Education

Degree	Institution	Major
Other	Vanier College	Health Sciences
Other	McGill Medical School	Medicine

Post-Graduate Training

Training	Institution	Specialty
Internship	Montreal General Hospital	Internal Medicine
Residency	Montreal General Hospital	Internal Medicine
Postdoctoral	Harvard Medical School	Kaiser, Faculty Development Program in General Internal Medicine
Fellowship	Harvard Medical School, Division on Aging and Beth Israel Hospital	Geriatrics and Gerontology
Postdoctoral	Harvard Medical School	Biological Chemistry and Molecular Pharmacology
Postdoctoral	Mount Sinai Medical Center	Neurobiology and Gerontology

Awards

Name of Award/Honor	Awarding Organization
Brookdale Senior Fellow, New York	Brookdale Foundation
John A. Hartford Leadership Award
Travelers/Citicorp Chair in Geriatrics and Gerontology	University of Connecticut
Montreal General Hospital 175th Anniversary Award	Montreal General Hospital
Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec
Fellowship	Medical Research Council of Canada
Brookdale National Fellow	Brookdale Foundation
Royal Canadian Legion Fellowship in Geriatric Medicine
Mona Bronfman Scheckman Prize in Psychiatry	McGill
University Scholar	McGill

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Aging Systems and Geriatrics Study Section, NIH/CSR	Study Section	Chair	External	National	2008	2011
Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR	Study Section	Member	External	National	2007	2011
Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut	Advisory Committee	Advisory Board	External	University	2002
Older Americans Independence Center, University of Connecticut	Professional/Scientific Organization	Director	External	University	2001	2004
MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill	Education Committee	Committee Member	External	University	1998	2001
Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ	Professional/Scientific Organization	Director	External	University	1998	2001
Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ	Professional/Scientific Organization	Co-PI	External	University	1996	1999
Research fellow, Neurobiology, Mount Sinai School of Medicine, New York	Professional/Scientific Organization	Fellow	External	University	1989	1992
Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School	Professional/Scientific Organization	Fellow	External	University	1987	1989
Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School	Education Committee	Member	External	University	1985	1986

RESEARCH INTERESTS:

 

1.      Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense

2.      Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging

3.      Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”

Current Grant Support:  

NIA/NIH; Immune Response to High-Dose vs. Standard Dose Influenza Vaccine

R01 AG048023; George Kuchel, MD (communicating PI) and Janet McElhaney (PI)

Total Budget: $ 1,934,901; 7/15/2014-5/31/2019

 

NIAID/NIH; Combination Adjuvants to Activate Human Dendritic Cell Subsets & B Cells

U01 AI124297; Jacques Banchereau (PI) Jackson Lab for Genomic Medicine, Farmington, CT

George Kuchel, MD (co-investigator)

Budget: $ 3,296,716; Award to UCHC: $104,460; 4/15/2016-3/31/2021 

 

NIA/NIH; Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines.

R01 AG052608; Jacques Banchereau (PI) Jackson Laboratory for Genomic Medicine, Farmington, CT

Budget: $ 1,580,481(total), $ 572,170 (UCH total direct); 9/15/2016-9/15/2021

 

PCORI (Patient-Centered Outcomes Research Institute); 3D Team Care for Cognitively Vulnerable Older Adults

PCORI-PFA-2015-Spring;                   

IHS-1502-27171; Fortinsky (PI)                                                                       

Total Budget: $6,219,556; 04/01/2016-03/31/2021                    

Role: Co-Investigator 

 

NIGMS/NIH; Chromatin Changes Associated with Aging of Human Immune Cells

R35 GM124922; Maximizing Investigators Research Award for New & Early-Stage Investigators

Duygu Ucar (PI), Jackson Lab for Genomic Medicine

07/01/2017-06/30/2022

Role: Co-Investigator 

 

NIA/NIH; Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME Collaborative)

UH2 AG056925; Predictors and Determinants of Age-Related Changes in Resiliencies to Physical Stressors in Humans (UH2/UH3)

Cathleen Colon-Emeric and Heather Whitson (Multiple PIs); Duke University Medical Center

09/30/2017-05/31/2019

Role: Immunology Group Lead; Consortium Co-Investigator 

 

NIA/NIH; Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture

R01 AG051647

Multiple PI Plan: Binder, E. (communicating PI/Wash U), Schechtman, K. (Wash U), Volpi, E. (UTMB), Kuchel, G.(UCONN), Orwig, D. (U Maryland), Schwartz, R. (U Colorado), Magaziner, J. (U Maryland), Kiel, D. (Harvard)

UCHC Budget: $272,235/yr; 09/15/2017 – 05/31/2022

Role: Co-Investigator

 

CMMS/DHHS; Transforming Clinical Practices: Practice Transformation Network          

1L1 CMS331467-01

PI: Dr Bruce Liang (UConn) and Dr David Polakoff (UMass)

Annual Budget: $ 1,305,264; 9/29/2015-9/28/2019                                          

Role: co-investigator 

 

NIA/NIH; R21 AG060018. Understanding the role of ApoE2 in longevity and age-related diseases and conditions using 500,000 UK Biobank participants

PI: Chia-Ling Kuo (UConn Biostatistics), David Melzer (UConn Center on Aging & U Exeter), George Kuchel (UConn Center on Aging).

Budget: $357,374; 7/1/2018-6/30/2020

Role: Co-Investigator 

 

NIA/NIH; NIA Translational Geroscience Network (TGN)

R33 AG061456; Multiple PI Plan: Kirkland JL (Mayo), Kritchevsky S (Wake Forest), Kuchel G (UConn) and Tchkonia T (Mayo)

UCHC Budget (Direct): $ 174,394; 02/01/2019-11/30/2023

Roles: Multiple PI; Chair of Biobanking and Repository Committee 

 

NIAID/NIH; High-resolution single cell profiling of vaccine responsiveness in the elderly

R01 AI142086; PI: J Banchereau (Jackson Lab for Genomic Medicine)

UCHC Budget (Direct): $19,232; 10/01/2018-9/30/2023

Role: Co-Investigator 

 

Current Grant Support(Roles without a funded effort):   

NIA/NIH; Cytoskeletal functions in cell aging and disease

K02 AG050774; Ken Campellone – PI (Mol Cell Bio; UConn, Storrs); Co-Mentors: G Kuchel and Laura Haynes (UConn); Ron Korstanje (JAX BH)

09/15/2016-04/30/2021

Role: Co-Mentor (No Funded Effort)

 

NIA/NIH; Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding and Incontinence

K76 AG054777; Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)

Phillip P Smith, MD (PI)

George A Kuchel, MD (Primary Mentor)

Eric Levine, PhD (Neuroscience); Laura Haynes, PhD (Aging/Immunology), and Lori Birder, PhD (Cell Biology/U Pittsburgh) co-mentors

Total Budget: $646,773; 9/1/2016-10/30/2019.

Role: Primary Mentor (No funded effort)

 

AFAR; Effect of Metformin on Influenza Vaccine Responses and T cell Function in the Elderly

2018 Irene Diamond Fund/AFAR Postdoctoral Transition Award in Aging

Jenna Bartley, PhD (PI)

George A Kuchel, MD (Primary Mentor)

Laura Haynes, PhD (Aging/Immunology) co-mentor

7/1/2018-6/31/2020

 

CICATS (Connecticut Institute for Clinical and Translational Sciences)

Effect of Metformin on Influenza Vaccine Responses and T cell Function in the Elderly

2018 Irene Diamond Fund/AFAR Postdoctoral Transition Award in Aging

Jenna Bartley, PhD (PI)

George A Kuchel, MD (Primary Mentor)

Laura Haynes, PhD (Aging/Immunology) co-mentor

7/1/2018-6/31/2020

 

UConn Microbiome Research Seed Grant; Microbiome Plasticity and Pathogenicity in Older Adults: Baselines of Community Dwelling Adults

George Kuchel (PI); Julia Oh, Jackson Lab (MPI), Julie Robison, Center on Aging (MPI),                

Jamie Grady, Biostatistics (co-investigator), Ock K Chun, Nutritional Sciences (co-investigator)

Budget: $ 50,000; 01/01/19-12/31/19

NIA/NIH; Delirium, Dementia and the Vulnerable Brain: An Integrative Approach

P01 AG031720

Sharon K. Inouye, MD, MPH, Principal Investigator (Harvard/Beth Israel).

9/15/19-5/31/2023

Role: Chair, Scientific Advisory Board (No Funded Effort).

 

 

Accepting Lab Rotation Students: Summer '19, Fall '19, Spring '20

Research Rotation Projects

Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases  training in the translational T1 (bench to bedside) sciences.

Journal Articles

Book Chapters

Abstracts

Conference Papers

Editorials

Erratums

Letters

Reviews

Short Surveys

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective.	Plenary Lecture	SUFU Annual Meeting	2019	Miami, FL
Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience.	Talk	Robert and Arlene Kogod Aging Center, Mayo Clinic	2018	Mayo Clinic, Rochester, MN
Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights.	Talk	Department of Medicine, Montefiore Medical Center	2018	New York, NY
Biomarkers for geroscience-guided clinical trials	Talk	NIA P30 Claude D. Pepper Older Americans Independence Center	2018	Arlington, VA
Role of Biomarkers in Aging and Vitality	Talk	WHO Clinical Consortium on Healthy Aging meeting on Vitality	2018	New York, NY
Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME.	Talk	9th Annual Alliance for Healthy Aging Research, Mayo Clinic	2018	Rochester, MN
New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms.	Talk	NIA Workshop on the Epidemiology of Aging. NIA Intramural Program	2018	Baltimore, MD
Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience.	Plenary Lecture	31st Annual Meeting of the Canadian Society for Immunology	2018	London, Ont. Canada