George A. Kuchel, M.D., FRCP, AGSFTravelers Chair in Geriatrics and Gerontology
Professor of Medicine
Director, UConn Center on Aging
Chief of Geriatric Medicine
- Education & Training
- Committees & Organizations
- Research Opportunities
- Lab Rotations
|Other||Vanier College||Health Sciences|
|Other||McGill Medical School||Medicine|
|Internship||Montreal General Hospital||Internal Medicine|
|Residency||Montreal General Hospital||Internal Medicine|
|Postdoctoral||Harvard Medical School||Kaiser, Faculty Development Program in General Internal Medicine|
|Fellowship||Harvard Medical School, Division on Aging and Beth Israel Hospital||Geriatrics and Gerontology|
|Postdoctoral||Harvard Medical School||Biological Chemistry and Molecular Pharmacology|
|Postdoctoral||Mount Sinai Medical Center||Neurobiology and Gerontology|
|Name of Award/Honor||Awarding Organization|
|Brookdale Senior Fellow, New York||Brookdale Foundation|
|John A. Hartford Leadership Award|
|Travelers/Citicorp Chair in Geriatrics and Gerontology||University of Connecticut|
|Montreal General Hospital 175th Anniversary Award||Montreal General Hospital|
|Chercheur-Boursier Award, Fonds de la Recherche en Santé du Québec|
|Fellowship||Medical Research Council of Canada|
|Brookdale National Fellow||Brookdale Foundation|
|Royal Canadian Legion Fellowship in Geriatric Medicine|
|Mona Bronfman Scheckman Prize in Psychiatry||McGill|
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|Aging Systems and Geriatrics Study Section, NIH/CSR||Study Section||Chair||External||National||2008||2011|
|Chartered Member, Aging Systems and Geriatrics Study Section, NIH/CSR||Study Section||Member||External||National||2007||2011|
|Advisor, Doctoral Program in Biomedical Science (Developmental Biology), U. of Connecticut||Advisory Committee||Advisory Board||External||University||2002|
|Older Americans Independence Center, University of Connecticut||Professional/Scientific Organization||Director||External||University||2001||2004|
|MD-PhD Training Program Coordinating Committee, Faculty of Medicine, McGill||Education Committee||Committee Member||External||University||1998||2001|
|Incontinence Research Group, Research Network in Gerontology & Geriatrics, FRSQ||Professional/Scientific Organization||Director||External||University||1998||2001|
|Co-PI, The Quebec Research Network in Gerontology & Geriatrics, FRSQ||Professional/Scientific Organization||Co-PI||External||University||1996||1999|
|Research fellow, Neurobiology, Mount Sinai School of Medicine, New York||Professional/Scientific Organization||Fellow||External||University||1989||1992|
|Research fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School||Professional/Scientific Organization||Fellow||External||University||1987||1989|
|Faculty Development in General Internal Medicine,"Kaiser" Curriculum, Harvard Medical School||Education Committee||Member||External||University||1985||1986|
- Multidisciplinary approaches to the study of aging emphasizing inter-individual variability and resilience mechanisms pertaining to mobility, voiding, cognition and host defense
- Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging
- Personalized and mechanism-guided approaches to the diagnosis and management of common geriatric syndromes – “Precision Geroscience”
Current Research Support
NIH/NIA R33 AG061456 Kirkland, Kritchevsky, Kuchel (MPIs) 02/01/2019-11/30/2023
Translational Geroscience Network
The role of the NIA Translational Geroscience Network (TGN) is to develop a consortium of academic programs in geriatrics focused on overcoming barriers to the translation of new geroscience-guided therapies from bench research to human studies and ultimately clinical care.
Role: Multiple PI (MPI)
NIH/NIA R21 AG063528 Kuchel, Xu, Smith (MPIs) 04/15/2019-12/31/2020
Role of Senolytics in Lower Urinary Tract Aging and Voiding Disorders
Our goal is to test senolytic drugs that target senescent cells throughout the body including the bladder and nervous system for their ability to prevent or slow the onset of bladder dysfunction in mouse models of aging.
Role: Multiple PI
NIH/NIA R56 AG060746 Oh, Robison, Kuchel (MPIs) 09/01/2019-08/31/2020
Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing Care
We will examine differences in microbiomes between older adults residing in different long-term care facilities and follow their return to the community, assessing baseline differences and microbiome “plasticity” on transition.
Role: Multiple PI
IHS-1502-27171 (PCORI) Fortinsky (PI) 05/01/2016-09/30/2023
3D Team Care for Cognitively Vulnerable Older Adults
Achieving better outcomes for cognitively vulnerable community-dwelling older adults living with dementia, depression, and/or delirium via home-based clinical care teams guided by APRNs with geriatrics expertise.
NIH/NIA R01 AG051647 Binder (PI; Washington U) 09/15/2017-05/31/2022
Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture
Dr. Fortinsky and Dr. Kuchel (site Co-PIs) will work with others to perform a multicenter randomized clinical trial of testosterone therapy and exercise training on functional capacity in frail older women post hip fracture.
NIH/NIGMS R35 GM124922 Ucar (PI; Jackson Lab) 08/01/2017-07/31/2022
Identification and Interpretation of Chromatin Changes Associated with the Aging of Human Immune Cells
The goal of these studies is to define chromatin changes associated with aging in human immune cells.
NIH/NIAID R01 AG052608 Banchereau (PI; Jackson Lab) 09/01/2016-04/30/2020
Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
We are evaluating the impact of aging on genomic and epigenomic responses within peripheral white blood cells upon administration of pneumococcal vaccines, PPSV23 (Pneumovax®) and PCV13 (Prevnar®).
NIH/NIAID U01 AI124297 Banchereau (PI; Jackson Lab) 04/15/2016-03/31/2021
Combination Adjuvants to Activate Human Dendritic Cell Subsets and B Cells
We are studying human dendritic cell (DC) subsets exposed to adjuvants ex vivo and in vivo, assessing capacity of adjuvant-activated human DC subsets to skew differentiation of naïve CD4+ T cells into Tfh cells.
NIH/NIA K76 AG054777 Smith (PI) 09/15/2016-05/31/2020
Regulatory Mechanisms in a Homeostatic Model of Geriatric Voiding Problems and Incontinence
Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)
Role: Primary Mentor; Eric Levine, PhD; Laura Haynes, PhD, and Lori Birder, PhD (co-mentors)
NIH/NIA R21 AG060018 Kuo (PI) 09/01/2018-06/30/2020
Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions using 500,000 UK Biobank Participants
We will use UK Biobank data, which features a very large sample size (500,000 participants) and rich genetic and phenotypic data, to characterize associations between ApoE2 and age-related health outcomes.
NIH/NIA R01 AG058814 Smith (PI) 05/15/2019-01/31/2024
Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
The main goal of this project is to investigate the role of a “pacemaker” ion channel in the age evolution of a control mechanism critical to neural regulation of bladder volume sensitivity.
NIH/NIA 75N95019P00538 Kuchel (PI) 08/19/2019-08/18/2020
Precision Geroscience: Heterogeneity in the Genetics of Inflammatory Variants and Immunogenic Responses to Exercise and Dietary Restriction with Aging
We will establish the roles of inflammatory cytokines in chronic diseases of aging, healthspan, and lifespan by examining GWAS variants in UK Biobank and gene expression data in human PBMCs after clinical interventions.
NIH/NIAID R01 AI142086 Banchereau (PI; Jackson Lab) 02/14/2020-01/31/2024
High-Resolution Single Cell Profiling of Vaccine Responsiveness in the Elderly
Drs. Kuchel and McElhaney will provide cryopreserved PBMC samples from earlier study of high-dose (HD) vs. standard dose (SD) flu vaccine to define key determinants of cell-mediated vaccine protection in frail older subjects. They will also assist with data analysis and manuscript preparation.
NIH/NIA UH3AG056925-S1 Colon-Emeric, Whitson (PIs; Duke) 10/01/2019-09/30/2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative-Administrative Supplement
Drs. Kuchel and Banchereau will oversee study design, execution and data analysis of study of genome-wide signatures of poor and high resiliency using baseline samples of subjects with PCR-proven flu infection.
Role: Consortium Co-Investigator
NIH/NIA UH3AG056925-03 Colon-Emeric, Whitson (PIs; Duke) 10/01/2019-09/30/2022
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
Dr. Kuchel will advise on proposed analyses regarding stimulation of PBMCs as part of the PRIME-KNEE study. He will also join the study steering committee.
NIH/NIA U24AG065204 Van der Willik, Gill, Walston, Yaffe (PIs) 09/30/2019-04/30/2024
Clin-STAR Coordinating Center
Role: Member, External Advisory Committee
Accepting Lab Rotation Students: Summer '20, Fall '20, Spring '21
Research Rotation Projects
Depending on trainee background and career interests they may include experiences involving basic bench science, human subject research or in selected cases training in the translational T1 (bench to bedside) sciences.
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|Importance of Mitochondrial Heath in the Aging Bladder: A Translational Perspective.||Plenary Lecture||2019 SUFU Annual Meeting||2019||Miami, FL|
|Precision Gerontology: Translational Insights into the Biological Basis of Physical Resilience.||Talk||Robert and Arlene Kogod Aging Center, Mayo Clinic||2018||Mayo Clinic, Rochester, MN|
|Voiding Disorders and Incontinence in Frail Older Adults: A clinical update and some novel pathophysiological insights.||Talk||Department of Medicine, Montefiore Medical Center||2018||New York, NY|
|Biomarkers for geroscience-guided clinical trials||Talk||NIA P30 Claude D. Pepper Older Americans Independence Center||2018||Arlington, VA|
|Role of Biomarkers in Aging and Vitality||Talk||WHO Clinical Consortium on Healthy Aging meeting on Vitality||2018||New York, NY|
|Biomarkers for early identification of “response to treatment” in Geroscience-guided clinical trials: Insights from TAME.||Talk||9th Annual Alliance for Healthy Aging Research, Mayo Clinic||2018||Rochester, MN|
|New Approaches to the Study of Geriatric Syndromes: Moving from Beliefs, Opinions and Associations to Mechanisms.||Talk||NIA Workshop on the Epidemiology of Aging. NIA Intramural Program||2018||Baltimore, MD|
|Immune Responses to Vaccination in Aging: Insights into Frailty and Physical Resilience.||Plenary Lecture||31st Annual Meeting of the Canadian Society for Immunology||2018||London, Ont. Canada|