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Metabolism of serine/glycine lipids by human gingival cells in culture.
Guido, Tyler M; Ratcliffe, Samuel D; Rahmlow, Amanda; Zambrello, Matthew A; Provates, Anthony A; Clark, Robert B; Smith, Michael B; Nichols, Frank C Molecular oral microbiology 2023 Oct;
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Gut Microbiome-Derived Glycine Lipids Are Diet-Dependent Modulators of Hepatic Injury and Atherosclerosis.
Millar, Courtney L; Anto, Liya; Garcia, Chelsea; Kim, Mi-Bo; Jain, Anisha; Provatas, Anthony A; Clark, Robert B; Lee, Ji-Young; Nichols, Frank C; Blesso, Christopher N Journal of lipid research 2022 Mar;100192
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Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8)
Basole, Chaitali P; Nguyen, Rebecca K; Lamothe, Katie; Billis, Puja; Fujiwara, Mai; Vang, Amanda G; Clark, Robert B; Epstein, Paul M; Brocke, Stefan* Cells 2022 Feb;11,(4):
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A novel phosphoglycerol serine-glycine lipodipeptide of Porphyromonas gingivalis is a TLR2 ligand.
Nichols, Frank C; Clark, Robert B; Maciejewski, Mark W; Provatas, Anthony A; Balsbaugh, Jeremy L; Dewhirst, Floyd E; Smith, Michael B; Rahmlow, Amanda Journal of Lipid Research 2020 Dec;121645-1657
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Glycine lipids of Porphyromonas gingivalis are agonists for Toll-like receptor 2.
Nichols, Frank C; Clark, Robert B; Liu, Yaling; Provatas, Anthony A; Dietz, Christopher J; Zhu, Qiang; Wang, Yu-Hsiung; Smith, Michael B Infection and Immunity 2020 Mar;88(4):00877-19
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Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis.
Wasko NJ, Nichols F, Clark RB Autoimmunity Reviews 2020 Jan;19(1):102430
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Systemic TLR2 tolerance enhances central nervous system remyelination.
Wasko, Nicholas J; Kulak, Meghan Horne; Paul, Debayon; Nicaise, Alexandra M; Yeung, Stephen T; Nichols, Frank C; Khanna, Kamal M; Crocker, Stephen; Pachter, Joel S; Clark, Robert B Journal of neuroinflammation 2019 Jul;16(1):158
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The role of phospholipase A2 in multiple Sclerosis: A systematic review and meta-analysis.
Trotter, Austin; Anstadt, Emily; Clark, Robert B; Nichols, Frank; Dwivedi, Alok; Aung, Koko; Cervantes, Jorge L Multiple sclerosis and related disorders 2019 Jan;27206-213
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Enhanced TLR2 responses in multiple sclerosis.
Fujiwara, M; Anstadt, E J; Flynn, B; Morse, K; Ng, C; Paczkowski, P; Zhou, J; Mackay, S; Wasko, N; Nichols, F; Clark, R B Clinical and experimental immunology 2018 Jul;193313-326
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PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.
Basole, Chaitali P; Nguyen, Rebecca K; Lamothe, Katie; Vang, Amanda; Clark, Robert; Baillie, George S; Epstein, Paul M; Brocke, Stefan Cellular signalling 2017 Aug;4062-72
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Deposition and Hydrolysis of Serine Dipeptide Lipids of Bacteroidetes Bacteria in Human Arteries: Relationship to Atherosclerosis.
Nemati, Reza; Dietz, Christopher; Anstadt, Emily J; Cervantes, Jorge; Liu, Yaling; Dewhirst, Floyd E; Clark, Robert B; Finegold, Sydney; Gallagher, James J; Smith, Michael B; Yao, Xudong; Nichols, Frank C Journal of lipid research 2017 Aug;581999-2007
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Convergent Synthesis of a Deuterium Labeled Serine Dipeptide Lipid for Analysis of Biological Samples.
Dietz, Christopher; Clark, Robert B; Nichols, Frank C; Smith, Michael B Journal of labelled compounds & radiopharmaceuticals 2017 Mar;60274-285
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Simultaneous Determination of Absolute Configuration and Quantity of Lipopeptides Using Chiral Liquid Chromatography/Mass Spectrometry and Diastereomeric Internal Standards.
Nemati, Reza; Dietz, Christopher; Anstadt, Emily; Clark, Robert; Smith, Michael; Nichols, Frank; Yao, Xudong Analytical chemistry 2017 Feb;893583-3589
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TLR Tolerance as a Treatment for Central Nervous System Autoimmunity.
Anstadt, Emily J; Fujiwara, Mai; Wasko, Nicholas; Nichols, Frank; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2016 Sep;197(6):2110-8
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Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.
Vang, Amanda G; Basole, Chaitali; Dong, Hongli; Nguyen, Rebecca K; Housley, William; Guernsey, Linda; Adami, Alexander J; Thrall, Roger S; Clark, Robert B; Epstein, Paul M; Brocke, Stefan Frontiers in pharmacology 2016 Jan;7259
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Serine dipeptide lipids of Porphyromonas gingivalis inhibit osteoblast differentiation: Relationship to Toll-like receptor 2.
Wang, Yu-Hsiung; Nemati, Reza; Anstadt, Emily; Liu, Yaling; Son, Young; Zhu, Qiang; Yao, Xudong; Clark, Robert B; Rowe, David W; Nichols, Frank C Bone 2015 Sep;81654-61
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Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.
Fujiwara, Mai; Anstadt, Emily J; Khanna, Kamal M; Clark, Robert B Clinical immunology (Orlando, Fla.) 2015 Mar;158(1):103-13
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Biologic activity of porphyromonas endodontalis complex lipids.
Mirucki, Christopher S; Abedi, Mehran; Jiang, Jin; Zhu, Qiang; Wang, Yu-Hsiung; Safavi, Kamran E; Clark, Robert B; Nichols, Frank C Journal of endodontics 2014 Sep;40(9):1342-8
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Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
Vang, Amanda G; Housley, William; Dong, Hongli; Basole, Chaitali; Ben-Sasson, Shlomo Z; Kream, Barbara E; Epstein, Paul M; Clark, Robert B; Brocke, Stefan The Biochemical journal 2013 Dec;456(3):463-73
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Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis.
Farrokhi, Vahid; Nemati, Reza; Nichols, Frank C; Yao, Xudong; Anstadt, Emily; Fujiwara, Mai; Grady, James; Wakefield, Daniel; Castro, Wanda; Donaldson, James; Clark, Robert B Clinical & translational immunology 2013 Nov;2(11):e8
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Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands.
Clark, Robert B; Cervantes, Jorge L; Maciejewski, Mark W; Farrokhi, Vahid; Nemati, Reza; Yao, Xudong; Anstadt, Emily; Fujiwara, Mai; Wright, Kyle T; Riddle, Caroline; La Vake, Carson J; Salazar, Juan C; Finegold, Sydney; Nichols, Frank C Infection and immunity 2013 Sep;81(9):3479-89
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Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples.
Nichols, Frank C; Bajrami, Bekim; Clark, Robert B; Housley, William; Yao, Xudong Infection and immunity 2012 Feb;80(2):860-74
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Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity.
Housley, William J; Adams, Catherine O; Vang, Amanda G; Brocke, Stefan; Nichols, Frank C; LaCombe, Melissa; Rajan, Thiruchandurai V; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2011 Oct;187(8):4161-9
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Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function.
Wang, Yu-Hsiung; Jiang, Jin; Zhu, Qiang; AlAnezi, Amer Z; Clark, Robert B; Jiang, Xi; Rowe, David W; Nichols, Frank C Infection and immunity 2010 Sep;78(9):3726-35
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Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta.
Adams, Catherine O; Housley, William J; Bhowmick, Sourojit; Cone, Robert E; Rajan, Thiruchandurai V; Forouhar, Faripour; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2010 Aug;185(4):2051-8
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The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism.
Bhowmick, Sourojit; Singh, Anurag; Flavell, Richard A; Clark, Robert B; O'Rourke, James; Cone, Robert E Journal of leukocyte biology 2009 Dec;86(6):1275-83
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Unique lipids from a common human bacterium represent a new class of Toll-like receptor 2 ligands capable of enhancing autoimmunity.
Nichols, Frank C; Housley, William J; O'Conor, Catherine A; Manning, Thomas; Wu, Shuang; Clark, Robert B The American journal of pathology 2009 Dec;175(6):2430-8
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The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells.
St Rose, Marie-Clare; Qui, Harry Z; Bandyopadhyay, Suman; Mihalyo, Marianne A; Hagymasi, Adam T; Clark, Robert B; Adler, Adam J Journal of immunology (Baltimore, Md. : 1950) 2009 Oct;183(8):4975-83
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PPARgamma regulates retinoic acid-mediated DC induction of Tregs.
Housley, William J; O'Conor, Catherine A; Nichols, Frank; Puddington, Lynn; Lingenheld, Elizabeth G; Zhu, Li; Clark, Robert B Journal of leukocyte biology 2009 Aug;86(2):293-301
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T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber.
Cone, Robert E; Chattopadhyay, Subhasis; Sharafieh, Roshanak; Lemire, Yen; O'Rourke, James; Flavell, Richard A; Clark, Robert B International immunology 2009 May;21(5):567-74
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Regulatory role of B cells in a murine model of allergic airway disease.
Singh, Anurag; Carson, William F; Secor, Eric R; Guernsey, Linda A; Flavell, Richard A; Clark, Robert B; Thrall, Roger S; Schramm, Craig M Journal of immunology (Baltimore, Md. : 1950) 2008 Jun;180(11):7318-26
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Maternal transmission of resistance to development of allergic airway disease.
Matson, Adam P; Zhu, Li; Lingenheld, Elizabeth G; Schramm, Craig M; Clark, Robert B; Selander, Dawn M; Thrall, Roger S; Breen, Elena; Puddington, Lynn Journal of immunology (Baltimore, Md. : 1950) 2007 Jul;179(2):1282-91
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Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms.
Wohlfert, Elizabeth A; Nichols, Frank C; Nevius, Erin; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2007 Apr;178(7):4129-35
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'Vive la Résistance!'--the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression.
Wohlfert, Elizabeth A; Clark, Robert B Trends in immunology 2007 Apr;28(4):154-60
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Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Wohlfert, Elizabeth A; Gorelik, Leonid; Mittler, Robert; Flavell, Richard A; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2006 Feb;176(3):1316-20
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Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice.
Wohlfert, Elizabeth A; Callahan, Margaret K; Clark, Robert B Journal of immunology (Baltimore, Md. : 1950) 2004 Jul;173(2):1059-65
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cAMP-mediated suppression of a Th1 clone associated with an alteration of the intracellular redox environment.
Cochrane, R; Clark, R B; Maulik, N; Cordis, G; Cone, R E Cellular and molecular biology (Noisy-le-Grand, France) 2003 Mar;49(2):301-6
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Differential regulation of T cell receptor-mediated Th1 cell IFN-gamma production and proliferation by divergent cAMP-mediated redox pathways.
Cochrane, R; Clark, R B; Huang, C K; Cone, R E Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001 Oct;21(10):797-807
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The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses.
Clark, R B; Bishop-Bailey, D; Estrada-Hernandez, T; Hla, T; Puddington, L; Padula, S J Journal of immunology (Baltimore, Md. : 1950) 2000 Feb;164(3):1364-71
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The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis.
Graesser, D; Mahooti, S; Haas, T; Davis, S; Clark, R B; Madri, J A Laboratory investigation; a journal of technical methods and pathology 1998 Nov;78(11):1445-58
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Adoptively transferred EAE in gamma delta T cell-knockout mice.
Clark, R B; Lingenheld, E G Journal of autoimmunity 1998 Feb;11(1):105-10
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Forskolin induces an anergic-like state and a decrease in the expression of LCK in a TH1 clone
Cochrane R., Clark R.B., Huang C.-K., Cone R.E. FASEB Journal 1998 Jan;12(5):
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Adoptively transferred EAE in mice bearing the lpr mutation.
Clark, R B; Grunnet, M; Lingenheld, E G Clinical immunology and immunopathology 1997 Dec;85(3):315-9
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The generation of encephalitogenic T cell lines from experimental allergic encephalomyelitis-resistant strains of mice.
Clark, R B; Grunnet, M L; Lingenheld, E G International immunology 1997 Oct;9(10):1415-22
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Elevation of intracellular cyclic AMP induces an anergic-like state in Th1 clones.
Cone, R E; Cochrane, R; Lingenheld, E G; Clark, R B Cellular immunology 1996 Nov;173(2):246-51
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Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions.
Barten, D M; Clark, R B; Ruddle, N H Journal of immunology (Baltimore, Md. : 1950) 1995 Dec;155(11):5409-18
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Comparison of CNS homing pattern among murine TH cell lines responsive to myelin basic protein.
Barbarese, E; Soares, H; Yang, S; Clark, R B Journal of neuroimmunology 1992 Jul;39(1-2):151-62
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Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis is correlated with high and low responsiveness to myelin basic protein.
Binder, T A; Clark, R B; Goldschneider, I Journal of neuroimmunology 1991 Dec;35(1-3):31-43
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T cell non-MHC-restricted antigen-binding molecules secreted or associated with the cell membrane are antigenically distinct.
Cone, R E; Clark, R B; Kristie, J; Wong, R; Rellahan, B L Cellular immunology 1991 Oct;137(2):529-38
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Identification of encephalitogenic V beta-4-bearing T cells in SJL mice. Further evidence for the V region disease hypothesis?
Padula, S J; Lingenheld, E G; Stabach, P R; Chou, C H; Kono, D H; Clark, R B Journal of immunology (Baltimore, Md. : 1950) 1991 Feb;146(3):879-83
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An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.
Ruddle, N H; Bergman, C M; McGrath, K M; Lingenheld, E G; Grunnet, M L; Padula, S J; Clark, R B The Journal of experimental medicine 1990 Oct;172(4):1193-200
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A cytoplasmic activator of DNA replication is involved in signal transduction in antigen-specific T cell lines.
Wong, R L; Clark, R B; Gutowski, J K; Katz, M E; Fresa, K L; Cohen, S Cellular immunology 1990 May;127(2):382-90
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Murine T helper cell clones secrete granulocyte-macrophage colony-stimulating factor (GmCSF) by both interleukin-2-dependent and interleukin-2-independent pathways.
Wong, R L; Lingenheld, E G; Fitzgerald, L; Clark, R B Cellular immunology 1989 Oct;123(2):445-55
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Effects of H-7 are not exclusively mediated through protein kinase C or the cyclic nucleotide-dependent kinases.
Love, J T; Padula, S J; Lingenheld, E G; Amin, J K; Sgroi, D C; Wong, R L; Sha'fi, R I; Clark, R B Biochemical and biophysical research communications 1989 Jul;162(1):138-43
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Subtypes of helper cells. Non-inflammatory type 1 helper T cells.
Wong, R L; Ruddle, N H; Padula, S J; Lingenheld, E G; Bergman, C M; Rugen, R V; Epstein, D I; Clark, R B Journal of immunology (Baltimore, Md. : 1950) 1988 Nov;141(10):3329-34
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T cell receptor beta chain gene rearrangement shared by murine T cell lines derived from a site of autoimmune inflammation.
Padula, S J; Sgroi, D C; Lingenheld, E G; Love, J T; Chou, C H; Clark, R B The Journal of clinical investigation 1988 Jun;81(6):1810-8
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Carbamate formation on tubulin: CO2/bicarbonate buffers protect tubulin from inactivation by reductive methylation and carbamoylation and promote microtubule assembly at alkaline pH.
Clark, R W; Volpi, M; Berlin, R D Biochemistry 1988 Feb;27(3):1025-33
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The protein kinase C inhibitor H-7, inhibits antigen and IL-2-induced proliferation of murine T cell lines.
Clark, R B; Love, J T; Sgroi, D; Lingenheld, E G; Sha'afi, R I Biochemical and biophysical research communications 1987 Jun;145(2):666-72
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Allogeneic fibroblasts and endothelial cells support mitogen but not antigen responses of tetanus-responsive T-cell lines.
Shanahan, W R; Padula, S J; Clark, R B; Korn, J H Clinical immunology and immunopathology 1987 May;43(2):204-10
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T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive
Sgroi D, Cohen RN, Lingenheld EG, Strong MK, Binder T, Goldschneider I, Greiner D, Grunnet M, Clark RB J Immunol. 1986 Jan;1371850-1854
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Compartmentalized immune responses: antigen-specificity of cerebrospinal fluid T-cell lines maintained in the absence of antigen.
Clark, R B; Lingenheld, E G; Donaldson, J O; Pollard, M K Clinical immunology and immunopathology 1985 Aug;36(2):176-86
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Maintenance of antigen specificity by human interleukin-2-dependent T cell lines. Use of antigen-presenting cells and OKT3 antibody in the absence of antigen.
Padula, S J; Pollard, M K; Lingenheld, E G; Clark, R B The Journal of clinical investigation 1985 Mar;75(3):788-97
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Generation of long-term T-cell lines from synovial fluid.
Clark, R B; Muirhead, S P; Pollard, M K Clinical immunology and immunopathology 1984 Nov;33(2):287-92
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Long-term T-cell lines from the tears of patients with vernal conjunctivitis.
Clark, R B; Ballow, M Journal of clinical & laboratory immunology 1984 Oct;15(2):91-4
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Generation of phenotypic helper/inducer and suppressor/cytotoxic T-cell lines from cerebrospinal fluid in multiple sclerosis.
Clark, R B; Dore-Duffy, P; Donaldson, J O; Pollard, M K; Muirhead, S P Cellular immunology 1984 Apr;84(2):409-14
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T-cell colonies recognize antigen in association with specific epitopes on Ia molecules.
Clark, R B; Chiba, J; Zweig, S E; Shevach, E M Nature 1982 Feb;295(5848):412-4
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Generation of T cell colonies from responder strain 2 guinea pigs that recognize the copolymer L-glutamic acid, L-lysine in association with nonresponder strain 13 Ia antigens.
Clark, R B; Shevach, E M The Journal of experimental medicine 1982 Feb;155(2):635-40
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Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. I. Production and initial characterization.
Malek, T R; Clark, R B; Shevach, E M Journal of immunology (Baltimore, Md. : 1950) 1981 Aug;127(2):616-21
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The selective in vivo incorporation and metabolism of radioactive putrescine in the adult male rat.
Clark, R B; Fair, W R Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1975 May;16(5):337-42
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A correlation of seminal polyamine levels and semen analysis in the human.
Fair, W R; Clark, R B; Wehner, N Fertility and sterility 1972 Jan;23(1):38-42
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Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.
Carson, William F; Guernsey, Linda A; Singh, Anurag; Secor, Eric R; Wohlfert, Elizabeth A; Clark, Robert B; Schramm, Craig M; Kunkel, Steven L; Thrall, Roger S Frontiers in immunology 6592
