Marja Hurley, MD FASBMRUniversity of Connecticut Distinguished ProfessorProfessor of Medicine and Orthopedic Surgery Associate Dean Health Career Opportunity Programs
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- Overview
- Education & Training
- Teaching
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
General Overview: Dr. Marja Hurley is a UConn Board of Trustees Distinguished Professor, and tenured Professor of Medicine and Orthopedics at the UConn School of Medicine. Dr. Hurley has made outstanding contributions as a physician scientist, educator and administrator at UConn Health and received local, national and international recognition and awards for her accomplishments in several of these domains. These include election to the Connecticut Academy of Science and Engineering; elected Fellow of the American Society for Bone and Mineral Research; Chair of the International FGF Gordon Conference; recipient of the University of Connecticut School of Medicine Distinguished Alumni Award; recipient of the prestigious Lawrence G Raisz Esteemed Award from the American Society for Bone Mineral Research for preclinical translational research; UConn Health Board of Directors Faculty Recognition Award and the Neag Medal of Honor. She also received the University of Connecticut first Martin Luther King Award for Achievement in Science and was recognized as one of the outstanding women in 100 years at the University of Connecticut. Dr. Hurley was the winner of the Connecticut Technology Council Women of Innovation and Leadership Award and she also serves as liaison to the AAMC Group on Women in Medicine and Science. In recognition of her contributions to educational equity, Dr. Hurley has received numerous awards including the first New England Board of Higher Education Award for innovation and excellence in higher education; the West Indian Foundation Community Service Award; the Community Service Award from the Capital Area Health Consortium and the Distinguished Service Award from the Foundation for Educational Achievement at Central Connecticut State University. She was also appointed a Commissioner of the Connecticut Legislative Commission on Health Equity.
Research: Dr. Hurley is recognized nationally and internationally for her expertise on the role of fibroblast growth factor-2 in skeletal biology and maintains an active NIH funded basic research laboratory that focuses on the molecular mechanisms of osteoarthritis, osteoporosis fracture repair and the role of FGF2 in bone, cartilage and phosphate homeostasis. A new area of research focus in her laboratory seeks to determine the molecular mechanism(s) of bone loss using Sickle Cell Disease and Sickle Cell Trait transgenic mouse models. Dr. Hurley's outstanding research productivity is demonstrated by her 204 peer reviewed publications including 83 manuscripts, 14 invited reviews and book chapters and 107 abstracts as well as NIH and Foundation research funding since 1989. Dr. Hurley currently serves as a member of ASBMR Council and NIH/NIDCR Board of Scientific Counselors.,
Education Initiatives: Dr. Hurley has made significant contributions in medical education equity as Associate Dean and Director of the Health Career Opportunity Programs at UConn Health. She has fostered the enrollment and career development of students in biomedical science at every level of the pipeline and substantially increased the number of underrepresented and first generation students attending the UConn Schools of Medicine and Dental Medicine. Dr. Hurley is the Founding Director of the Aetna Health Professions Partnership Initiative at UConn Health that now consists of 14 distinct programs for which she secured more than $14 million in extramural grants. These programs were endowed as The Aetna Health Professions Partnership Initiative with a 2-million-dollar gift from the Aetna Foundation. The success of this initiative can be assessed by the more than 700 students who have gained acceptance to U.S. Health Professions and Graduate Schools. Dr. Hurley is recognized nationally as a leader in education equity and has been an invited speaker at national meetings sponsored by the National Academy of Sciences, the Association of American Medical Colleges, the American Dental Education Association, the Kellogg and Robert Wood Johnson Foundations, and more. She served as Chair of the Women’s Affairs Committee of the American Dental Education Association and was an invited speaker/panelist at the Sullivan Alliance National Leadership Symposium on Health Professions Diversity. She was invited to present by the CT Governor’s Office for Workforce Development on the UConn Health Professions Partnership Initiative as a successful model of Connecticut Career Choices. She was appointed to the Connecticut State Department of Education and the Department of Higher Education College Ready Advisory Subcommittee of the Higher Education PK-16 Council. She also served as a panelist for Harvard Medical School, Biomedical Science Careers Student Conferences. Dr. Hurley recently served as Chair of the Oversight Board of NIH, NIDDK Network of Minority Health Research Investigators.
Administration: Dr. Hurley’s commitment to education of UConn medical students is exemplified by her willingness in 2010-2011 to serve as Interim Senior Associate Dean for Education and Academic Affairs. During this period, she played a key role in establishing new UConn School of Medicine governance for medical student education; development and implementation of the LCME action plan for reaccreditation of the School of Medicine. She served as Chair of the Education Council, Chair of the Committee on Undergraduate Medical Education (CUME) and Liaison to the Academic Affairs Committee of the Board of Directors of UConn Health. In recognition of her outstanding administrative leadership at UCONN Health, she has served on the Executive Vice President’s Advisory Committee; Chancellors Advisory Committee; Senior Appointments and Promotion Committee, Senior Administrative Group and Special Assistant to the Dean School of Medicine. Dr. Hurley currently serves as a voting member of the Academic Affairs Sub Committee of the UConn Health Board of Directors.
Degree | Institution | Major |
---|---|---|
BA | University of Connecticut | Biology |
MD | University of Connecticut Health Center | Medicine |
Post-Graduate Training
Training | Institution | Specialty |
---|---|---|
Residency | University of Connecticut Health Center | Internal Medicine |
Fellowship | University of Connecticut Health Center | Endocrinology |
Awards
Name of Award/Honor | Awarding Organization |
---|---|
Board Of Trustees Distinguished Professor | University of Connecticut |
Elected Member Association of Osteobiology | Association of Osteobiology |
Stem Achievement Award Organization Honoree | Connecticut Science Center |
Elected Council Member American Society for Bone and Mineral Research | American Society for Bone and Mineral Research |
Scientific Session Chair FGF Fusion Conference | FGF Fusion Conference |
Fellow of the American Society For Bone and Mineral Research | American Society For Bone and Mineral Research |
Alumni Distinguished Faculty Award, UCONN School of Medicine | UCONN School of Medicine |
Chair 2018 Fibroblast Growth Factors in Development and Disease Gordon Research Conference | Gordon Research Conference |
Elected Vice Chair FGF Gordon Research Conference, Hong Kong, China, 2016 | FGF Gordon Research Conference, Hong Kong, China, |
American Society of Bone and Mineral Research Lawrence G. Raisz, Esteemed Award for outstanding achievement in preclinical translational research | American Society of Bone and Mineral Research |
Spotlight SpeakerOrthopedic Research Society, Annual Meeting, March 2014 | Orthopedic Research Society |
Elected Chairman | American Dental Education Association Women’s Affairs Advisory Committee |
Elected as a Member of the Connecticut Academy of Science and Engineering | Connecticut Academy of Science and Engineering |
Recipient of the Greater Hartford West Indian Lions Club Community Service Award | Greater Hartford West Indian Lions Club |
University of Connecticut Health Center Board of Directors Faculty Recognition Award | University of Connecticut School of Medicine |
Recipient Neag Medal of Honor | University of Connecticut Health Center |
Faculty Honoree | University of Connecticut Health Center, White Coat GALA |
Winner Connecticut Science and Technology Woman of Innovation and Leadership Award | Connecticut Science and Technology Council |
Recipient of the West Indian Foundation Outstanding Community Service Award | West Indian Foundation |
New England Higher Education Excellence Award for Innovation in Education | New England Board of Higher Education |
Distinguished Service Award; Foundation for Education Advancement | Central Connecticut State University |
Community Service Award | Capital Area Health Consortium |
Nominated by the Chancellor and Selected for Participation in Summer Institute for Women in Higher Education | Bryn Mawr College |
Award Winner, 100 Years of Women at the University of Connecticut | University of Connecticut |
Martin Luther King Award for Achievement in Science | University of Connecticut |
National Research Service Award, National Institutes of Health | NIH |
Honoree | University of Connecticut |
Recipient NIH Endocrine Student Fellowship | National Institute of Health |
Mosby Publishing Award for Excellence in Clinical Medicine | University of Connecticut School of Medicine |
Clinical Case Conference Leader; Organ Systems 3 course for UConn first year medical and dental students;Clinical Case Conference Leader; Disorders of bone and mineral metabolism course for UConn second year medical and dental students. I supervise graduate students in the Skeletal Oral Biology area of concentration.
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
---|---|---|---|---|---|---|
Board of Scientific Counselors of the National Institute of Dental and Craniofacial Research (NIDCR) | Advisory Committee | Member | External | National | 2021 | 2026 |
Association of American Medical Colleges (AAMC): Appointed Scientific Research Mentor for the AAMC/NIH Mosaic Scholars | Advisory Committee | Scientific Mentor | External | National | 2021 | 2026 |
Chair Oversight Board 2021, National Institutes of Health/NIDDK/Network of Minority Research Investigators (NMRI) | Advisory Committee | Chair | External | National | 2021 | 2022 |
University of Connecticut President Strategic Planning Steering Committee | Advisory Committee | Member | UConn-Storrs | State | 2021 | 2022 |
Oversight Committee Network of Minority Health Research Investigators NIH/NIDDK | Advisory Committee | Chair Elect | External | National | 2020 | 2021 |
American Society Bone Mineral Research Council | Advisory Committee | Member | External | National | 2019 | 2022 |
Elected to American Society Bone Mineral Research Council 2019-2022 | Professional/Scientific Organization | Council Member | External | International | 2019 | 2022 |
The Society for Osteobiology | Professional/Scientific Organization | Member | External | International | 2019 | |
Medical Deans Council | Advisory Committee | Member | UConn Health | University | 2019 | |
Nature Reviews Rheumatology | Other | International | 2019 | |||
Fibroblast Growth Factor in Development and Disease GORDON Research Conference | Professional/Scientific Organization | Chair | External | International | 2017 | 2018 |
Elected Member Publications Committee, American Society for Bone and Mineral Research | Professional/Scientific Organization | Member | External | National | 2017 | 2020 |
American Society of Bone and Mineral Research 2018 Annual Meeting Planning Committee | Professional/Scientific Organization | Chair, Translational Program | External | International | 2017 | 2018 |
NIH Study Section | Study Section | Ad-Hoc reviewer | External | National | 2016 | 2016 |
NIDDK, Network of Minority Health Research Investigators. | Advisory Committee | Member | External | National | 2016 | 2019 |
Elected Member of the Women in Bone and Mineral Research Committee of ASBMR | Professional/Scientific Organization | Elected Member | External | National | 2014 | 2017 |
Connecticut Academy of Science and Engineering | Professional/Scientific Organization | Member | External | State | 2012 | |
American Federation for Medical Research | Professional/Scientific Organization | Member | External | National | 2012 | |
American Dental Education Association: Affairs Advisory Committee | Advisory Committee | Member | External | National | 2012 | |
European Calcified Tissue Society: Review Panel for the 2011-2012 Grants and Awards | Professional/Scientific Organization | Member | External | International | 2011 | 2012 |
Gene | Editorial Board | Associate Editor | External | National | 2011 | 2013 |
University of Connecticut Health Center: Search Committee, Director MD/PhD Program | Professional/Scientific Organization | Member | UConn Health | University | 2011 | 2011 |
American Society for Bone and Mineral Research: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 2010 | 2010 |
University of Connecticut Health Center: LCME Action Plan Committee | Education Committee | Member | UConn Health | University | 2010 | 2012 |
University of Connecticut Health Center: Search Committee Senior Associate Dean of Education, School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 2010 | 2011 |
University of Connecticut Health Center: Search Committee Assistant Dean, School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 2010 | 2010 |
University of Connecticut Health Center: Search Committee, Student Services Director | Professional/Scientific Organization | Member | UConn Health | University | 2010 | 2010 |
ASBMR: Membership Development Committee | Professional/Scientific Organization | Member | External | National | 2009 | 2012 |
University of Connecticut Health Center: Representative to the Association of American Medical Colleges Group on Women in Medicine and Science (GWIMS) | Professional/Scientific Organization | Representative | UConn Health | University | 2009 | |
University of Connecticut Health Center: DMD/MPH Advisory Committee School of Dental Medicine | Advisory Committee | Member | UConn Health | University | 2009 | 2014 |
University of Connecticut Health Center: UCONN/COBB/NMA Planning Committee | Professional/Scientific Organization | Member | UConn Health | University | 2009 | 2011 |
University of Connecticut Health Center: School of Medicine Academic Plan Development Committee | Professional/Scientific Organization | Co-leader | UConn Health | University | 2009 | 2009 |
University of Connecticut Health Center: Employee Philanthropy Committee | Professional/Scientific Organization | Member | UConn Health | University | 2009 | 2010 |
Association of American Medical Colleges Group on Women in Medicine and Science | Professional/Scientific Organization | Representative | External | National | 2009 | |
State of Connecticut Legislative Commission on Health Equity | Professional/Scientific Organization | Commissioner | External | State | 2009 | |
The Science Engineering & Health Professions Collaborative Symposium | Workshop/Conference | Leader | UConn Health | University | 2009 | 2009 |
New York Academy of Sciences | Professional/Scientific Organization | Member | External | State | 2008 | |
NIH: Skeletal Biology Development and Disease Study Section | Professional/Scientific Organization | Member | External | National | 2008 | 2012 |
University of Connecticut Health Center: LCME Institutional Self-Study Committee | Professional/Scientific Organization | Member | UConn Health | University | 2008 | 2010 |
University of Connecticut Health Center: Clinical and Translational Research Training Grant Planning Committee | Professional/Scientific Organization | Member | UConn Health | University | 2008 | 2010 |
Biomedical Science Careers Student Conference: Harvard Medical School | Workshop/Conference | Panelist | External | University | 2008 | 2008 |
American Society for Bone and Mineral Research: Bone and Cartilage | Professional/Scientific Organization | Session Co-Chair | External | National | 2007 | 2007 |
University of Connecticut Health Center: Institutional Self-Study Committee | Professional/Scientific Organization | Member | UConn Health | University | 2007 | 2008 |
University of Connecticut Health Center: Search Committee, Vice President/Dean School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 2007 | 2008 |
Connecticut State Department of Education and the Department of Higher Education College Ready Advisory Sub-Committee of the Higher Education PK-16 Council | Professional/Scientific Organization | Member | External | University | 2007 | |
American Society for Bone and Mineral Research: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 2006 | 2006 |
NIH Study Section: Special Emphasis Panel/Scientific Review Group | Professional/Scientific Organization | Member | External | National | 2006 | |
University of Connecticut Health Center: MD/PhD Steering Committee | Professional/Scientific Organization | Member | UConn Health | University | 2006 | |
University of Connecticut Health Center: Senior Appointments and Promotions Committee | Professional/Scientific Organization | Member | UConn Health | University | 2006 | 2009 |
University of Connecticut Health Center: Search Committee, Dean, School of Nursing | Professional/Scientific Organization | Member | UConn Health | University | 2006 | 2006 |
American Dental Education Association: Advisory Committee | Professional/Scientific Organization | Chairman | External | National | 2006 | 2006 |
American Dental Education Association Institutes for Policy and Advocacy: Minority Affairs Committee | Professional/Scientific Organization | Chair | External | National | 2006 | 2006 |
Seventh Annual Diversity and Access to Dental Careers conference | Workshop/Conference | Opening Session Moderator | External | National | 2006 | 2006 |
American Society for Bone and Mineral Research: Peptide Calciotropic Hormones | Professional/Scientific Organization | Session Co-Chair | External | National | 2005 | 2005 |
Endocrine Society: Steering Committee | Professional/Scientific Organization | Member | External | National | 2005 | 2008 |
Endocrine Society: Basic Insights into Osteoporosis | Professional/Scientific Organization | Chairman | External | National | 2005 | 2005 |
Association of American Medical Colleges: Building Diversity in Medicine Working Group | Professional/Scientific Organization | Member | External | National | 2005 | 2005 |
University of Connecticut: Skeletal Craniofacial and Oral Biology Research Symposium | Professional/Scientific Organization | Session Chair | UConn Health | University | 2004 | 2004 |
American Society for Bone and Mineral Research: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 2004 | 2004 |
MAS, Advisory Committee of the American Dental Education Association | Advisory Committee | Member | External | National | 2004 | 2007 |
UCONN Center for Public Health and Health Policy: Advisory Board | Advisory Committee | Member | UConn Health | University | 2004 | 2004 |
Bone | Professional/Scientific Journal | Member | External | National | 2003 | |
Cell and Tissue Research | Professional/Scientific Journal | Member | External | National | 2003 | |
Developmental Biology | Professional/Scientific Journal | Member | External | National | 2003 | |
Endocrinology | Professional/Scientific Journal | Member | External | National | 2003 | |
Gene | Professional/Scientific Journal | Member | External | National | 2003 | |
Inflammatory Bowel Diseases | Professional/Scientific Journal | Member | External | National | 2003 | |
Journal Bone and Mineral Research | Professional/Scientific Journal | Member | External | National | 2003 | |
Journal Clinical Orthopaedic and Related Research | Professional/Scientific Journal | Member | External | National | 2003 | |
Journal Cell Science | Professional/Scientific Journal | Member | External | National | 2003 | |
Osteoporosis International | Professional/Scientific Journal | Member | External | National | 2003 | |
American Society for Bone and Mineral Research: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 2002 | 2002 |
International Bone and Mineral Society | Professional/Scientific Organization | Member | External | International | 2001 | |
American Society for Bone and Mineral Research: Education Committee | Professional/Scientific Organization | Member | External | National | 2001 | 2004 |
American Society for Bone and Mineral Research: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 2001 | 2001 |
NIH: Orthopedic and Musculoskeletal Study Section | Professional/Scientific Organization | Member | External | National | 2000 | 2004 |
University of Connecticut Health Center: Graduate Program Ph.D. Strategic Planning Committee | Professional/Scientific Organization | Member | UConn Health | University | 2000 | 2000 |
American Society for Bone and Mineral Research: BMP’s, TGF-Beta and Other Growth Factors | Professional/Scientific Organization | Co-Chair Scientific Session | External | National | 1999 | 1999 |
University of Connecticut Health Center: Graduate Programs Committee | Professional/Scientific Organization | Member | UConn Health | University | 1999 | |
American Society for Bone and Mineral Research-International Bone and Mineral Society: Scientific Program Committee | Professional/Scientific Organization | Member | External | National | 1998 | 1998 |
American Society for Bone and Mineral Research: BMP’s, TGF-Beta and Other Growth Factors | Professional/Scientific Organization | Co-Chair Scientific Session | External | National | 1997 | 1997 |
University of Connecticut Health Center: Chancellor’s Advisory Committee | Advisory Committee | Member | UConn Health | University | 1996 | 1999 |
Connecticut State Medical Society | Professional/Scientific Organization | Member | External | State | 1995 | |
The American Society for Cell Biology | Professional/Scientific Organization | Member | External | National | 1994 | |
University of Connecticut Health Center: Institutional Accreditation Self-Study Committee | Professional/Scientific Organization | Member | UConn Health | University | 1994 | 1995 |
NIH: Comparative Medicine Review Committee NCRR | Professional/Scientific Organization | Study Section Member | External | National | 1993 | 1997 |
University of Connecticut Health Center: Admissions Committee –College Student Summer Programs | Education Committee | Co -Chairperson | UConn Health | University | 1992 | |
University of Connecticut Health Center: Vice President’s Advisory Committee | Professional/Scientific Organization | Member | UConn Health | University | 1992 | 1996 |
University of Connecticut Health Center: Search Committee Dean School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1992 | 1993 |
University of Connecticut Health Center: Search Committee, Vice President and Provost for Health Affairs | Professional/Scientific Organization | Member | UConn Health | University | 1992 | 1993 |
University of Connecticut Health Center: Institutional Self-Study Committee | Professional/Scientific Organization | Member | UConn Health | University | 1992 | 1993 |
University of Connecticut Health Center: MD/PhD. Combined Degree Steering Committee | Education Committee | Member | UConn Health | University | 1992 | 1992 |
National Association of Advisors to the Health Profession | Professional/Scientific Organization | Member | External | National | 1991 | |
The Endocrine Society | Professional/Scientific Organization | Member | External | National | 1991 | |
Science Museum of Connecticut: Board of Trustees | Professional/Scientific Organization | Member | External | State | 1991 | 1997 |
National Medical Association | Professional/Scientific Organization | Member | External | National | 1990 | |
University of Connecticut Health Center: Selection Committee High School Science Teacher Research Program | Professional/Scientific Organization | Chairperson | UConn Health | University | 1990 | |
University of Connecticut Health Center: Search Committee | Professional/Scientific Organization | Member | UConn Health | University | 1990 | 1990 |
State of Connecticut Department of Higher Education: Peer Review Committee | Professional/Scientific Organization | Member | External | State | 1990 | 1994 |
Association of American Medical Colleges: Focus Group on “The Selection Process of Underrepresented Students in Medical Schools” | Professional/Scientific Organization | Member | External | National | 1990 | 1990 |
American Lung Association of Connecticut: Research and Grants Committee | Professional/Scientific Organization | Member | External | National | 1989 | 1991 |
University of Connecticut Health Center: Commencement Committee | Professional/Scientific Organization | Member | UConn Health | University | 1989 | |
University of Connecticut Health Center: Board of Directors, Parent’s Association, School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1989 | 1992 |
University of Connecticut Health Center: Introduction to Clinical Medicine Committee | Professional/Scientific Organization | Member | UConn Health | University | 1989 | 1989 |
West Indian Foundation: Board of Directors | Professional/Scientific Organization | Member | External | State | 1989 | 1991 |
American Lung Association of Connecticut: Board of Directors | Professional/Scientific Organization | Member | External | State | 1989 | 1991 |
University of Connecticut School of Nursing Recruitment and Retention Campaign: Task Force-Executive Planning Group | Professional/Scientific Organization | Member | UConn Health | University | 1989 | 1989 |
University of Connecticut Health Center: Search Committee Assistant Dean, Minority Student Affairs | Professional/Scientific Organization | Chairperson | UConn Health | University | 1988 | 1988 |
American Society for Bone and Mineral Research | Professional/Scientific Organization | Member | External | National | 1987 | |
University of Connecticut Health Center: School of Medicine Institutional Self-Study Task Force | Professional/Scientific Organization | Member | UConn Health | University | 1987 | 1988 |
University of Connecticut Health Center: Search Committee Assistant Dean, Dental Student Affairs | Professional/Scientific Organization | Member | UConn Health | University | 1987 | 1987 |
University of Connecticut Health Center: Promotions Committee-School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: Predoctoral Admissions Committee-School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: Medical Student Evaluation and Appeals Committee | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: Academic Performance Committees, I & II School of Dental Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: School of Dental Medicine Predoctoral Admissions Committee | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: Elbert Powell Seminar Series | Professional/Scientific Organization | Chairperson | UConn Health | University | 1986 | |
University of Connecticut Health Center: Associate Dean and Director Health Career Opportunity Programs | Professional/Scientific Organization | Member | UConn Health | University | 1986 | |
University of Connecticut Health Center: Medical Deans Advisory Committee | Professional/Scientific Organization | Member | UConn Health | University | 1986 | 2006 |
University of Connecticut Health Center: Admissions Committee Minority Student Summer Programs | Education Committee | Chairperson | UConn Health | University | 1986 | 1992 |
University of Connecticut Health Center: Affirmative Action Committee | Professional/Scientific Organization | Member | UConn Health | University | 1986 | 1987 |
Connecticut Endocrine Society | Professional/Scientific Organization | Member | External | State | 1984 | |
University of Connecticut Health Center: Search Committee Dean, School of Medicine | Professional/Scientific Organization | Member | UConn Health | University | 1984 | 1984 |
Catholic Family Services Advisory Board | Advisory Committee | Member | External | State | 1982 | 1983 |
Connecticut State Medical Society | Professional/Scientific Organization | Member | External | State | 1981 | 1981 |
American Medical Women’s Association | Professional/Scientific Organization | Member | External | National | 1981 | 1981 |
Hartford County Medical Association | Professional/Scientific Organization | Member | External | Local | 1981 | 1981 |
American Medical Association | Professional/Scientific Organization | Member | External | National | 1976 | 1991 |
University of Connecticut Health Center: Committee on Women and Minorities | Professional/Scientific Organization | Member | UConn Health | University | 1976 | 1976 |
Connecticut Women’s Career Council | Professional/Scientific Organization | Member | External | State | 1974 | 1974 |
Student National Medical Association | Professional/Scientific Organization | Member | External | National | 1972 | 1972 |
University of Connecticut Health Center; Admissions Committee, School of Medicine | Education Committee | Member | UConn Health | University | 1972 | 1972 |
Student National Medical Association Meeting | Professional/Scientific Organization | Representative | External | National | 1972 | 1972 |
University of Connecticut Health Center: Minority and Women’s Day, Career Opportunities | Professional/Scientific Organization | Organizer | UConn Health | University | 1972 | 1972 |
Dr. Hurley is a physician scientist who is recognized nationally and internationally for her expertise on the role of fibroblast growth factor-2 (FGF2) in bone. She has supervised and mentored more than fifty students in research including women and underrepresented students many of whom have gone on to outstanding careers in academic medicine, dental medicine or biomedical research. Dr. Hurley’s research laboratory has made seminal observations on the importance of FGF2 in maintaining bone mass in mice as demonstrated by her publication in the premier Journal of Clinical Investigation. She has also co-authored papers in the Proceedings of the National Academy of Sciences and Nature Genetics. Dr. Hurley’s lab was the first to demonstrate that FGF2 expression in bone cells is increased by parathyroid hormone (PTH); the first anabolic agent approved by the FDA for osteoporosis treatment in the USA. Recently, Dr. Hurley’s lab demonstrated a novel role for the nuclear isoforms of FGF2 in phosphate homeostasis and was awarded a grant from NIDDK to study the potential role of these isoforms in human disorder X-Linked Hypophosphatemic Rickets. Dr. Hurley’s outstanding research productivity is demonstrated by her 162 peer reviewed publications as well as NIH research funding since 1989. Dr. Hurley has held leadership positions and has been an invited speaker at International Gordon Conferences, European Calcified Tissue Society, International Bone and Mineral Society, Endocrine Society, the American Society of Bone and Mineral Research (ASBMR) and the Orthopedic Research Society. She was elected Vice Chairman for the 2016 Gordon Conferences on Fibroblast Growth Factors in Development and Disease. Dr. Hurley has been highly sought to serve on NIH Scientific Review Panels and has served as a permanent member of several NIH Institutes. She serves as a reviewer of research proposals for the National Science Foundation and as a reviewer for several scientific journals in the field of bone research. She also serves as a reviewer of scientific articles for several specialty journals and served on the Editorial Board of Gene and currently serves on the Editorial Board of the Journal of Racial and Ethnic Health Disparities. Dr. Hurley is dedicated to the training and mentoring of the next generation of biomedical scientists. She is a member of the UConn graduate faculty for the Skeletal Biology and Regeneration and the Cell Biology areas of concentration in the Biomedical Sciences. Dr. Hurley was elected Chair of the prestigious international 2018 Gordon Conferences on Fibroblast Growth Factors in Development and Disease.
Accepting Lab Rotation Students: Spring 1 and 2 Block 2025
Lab Rotation Projects Areas of interest; Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families regulate bone development, remodeling and disorders of bone and cartilage. Specific projects involve use of germline and conditional Fgf2 knockout and Fgf2 isoform transgenic mice in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone, skeletal muscle and cartilage including osteomalacia, osteoporosis, fracture healing, myopathy and osteoarthritis.
Journal Articles
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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice.
Endocrinology 2023 Nov;164(12):
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FGF Ligands and Receptors in Osteochondral Tissues of the Temporomandibular Joint in Young and Aging Mice.
Cartilage 2023 Apr;19476035231163691
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Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice.
Scientific reports 2022 Nov;12(1):20638
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FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms.
Scientific reports 2022 Sep;12(1):15968
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Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization.
Calcified tissue international 2021 Jul;
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Endogenous FGF-2 levels impact FGF-2/BMP-2 growth factor delivery dosing in aged murine calvarial bone defects.
Journal of Biomedical Materials Research. Part A 2021 Jun;
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Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice.
Scientific reports 2021 May;11(1):11005
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Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice
Cartilage 2020 Oct;1947603520962565
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Creating a Comprehensive Approach to Exposing Underrepresented Pre-health Professions Students to Clinical Medicine and Health Research.
Journal of the National Medical Association 2020 Jan;
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms.
Endocrinology 2020 Jan;161(1):
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Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Journal of cellular physiology 2019 Apr;2344418-4431
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A Health Professions Pipeline for Underrepresented Students: Middle and High School Initiatives.
Journal of racial and ethnic health disparities 2019 Jan;6(1):207-213
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FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation.
Bone reports 2018 Dec;9136-144
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Cell type influences local delivery of biomolecules from a bioinspired apatite drug delivery system.
Materials. 2018 Sep;11(9):
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FGF23 regulates Wnt/β-catenin signaling-mediated osteoarthritis in mice overexpressing high molecular weight FGF2.
Endocrinology 2018 Apr;1592386-2396
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FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms Transgenic Female Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 Mar;331347-1361
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Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice.
Endocrinology 2017 Oct;158(10):3629-3646
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Calvarial bone regeneration is enhanced by sequential delivery of FGF-2 and BMP-2 from layer-by-layer coatings with a biomimetic calcium phosphate barrier layer.
Tissue Engineering, Part A 2017 Sep;23(23-24):1490-1501
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Biomimetic calcium phosphate/polyelectrolyte multilayer coatings for sequential delivery of multiple biological factors.
Journal of Biomedical Materials Research, Part A 2016 Dec;105(5):1500-1509
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FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Endocrinology 2016 Oct;1574602-4614
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FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of HMWFGF2 Transgenic Mice.
Journal of cellular physiology 2016 Jun;232610-616
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Loss of Bone in Sickle Cell Trait and Sickle Cell Disease Female Mice Is Associated with Reduced IGF-1 in Bone and Serum.
Endocrinology 2016 May;1573036-46
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Age-related changes in FGF-2, fibroblast growth factor receptors and β-catenin expression in human osteoblasts (mesenchyme-derived progenitor cells).
Journal of Cellular Biochemistry 2016 Mar;117(3):721-9
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FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Journal of cellular biochemistry 2016 Jan;1171991-2000
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Accelerated Fracture Healing in Transgenic Mice Overexpressing an Anabolic Isoform of Fibroblast Growth Factor 2.
Journal of cellular biochemistry 2015 Aug;117599-611
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Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice.
Experimental Gerontology 2015 Apr;6462-69
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Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.
The Journal of biological chemistry 2014 Nov;289(52):36303-14
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Optimizing BMP-2-induced bone repair with FGF-2.
The Journal of the American Academy of Orthopaedic Surgeons 2014 Oct;22(10):677-679
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Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice.
Endocrinology 2014 Mar;155(3):965-974
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FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.
Journal of cellular physiology 2013 Nov;228(11):2149-58
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Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2013 Oct;68(10):1170-1180
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BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice.
Endocrinology 2013 Aug;154(8):2723-33
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Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jan;28(1):35-45
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Prostaglandin F2α: a bone remodeling mediator.
Journal of cellular physiology 2013 Jan;228(1):25-9
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Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.
The Journal of biological chemistry 2011 Nov;286(47):40575-83
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The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Biochemical and biophysical research communications 2011 Aug;412(1):160-4
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Fibroblast growth factor-2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010 Oct;65(10):1051-9
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Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.
Bone 2010 Aug;47(2):360-70
-
Signaling pathways implicated in PGF2alpha effects on Fgf2+/+ and Fgf2-/- osteoblasts.
Journal of cellular physiology 2010 Aug;224(2):465-74
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Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul;107(29):12901-6
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Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
The Journal of biological chemistry 2010 Jan;285(4):2834-46
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Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts.
Biochemical and biophysical research communications 2010 Jan;391(1):335-9
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Endogenous FGF-2 is critically important in PTH anabolic effects on bone.
Journal of cellular physiology 2009 Apr;219(1):143-51
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Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
The Journal of biological chemistry 2009 Jan;284(5):3170-82
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Prostaglandin F2alpha involves heparan sulphate sugar chains and FGFRs to modulate osteoblast growth and differentiation.
Journal of cellular physiology 2008 Oct;217(1):48-59
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Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.
Journal of cellular biochemistry 2008 Apr;103(6):1975-88
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Anti-apoptotic Bcl-2 enhancing requires FGF-2/FGF receptor 1 binding in mouse osteoblasts.
Journal of cellular physiology 2008 Jan;214(1):145-52
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Benzyl butyl phthalate influences actin distribution and cell proliferation in rat Py1a osteoblasts.
Journal of cellular biochemistry 2007 Jun;101(3):543-51
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University of Connecticut HPPI pipeline.
Academic medicine : journal of the Association of American Medical Colleges 2006 Jun;81(6 Suppl):S25-7
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PGF2alpha increases FGF-2 and FGFR2 trafficking in Py1a rat osteoblasts via clathrin independent and importin beta dependent pathway.
Journal of cellular biochemistry 2006 Apr;97(6):1379-92
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Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.
Biochemical and biophysical research communications 2006 Mar;341(4):989-94
-
In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice.
Biochemical and biophysical research communications 2006 Jan;339(2):490-8
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Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34).
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2005 Dec;16(12):2080-4
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FGF and FGFR signaling in chondrodysplasias and craniosynostosis.
Journal of cellular biochemistry 2005 Dec;96(5):888-96
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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation.
Nature genetics 2005 Sep;37(9):945-52
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Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice.
Journal of cellular biochemistry 2005 May;95(1):83-94
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Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase.
Cell and tissue research 2005 Feb;319(2):267-78
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Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
The Journal of biological chemistry 2004 Jun;279(26):27743-52
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Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells.
Journal of cellular biochemistry 2003 Aug;89(6):1291-301
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Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone.
The Journal of biological chemistry 2003 Jun;278(23):21258-66
-
Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin.
Journal of cellular biochemistry 2003 Apr;88(6):1168-76
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Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts.
Histology and histopathology 2002 Oct;17(4):1061-6
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Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Mar;17(3):502-12
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FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells.
Biochemical and biophysical research communications 2002 Jan;290(1):526-31
-
Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts.
Biochemical and biophysical research communications 2001 Aug;286(1):33-40
-
Phthalate esters influence FGF-2 translocation in Py1a rat osteoblasts.
European journal of morphology 2001 Jul;39(3):155-62
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Nuclear and cytoplasmic lectin receptor sites in rat Py1a osteoblasts.
Histology and histopathology 2000 Oct;15(4):1107-17
-
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation.
The Journal of clinical investigation 2000 Apr;105(8):1085-93
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Parathyroid hormone regulates the expression of fibroblast growth factor-2 mRNA and fibroblast growth factor receptor mRNA in osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999 May;14(5):776-83
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PNA lectin as marker of Py1a cell cycle.
European journal of histochemistry : EJH 1999 Jan;43(1):85-7
-
Prostaglandins regulate the expression of fibroblast growth factor-2 in bone.
Endocrinology 1999 Jan;140(1):434-44
-
Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures.
Bone 1998 Apr;22(4):309-16
-
Signal transduction by basic fibroblast growth factor in rat osteoblastic Py1a cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996 Sep;11(9):1256-63
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Regulation of NFIL-6 and IL-6 expression by basic fibroblast growth factor in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996 Jun;11(6):760-7
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Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonatal mouse calvariae by parathyroid hormone and prostaglandin E2-treatment.
Journal of cellular physiology 1996 Feb;166(2):370-9
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Transcriptional regulation of the collagenase gene by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
Biochemical and biophysical research communications 1995 Sep;214(2):331-9
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Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor.
The Journal of clinical investigation 1995 Aug;96(2):923-30
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Basic fibroblast growth factor regulates IGF-I binding proteins in the clonal osteoblastic cell line MC3T3-E1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995 Feb;10(2):222-30
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Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells.
The Journal of biological chemistry 1994 Mar;269(12):9392-6
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Stimulatory effect of a phorbol ester on expression of insulin-like growth factor (IGF) binding protein-2 and level of IGF-I receptors in mouse osteoblastic MC3T3-E1 cells.
Journal of cellular physiology 1994 Mar;158(3):444-50
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Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells.
The Journal of biological chemistry 1993 Mar;268(8):5588-93
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Interactive effects of basic fibroblast growth factor and heparin on bone in 21-day fetal rat calvariae.
Connecticut medicine 1993 Jan;57(1):9-11
-
The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae.
Endocrinology 1992 May;130(5):2675-82
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Structural determinants of the capacity of heparin to inhibit collagen synthesis in 21-day fetal rat calvariae.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1990 Nov;5(11):1127-33
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Effect of heparin on bone formation in cultured fetal rat calvaria.
Calcified tissue international 1990 Mar;46(3):183-8
-
Effects of ethanol and acetaldehyde on collagen synthesis, prostaglandin release and resorption of fetal rat bone in organ culture.
Bone 1990 Jan;11(1):47-51
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Effects of transforming growth factor alpha and interleukin-1 on DNA synthesis, collagen synthesis, procollagen mRNA levels, and prostaglandin E2 production in cultured fetal rat calvaria.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1989 Oct;4(5):731-6
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Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia: a reanalysis.
The American journal of the medical sciences 1987 Dec;294(6):415-8
-
Changes in ethanol concentration during incubation in multiwell tissue culture trays.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1987 Nov;186(2):139-41
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Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987 Jun;2(3):183-9
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A Health Professions Pipeline for Underrepresented Students:Middle and High School Initiatives
J Racial Ethn Health Disparities 6(1):207-213
Book Chapters
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Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
Principles of Bone Biology 825-851
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Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
Principles of Bone Biology 1103-1132
-
Fibroblast Growth Factor and Vascular Endothelial Fibroblast Growth Factor Families
Principles of Bone Biology 627-646
-
Systemic and Local Regulators of Bone Remodeling
Bone Formation 44-70
Abstracts
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BMP-2 Synergizes the Bone Healing Effect of Low Molecular Weight FGF-2 on Calvarial Defects in Mice
J. Bone Miner Res. 2012 Jan;27
-
HMWFGF2 Isoforms Regulate Bone Mineralization via Modulation of Pyrophosphate Genes in Mouse Bone Marrow Cultures
J. Bone Miner Res 2012 Jan;27
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Impaired Anabolic Action of PTH on Bone Formation in Fgf2 Knockout Mice is mediated by Attenuated Wnt Signaling
J. Bone Miner Res. 2012 Jan;27
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Selective Knockout of HMWFGF2 Isoforms in Mice Increases Serum Phosphate and Increases Bone Formation In Vivo and In Vitro
J. Bone Miner Res. 2012 Jan;27
-
Age Related Changes in FGF2 and Beta-Catenin Expression in Osteoblasts from Young, Middle Aged and Elderly Female
J. Bone Miner Res. 2011 Jan;26
-
Exported 18kDa Isoform of Fibroblast Growth Factor-2 Improved Bone Regeneration in Critical Size Mice Calvarial Defects
J. Bone Miner Res. 2011 Jan;26
-
HMW FGF2 Isoforms Regulate Bone Nodule Formation via Modulating FGFR/FGF23/ERK Signaling in BMSCs
J. Bone Miner Res. 2011 Jan;26
-
Positive Regulation of Osteoblasts Differentiation and Bone Formation is Partially Mediated by Modulation of the Wnt Pathway
2011 Jan;
-
Serum Sclerostin Levels Correlate Positively with Bone Mineral Density at Multiple Skeletal Sites in Postmenopausal Women
J. Bone Miner Res. 2011 Jan;26
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Nuclear HMWFGF2 Isoforms are Novel Regulators of Fgf23 Promoter Activity in ROS17/2.8.Osteoblasts
J. Bone Miner Res. 2010 Jan;25
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Phosphate Independent Effects of Nuclear HMWFGF2 Isoforms on Bone Formation In Vitro
J. Bone Miner Res. 2010 Jan;25
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Disruption of the Fibroblast Growth Factor -2 Gene Resulted in Decreased Expression of Activating Transcription Factor 4
J. Bone Miner. Res 2009 Jan;24
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Overexpression of the Nuclear HMW FGF2 Isoforms in Osteoblasts Results in Reduced Mineralization and Reduced Expression of their Nuclear Partner FIF
J. Bone Miner. Res. 2009 Jan;24
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Targeted Overexpression of the Nuclear FGF2 Isoforms in Osteoblasts induces Hypophosphatemia via Modulation of FGF23 and Klotho in Mice
J. Bone Miner. Res. 2008 Jan;23S25
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Overexpression of the Low Molecular Weight Isoform of FGF2 Partly Prevents Bone Loss in Ovariectomized Mice
J. Bone Miner. Res 2007 Jan;22S270
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Transgenic Mice Expressing High Molecular Weight Isoforms of FGF2 Exhibits Decreased Bone Mass and Disturbed Phosphate Homeostasis
J. Bone Miner. Res. 2006 Jan;21S19
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Endogenous FGF2 Is Critically Important in PTH Induction of Bcl2, Phosphorylation of CREB and Runx2 Nuclear Accumulation in Osteoblasts
J Bone Miner. Res. 2005 Jan;20S71
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The Anabolic Response to Bone Morphogenetic Protein-2 is Impaired in Fibroblast Growth Factor-2 Null Mice
J Bone Miner Res 2004 Jan;19S60
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Disruption of the FGF-2 Gene in Mice Reduces the Expression of Key Regulators of Osteoblast Precursor Proliferation and Differentiation
J Bone Miner. Res. 2003 Jan;18S329
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Fibroblast Growth Factor 2 Directly Inhibits Expression of Osterix mRNA in Osteoblastic Cells
J Bone. Miner. Res. 2003 Jan;18S138
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Phenotypic Characterization of Bones of Transgenic Mice Overexpressing Fibroblast Growth Factor-2
J Bone Miner. Res. 2002 Jan;17S425
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Prostaglandins increase FGF-2 and FGF Receptor Expression and Nuclear Accummulation in Osteoblasts via Mitogen Activated Protein Kinase
J. Bone Miner. Res. 2002 Jan;17S239
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The Anabolic Effect of Parathyroid Hormone is Impaired in Bones of Fgf2 Null Mice
J Bone Miner. Res. 2002 Jan;17S83
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Disruption of the Fgf2 Gene in Mice Impairs Prostaglandin E2 Stimulation of Osteoclast Formation and Cyclo-Oxygenase-2 in Primary Osteoblastic Cells.
J Bone Miner. Res. 2001 Jan;16S490
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In vivo Administration of Interleukin-1 Enhances Osteoblast Proliferation and Differeation in Ex-vivo Bone Marrow Cultures From Fgf2 Null Mice but not Osteoclast Formation in Calvariae of Fgf2 Null Mice
J. Bone Miner. Res. 2001 Jan;16S198
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Osteoclast Formation in Transgenic Mice Overexpressing Fibroblast Growth Factor 2
Bone Miner. Res. 16 2001 Jan;S198
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Interleukin-1 Regulates FGF2 Expression in Osteoblasts and IL-1 Induced Osteoclast Formation is Impaired in Fgf2 Null Mice
Bone & Tooth Society. J. Bone Miner. Res 2000 Jan;
-
Overexpression of FGF-2 in Transgenic Mice Causes Premature and Enhanced Apoptotic Chondrocyte Cell Death at the Epiphyseal Growth Plate
J Bone & Miner Res 2000 Jan;S90
-
Endocrine Disrupting Chemicals and Growth Factors. In Vitro Effects of Pthalates on Rat Osteoblasts
Eur. J. Histochem 1999 Jan;432
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Impaired Osteoclast Formation in Murine Bone Marrow Cultures of Fibroblast Growth Factor-2 Null Mice in Response to Parathyroid Hormone and Prostaglandin E2
J Bone Miner Res 1999 Jan;S241
-
Lectin Affinity Patterns in Rat Osteoblastic Py1a Cells
Eur. J. Histochem 1999 Jan;432
-
AP-1 and CRE sites jointly mediate the induction of prostaglandin G/H synthase-2 promoter activity basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
J Bone Miner Res 1998 Jan;13(S1)S245
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Decreased osteoclastogenic responses in marrow cultures from mice with disruption of the PGHS-2 gene.
J Bone Miner Res 1998 Jan;13(S1)S330
-
Expression and regulation of fibroblast growth factor-2 by cytokines and growth factors in human osteoblasts.
J Bone Miner Res 1998 Jan;13(S1)S440
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Expression of D-Type Cyclins After bFGF Treatment of Human Osteosarcoma Cells and a Mouse Osteoblastic Cell Line
Bone 1998 Jan;22(5):S206
-
Basic fibroblast growth factor stimulates bone resorption through mitogenic effects on immature osteoblastic cells as well as cyclooxygenase-2 induction.
J Bone Min Res 1997 Jan;12(S1)S209
-
Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone
J Bone Miner Res 1997 Jan;S208
-
Basic Fibroblast Growth Factor Induces Osteoclastogenesis in Bone Marrow Cultures by a Prostaglandin Mediated Mechanism
J. Bone Miner. Res. 10 1995 Jan;1
-
Localization of an FGF-2 Inhibitory Element in the COL1A1 Gene in Transgenic Mice
J. Bone Miner. Res. 10 1995 Jan;1
-
Regulation of inducible prostaglandin G/H synthase mRNA levels and promoter activity by basic fibroblast growth factor in osteoblastic cells.
J Bone Min Res 1994 Jan;9(S1)S124
-
Regulation of the Collagenase Promoter and Collagenase mRNA and Stimulation of Collagenase Activity by Basic Fibroblast Growth Factor in Osteoblastic MC3T3-E1 Cells
Arthritis & Rheumatism Suppl. 1994 Jan;37
-
Insulin like growth factor binding protein 5 accumulates in bone matrix and is released by parathyroid hormone and prostaglandin E2.
J Bone Miner Res 1993 Jan;8(S1)S237
-
Heparin Inhibits Collagen Synthesis and Steady-State Levels of Procollagen mRNA
J Bone Miner Res 4 1989 Jan;
-
Effects of Ethanol and Acetaldehyde on Collagen Synthesis and Prostaglandin Release from 21-day Old Fetal Rat Calvaria
J Bone Miner Res 1 1986 Jan;
-
Comparison of Effects on Auronofin, Gold Sodium Thiomalate, and Penicillamine on Bone Resorption
Calcif Tissue Int 1985 Jan;
-
Basic Fibroblast Growth Factor Inhibits IGF-1 mRNA in the Clonal Osteoblastic Cell Line MC3T3-E1
Bone and Mineral 17 89
-
Disruption of the Fibroblast Growth Factor 2 Gene in Mice Results in Diminished Formation of Osteoclasts in Bone Marrow Culture in Response to RANKL
J Bone & Miner Res S50
-
Effect of Parathyroid Hormone (1-34) on Temporal Expression of Cell Growth, Growth Factors and Osteoblast Phenotype-Related Genes in Rat Bone Cells In Vivo
J. Bone Miner. Res. 1
-
Expression of Basic Fibroblast Growth Factor (bFGF) by Human Blood Lymphocytes
-
Expression of Basic Fibroblast Growth Factor mRNA Levels in Osteoblasts
J Bone Miner Res. S127
-
Function of p21/p53 Pathway in regulating Chondrocyte Apoptosis and Proliferation in Dwarf Mice
J Bone Miner. Res. 17S403
-
Functional Redundancy of FGFs in Odontogenesis
J. Den. Res. 79 (412):
-
Overexpression of FGF-2 Protein Isoforms in Osteoblasts. Effects on Proliferation and Differentiation
J. Bone Miner. Res. 17S425
-
Prostaglandins Influence Lectin and Fibroblast Growth Factor-2 Distributional Patterns in Osteoblasts
Bone 23(5):S535
-
Regulation of NF-IL6 and IL-6 Expression by Basic Fibroblast Growth Factor in Osteoblastic MC3T3-E1 Cells
J. Bone Miner Res 9 S164
-
Short Term Fibroblast Growth Factor Treatment Increases Osteoblast Differentiation and Bone Nodule Formation in Bone Marrow Cultures from Young and Adult Mice
J. Bone Miner. Res. 16S250
-
Signal Transduction by Basic Fibroblast Growth Factor in Rat Osteoblastic Py1a Cells
J. Bone Miner. Res. 101
-
Stimulation of Fibroblast Growth Factor-2 mRNA Levels by Prostaglandins
Bone (22):15S
Conference Papers
-
Localization of an FGF-2 inhibitory element in the COL1A1 gene in transgenic mice
Matrix Biology 1998 Jan;17(2):155-156
Reviews
-
Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease.
Journal of the Endocrine Society 2018 Jul;2(7):657-671
-
Fibroblast growth factor-2, bone homeostasis and fracture repair.
Current pharmaceutical design 2013 Oct;19(19):3354-63
-
Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation.
Journal of cellular physiology 2012 Nov;227(11):3539-45
-
Stem cell-based bone repair.
American journal of stem cells 2012 Jan;1(2):106-13
-
Prostaglandin F2A: A Bone Remodeling Mediator
J. Cell Physiol 228(1):25-29
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
---|---|---|---|---|
Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High-Molecular Weight FGF2 | Talk | American Society Bone and Mineral Research | 2019 | Orlando, FL, USA |
High Molecular Weight Isoforms of Fibroblast growth factor 2, new players in Osteoarthritis | Lecture | 2019 | UCONN HEALTH | |
High Molecular Weight Isoforms of Fibroblast growth factor 2, new players in Osteoarthritis | Lecture | 2019 | UCONN HEALTH | |
Automated Indentation of Femoral and Temporomandibular Joints for Characterization of Cartilage Tissue Quality in Fgf2 KO Mice. | Poster | American Society for Bone and Mineral Research | 2019 | Orlando, FL, USA |
FGF23 in crosstalk of bone, kidney and hematopoiesis in sickle cell bone disease. | Talk | American Society Bone Mineral Research | 2019 | Orlando, FL, USA |
Impaired PTH-stimulated periosteal proliferation, Wnt activity and fracture healing in Fgf2 knockout mice. | Poster | American Society Bone Mineral Research | 2019 | Orlando, FL, USA |
Fracture Healing in Fgf2 Heterozygous and Homozygous Knockout Mice | Talk | FGF Fusion Conference | 2019 | Nassau Bahamas |
High Molecular Weight Isoforms of Fibroblast Growth Factor 2, New Players in Osteoarthropathy” | Talk | Avioli Musculoskeletal Research Seminar | 2018 | Washington University, St Louis, MO |
FGF2 isoforms and osteoarthritis | Talk | FGF Fusion Conference | 2017 | Cancun, Mexico |
FGF2 Isoforms in Bone and Phosphate Homeostasis | Talk | Chinese Academy of Science | 2016 | Beijing, China |
Impaired Fracture Healing in Fgf2 Heterozygous and Homozygous Knockout Mice. Annual Meeting of the American Society for Bone & Mineral Research. | Talk | American Society for Bone and Mineral Research | 2016 | Atlanta, Georgia |
knockout of nuclear FGF2 isoforms modulate bone and phosphate homeostasis | Talk | Gordon Conference | 2014 | Ventura, CA, USA |
Exported 18kDa isoform of FGF2 and low dose BMP-2 improved bone regeneration in critical size mice calvarial defects via wnt signaling | Talk | Orthopedic Research Society | 2014 | New Orleans, LA, USA |
Role of PTH in Fgf2 mutant and WT aged mice | Talk | UCONN-Jackson Laboratory Aging Symposium | 2014 | Storrs, CT, USA |
Nuclear FGF2 isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK. | Talk | Endocrine Society | 2013 | San Francisco California |
Nuclear FGF2 isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK | Talk | Endocrine Society | 2013 | San Francisco, USA |
Impaired Anabolic Action of PTH on Bone Formation in Fgf2 Knockout Mice is Mediated by Attenuated Wnt Signaling | Talk | American Society for Bone & Mineral Research | 2012 | Minneapolis, Minnesota |
FGF2 nuclear isoforms and bone matrix mineralization | Lecture | Gordon Research Conference | 2012 | Les Diablerets, Switzerland |
FGF2 nuclear isoforms and bone matrix mineralization | Talk | Gordon conference | 2012 | Switzerland |
The Impaired Anabolic Effect of PTH In the Absence of Endogenous FGF2 Is Partially Due to Reduced ATF4 Expression | Talk | American Society for Bone & Mineral Research | 2011 | San Diego, California |
FGF2 Positive Regulation of Osteoblasts Differentiation and Bone Formation is Partially Mediated by Modulation of the Wnt pathway | Talk | Extracellular Matrix in Health and Disease Symposium | 2011 | Boston, Massachusetts |
Anabolic Action of FGF2 on Bone Formation is Mediated in Part by Modulation of Wnt Pathway | Talk | University of Connecticut Health Center | 2011 | Farmington, Connecticut |
Osteoporosis | Lecture | University of Connecticut Health Center | 2011 | Farmington, Connecticut |
Nuclear FGF2 Isoforms are novel regulators of phosphate Homeostasis” | Talk | FGF Gordon Conference | 2010 | Ventura, California |
Effect Anabolic Factors on Bone and Fat Formation in Old Age” | Talk | University of Connecticut School of Medicine Center on Aging | 2010 | University of Connecticut Health Center |
Novel Effects of FGF23 Protein Isoforms on Bone Formation and Phosphate Homeostasis | Talk | AMGEN | 2009 | Thousand Oaks, California |
FGFs and Bone” | Talk | Endocrine Society, Annual Meeting | 2009 | Washington DC |
Diabetes Mellitus, Diagnosis and Management | Lecture | University of Connecticut | 2009 | West Hartford, Connecticut |
Novel Effects of FGF2 Protein Isoforms on Bone Formation and Phosphate Homeostasis” | Talk | Indiana University School of Medicine | 2008 | Indianapolis, Indiana |
“Effects of Global Knockout or Over-Expression Of Fibroblast Growth Factor-2 In Osteoblasts on Fracture Healing In Transgenic Mice | Talk | International Bone and Mineral Society | 2008 | Davos, Switzerland |
The Exported 18kDa Isoform of FGF-2 is a Critical Determinant of Bone Mass in Mice | Talk | New England Musculoskeletal Research Symposium | 2008 | Farmington, Connecticut |
Targeted Overexpression of the Nuclear FGF2 Isoforms in Osteoblasts Induces Hypophosphatemia via Modulation of FGF23 and Klotho in Mice | Talk | American Society for Bone & Mineral Research | 2008 | Montreal, Canada |
FGF signaling pathways in bone formation and maintenance” | Talk | American Academy of Orthopaedic Surgeons Research Symposium | 2007 | Miami, Florida |
Role of Fibroblast Growth Factor-2 in Adipogenesis | Talk | University of Connecticut Health Center | 2007 | Farmington, Connecticut |
Diabetes Mellitus, Diagnosis and Management | Lecture | University of Connecticut | 2007 | Hartford, Connecticut |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 2007 | Farmington, Connecticut |
Health Professions Partnership Initiative | Lecture | Connecticut State Legislature | 2007 | |
Health Professions Diversity | Lecture | Sullivan Alliance National Leadership Symposium | 2007 | Washington, DC |
“PTH induced Osteoclastogenesis and Osteoblastogenesis is markedly impaired in bone marrow cultures of Fgf2 knockout mice”. | Talk | University of Camerino | 2006 | Camerino, Italy |
“Disruption of the Fgf2 Gene activates the adipogenic and suppresses the osteogenic program in Marrow stromal cells. | Talk | American Society of Bone & Mineral Research Annual Meeting | 2006 | Philadelphia, PA |
"Role of Exported and Intracellular FGF-2 Isoforms in Bone | Talk | FGF Gordon Research Conference | 2006 | Ventura, California |
Transgenic Mice Expressing High Molecular Weight Isoforms of FGF2 Exhibits Decreased Bone Mass and Disturbed Phosphate Homeostasis | Talk | American Society for Bone & Mineral Research | 2006 | Philadelphia, Pennsylvania |
FGF-2 and Musculoskeletal Aging | Talk | University of Connecticut Health Center | 2006 | Farmington, Connecticut |
Fibroblast Growth Factors in Bone | Talk | University of Connecticut Health Center Musculoskeletal Institute | 2006 | Farmington, Connecticut |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 2006 | Farmington, Connecticut |
Fibroblast Growth Factor2: Paracrine and Intracrine Effects on Bone | Talk | Yale, School of Medicine | 2005 | New Haven, CT |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 2005 | Farmington, Connecticut |
The UCHC Health Professions Partnership Initiative as a Successful Model of Connecticut Career Choices | Lecture | The Governor’s Office for Workforce Development | 2005 | Rocky Hill, Connecticut |
The Exported 18 kDa Isoform of FGF2 is a Critical Determinant of Bone Mass in Mice | Talk | American Society for Bone & Mineral Research | 2004 | Seattle, Washington |
Regulation of Bone Formation by the FGF2 Pathway | Talk | Annual Symposium on Calcified Tissues | 2004 | Nice, France |
Fibroblast Growth Factor-2 and Bone Remodeling | Talk | NIH and The American Society for Bone and Mineral Research | 2004 | Washington, D.C. |
Osteoporosis of Mice and Men, Anabolic Response to PTH | Lecture | University of Connecticut Health Center | 2004 | Farmington, Connecticut |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 2004 | Farmington, Connecticut |
UCHC Health Professions Partnership Initiative | Talk | Association of American Medical Colleges | 2004 | Boston, Massachusetts |
Sustainability of the Health Professions Partnership Initiative | Talk | Association of American Medical Colleges | 2004 | Scottsdale, Arizona |
The Transcription Factor STAT1 is a Novel Negative Regulator of Bone Mass and Bone Formation | Talk | American Society for Bone and Mineral Research | 2003 | Minneapolis, Minnesota |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 2003 | Farmington, Connecticut |
“Fibroblast Growth Factor-2 and Bone Remodeling”, | Talk | Endocrine Society, Annual Meeting | 2002 | San Francisco, CA |
The Anabolic Effect of Parathyroid Hormone is Impaired in Bones of Fgf2 Null Mice | Talk | American Society for Bone and Mineral Research | 2002 | San Antonio, Texas |
Osteoporosis, What is it? | Lecture | University of Connecticut Health Center | 2002 | Farmington, Connecticut |
“Disruption of the Fgf2 gene in mice results in impaired bone formation | Talk | Wesleyan University | 2001 | Middletown, CT |
“Disruption of the fibroblast growth factor gene in mice results in diminished formation of osteoclasts in bone marrow culture in response to Prostaglandins”. | Talk | University of Montana | 2001 | Missoula, Montana |
Prostaglandins Regulate FGF-2 and FGF Receptor Expression and Subcellular Localization in Osteoblasts | Talk | International Bone & Mineral Society and the European Calcified Tissue | 2001 | Madrid, Spain |
An Overall Perspective on Women’s Health | Lecture | University of Connecticut School of Allied Health | 2001 | Farmington, Connecticut |
“Disruption of the fibroblast growth factor gene in mice results in diminished formation of osteoclasts in bone marrow culture in response to RANKL” | Talk | American Society of Bone & Mineral Research Annual Meeting | 2000 | Toronto, Canada |
Regulation of Fibroblast Growth Factor-2 and Fibroblast Growth Factor Receptors by Transforming Growth Factor Beta in Human Osteoblastic MG-63 Cells | Talk | International Conference on Progress in Bone and Mineral Research | 2000 | Vienna, Austria |
Overexpression of FGF-2 in Transgenic Mice Causes Premature and Enhanced Apoptotic Chondrocyte Cell Death at the Epiphyseal Growth Plate | Talk | American Society of Bone and Mineral Research | 2000 | Toronto, Canada |
Disruption of the Fibroblast Growth Factor-2 Gene in Mice Results in Decreased Bone Mass and Bone Formation | Talk | University of Camerino | 2000 | Camerino, Italy |
Prostaglandin Induced Osteoclastogenesis is Markedly Impaired in Bone Marrow Cultures of Fgf2 Knockout Mice | Talk | University of Camerino | 2000 | Camerino, Italy |
Interleukin-1 and Prostaglandins Regulate Fibroblast Growth Factor-2 Gene Expression in Osteoblasts | Talk | University of Connecticut Health Center | 2000 | Farmington, Connecticut |
Disruption of the Fibroblast Growth Factor-2 Gene in Mice Results in Decreased Bone Mass and Bone Formation | Talk | University of Connecticut Health Center | 2000 | Farmington, Connecticut |
Disruption of the Fibroblast Growth Factor-2 Gene in Mice Results in Decreased Bone Mass and Bone Formation | Talk | American Society of Bone and Mineral Research Meeting | 1999 | |
Fibroblast Growth Factors in Bone Remodeling | Talk | University of Connecticut School of Dental Medicine | 1999 | Farmington, Connecticut |
Bone Metabolism | Lecture | University of Connecticut Health Center | 1999 | Farmington, Connecticut |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 1999 | Farmington, Connecticut |
Epiphysial Growth Plate Defects in Basic FGF Transgenic and FGF-2 Null Mice | Talk | American Society of Biochemistry and Molecular Biology | 1998 | Taos, New Mexico |
Fibroblast Growth Factors in Bone Remodeling | Talk | University of Connecticut School of Dental Medicine | 1998 | Farmington, Connecticut |
Bone Metabolism | Talk | University of Connecticut Health Center | 1998 | Farmington, Connecticut |
Role of Prostaglandins in FGF-2 Mediated Osteoclastogenesis | Talk | University of Camerino | 1998 | Camerino, Italy |
Prostaglandins and FGF-2 Mediated Osteoclastogenesis | Talk | University of Connecticut Health Center | 1998 | Farmington, Connecticut |
Localization of an FGF-2 Inhibitory Element in the COL1A1 Gene in Transgenic Mice | Talk | University of Pennsylvania | 1998 | Philadelphia, Pennsylvania |
Osteoporosis and Cytokines | Lecture | University of Connecticut Health Center | 1998 | Farmington, Connecticut |
Osteoporosis The Silent Disease | Lecture | West Indian Foundation | 1998 | Hartford, Connecticut |
Osteoporosis The Silent Disease | Lecture | WVIT-TV Channel 30 | 1998 | New Britain, Connecticut |
Regulation of FGF-2 in Bone | Talk | University of Connecticut Health Center | 1997 | Farmington, Connecticut |
Regulation of FGF-2 in Bone | Talk | Prizm Pharmaceuticals | 1996 | San Diego, California |
Adrenal Disorder | Lecture | University of Connecticut School of Medicine | 1995 | Farmington, Connecticut |
Regulation of Inducible Prostaglandin G/H Synthase mRNA Levels and Promoter Activity by Basic Fibroblast Growth Factor in Osteoblastic Cells | Talk | American Society for Bone & Mineral Research | 1994 | Kansas City, Missouri |
Osteoporosis and Growth Factors | Lecture | University of Connecticut School of Medicine | 1994 | Farmington, Connecticut |
Hypoparathyroidism | Lecture | University of Connecticut School of Medicine | 1994 | Farmington, Connecticut |
Basic Fibroblast Growth Factor Expression and Regulation in Bone Cells | Talk | University of Connecticut | 1993 | Farmington, Connecticut |
Hirsutism | Lecture | University of Connecticut School of Medicine | 1993 | Farmington, Connecticut |
Basic Fibroblast Growth Factor Inhibits IGF-1 mRNA in the Clonal Osteoblastic Cell Line MC3T3-E1 | Talk | International Conference on Calcium Regulating Hormones | 1992 | Florence, Italy |
Adrenal Insufficiency | Lecture | University of Connecticut School of Medicine | 1992 | Farmington, Connecticut |
Mechanisms by which Heparin and Heparin Binding Growth Factors Act on Type I Collagen Synthesis in Bone | Talk | University of Connecticut Department of Medicine | 1991 | Farmington, Connecticut |
Connective Tissue Matrix Proteins | Lecture | University of Connecticut School of Medicine | 1991 | Farmington, Connecticut |
Adrenal Insufficiency | Lecture | University of Connecticut School of Medicine | 1991 | Farmington, Connecticut |
Pagets Disease | Lecture | University of Connecticut School of Medicine | 1990 | Farmington, Connecticut |
Cell Cycle | Lecture | University of Connecticut School of Medicine | 1989 | Farmington, Connecticut |
Hirsutism | Lecture | University of Connecticut School of Medicine | 1989 | Farmington, Connecticut |
Systemic Hormones | Lecture | University of Connecticut School of Medicine | 1988 | Farmington, Connecticut |
Hirsutism | Lecture | University of Connecticut School of Medicine | 1987 | Farmington, Connecticut |
Amenorrhea and Infertility | Lecture | St. Joseph’s College | 1986 | West Hartford, Connecticut |