Anne M. Delany, Ph.D.Professor, Medicine
- Education & Training
- Committees & Organizations
- Lab Rotations
Regulation of osteoblast gene expression by microRNAs; Molecular mechanisms controlling bone remodeling.
|B.S.||Roger Williams College||Chemistry|
|Ph.D.||Dartmouth Medical School||Biochemistry|
|Postdoctoral||Dartmouth Medical School||Biochemistry (Constance Brinckerhoff, PhD)|
|Postdoctoral||Saint Francis Hospital & Medical Center||Postdoctoral Fellow, Bone Biology (Ernesto Canalis, MD)|
|Name of Award/Honor||Awarding Organization|
|Young Investigator Award||American Society for Bone and Mineral Research|
l am very interested in mentoring and I am committed to the success of my graduate students. Recognizing that each student is different, I enjoy learning about my students and finding ways to help them build on their strengths and work on skills needing improvement.
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|MD/PhD Admissions Committee||Advisory Committee||committee member||UConn Health||University||2023|
|Skeletal Biology Development and Disease (SBDD) Study Section||Study Section||ad hoc committee member||External||National||2022|
|Vidi-programme NWO/ZonMw / Dutch Research Council||Study Section||ad hoc committee member||External||International||2022|
|MD/PhD Executive Committee||Advisory Committee||committee member||UConn Health||University||2022|
|Skeletal Biology Structure and Regeneration (SBSR) study section/NIH||Study Section||ad hoc committee member||External||National||2021|
|Member Conflict: Skeletal and Dental Biology and Tissue Engineering SEP/ NIH||Study Section||Committee Chair||External||National||2021|
|Graduate School Diversity, Equity and Inclusion Committee||Advisory Committee||committee member||UConn Health||University||2021|
|Skeletal Biology and Regeneration Recruitment Committee||Advisory Committee||Chair||UConn Health||University||2020||2022|
|Graduate Programs Committee||Advisory Committee||Chair||UConn Health||University||2020||2022|
|Education Council||Advisory Committee||committee member||UConn Health||University||2020||2022|
|Academic Advancement Committee||Advisory Committee||committee member||UConn Health||University||2020||2024|
|Graduate Faculty Council||Advisory Committee||member||UConn Health||University||2019||2020|
|Institutional Animal Care and Use Committee||Advisory Committee||member||UConn Health||Local||2018|
|Graduate Programs Committee||Advisory Committee||vice chair||UConn Health||Local||2018||2020|
|microCT Core Advisory Committee||Advisory Committee||UConn Health||University||2018|
|Skeletal Biology and Regeneration Program||Advisory Committee||director||UConn Health||Local||2016||2018|
|Skeletal Biology Structure and Regeneration (SBSR) Study Section||Study Section||Member||External||National||2015||2019|
|Society for Osteobiology||Professional/Scientific Organization||member||External||International||2015|
|Skeletal Biology and Regeneration Program||Advisory Committee||associate director||UConn Health||Local||2014||2016|
|Skeletal Biology and Regeneration Program Executive Committee||Advisory Committee||member||UConn Health||Local||2014||2020|
|Abstract Review Committee American Society for Bone and Mineral Research||Professional/Scientific Organization||member||External||International||2013||2013|
|Abstract Review Committee Member American Society for Bone and Mineral Research||Professional/Scientific Organization||member||External||International||2011||2011|
|Skeletal Craniofacial Oral Biology Graduate Program, Preliminary Exam Review Committee||Advisory Committee||member||UConn Health||University||2011||2011|
|Skeletal Craniofacial Oral Biology Graduate Program: Preliminary Exam Review Committee||Professional/Scientific Organization||Member||External||National||2011|
|Curriculum Policy Subcommittee||Advisory Committee||Vice Chair||UConn Health||University||2010|
|Endocrine Society||Professional/Scientific Organization||Member||External||National||2010|
|Curriculum Policy Subcommittee||Professional/Scientific Organization||Vice Chair||External||National||2010|
|Science Policy Committee American Society for Bone and Mineral Research||Professional/Scientific Organization||member||External||International||2008||2011|
|Molecular Core Advisory Committee||Advisory Committee||Member||UConn Health||University||2008|
|International Bone and Cancer Society||Professional/Scientific Organization||Member||External||International||2008|
|American Society for Bone and Mineral Research: Science Policy Committee||Professional/Scientific Organization||Member||External||National||2008||2011|
|Molecular Core Advisory Committee||Professional/Scientific Organization||Member||External||National||2008||2013|
|Faculty Search Committee, Center for Molecular Medicine||Professional/Scientific Organization||Member||External||National||2008||2009|
|Biomedical Sciences Graduate Admissions Committee||Professional/Scientific Organization||Application reviews, interviews||External||National||2007||2011|
|Abstract Review Committee Member American Society for Bone and Mineral Research||Professional/Scientific Organization||member||External||International||2004||2004|
|American Society for Bone and Mineral Research: Abstract Review Committee||Professional/Scientific Organization||Member||External||National||2004|
|Current Rheumatology Reviews||Editorial Board||Member||External||National||2004|
|Pilot & Feasibility Core UCHC Musculoskeletal Core Center Grant||Professional/Scientific Organization||Co-Director||External||University||2002||2004|
|American Society for Matrix Biology||Professional/Scientific Organization||Member||External||National||2000|
|Arthritis Research and Therapy||Professional/Scientific Journal||Member||External||National||1999||2009|
|American Society for Microbiology||Professional/Scientific Organization||Member||External||National||1995||2004|
|American Society for Bone and Mineral Research||Professional/Scientific Organization||member||External||International||1993|
My laboratory is focused on understanding how microRNAs (miRNAs), which are a class of small non-coding RNAs, regulate gene expression in bone cells. Osteoblasts are the cells responsible for bone formation, and we are interested in determining the molecular mechanisms by which miRNAs control the differentiation and function of these cells. In the osteoblast lineage, we are currently studying the function and regulation of miR-433-3p. In collaboration with Dr. Sun-Kyeong Lee (Center on Aging) we are also investigating how the miR-29-3p family of miRNAs regulates the commitment and function of bone-resorbing osteoclasts.
We utilize in vitro studies to identify specific mRNAs and signaling pathways regulated by miRNAs. We follow up on these observations by examining the skeletal phenotype of mouse models in which the expression of either miR-29 or miR-433 is inhibited in a lineage-restricted manner. These mouse models are also useful for determining how miRNAs affect the response of the skeleton to intermittently administered parathyroid hormone (PTH), which is a bone anabolic therapy, or to exogenous glucocorticoids, which can cause bone loss.
In additional collaborative studies with Dr. Archana Sanjay (Department of Orthopedics), we are investigating how miRNAs regulate the process of fracture repair in young vs aged mice and in healthy vs diabetic mice.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
Potential Lab Rotation Projects
1. Wnt signaling promotes commitment to the osteoblast lineage and is important for osteoblast function. miR-433 dampens Wnt signaling and we are interested in identifying components of the Wnt pathway that are targeted by miR-433.
2. A common progenitor gives rise to osteoclasts, macrophages and dendritic cells. Since miR-29 promotes osteoclast commitment in vitro, we are interested in determining whether progenitor cells from mice expressing a miR-29 inhibitor are more likely to differentiate towards the macrophage fate and whether RNAs important for macrophage commitment are targeted by miR-29.
3. Intermittent administration of PTH is a clinically relevant bone anabolic therapy. miR-433 targets Creb1, which is a transcription factor critical for signaling down stream of PTH receptor activation. We are interested in determining whether mice expressing a miR-433 inhibitor in bone are more responsive to intermittent PTH therapy.
Inhibition of miR-29 activity in the myeloid lineage increases response to calcitonin and trabecular bone volume in mice.
Endocrinology 2021 Jun;
miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 May;
Inhibition of miR-29-3p isoforms via tough decoy suppresses osteoblast function in homeostasis but promotes intermittent parathyroid hormone-induced bone anabolism.
Bone 2021 Feb;143115779
Rac1 inhibition via Srgap2 restrains inflammatory osteoclastogenesis and limits the clastokine, SLIT3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Jan;
Impaired osteocyte maturation in the pathogenesis of renal osteodystrophy.
Kidney international 2018 Nov;94(5):1002-1012
microRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression.
The Journal of biological chemistry 2016 Aug;29121717-21728
The microRNA-29 family in cartilage homeostasis and osteoarthritis.
Journal of molecular medicine (Berlin, Germany) 2015 Dec;94583-96
Primary osteoblast-like cells from patients with end-stage kidney disease reflect gene expression, proliferation, and mineralization characteristics ex vivo.
Kidney international 2014 Oct;87(3):593-601
A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Sep;30(4):723-32
Post-transcriptional regulation in osteoblasts using localized delivery of miR-29a inhibitor from nanofibers to enhance extracellular matrix deposition.
Acta biomaterialia 2014 May;10(8):3571-80
Pathway analysis of microRNA expression profile during murine osteoclastogenesis.
PloS one 2014 Jan;9(9):e107262
miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration.
The Journal of biological chemistry 2013 Oct;288(46):33347-60
IGF-I 3' untranslated region: strain-specific polymorphisms and motifs regulating IGF-I in osteoblasts.
Endocrinology 2013 Jan;154(1):253-62
Bone matrix osteonectin limits prostate cancer cell growth and survival.
Matrix biology : journal of the International Society for Matrix Biology 2012 Jun;31(5):299-307
MicroRNA biogenesis and regulation of bone remodeling.
Arthritis research & therapy 2011 Jan;13(3):220
Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.
Endocrinology 2010 Oct;151(10):4861-70
miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.
The Journal of biological chemistry 2010 Aug;285(33):25221-31
miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling.
Journal of cellular biochemistry 2009 Sep;108(1):216-24
Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice.
Bone 2008 Aug;43(2):264-73
Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008 Jul;19(7):969-78
Increased Notch 1 expression and attenuated stimulatory G protein coupling to adenylyl cyclase in osteonectin-null osteoblasts.
Endocrinology 2007 Apr;148(4):1666-74
AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts.
The Journal of biological chemistry 2004 Dec;279(7):5397-404
CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
Endocrinology 2004 Apr;145(4):1952-60
Notch 1 impairs osteoblastic cell differentiation.
Endocrinology 2003 Dec;144(12):5631-9
Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Jun;18(6):1005-11
Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression.
Bone 2002 May;30(5):685-91
Cortisol regulates the expression of Notch in osteoblasts.
Journal of cellular biochemistry 2002 Jan;85(2):252-8
The cellular and molecular basis of glucocorticoid actions in bone.
Frontiers of hormone research 2002 Jan;302-12
Glucocorticoid suppression of IGF I transcription in osteoblasts.
Molecular endocrinology (Baltimore, Md.) 2001 Oct;15(10):1781-9
Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture.
Bone 2001 May;28(5):484-90
The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts.
Endocrinology 2001 Apr;142(4):1561-6
Measuring transcription of metalloproteinase genes. Nuclear run-off assay vs analysis of hnRNA.
Methods in molecular biology (Clifton, N.J.) 2001 Jan;151321-33
Osteopenia and decreased bone formation in osteonectin-deficient mice.
The Journal of clinical investigation 2000 Apr;105(7):915-23
Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts.
Endocrinology 1999 Mar;140(3):1069-74
Dual regulation of stromelysin-3 by fibroblast growth factor-2 in murine osteoblasts.
The Journal of biological chemistry 1998 Jun;273(26):16595-600
Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts.
The American journal of physiology 1998 Mar;274(3 Pt 1):C734-40
Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures.
Journal of cellular biochemistry 1997 Nov;67(2):176-83
Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures.
The Journal of biological chemistry 1997 May;272(18):12144-50
Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors.
Endocrinology 1996 Nov;137(11):4665-70
Cortisol inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures by transcriptional mechanisms.
The Journal of biological chemistry 1996 Apr;271(15):9033-8
Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures.
Endocrinology 1996 Feb;137(2):431-7
Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms.
The Journal of biological chemistry 1995 Nov;270(44):26607-12
Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells.
Endocrinology 1995 Nov;136(11):4776-81
Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms.
Journal of cellular biochemistry 1995 Mar;57(3):488-94
Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.
Endocrinology 1995 Jan;136(1):33-8
Cytokines and Growth Factors in Arthritic Diseases: Mechanisms of Cell Proliferation and Matrix Degradation in Rheumatoid Arthritis
Cytokines in Inflammation
Growth Factors and Bone
Growth Factors and Cytokines in Health and Disease
Measuring Transcription of Matrix Metalloproteinases: Run-On vs. hnRNA
Matrix Metalloproteinase Protocols
miRNAs in bone repair
miRNA in Regenerative Medicine 653-683
The Cellular and Molecular Basis of Glucocorticoid Actions in Bone
Frontiers of Hormone Research: Glucocorticoid Induced Osteoporosis 2-12
. Inhibition of miR-29 activity in the myeloid lineage by expression of a miR-29 tough decoy enhances trabecular bone volume in male mice.
J Bone Miner Res 34(Suppl 1,):
Aberrant In Vitro Differentiation of Marrow Stromal Cells from Osteonectin-Null Mice Correlates with Osteopenic Phenotype In Vivo
J. Bone Mineral Res. 15(1):S344
Absence of Mineral Maturation in the Osteonectin-Null Mouse: An Age Dependent Study
J. Bone Mineral Res. 15(1):S205
Absence of Mineral Maturation in the Osteonectin-Null Mouse: An Age Dependent Study
J. Bone Mineral Res. 15(1):S04
Alternative Splicing, Polyadenylation, and MicroRNAs Targeting Insulin-Like Growth Factor-1 in Osteoblasts
J Bone Miner Res. 27(1):S94
Analysis of the 3' Untranslated Region of the IGF-I Gene: Implications for mRNA Stability and Serum IGF-I Levels
J. Bone Mineral Res. 24(1):S134
Basic Fibroblast Growth Factor (bFGF) Down-Regulates Osteonectin Expression in Osteoblasts by Transcriptional Mechanisms
J. Bone Mineral Res. 11(1):S403
CAAT Enhancer Binding Proteins Mediate Down Regulation of Insulin-Like Growth Factor I by Cortisol in Osteoblasts
J. Bone Mineral Res. 14(1):S234
Collagenase and its Activator: Members of a New Supergene Family of Metalloproteinases Which Induce an Oncogene Induced mRNA
Arthritis Rheum. 30S16
Cortisol Increases the Number of Cells of the Osteoblastic Lineage, but Precludes their Differentiation into Functional Osteoblasts
J. Bone Mineral Res. 15(1):S275
Cortisol Prevents the Differentiation of Stromal Cells into Mature Osteoblasts
J. Bone Mineral Res. 15(1):S240
Disparate regulation of EGF-induced metalloproteinase expression and proliferation in fibroblasts
Arthritis Rheum 31S93
Expression of Scatter Factor by Osteoblasts and Induction by Factors Promoting Fracture Healing
J. Bone Mineral Res. 12(1):S209
Fibroblast Growth Factor-2 (FGF-2) Modulates the Breast Cancer Associated Metalloproteinase, Stromelysin-3, in Osteoblasts
J. Bone Mineral Res 12(1):S432
Fibroblast Growth Factor-2 Decreases Osteonectin RNA Stability and Regulates Novel RNA Binding Proteins Associated with Its 3’-Untranslated Region
J. Bone Mineral Res. 14(1):S329
Glucocorticoids Regulate a Novel Cytosolic Protein that Binds to the Coding Region of Collagenase 3 mRNA
Glucocorticoids Regulate Novel Cytosolic Proteins Binding to the 3’ Untranslated Region of Collagenase 3 mRNA
J. Bone Mineral Res. 14(1):S297
Glucocorticoids Regulate Novel Cytosolic Proteins that Bind Specifically to the 3’ Untranslated Region of Collagenase 3 mRNA
J. Bone Mineral Res. 15(1):S250
Increased Notch 1 in Osteonectin-Null Osteoblasts: A Potential Mechanism for Aberrant Maturation
J. Bone Mineral Res. 19(1):S220
Inhibition of miR-433-3p activity in osteoblastic cells attenuates glucocorticoid-mediated trabecular bone loss
J Bone Miner Res
Inhibition of miR-433-3p activity in osteoblastic cells attenuates glucocorticoid-mediated trabecular bone loss
J Bone Miner Res 37(S1):
Insulin-Like Growth Factor (IGF) I is Required for the Expression of IGF Binding Protein-5 by the Osteoblast
J. Bone Mineral Res. 11(1):S177
Interaction of Prostate Cancer Cells with Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In Vitro
J. Bone Mineral Res. 24(1):S134
MicroRNA (miRNA) Binding Sites in the Osteonectin 3’ Untranslated Region (UTR) Regulate Expression
J. Bone Mineral Res. 20(1):S207
miR-29 Regulates Wnt Signaling in Human Osteoblasts Through a Positive Feedback Loop
J. Bone Mineral Res. 25(1):S65
Noggin Overexpression Precludes the Differentiation of Stromal Cells into Functional Osteoblasts
J. Bone Mineral Res. 16(1):S370
Notch 1 Constitutive Activation Induces a Shift From Osteoblastogenesis to Adipogenesis in Marrow Stromal Cells
J. Bone Mineral Res. 18(1):S6
Osteonectin 3’ Untranslated Region Single Nucleotide Polymorphisms Differentially Regulate Gene Expression: MicroRNAs Target SNP Regions
J. Bone Mineral Res. 25(1):S275
Osteonectin/SPARC is Critical for Anabolic Response to PTH in the Skeleton
J. Bone Mineral Res. 21(1):S134
Overexpression of CHOP, A Dominant-Negative C/EBP, Accelerates and Enhances Osteoblastic Differentiation
J. Bone Mineral Res. 17(1):S249
Overexpression of Notch 1 Receptor Intracellular Domain Inhibits Differentiation of Cells of the Osteoblastic Lineage
J. Bone Mineral Res. 17(1):S194
Poorly Structured Bone Matrix, Reminiscent of an “Osteoblastic” Lesion Promotes an Aggressive Gene Expression Profile in Prostate Carcinoma Cells In Vitro
Cancer Treatment Rev 42(1):S57
Slit-ROBO Rho GTPase activating protein 2 (SRGAP2) in osteoclasts limits inflammatory osteoclastogenesis and inhibits expression of the coupling clastokine SLIT3. J Bone
J Bone Miner Res. co-corresponding authors(Suppl 1,):
Specific Osteoblast Cytosolic Proteins Bind and Stabilize Collagenase 3 mRNA
J. Bone Mineral Res. 17(1):S405
Study of Osteonectin Gene Polymorphisms in Men with Idiopathic Osteoporosis
J. Bone Mineral Res. 18(1):S129
The Synthetic Retinoid (4-hydroxyphenyl)Retinamide Antagonizes TGFß Induced α1(I) Collagen mRNA
Arthritis Rheum. 33R39
Transcriptional Regulation of Insulin-Like Growth Factor-I (IGF-I) by Prostaglandin E2 (PGE2) in Osteoblasts
J. Bone Mineral Res. 9(1):S124
Transcriptional Repression of Insulin-Like Growth Factor I by Transforming Growth Factor β1 in Rat Osteoblastic Cells
J. Bone Mineral Res. 10(1):S144
Transcriptional Repression of Matrix Metalloproteinase I by Insulin-Like Growth Factor I in Rat Osteoblasts
J. Bone Mineral Res. 10(1):S164
Wnt 1 Induces the Differentiation of Stromal Cells into Mature Osteoblasts
J. Bone Mineral Res. 16(1):S492
Osteonectin-null mutation compromises osteoblast formation, maturation, and survival.
Endocrinology 2003 Jun;144(6):2588-96
Mechanisms of glucocorticoid action in bone.
Annals of the New York Academy of Sciences 2002 Jun;96673-81
Matricellular proteins osteopontin and osteonectin/SPARC in pancreatic carcinoma.
Cancer biology & therapy 2010 Jul;10(1):65-7
MicroRNAs regulating TGFβ and BMP signaling in the osteoblast lineage.
Bone 2021 Feb;143115791
MicroRNAs are Critical Regulators of Osteoclast Differentiation.
Current molecular biology reports 2019 Feb;5(1):65-74
MicroRNAs are critical regulators of osteoclast differentiation
Curr Mol Bio Rep 2019 Jan;5(1):65-74
MicroRNA variants as genetic determinants of bone mass.
Bone 2015 Dec;8457-68
Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling.
Journal of cell communication and signaling 2009 Dec;3(3-4):227-38
Mechanisms of glucocorticoid action in bone cells.
Journal of cellular biochemistry 1994 Nov;56(3):295-302
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|miRNAs in bone cells||Lecture||2021||University of Minnesota|
|miRNA regulation of gene expression in bone cells||Lecture||UConn RNA Salon||2019||UConn Storrs|
|Inhibition of miR-29 activity in the myeloid lineage by expression of a miR-29 tough decoy enhances trabecular bone volume in male mice||Poster||ASBMR||2019||Tampa, fl|
|Slit-ROBO Rho GTPase activating protein 2 (SRGAP2) in osteoclasts limits inflammatory osteoclastogenesis and inhibits expression of the coupling clastokine SLIT3.||Poster||ASBMR||2019||Tampa, fl|
|Meet the Professor: microRNAs and Bone||Lecture||American Society for Bone and Mineral Research||2018||Montreal, Canada|
|microRNA regulation of circadian rhythm in the osteoblastic lineage||Talk||Keystone Symposium: Small RNA Silencing: Little Guides, Big Biology||2016||Keystone, CO|
|Meet the Professor: microRNAs and Bone Homeostasis||Lecture||American Society for Bone and Mineral Research||2016||Atlanta, GA|
|miR-29 and Bone||Lecture||University of Uppsala||2014||Sweden|
|Polyadenylation, and MicroRNAs Targeting Insulin-like Growth Factor-1 in Osteoblasts||Poster||American Society for Bone and Mineral Research||2012||Minneapolis, Minnesota|
|miR-29 regulates osteoclastogenesis||Poster||American Society for Bone and Mineral Research||2012||Minneapolis, Minnesota|
|Role of miR-29 in bone||Lecture||Endocrine Society||2011||Boston,MA|
|MicroRNAs: No Small Role in Skeletal Regulation||Lecture||Endocrine Society||2011||Boston, Massachusetts|
|miR-29 Regulates Wnt Signaling in Human Osteoblasts Through A Positive Feedback Loop||Talk||American Society for Bone and Mineral Research||2010||Toronto, Canada|
|Bone Cartilage: Matrix Formation and Mineralization||Talk||American Society for Bone and Mineral Research||2010||Toronto, Canada|
|Osteonectin 3’ Untranslated Region Single Nucleotide Polymorphisms Differentially Regulate Gene Expression: microRNAs Target SNP Regions||Poster||American Society for Bone and Mineral Research||2010||Toronto, Canada|
|Analysis of the 3' Untranslated Region of the IGF-I Gene: Implications for mRNA Stability and Serum IGF-I Levels||Poster||American Society for Bone and Mineral Research||2009||Denver, Colorado|
|Interaction of Prostate Cancer Cells with Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In Vitro||Poster||American Society for Bone and Mineral Research||2009||Denver, Colorado|
|Association of Prostate Cancer Cells With Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In Vitro||Talk||International Meeting on Cancer Induced Bone Disease||2009||Arlington, Virgina|
|Function of Osteonectin in Bone, and its Post-transcriptional Regulation||Talk||American Society for Matrix Biology||2008||San Diego, CA|
|Regulation of Osteonectin/SPARC by MicroRNA-29||Talk||American Society for Bone and Mineral Research||2008||Montreal, Canada|
|Pediatric Nephrology Seminar Series||Talk||University of California||2008||Los Angeles, California|
|Special Interest Group – Bone Biology||Talk||American Society for Matrix Biology||2008||San Diego, California|
|Poorly Structured Bone Matrix, Reminiscent of an “Osteoblastic” Lesion Promotes an Aggressive Gene Expression Profile in Prostate Carcinoma Cells In vVtro||Talk||International Meeting on Cancer Induced Bone Disease||2008||Edinburgh, Scotland|
|Differential Regulation of Gene Expression by SNPs in the Osteonectin/SPARC 3’ Untranslated Region (UTR): A Mechanism for Modulation of Bone Mass||Poster||American Society for Bone and Mineral Research||2008||Montreal, Canada|
|Skeletal Biology Seminar Series||Talk||The Jackson Laboratories||2007||Bar Harbor, Maine|
|microRNAs and Bone||Lecture||American Society for Bone and Mineral Research||2006||Philadelphia, PA|
|Bone Rounds||Talk||Columbia University College of Physicians and Surgeons||2006||New York, New York|
|Trinity College Biology Department Seminar Series||Talk||Trinity College||2006||Hartford, Connecticut|
|Bone, Cartilage, Connective Tissue Matrix III||Talk||American Society for Bone and Mineral Research||2006||Philadelphia, Pennsylvania|
|“Meet the Professor” – MicroRNAs and Bone||Talk||American Society for Bone and Mineral Research||2006||Philadelphia, Pennsylvania|
|Osteonectin/SPARC is critical for anabolic response to PTH in the skeleton||Poster||American Society for Bone and Mineral Research||2006||Philadelphia, Pennsylvania|
|MicroRNA (miRNA) Binding Sites in the Osteonectin 3’ Untranslated Region (UTR) Regulate Expression||Talk||American Society for Bone and Mineral Research||2005||Nashville, Tennessee|
|Increased Notch 1 in Osteonectin-Null Osteoblasts: A Potential Mechanism for Aberrant Maturation||Poster||American Society for Bone and Mineral Research||2004||Seattle, Washington|
|Function and regulation of osteonectin in bone||Talk||Henry Ford Hospital||2003||Detroit, MI|
|State of the Art Lecture - Glucocorticoid Action||Talk||American Society for Bone and Mineral Research||2003||Minneapolis, Minnesota|
|Matricellular Proteins in Normal and Cancer Cell-Matrix Interactions||Talk||International Hermelin Brain Tumor Center Symposium||2003||Detroit, Michigan|
|Study of Osteonectin Gene Polymorphisms in Men With Idiopathic Osteoporosis||Poster||American Society for Bone and Mineral Research||2003||Minneapolis, Minnesota|
|Osteonectin in Bone||Panel Discussion||National Institutes of Health||2002||Bethesda, MD|
|Osteonectin Supports Osteoblast Maturation and Survival||Talk||American Society for Bone and Mineral Research||2002||San Antonio, Texas|
|Extracellular Matrix and Aging: Musculoskeletal System and Skin||Talk||National Institute on Aging Workshop||2002||Bethesda, Maryland|
|Osteonectin Supports Osteoblast Maturation and Survival||Poster||American Society for Bone and Mineral Research||2002||San Antonio, Texas|
|BMPs, TGF-beta, Other Growth Factors/Cytokines II||Talk||American Society for Bone and Mineral Research||2001||Phoenix, Arizona|
|The Osteonectin-Null Mutation Compromises Osteoblast Formation and Maturation||Poster||American Society for Bone and Mineral Research||2001||Toronto, Canada|
|Bone Cells – Osteoblasts II||Talk||American Society for Bone and Mineral Research||2000||Toronto, Canada|
|Aberrant In Vitro Differentiation of Marrow Stromal Cells from Osteonectin-Null Mice Correlates with Osteopenic Phenotype In Vivo||Poster||American Society for Bone and Mineral Research||2000||Toronto, Canada|
|Osteonectin-Null Mice Develop Severe Osteopenia||Talk||American Society for Bone and Mineral Research||1999|
|CAAT Enhancer Binding Proteins Mediate Down Regulation of Insulin-Like Growth Factor I by Cortisol in Osteoblasts||Poster||American Society for Bone and Mineral Research||1999|
|Fibroblast Growth Factor-2 Decreases Osteonectin RNA Stability and Regulates Novel RNA Binding Proteins Associated with its 3’-Untranslated Region||Poster||American Society for Bone and Mineral Research||1999|
|Fibroblast Growth Factor-2 (FGF-2) Modulates the Breast Cancer Associated Metalloproteinase, Stromelysin-3, in Osteoblasts||Poster||American Society for Bone and Mineral Research||1997|
|Basic Fibroblast Growth Factor (bFGF) Down-Regulates Osteonectin Expression in Osteoblasts by Transcriptional Mechanisms||Poster||American Society for Bone and Mineral Research||1996|
|Autocrine Suppression of Osteoblast Matrix Metalloproteinase I by Insulin-Like Growth Factor I||Talk||Endocrine Society||1995|
|Transcriptional Repression of Insulin-Like Growth Factor I by Transforming Growth Factor ß1 in Rat Osteoblast Cells||Talk||American Society for Bone and Mineral Research||1995|
|Transcriptional Repression of Matrix Metalloproteinase I by Insulin-Like Growth Factor I in Rat Osteoblast Cells||Talk||American Society for Bone and Mineral Research||1995|
|Cortisol Inhibits Insulin-Like Growth Factor-I (IGF-I) Expression in Osteoblasts by Transcriptional Mechanisms||Talk||American Society for Bone and Mineral Research||1994|
|Transcriptional Repression of the a1(I) Procollagen Gene by Cortisol in Cultured Rat Osteoblasts||Poster||Endocrine Society||1994|
|Cortisol Increases Interstitial Collagenase Expression in Osteoblasts by Post-Transcriptional Mechanisms||Poster||American Society for Bone and Mineral Research||1994|
|The Synthetic Retinoid (4-hydroxyphenyl)Retinamide Antagonizes TGFß Induced a1(I) Collagen mRNA||Poster||American College of Rheumatology||1990|
|Disparate Regulation of EGF-Induced Metalloproteinase Expression and Proliferation in Fibroblasts||Poster||American College of Rheumatology||1988|