrucci, Luigi; Melzer, David Age and ageing 2019 Feb;
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Inclusion of Older Adults in Research: Ensuring Relevance, Feasibility, and Rigor.
Kuchel, George A Journal of the American Geriatrics Society 2019 Feb;67(2):203-204
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Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
Hurria, Arti; Carpenter, Christopher R; McFarland, Frances; Lundebjerg, Nancy E; de Cabo, Rafael; Ferrucci, Luigi; Studenski, Stephanie A; Barzilai, Nir; Briggs, Josephine P; Ix, Joachim H; Kitzman, Dalane W; Kuchel, George A; Musi, Nicolas; Newman, John C; Rando, Thomas A; Smith, Alexander K; Walston, Jeremy D; Kirkland, James L; Yung, Raymond Journal of the American Geriatrics Society 2019 Jan;
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Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.
Pilling, Luke C; Tamosauskaite, Jone; Jones, Garan; Wood, Andrew R; Jones, Lindsay; Kuo, Chai-Ling; Kuchel, George A; Ferrucci, Luigi; Melzer, David BMJ (Clinical research ed.) 2019 Jan;364k5222
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Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.
Vasunilashorn, Sarinnapha M; Ngo, Long H; Chan, Noel Y; Zhou, Wenxiao; Dillon, Simon T; Otu, Hasan H; Inouye, Sharon K; Wyrobnik, Iris; Kuchel, George A; McElhaney, Janet E; Xie, Zhongcong; Alsop, David C; Jones, Richard N; Libermann, Towia A; Marcantonio, Edward R The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Jan;74(2):261-268
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Risk Factors for Falls Among Older Adults Following Transition From Nursing Home to the Community.
Marrero, Jing; Fortinsky, Richard H; Kuchel, George A; Robison, Julie Medical care research and review : MCRR 2019 Jan;1077558717697012
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Reply to: Hands-free but Nonwearable Technology Needed for Outpatient Clinical Gait-speed Assessment.
Barry, Lisa C; Hatchman, Laura; Fan, Zhaoyan; Guralnik, Jack M; Gao, Robert X; Kuchel, George A Journal of the American Geriatrics Society 2018 Oct;67184-185
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Implementing "Patient-Centered Care": A Revolutionary Change in Health Care Delivery.
Applegate, William B; Ouslander, Joseph G; Kuchel, George A Journal of the American Geriatrics Society 2018 Oct;66(10):1863-1865
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HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation.
Al-Naggar, Iman M; Hardy, Cara C; Taweh, Omar G; Grabauskas, Titas; Mulkey, Daniel K; Kuchel, George A; Smith, Phillip P The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Aug;
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Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
Hadley, Evan C; Kuchel, George A; Newman, Anne B; Allore, Heather G; Bartley, Jenna M; Bergeman, Cindy S; Blinov, Michael L; Colon-Emeric, Cathleen S; Dabhar, Firdaus S; Dugan, Laura L; Dutta, Chhanda; Eldadah, Basil A; Ferrucci, Luigi; Kirkland, James L; Kritchevsky, Stephen B; Lipsitz, Lewis A; Nadkarni, Neelesh K; Reed, May J; Schmader, Kenneth E; Sierra, Felipe; Studenski, Stephanie A; Varadhan, Ravi; Walston, Jeremy D; Whitson, Heather E; Yung, Raymond The journals of gerontology. Series A, Biological sciences and medical sciences 2018 May;73995
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A Relationship Between Blood Levels of Otolin-1 and Vitamin D.
Parham, Kourosh; Kuchel, George A; McElhaney, Janet E; Haynes, Laura Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2018 Apr;39(4):e269-e273
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Design and Validation of a Radio-Frequency Identification-Based Device for Routinely Assessing Gait Speed in a Geriatrics Clinic.
Barry, Lisa C; Hatchman, Laura; Fan, Zhaoyan; Guralnik, Jack M; Gao, Robert X; Kuchel, George A Journal of the American Geriatrics Society 2018 Feb;66982-986
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Blood Pressure Trajectories in the 20 Years Before Death.
Delgado, João; Bowman, Kirsty; Ble, Alessandro; Masoli, Jane; Han, Yang; Henley, William; Welsh, Scott; Kuchel, George A; Ferrucci, Luigi; Melzer, David JAMA internal medicine 2018 Jan;178(1):93-99
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Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years.
Pilling, Luke C; Atkins, Janice L; Kuchel, George A; Ferrucci, Luigi; Melzer, David PloS one 2018 Jan;13(9):e0203504
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Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Pilling, Luke C; Kuo, Chia-Ling; Sicinski, Kamil; Tamosauskaite, Jone; Kuchel, George A; Harries, Lorna W; Herd, Pamela; Wallace, Robert; Ferrucci, Luigi; Melzer, David Aging 2017 Dec;9(12):2504-2520
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Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.
Vaughan, Camille P; Markland, Alayne D; Smith, Phillip P; Burgio, Kathryn L; Kuchel, George A; American Geriatrics Society/National Institute on Aging Urinary Incontinence Conference Planning Committee and Faculty Journal of the American Geriatrics Society 2017 Dec;66773-782
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Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.
Merani, Shahzma; Kuchel, George A; Kleppinger, Alison; McElhaney, Janet E Experimental gerontology 2017 Sep;107116-125
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The chromatin accessibility signature of human immune aging stems from CD8(+) T cells.
Ucar, Duygu; Márquez, Eladio J; Chung, Cheng-Han; Marches, Radu; Rossi, Robert J; Uyar, Asli; Wu, Te-Chia; George, Joshy; Stitzel, Michael L; Palucka, A Karolina; Kuchel, George A; Banchereau, Jacques The Journal of experimental medicine 2017 Sep;2143123-3144
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Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants.
Bowman, Kirsty; Atkins, Janice L; Delgado, João; Kos, Katarina; Kuchel, George A; Ble, Alessandro; Ferrucci, Luigi; Melzer, David The American journal of clinical nutrition 2017 Jul;106(1):130-135
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Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium.
Ngo, Long H; Inouye, Sharon K; Jones, Richard N; Travison, Thomas G; Libermann, Towia A; Dillon, Simon T; Kuchel, George A; Vasunilashorn, Sarinnapha M; Alsop, David C; Marcantonio, Edward R BMC medical research methodology 2017 Jun;17(1):88
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Age-related Increase in Blood Levels of Otolin-1 in Humans.
Tabtabai, Ryan; Haynes, Laura; Kuchel, George A; Parham, Kourosh Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2017 May;38865-869
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Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dhabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R The journals of gerontology. Series A, Biological sciences and medical sciences 2017 May;72980-990
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Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.
Delgado, João; Masoli, Jane A H; Bowman, Kirsty; Strain, W David; Kuchel, George A; Walters, Kate; Lafortune, Louise; Brayne, Carol; Melzer, David; Ble, Alessandro; As part of the Ageing Well Programme of the NIHR School for Public Health Research, England Journal of the American Geriatrics Society 2017 May;65(5):995-1003
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MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.
Lee, Benjamin P; Buric, Ivana; George-Pandeth, Anupriya; Flurkey, Kevin; Harrison, David E; Yuan, Rong; Peters, Luanne L; Kuchel, George A; Melzer, David; Harries, Lorna W Scientific reports 2017 Mar;744620
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Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study.
Dillon, Simon T; Vasunilashorn, Sarinnapha M; Ngo, Long; Otu, Hasan H; Inouye, Sharon K; Jones, Richard N; Alsop, David C; Kuchel, George A; Metzger, Eran D; Arnold, Steven E; Marcantonio, Edward R; Libermann, Towia A Biological psychiatry 2017 Jan;81(2):145-153
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Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses.
Bartley, Jenna M; Zhou, Xin; Kuchel, George A; Weinstock, George M; Haynes, Laura Frontiers in immunology 2017 Jan;81164
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
Pilling, Luke C; Atkins, Janice L; Duff, Michael O; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Kuo, Chia-Ling; Ruth, Katherine S; Tuke, Marcus A; Yaghootkar, Hanieh; Wood, Andrew R; Murray, Anna; Weedon, Michael N; Harries, Lorna W; Kuchel, George A; Ferrucci, Luigi; Frayling, Timothy M; Melzer, David PloS one 2017 Jan;12(9):e0185083
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Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.
Fung, Constance H; Vitiello, Michael V; Alessi, Cathy A; Kuchel, George A; AGS/NIA Sleep Conference Planning Committee and Faculty Journal of the American Geriatrics Society 2016 Nov;64e238-e247
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Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients.
Bowman, Kirsty; Delgado, João; Henley, William E; Masoli, Jane A; Kos, Katarina; Brayne, Carol; Thokala, Praveen; Lafortune, Louise; Kuchel, George A; Ble, Alessandro; Melzer, David; as part of the Ageing Well Programme of the NIHR School for Public Health Research, England The journals of gerontology. Series A, Biological sciences and medical sciences 2016 Aug;72203-209
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Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.
Lee, Benjamin P; Pilling, Luke C; Emond, Florence; Flurkey, Kevin; Harrison, David E; Yuan, Rong; Peters, Luanne L; Kuchel, George A; Ferrucci, Luigi; Melzer, David; Harries, Lorna W Aging cell 2016 Jun;15903-13
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IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.
Zhou, Xin; Hopkins, Jacob W; Wang, Chongkai; Brahmakshatriya, Vinayak; Swain, Susan L; Kuchel, George A; Haynes, Laura; McElhaney, Janet E Oncotarget 2016 Jun;739171-39183
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Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span.
Losada, Liliana; Amundsen, Cindy L; Ashton-Miller, James; Chai, Toby; Close, Clare; Damaser, Margot; DiSanto, Michael; Dmochowski, Roger; Fraser, Matthew O; Kielb, Stephanie J; Kuchel, George; Mueller, Elizabeth R; Parker-Autry, Candace; Wolfe, Alan J; Mallampalli, Monica P Journal of women's health (2002) 2016 Jun;251086-1096
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Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.
Pilling, Luke C; Atkins, Janice L; Bowman, Kirsty; Jones, Samuel E; Tyrrell, Jessica; Beaumont, Robin N; Ruth, Katherine S; Tuke, Marcus A; Yaghootkar, Hanieh; Wood, Andrew R; Freathy, Rachel M; Murray, Anna; Weedon, Michael N; Xue, Luting; Lunetta, Kathryn; Murabito, Joanne M; Harries, Lorna W; Robine, Jean-Marie; Brayne, Carol; Kuchel, George A; Ferrucci, Luigi; Frayling, Timothy M; Melzer, David Aging 2016 Mar;8(3):547-60
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Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.
Bartley, Jenna M; Pan, Sarah J; Keilich, Spencer R; Hopkins, Jacob W; Al-Naggar, Iman M; Kuche, George A; Haynes, Laura Aging 2016 Feb;8620-35
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A Geriatric Perspective on Benign Paroxysmal Positional Vertigo.
Parham, Kourosh; Kuchel, George A Journal of the American Geriatrics Society 2016 Jan;64378-85
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Functional Brain Imaging and the Neural Basis for Voiding Dysfunction in Older Adults.
Smith, Phillip P*; Kuchel, George A; Griffiths, Derek Clinics in geriatric medicine 2015 Nov;31(4):549-65
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Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice.
Kim, J; Carlson, M E; Kuchel, G A; Newman, J W; Watkins, B A International journal of obesity (2005) 2015 Jul;40129-37
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Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery.
Vasunilashorn, Sarinnapha M; Ngo, Long; Inouye, Sharon K; Libermann, Towia A; Jones, Richard N; Alsop, David C; Guess, Jamey; Jastrzebski, Sandra; McElhaney, Janet E; Kuchel, George A; Marcantonio, Edward R The journals of gerontology. Series A, Biological sciences and medical sciences 2015 Jul;70(10):1289-95
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Urinary incontinence in frail elderly persons: Report from the 5th International Consultation on Incontinence.
Wagg, Adrian; Gibson, William; Ostaszkiewicz, Joan; Johnson, Theodore; Markland, Alayne; Palmer, Mary H; Kuchel, George; Szonyi, George; Kirschner-Hermanns, Ruth Neurourology and urodynamics 2015 Jun;34(5):398-406
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Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12.
Ble, Alessandro; Masoli, Jane A H; Barry, Heather E; Winder, Rachel E; Tavakoly, Behrooz; Henley, William E; Kuchel, George A; Valderas, Jose M; Melzer, David; Richards, Suzanne H BMC geriatrics 2015 Jan;15146
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Advanced therapeutic directions to treat the underactive bladder.
Smith, Phillip P; Tyagi, Pradeep; Kuchel, George A; Pore, Subrata; Chermansky, Christopher; Chancellor, Michael; Yoshimura, Naoki; Levanovich, Peter International urology and nephrology 2014 Sep;46 Suppl 1S35-44
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Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston study.
Wang, Yi; Eliot, Melissa N; Kuchel, George A; Schwartz, Joel; Coull, Brent A; Mittleman, Murray A; Lipsitz, Lewis A; Wellenius, Gregory A Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2014 Sep;56(9):e73-7
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Vitamin D insufficiency and abnormal hemoglobin a1c in black and white older persons.
Kositsawat, Jatupol; Kuchel, George A; Tooze, Janet A; Houston, Denise K; Cauley, Jane A; Kritchevsky, Stephen B; Strotmeyer, Elsa S; Kanaya, Alka M; Harris, Tamara B; Johnson, Karen C; Barry, Lisa C The journals of gerontology. Series A, Biological sciences and medical sciences 2014 Aug;70(4):525-31
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HIV and aging: a clinical journey from Koch's postulate to the chronic disease model and the contribution of geriatric syndromes.
Chirch, Lisa M; Hasham, Mohamed; Kuchel, George A Current opinion in HIV and AIDS 2014 Jul;9(4):405-11
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Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.
Cai, Weijing; Uribarri, Jaime; Zhu, Li; Chen, Xue; Swamy, Shobha; Zhao, Zhengshan; Grosjean, Fabrizio; Simonaro, Calogera; Kuchel, George A; Schnaider-Beeri, Michal; Woodward, Mark; Striker, Gary E; Vlassara, Helen PNAS. Proceedings of the National Academy of Sciences of the United States of America. 2014 Apr;111(13):4940-5
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Overactive bladder in the vulnerable elderly.
Wolff, Gillian F; Kuchel, George A; Smith, Phillip P Research and reports in urology 2014 Jan;6131-8
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C-reactive protein, vitamin D deficiency, and slow gait speed.
Kositsawat, Jatupol; Barry, Lisa C; Kuchel, George A Journal of the American Geriatrics Society 2013 Aug;61(9):1574-9
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Editorial comment.
Smith, Phillip P; Kuchel, George A The Journal of urology 2013 May;189(5):1810
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Stroke severity and outcomes for octogenarians receiving statins.
Phipps, Michael S; Zeevi, Neer; Staff, Ilene; Fortunato, Gil; Kuchel, George A; McCullough, Louise D Archives of gerontology and geriatrics 2013 Jan;57(3):377-82
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Gender differences in anthropometric predictors of physical performance in older adults.
Fragala, Maren S; Clark, M H; Walsh, Stephen J; Kleppinger, Alison; Judge, James O; Kuchel, George A; Kenny, Anne M Gender medicine 2012 Dec;9(6):445-56
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Interventional stroke therapies in the elderly: are we helping?
Zeevi, N; Kuchel, G A; Lee, N S; Staff, I; McCullough, L D AJNR. American journal of neuroradiology 2012 Apr;33(4):638-42
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Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse.
Smith, Phillip P; DeAngelis, Anthony; Kuchel, George A American journal of physiology. Regulatory, integrative and comparative physiology 2012 Mar;302(5):R577-86
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Evidence of central modulation of bladder compliance during filling phase.
Smith, Phillip P; Deangelis, Anthony M; Kuchel, George A Neurourology and urodynamics 2012 Jan;31(1):30-5
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Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons.
Ma, Xin-Ming; Huang, Jian-Ping; Kim, Eun-Ji; Zhu, Qing; Kuchel, George A; Mains, Richard E; Eipper, Betty A Hippocampus 2011 Jun;21(6):661-77
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The blood-brain barrier: geriatric relevance of a critical brain-body interface.
Zeevi, Neer; Pachter, Joel; McCullough, Louise D; Wolfson, Leslie; Kuchel, George A Journal of the American Geriatrics Society 2010 Sep;58(9):1749-57
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Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women.
Swanberg, Maria; McGuigan, Fiona; Ivaska, Kaisa K; Gerdhem, Paul; Lerner, Ulf H; Bucala, Richard; Kuchel, George; Kenny, Anne; Akesson, Kristina Bone 2010 Aug;47(2):424-9
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White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults.
Wakefield, Dorothy B; Moscufo, Nicola; Guttmann, Charles R; Kuchel, George A; Kaplan, Richard F; Pearlson, Godfrey; Wolfson, Leslie Journal of the American Geriatrics Society 2010 Feb;58(2):275-81
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Macrophage migration inhibitory factor inhibits osteoclastogenesis.
Jacquin, Claire; Koczon-Jaremko, Boguslawa; Aguila, Hector L; Leng, Lin; Bucala, Richard; Kuchel, George A; Lee, Sun-Kyeong Bone 2009 Oct;45(4):640-9
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Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults.
Kuchel, George A; Moscufo, Nicola; Guttmann, Charles R; Zeevi, Neer; Wakefield, Dorothy; Schmidt, Julia; Dubeau, Catherine E; Wolfson, Leslie The journals of gerontology. Series A, Biological sciences and medical sciences 2009 Aug;64(8):902-9
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Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice.
Taylor, John A; Ristau, Benjamin; Bonnemaison, Mathilde; Voznesensky, Olga S; Hegde, Poornima; Kuchel, George A; Pilbeam, Carol C Prostaglandins & other lipid mediators 2009 Jan;88(1-2):36-41
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Chemokines are associated with delirium after cardiac surgery.
Rudolph, James L; Ramlawi, Basel; Kuchel, George A; McElhaney, Janet E; Xie, Dongxu; Sellke, Frank W; Khabbaz, Kamal; Levkoff, Sue E; Marcantonio, Edward R The journals of gerontology. Series A, Biological sciences and medical sciences 2008 Feb;63(2):184-9
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Measurement of muscle disease by quantitative second-harmonic generation imaging.
Plotnikov, Sergey V; Kenny, Anne M; Walsh, Stephen J; Zubrowski, Beata; Joseph, Cherian; Scranton, Victoria L; Kuchel, George A; Dauser, Deborah; Xu, Manshan; Pilbeam, Carol C; Adams, Douglas J; Dougherty, Robert P; Campagnola, Paul J; Mohler, William A Journal of biomedical optics 2008 Jan;13(4):044018
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Functional impact of relative versus absolute sarcopenia in healthy older women.
Estrada, Marcos; Kleppinger, Alison; Judge, James O; Walsh, Stephen J; Kuchel, George A Journal of the American Geriatrics Society 2007 Nov;55(11):1712-9
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The effect of 3-year treatment with 0.25 mg/day of micronized 17beta-estradiol on cognitive function in older postmenopausal women.
Pefanco, Mary Ann; Kenny, Anne M; Kaplan, Richard F; Kuchel, George; Walsh, Stephen; Kleppinger, Alison; Prestwood, Karen Journal of the American Geriatrics Society 2007 Mar;55(3):426-31
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Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction.
Taylor, John A; Zhu, Qing; Irwin, Brian; Maghaydah, Yazeed; Tsimikas, John; Pilbeam, Carol; Leng, Lin; Bucala, Richard; Kuchel, George A American journal of physiology. Renal physiology 2006 Dec;291(6):F1343-53
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Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder.
Gingras, J; Spicer, J; Altares, M; Zhu, Q; Kuchel, G A; Ferns, M Cell and tissue research 2005 Apr;320(1):115-25
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Estrogen replacement raises rat CRP without evidence of complement activation.
Yang, S X; Diaz Padilla, N; Zhu, Q; Ma, X M; Sasso, D; Prestwood, K; Hack, C E; Kuchel, G A Endocrine research 2005 Jan;31(2):121-32
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Pelvic floor muscle training with biofeedback and bladder training in elderly women: a feasibility study.
Perrin, Louise; Dauphinée, Sharon Wood; Corcos, Jacques; Hanley, James A; Kuchel, George A Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society / WOCN 2005 Jan;32(3):186-99
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Estrogen and postnatal maturation increase caveolar number and caveolin-1 protein in bladder smooth muscle cells.
Zhu, Qing; Resnick, Neil M; Elbadawi, Ahmad; Kuchel, George A The Journal of urology 2004 Jan;171(1):467-71
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Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents.
Zhu, Q; Ritchie, J; Marouf, N; Dion, S B; Resnick, N M; Elbadawi, A; Kuchel, G A The Journal of urology 2001 Sep;166(3):1136-41
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Ovariectomy up-regulates neuronal neurofilament light chain mRNA expression with regional and temporal specificity.
Vaucher, E; Pierret, P; Julien, J P; Kuchel, G A Neuroscience 2001 Jan;103(3):629-37
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Book Chapters
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Chapter 2. Physiological and Clinical Considerations of Geriatric Patient Care
Jaeger, J. and Kuchel, G. The American Psychiatric Association Publishing Textbook of Geriatric Psychiatry, Sixth Edition 2023 Jan;
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Applied Clinical Geroscience. Ch. 40.
Espinoza SE, Justice JN, Newman JC, Pignolo RJ, Kuchel G.A. Hazzard's Geriatric Medicine and Gerontology. 2022 Dec;pages 593-604
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Systems Physiology of Aging and Selected Disorders of Homeostasis. Ch.39.
Kuchel, George. Hazzard's Geriatric Medicine and Gerontology. 2022 Dec;pages 575-591.
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Aging of the Urinary Tract
Smith PP, Kuchel G Brocklehurst's Textbook of Geriatrics and Clinical Gerontology 2010 Jan;
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Age-related changes that impact drug metabolism.
Kuchel, George National Academies of Sciences, Engineering, and Medicine 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop.
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Applied Geroscience. Chapter 40
Espinoza S., Justice J. Newman J. and Kuchel G.A.. Hazzard’s Principles of Geriatric Medicine and Gerontology. 8th Edition.
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Influenza Vaccination: Accelerating the process for new vaccine development in older adults
McElhaney J.E., Andrew M.K., Haynes L., Kuchel G.A., McNeill S.A. and Pawelec G. Vaccines for the older population
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Systems Physiology of Aging and Selected Disorders of Homeostasis. Chapter 39
Kuchel,George A. Hazzard’s Principles of Geriatric Medicine and Gerontology. 8th edition.
Conference Papers
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Mice with a null mutation for macrophage migration inhibitory factor have lower stage tumors in a model of bladder cancer.
Taylor won New Investigator Award.
Taylor JA, Kuchel GA, Hegde H, Voznesensky OS, Claffey K, Tsmikas J, Bucala R and Pilbeam C. 2006 Jan;
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Locomotion in vitamin D receptor gene knockout mice.
DuBose M, Sasso D, Kenny A, Pilbeam C, Demay M and Kuchel GA. 2005 Jan;
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Macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
Taylor JA, Zhu Q, Sasso D, Pilbeam C, Leng L, Bucala R and Kuchel GA. 2005 Jan;
Editorials
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Urinary Incontinence and Voiding Dysfunction with Aging: A Multifaceted Geriatric Syndrome in Search of Multidisciplinary Research Solutions.
Kuchel, George A The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Jun;79(6):
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Editorial Comment.
Kuchel, George A The Journal of urology 2019 Aug;10109701JU00005803687322725
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Frailty and Resilience as Outcome Measures in Clinical Trials and Geriatric Care: Are We Getting Any Closer?
Kuchel, George A Journal of the American Geriatrics Society 2018 Aug;661451-1454
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Reduce the burden of dementia now.
Hayden, Kathleen M; Inouye, Sharon K; Cunningham, Colm; Jones, Richard N; Avidan, Michael S; Davis, Daniel; Kuchel, George A; Tang, Yi; Khachaturian, Ara S Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Jul;14(7):845-847
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Physical Resilience: Not Simply the Opposite of Frailty.
Whitson, Heather E; Cohen, Harvey J; Schmader, Kenneth E; Morey, Miriam C; Kuchel, George; Colon-Emeric, Cathleen S Journal of the American Geriatrics Society 2018 Mar;661459-1461
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Function Begets Function and Resilience in Old Age: Is Precision Gerontology Possible?
Kuchel, George A Journal of the American Geriatrics Society 2017 May;651141-1144
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Clinical Meaning of a High Postvoid Residual: When the Value of a Result Is Less and More than One Would Expect.
Smith, Phillip P; Kuchel, George A Journal of the American Geriatrics Society 2015 Jul;63(7):1432-4
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Moving beyond static body composition paradigms to assessments of change, plasticity, and function.
Duque, Gustavo; Kuchel, George A Journal of the American Geriatrics Society 2010 Feb;58(2):377-9
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Frailty, allostatic load, and the future of predictive gerontology.
Kuchel, George A Journal of the American Geriatrics Society 2009 Sep;57(9):1704-6
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Nutrition and inflammation: the missing link between periodontal disease and systemic health in the frail elderly?
Jepsen, Rita; Kuchel, George A Journal of clinical periodontology 2006 May;33(5):309-11
Letters
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ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank.
Kuo, Chia-Ling; Pilling, Luke C; Atkins, Janice L; Masoli, Jane A H; Delgado, João; Kuchel, George A; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jul;
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APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort.
Kuo, Chia-Ling; Pilling, Luke C; Atkins, Janice L; Masoli, Jane A H; Delgado, João; Kuchel, George A; Melzer, David The journals of gerontology. Series A, Biological sciences and medical sciences 2020 May;
Reviews
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Major depression and the biological hallmarks of aging.
Lorenzo, Erica C; Kuchel, George A; Kuo, Chia-Ling; Moffitt, Terrie E; Diniz, Breno S Ageing Research Reviews. 2022 Oct;101805
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The heterogeneity of cellular senescence: insights at the single-cell level.
Cohn, Rachel L; Gasek, Nathan S; Kuchel, George A; Xu, Ming. Trends in Cell Biology. 2022 May;
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Senolytics: targeting senescent cells for age-associated diseases.
Al-Naggar, Iman M A; Kuchel, George A; Xu, Ming Current molecular biology reports 2020 Dec;6(4):161-172
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The Prevention of Infections in Older Adults: Vaccination.
Coll, Patrick P; Costello, Victoria W; Kuchel, George A; Bartley, Jenna; McElhaney, Janet E Journal of the American Geriatrics Society 2019 Oct;
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Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.
Andrew, Melissa K; Bowles, Susan K; Pawelec, Graham; Haynes, Laura; Kuchel, George A; McNeil, Shelly A; McElhaney, Janet E Drugs & aging 2018 Nov;3629-37
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Sex differences in lower urinary tract biology and physiology.
Abelson, Benjamin; Sun, Daniel; Que, Lauren; Nebel, Rebecca A; Baker, Dylan; Popiel, Patrick; Amundsen, Cindy L; Chai, Toby; Close, Clare; DiSanto, Michael; Fraser, Matthew O; Kielb, Stephanie J; Kuchel, George; Mueller, Elizabeth R; Palmer, Mary H; Parker-Autry, Candace; Wolfe, Alan J; Damaser, Margot S Biology of sex differences 2018 Oct;9(1):45
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A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.
Justice, Jamie N; Ferrucci, Luigi; Newman, Anne B; Aroda, Vanita R; Bahnson, Judy L; Divers, Jasmin; Espeland, Mark A; Marcovina, Santica; Pollak, Michael N; Kritchevsky, Stephen B; Barzilai, Nir; Kuchel, George A GeroScience 2018 Aug;40419-436
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Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.
Merani, Shahzma; Pawelec, Graham; Kuchel, George A; McElhaney, Janet E Frontiers in immunology 2017 Jan;8784
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T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines.
McElhaney, Janet E; Kuchel, George A; Zhou, Xin; Swain, Susan L; Haynes, Laura Frontiers in immunology 2016 Jan;741
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Incontinence in the frail elderly: report from the 4th International Consultation on Incontinence.
DuBeau, Catherine E; Kuchel, George A; Johnson, Theodore; Palmer, Mary H; Wagg, Adrian Neurourology and urodynamics 2010 Jan;29(1):165-78
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Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction.
Taylor, John A; Kuchel, George A Nature clinical practice. Urology 2009 Mar;6(3):135-44
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ELISA and multiplex technologies for cytokine measurement in inflammation and aging research.
Leng, Sean X; McElhaney, Janet E; Walston, Jeremy D; Xie, Dongxu; Fedarko, Neal S; Kuchel, George A The journals of gerontology. Series A, Biological sciences and medical sciences 2008 Aug;63(8):879-84
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Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.
Inouye, Sharon K; Studenski, Stephanie; Tinetti, Mary E; Kuchel, George A Journal of the American Geriatrics Society 2007 May;55(5):780-91
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Detrusor underactivity: Clinical features and pathogenesis of an underdiagnosed geriatric condition.
Taylor, John A; Kuchel, George A Journal of the American Geriatrics Society 2006 Dec;54(12):1920-32
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Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk.
Joseph, Cherian; Kenny, Anne M; Taxel, Pamela; Lorenzo, Joseph A; Duque, Gustavo; Kuchel, George A Molecular aspects of medicine 2005 Jun;26(3):181-201
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Evaluation and management of urinary incontinence in elderly women.
LaSala, Christine A; Kuchel, George A Connecticut medicine 2003 Sep;67(8):491-5
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Promoting healthy and successful aging in everyday clinical practice.
Fortinsky, Richard H; Kuchel, George A; Coll, Patrick P Connecticut medicine 2003 Sep;67(8):455-60
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Can variability in the hormonal status of elderly women assist in the decision to administer estrogens?
Kuchel, G A; Tannenbaum, C; Greenspan, S L; Resnick, N M Journal of women's health & gender-based medicine 2001 Mar;10(2):109-16
Short Surveys
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Pharmacological approaches to cognitive deficits and incontinence (1899-2002): progress in geriatric care.
Bellantonio, Sandra; Kuchel, George A Trends in pharmacological sciences 2002 Apr;23(4):192-3
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Heterogeneity of Heterogeneity: Finding Meaning and a Path Forward. | Talk | National Institute on Aging | 2024 | Rockville, MD |
| A Geriatric and Geroscience-Guided Approach to Lower Urinary Tract Symptoms and Incontinence. | Plenary Lecture | NIDDK Collaborating for Interdisciplinary Research in Benign Urology (CAIRIBU) Meeting. | 2024 | Milwaukee, WI. |
| The Path from Heterogeneity of Aging and Successful Aging to Precision Gerontology and Geroscience. | Lecture | National Institute on Aging | 2023 | Online |
| The Science of Aging: Lessons for HIV at the Interface of Commonality and Heterogeneity. | UConn School of Medicine | 2023 | ||
| Aging of the Immune System: A Translational Geroscience Perspective. | Lecture | Albert Einstein School of Medicine Biology of Aging Course. | 2023 | New York, NY |
| UConn Pepper Center: Early Insights into Precision Gerontology and Geroscience. | Lecture | Duke School of Medicine, Division of Geriatrics and Aging Center. | 2023 | Durham, NC |
| UConn Pepper Center: Early Insights into Precision Gerontology and Geroscience. | Lecture | Sealey Center on Aging. | 2023 | U Texas Medical Branch, Galveston, TX. |
| Frail Patients in Primary Care: I Know It When I See It, but Then What? | Lecture | Medical Grand Rounds. St. John's Episcopal Hospital | 2023 | Far Rockaway, NY |
| The Science of Aging: Lessons for HIV. | Plenary Lecture | Conference on Retroviruses and Opportunistic Infections (CROI). | 2023 | Seattle, WA. |
| UConn Pepper Center: Early Insights into Precision Gerontology and Geroscience. | Lecture | Northwestern School of Medicine. | 2023 | Chicago, IL |
| Perspectives on Cancer and Aging: The Arti Hurria Memorial Webinar Series. Improving Patient-Centered Outcomes for Older Cancer Patients via Precision Gerontology and Geroscience. | Lecture | National Cancer Institute | 2023 | Bethesda, MD |
| Training Translational Geroscientists and Geroscience-Savvy Clinicians. | Lecture | National Institutes of Health. | 2023 | Natcher Auditorium, Bethesda, MD. |
| Catalyzing Interdisciplinary Research: You have assembled your dream team, done everything right and yet the first meeting did not go well. | Lecture | OAIC Pepper National Coordinating Center. | 2023 | Arlington, VA. |
| AGS 2023 Update on Vaccination Strategies for Older Adults: Matching the approach to the Individual and the Care Setting. | Lecture | Presidential Session, Annual Meeting of the American Geriatrics Society. | 2023 | Long Beach, CA. |
| The Path from Heterogeneity of Aging and Successful Aging to Precision Gerontology and Geroscience. | Plenary Lecture | National Institute on Aging. | 2023 | Bethesda, MD. |
| Geroscience-Guided Clinical Trials: Lessons Learned and a Path Forward to Enhancing Function, Independence, and Immune Resilience. | Plenary Lecture | University of Pittsburgh. | 2023 | Pittsburgh, PA. |
| Update in Geroscience. The Role of the Behavioral and Social Sciences in Geroscience Workshop, | Talk | Division of Behavioral and Social Research, Division of Aging Biology, NIA. | 2023 | Onlinr |
| Applied Clinical Geroscience. 1st Canadian Conference on Translational Geroscience. Keynote Speaker. McGill University Health Center, Montréal, Québec, Canada. | Plenary Lecture | McGill University. | 2023 | Montréal, Québec, Canada. |
| Age and Its Effect on Pelvic Functiom. Phillip P. Smith Memorial lecture. | Plenary Lecture | The Society for Pelvic Research. | 2023 | Savannah, GA. |
| Precision Gerontology: Making Precision Medicine Relevant to the Needs of Geriatric Patients. Symposium on Precision Medicine through the Lens of an Older Adult. | Lecture | American Geriatrics Society | 2022 | Orlando, FL |
| Designing Your Next Geroscience-Guided Trial: From Drug Discovery to Repurposing and Modeling. Symposium on Clinical Trials in Geroscience. | Lecture | American Aging Association 50th Annual Meeting | 2022 | San Antonio, TX. |
| Frail Patients in Primary Care: I Know It When I See It, but Then What? | Lecture | SUNY Downstate SChool of Medicine | 2022 | New York, NY |
| Role of Frailty and Resilience in Improving Outcomes in Older Patients via Precision Gerontology | Lecture | Baylor School of Medicine | 2022 | Houston, TX |
| Get to Know Your Pepper Centers – UConn. | Talk | NIA OAIC (Pepper) National Coordinating Center. | 2022 | Washington, D.C. |
| Biology of Frailty. | Talk | NIA OAIC (Pepper) National Coordinating Center. | 2022 | Washington, D.C. |
| Senolytics in Aging Research: Implications for HIV Research and Clinical Care. | Lecture | 2022 Hybrid Annual ACTG Network Meeting. | 2022 | Washington, D.C. |
| Geroscience-Inspired Approaches to Understanding and Intervening in Human Frailty. | Lecture | Invited Speaker. Trans-NIH Geroscience Interest Group (GSIG) Seminar. | 2022 | Bethesda, MD |
| ACP Meet the Professor. Frail Patients in Primary Care: I Know It When I See It, but Then What? | Plenary Lecture | American College of Physicians. | 2022 | Chicago, IL |
| UConn Pepper Center: Early Insights into Precision Gerontology and Geroscience. | Lecture | University of Pittsburgh Pepper Center and Division of Geriatric Medicine. | 2022 | Pittsburgh, PA |
| Moving from Frailty and Resilience to Precision Gerontology and Geroscience. | Lecture | NIA/AFAR ClinSTAR Frailty SIG. | 2022 | New York, NY |
| Update on the Geroscience Education and Training Network. | Talk | Geroscience SIG, Gerontological Society of America Annual Meeting. | 2022 | Indianapolis, IN. |
| Update in Geroscience for Nonbiologists. | Other | Gerontological Society of America Annual Meeting. | 2022 | Indianapolis, IN. |
| COVID-19: A View from Geriatric Medicine and Geroscience | Lecture | Rush University School of Medicine | 2021 | Chicago, IL |
| A Randomized, Double-Blind, Placebo-Controlled Phase 2a Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Adults Age =65 Years | Lecture | NIA 2021 OAIC (Pepper Center ) ANNUAL MEETING | 2021 | |
| Extending Healthspan and Human Longevity Targeting Immunity: What is it about Immune Aging that Makes Older Adults So Vulnerable to COVID-19? | Lecture | The New York Academy of Sciences | 2021 | |
| COVID Vaccine Effectivity in Aging Population and Immune protection. | Lecture | International Workshop on HIV and Aging 2021.Virtual Conference. | 2021 | |
| Bridging the Translational Cancer and Aging Research Divide. New Interdisciplinary Research on Cancer and Aging | Lecture | National Cancer Institute, NIH | 2021 | Bethesda, MD |
| Integrative Immunology of Aging: Reconciling Reductionist and Systems-Based Perspectives. | Lecture | . University of Texas San Antonio, TX. | 2021 | |
| The “5Ws” of Geroscience-Guided Trials and HIV Care: Why, Who, When, What and Where. | Lecture | University of Miami | 2021 | University of Miami Center for AIDS Research |
| Making sense of the heterogeneity of clinical presentations and outcomes in older adults exposed to SARS CoV-2. | Lecture | NIA & NIAID Conference on Immunity, Aging, and COVID-19. | 2021 | Bethesda, MD |
| Vulnerability of Older Adults to COVID-19: Emerging role for biological hallmarks of aging and geroscience-guided therapies | Plenary Lecture | American College of Cardiology Annual Meeting | 2020 | Virtual Meeting |
| Age-related changes that impact drug metabolism. | Lecture | The National Academies of Sciences, Engineering, Medicine. | 2020 | Washington, DC |
| Nekolik težce vydelaných lekcí z USA, všudyprítomná role ageismu a vznik terapií vedených geroscience | Lecture | Institute for Social Policy and Research, Prague, Czech Republic. | 2020 | Prague, Czech Republic |
| Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective. | Plenary Lecture | 2019 SUFU Annual Meeting | 2019 | Miami, FL |
| Immune Responses to Vaccination on Aging: Translational Insights into Immune Resilience. | Talk | 2019 Barshop Symposium on Aging | 2019 | University of Texas San Antonio, Bandera, TX |
| Systems Biology of Aging. Data Science Meets Geroscience. Meeting Co-Organizer with D Ucar and J Banchereau. Jackson Laboratory for Genomic Medicine, Farmington, CT. 9/4-5/2019. | Lecture | NIA R13/Jackson Lab for Genomic Medicine | 2019 | Farmington CT |
| Immune Responses to Vaccination in Older Adults: Translational Insights into Physical Resilience, Frailty and Precision Gerontology. | Lecture | FAU Biomedical Research Institute Seminar series. | 2019 | Florida Atlantic University, Boca Raton, FL |
| Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience. | Talk | Robert and Arlene Kogod Aging Center, Mayo Clinic | 2018 | Mayo Clinic, Rochester, MN |
| Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights. | Talk | Department of Medicine, Montefiore Medical Center | 2018 | New York, NY |
| Biomarkers for geroscience-guided clinical trials | Talk | NIA P30 Claude D. Pepper Older Americans Independence Center | 2018 | Arlington, VA |
| Role of Biomarkers in Aging and Vitality | Talk | WHO Clinical Consortium on Healthy Aging meeting on Vitality | 2018 | New York, NY |
| ScRNAseq of PBMCs for discovery of biomarkers of physical resilience to influenza infection in older adults. | Talk | National Institute on Aging Resiliencies Grantees’ Meeting | 2018 | Bethesda, MD |
| Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME. | Talk | 9th Annual Alliance for Healthy Aging Research, Mayo Clinic | 2018 | Rochester, MN |
| New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms. | Talk | NIA Workshop on the Epidemiology of Aging. NIA Intramural Program | 2018 | Baltimore, MD |
| Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience. | Plenary Lecture | 31st Annual Meeting of the Canadian Society for Immunology | 2018 | London, Ont. Canada |