Photo of George A. Kuchel, M.D., FRCP, AGSF

George A. Kuchel, M.D., FRCP, AGSF

Travelers Chair in Geriatrics and Gerontology
Professor of Medicine
Director, UConn Center on Aging
Chief of Geriatric Medicine
Academic Office Location:
UConn Center on Aging
UConn Health
263 Farmington Avenue
Farmington, CT 06030-5215
Phone: 860-679-3956
860-679-6796
Fax: 860-679-1307
Website(s):

UConn Center on Aging

Genetics & Developmental Biology Graduate Program

Education
DegreeInstitutionMajor
OtherVanier CollegeHealth Sciences
OtherMcGill Medical SchoolMedicine

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipMontreal General HospitalInternal Medicine
ResidencyMontreal General HospitalInternal Medicine
PostdoctoralHarvard Medical SchoolKaiser, Faculty Development Program in General Internal Medicine
FellowshipHarvard Medical School, Division on Aging and Beth Israel HospitalGeriatrics and Gerontology
PostdoctoralHarvard Medical SchoolBiological Chemistry and Molecular Pharmacology
PostdoctoralMount Sinai Medical CenterNeurobiology and Gerontology

Awards
Name of Award/HonorAwarding Organization
Brookdale Senior Fellow, New York Brookdale Foundation
John A. Hartford Leadership Award
Travelers/Citicorp Chair in Geriatrics and GerontologyUniversity of Connecticut
Montreal General Hospital 175th Anniversary Award Montreal General Hospital
Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec
FellowshipMedical Research Council of Canada
Brookdale National FellowBrookdale Foundation
Royal Canadian Legion Fellowship in Geriatric Medicine
Mona Bronfman Scheckman Prize in PsychiatryMcGill
University ScholarMcGill
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Aging Systems and Geriatrics Study Section, NIH/CSR Study SectionChairExternalNational20082011
Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR Study SectionMemberExternalNational20072011
Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut Advisory CommitteeAdvisory BoardExternalUniversity2002
Older Americans Independence Center, University of Connecticut Professional/Scientific OrganizationDirectorExternalUniversity20012004
MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill Education CommitteeCommittee MemberExternalUniversity19982001
Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ Professional/Scientific OrganizationDirectorExternalUniversity19982001
Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ Professional/Scientific OrganizationCo-PIExternalUniversity19961999
Research fellow, Neurobiology, Mount Sinai School of Medicine, New York Professional/Scientific OrganizationFellowExternalUniversity19891992
Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School Professional/Scientific OrganizationFellowExternalUniversity19871989
Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School Education CommitteeMemberExternalUniversity19851986

RESEARCH INTERESTS:



  1. Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense

  2. Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging

  3. Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”

Current Research Support

NIH/NIA R33 AG061456       Kirkland, Kritchevsky, Kuchel (MPIs)       02/01/2019-11/30/2023
Translational Geroscience Network
The role of the NIA Translational Geroscience Network (TGN) is to develop a consortium of academic programs in geriatrics focused on overcoming barriers to the translation of new geroscience-guided therapies from bench research to human studies and ultimately clinical care.
Role: Multiple PI (MPI)

NIH/NIA R21 AG063528       Kuchel, Xu, Smith (MPIs)       04/15/2019-12/31/2020
Role of Senolytics in Lower Urinary Tract Aging and Voiding Disorders
Our goal is to test senolytic drugs that target senescent cells throughout the body including the bladder and nervous system for their ability to prevent or slow the onset of bladder dysfunction in mouse models of aging.
Role: Multiple PI

NIH/NIA R56 AG060746       Oh, Robison, Kuchel (MPIs)       09/01/2019-08/31/2020
Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing Care
We will examine differences in microbiomes between older adults residing in different long-term care facilities and follow their return to the community, assessing baseline differences and microbiome “plasticity” on transition.
Role: Multiple PI

IHS-1502-27171 (PCORI)       Fortinsky (PI)       05/01/2016-09/30/2023
3D Team Care for Cognitively Vulnerable Older Adults
Achieving better outcomes for cognitively vulnerable community-dwelling older adults living with dementia, depression, and/or delirium via home-based clinical care teams guided by APRNs with geriatrics expertise.
Role: Co-Investigator

NIH/NIA R01 AG051647       Binder (PI; Washington U)       09/15/2017-05/31/2022
Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture
Dr. Fortinsky and Dr. Kuchel (site Co-PIs) will work with others to perform a multicenter randomized clinical trial of testosterone therapy and exercise training on functional capacity in frail older women post hip fracture.
Role: Co-investigator

NIH/NIGMS R35 GM124922       Ucar (PI; Jackson Lab)       08/01/2017-07/31/2022
Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells
The goal of these studies is to define chromatin changes associated with aging in human immune cells.
Role: Co-Investigator

NIH/NIAID R01 AG052608       Banchereau (PI; Jackson Lab)       09/01/2016-04/30/2020
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
We are evaluating the impact of aging on genomic and epigenomic responses within peripheral white blood cells upon administration of pneumococcal vaccines, PPSV23 (Pneumovax®) and PCV13 (Prevnar®).
Role: Co-Investigator

NIH/NIAID U01 AI124297       Banchereau (PI; Jackson Lab)       04/15/2016-03/31/2021
Combination Adjuvants to Activate Human Dendritic Cell Subsets and B Cells
We are studying human dendritic cell (DC) subsets exposed to adjuvants ex vivo and in vivo, assessing capacity of adjuvant-activated human DC subsets to skew differentiation of naïve CD4+ T cells into Tfh cells.
Role: Co-Investigator

NIH/NIA K76 AG054777       Smith (PI)       09/15/2016-05/31/2020
Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding Problems and Incontinence
Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)
Role: Primary Mentor; Eric Levine, PhD; Laura Haynes, PhD, and Lori Birder, PhD (co-mentors)

NIH/NIA R21 AG060018       Kuo (PI)        09/01/2018-06/30/2020
Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions using 500,000 UK Biobank Participants
We will use UK Biobank data, which features a very large sample size (500,000 participants) and rich genetic and phenotypic data, to characterize associations between ApoE2 and age-related health outcomes.
Role: Co-Investigator

NIH/NIA R01 AG058814       Smith (PI)       05/15/2019-01/31/2024
Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
The main goal of this project is to investigate the role of a “pacemaker” ion channel in the age evolution of a control mechanism critical to neural regulation of bladder volume sensitivity.
Role: Co-Investigator

NIH/NIA 75N95019P00538       Kuchel (PI)       08/19/2019-08/18/2020
Precision Geroscience: Heterogeneity in the Genetics of Inflammatory Variants and Immunogenic Responses to Exercise and Dietary Restriction with Aging
We will establish the roles of inflammatory cytokines in chronic diseases of aging, healthspan, and lifespan by examining GWAS variants in UK Biobank and gene expression data in human PBMCs after clinical interventions.
Role: PI

NIH/NIAID R01 AI142086       Banchereau (PI; Jackson Lab)       02/14/2020-01/31/2024
High-Resolution Single Cell Profiling of Vaccine Responsiveness in the Elderly
Drs. Kuchel and McElhaney will provide cryopreserved PBMC samples from earlier study of high-dose (HD) vs. standard dose (SD) flu vaccine to define key determinants of cell-mediated vaccine protection in frail older subjects. They will also assist with data analysis and manuscript preparation.
Role: Co-Investigator

NIH/NIA UH3AG056925-S1       Colon-Emeric, Whitson (PIs; Duke)       10/01/2019-09/30/2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative-Administrative Supplement
Drs. Kuchel and Banchereau will oversee study design, execution and data analysis of study of genome-wide signatures of poor and high resiliency using baseline samples of subjects with PCR-proven flu infection. 
Role: Consortium Co-Investigator

NIH/NIA UH3AG056925-03       Colon-Emeric, Whitson (PIs; Duke)       10/01/2019-09/30/2022
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
Dr. Kuchel will advise on proposed analyses regarding stimulation of PBMCs as part of the PRIME-KNEE study. He will also join the study steering committee.
Role: Consultant

NIH/NIA U24AG065204       Van der Willik, Gill, Walston, Yaffe (PIs)        09/30/2019-04/30/2024
Clin-STAR Coordinating Center
Role: Member, External Advisory Committee

Accepting Lab Rotation Students: Summer '19, Fall '19, Spring '20


Research Rotation Projects


Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases  training in the translational T1 (bench to bedside) sciences.

Journal Articles

Book Chapters

  • Aging of the Urinary Tract
    Smith PP, Kuchel G Brocklehurst's Textbook of Geriatrics and Clinical Gerontology 2010 Jan;
  • Aging, Animal Model
    Kuchel, G.A., Zhu, Q., Rogina, B. and Clark, S.H. Encyclopedia of Endocrine Diseases 2004 Jan;126-130
  • Influenza Vaccination: Accelerating the process for new vaccine development in older adults
    McElhaney J.E., Andrew M.K., Haynes L., Kuchel G.A., McNeill S.A. and Pawelec G. Vaccines for the older population

Abstracts

  • Upside-Down Stomach in a 92-year-old Woman
    Maghaydah YS, Kuchel GA. J Am Geriatr Soc 2007 Jan;55(8):1307-9
  • Macrophage migration inhibitory factor mediates smooth muscle death in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. J Urol 2005 Jan;17338
  • Null mutation in macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. J Am Geriatr Soc. 2005 Jan;538

Conference Papers

  • Mice with a null mutation for macrophage migration inhibitory factor have lower stage tumors in a model of bladder cancer. Taylor won New Investigator Award.
    Taylor JA, Kuchel GA, Hegde H, Voznesensky OS, Claffey K, Tsmikas J, Bucala R and Pilbeam C. 2006 Jan;
  • Locomotion in vitamin D receptor gene knockout mice.
    DuBose M, Sasso D, Kenny A, Pilbeam C, Demay M and Kuchel GA. 2005 Jan;
  • Macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Pilbeam C, Leng L, Bucala R and Kuchel GA. 2005 Jan;

Editorials

Erratums

Letters

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective.Plenary LectureSUFU Annual Meeting2019Miami, FL
Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience.TalkRobert and Arlene Kogod Aging Center, Mayo Clinic2018Mayo Clinic, Rochester, MN
Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights.TalkDepartment of Medicine, Montefiore Medical Center2018New York, NY
Biomarkers for geroscience-guided clinical trialsTalkNIA P30 Claude D. Pepper Older Americans Independence Center2018Arlington, VA
Role of Biomarkers in Aging and VitalityTalkWHO Clinical Consortium on Healthy Aging meeting on Vitality2018New York, NY
Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME.Talk9th Annual Alliance for Healthy Aging Research, Mayo Clinic2018Rochester, MN
New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms.TalkNIA Workshop on the Epidemiology of Aging. NIA Intramural Program2018Baltimore, MD
Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience.Plenary Lecture31st Annual Meeting of the Canadian Society for Immunology2018London, Ont. Canada