Mina Mina, DMD, PhDProfessor and Chair, Pediatric DentistryDirector, DMD/PHD program. Co-Director , Skeletal, Craniofacial and Oral Biology training grant
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Degree | Institution | Major |
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DMD | National University of Iran | Dentistry |
MDentSc | Case Western Reserve Univeristy | Craniofacial Biology |
PhD | University of Connecticut Health Center | Biomedical Sciences |
Post-Graduate Training
Training | Institution | Specialty |
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Residency | Case Western Reserve University Program | Pediatric Dentistry |
Awards
Name of Award/Honor | Awarding Organization |
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UCHC Board of Directors Faculty Recognition Award | UCHC |
IADR Distinguished Scientist Award for Craniofacial Biology Research | IADR |
Graduate Student Award, American Academy of Pediatric Dentistry | AAPD |
My Labaratory is interested in the molecular and cellular mechanisms that regulate the formation of organs in embryos, their renewal and regeneration into adulthood. Most of our studies are focused in initiation and morphogenesis of organs in craniofacial regions including mandible and teeth.
Currently we also study the origin, maintenance, proliferation and differentiation of adult stem cells using adult stem cells in dental pulp.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
Lab Rotation Projects
Students with new and innovative ideas about craniofacial and tooth development are more than welcome to participate in rotation project in the laboratory. In addition the students can participate in the ongoing projects in the lab.
The current research projects in the laboratory are:
1. Characterization of adult dental pulp using various markers.
2. Understanding the differentiation potentials of dental pulp and its application towards tissue engineering.
3. Signaling pathways involved in cell fate determination of dental pulp stem cells
Journal Articles
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The chromatin accessibility landscape in the dental pulp of mouse molars and incisors.
Acta biochimica Polonica 2022 Feb;69(1):131-138
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Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners.
Stem cells international 2022 Jan;20224969441
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Single-cell transcriptome analysis defines mesenchymal stromal cells in the mouse incisor dental pulp.
Gene expression patterns : GEP 2021 Dec;119228
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Genome-wide distribution of 5hmC in the dental pulp of mouse molars and incisors.
Journal of biochemistry 2021 Oct;
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Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization.
Calcified tissue international 2021 Jul;
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Wnt/β-Catenin Signaling Promotes the Formation of Preodontoblasts In Vitro.
Journal of dental research 2020 Oct;22034520967353
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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
Nature communications 2020 Sep;11(1):4816
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Comparison of osteogenic and dentinogenic potentials of mice incisor and molar pulps in vitro.
Archives of oral biology 2020 Mar;111104647
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Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.
Journal of dental research 2020 Jan;99(1):89-97
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Women Recipients of IADR Distinguished Scientist Awards.
Advances in dental research 2019 Dec;30(3):85-94
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Generation and characterization of DSPP-Cerulean/DMP1-Cherry reporter mice.
Genesis (New York, N.Y. : 2000) 2019 Jul;e23324
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Activation of αSMA expressing perivascular cells during reactionary dentinogenesis.
International endodontic journal 2018 Jul;5268-76
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FGF2 Enhances Odontoblast Differentiation by αSMA+ Progenitors In Vivo.
Journal of dental research 2018 Apr;971170-1177
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Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016.
Journal of dental research 2018 Jan;97483-491
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Mineral trioxide aggregate improves healing response of periodontal tissue to injury in mice.
Journal of periodontal research 2017 Jul;521058-1067
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FGF Signaling Prevents the Terminal Differentiation of Odontoblasts.
Journal of dental research 2017 Feb;96663-670
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αSMA-Expressing Perivascular Cells Represent Dental Pulp Progenitors In Vivo.
Journal of dental research 2016 Nov;96323-330
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Enhanced Dentinogenesis of Pulp Progenitors by Early Exposure to FGF2.
Journal of dental research 2015 Aug;94(11):1582-90
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Stage-specific effects of fibroblast growth factor 2 on the differentiation of dental pulp cells.
Cells, tissues, organs 2015 Mar;199(5-6):311-28
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Biphasic effects of FGF2 on odontoblast differentiation involve changes in the BMP and Wnt signaling pathways.
Connective tissue research 2014 Aug;55 Suppl 153-6
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In vivo identification of periodontal progenitor cells.
Journal of dental research 2013 Aug;92(8):709-15
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A feasibility study for the analysis of reparative dentinogenesis in pOBCol3.6GFPtpz transgenic mice.
International endodontic journal 2012 Oct;45(10):907-14
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Analysis of the contribution of nonresident progenitor cells and hematopoietic cells to reparative dentinogenesis using parabiosis model in mice.
Journal of endodontics 2012 Sep;38(9):1214-9
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Identification of secretory odontoblasts using DMP1-GFP transgenic mice.
Bone 2011 Apr;48(4):927-37
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Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars.
Bone 2010 Jun;46(6):1639-51
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Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.
Developmental dynamics : an official publication of the American Association of Anatomists 2009 Oct;238(10):2599-613
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Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice.
Developmental biology 2009 Apr;328(1):13-23
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Signaling pathways regulating the expression of Prx1 and Prx2 in the chick mandibular mesenchyme.
Developmental dynamics : an official publication of the American Association of Anatomists 2008 Nov;237(11):3115-27
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Expression and function of Dlx genes in the osteoblast lineage.
Developmental biology 2008 Apr;316(2):458-70
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Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones.
Developmental biology 2008 Apr;316(2):336-49
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FGF signaling in mandibular skeletogenesis.
Orthodontics & craniofacial research 2007 May;10(2):59-66
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Mandibular phenotype of p20C/EBPbeta transgenic mice: Reduced alveolar bone mass and site-specific dentin dysplasia.
Bone 2006 Sep;39(3):552-64
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Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible.
Archives of oral biology 2006 Feb;51(2):134-45
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Analysis of developmental potentials of dental pulp in vitro using GFP transgenes.
Orthodontics & craniofacial research 2005 Nov;8(4):252-8
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Visualizing levels of osteoblast differentiation by a two-color promoter-GFP strategy: Type I collagen-GFPcyan and osteocalcin-GFPtpz.
Genesis (New York, N.Y. : 2000) 2005 Oct;43(2):87-98
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Histological analysis of GFP expression in murine bone.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005 May;53(5):593-602
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Distinct functions for Bmp signaling in lip and palate fusion in mice.
Development (Cambridge, England) 2005 Mar;132(6):1453-61
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Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.
Bone 2004 Jul;35(1):74-82
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Analysis of the odontogenic and osteogenic potentials of dental pulp in vivo using a Col1a1-2.3-GFP transgene.
The International journal of developmental biology 2003 May;47(4):281-92
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Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Jun;17(6):1008-14
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Region- and stage-specific effects of FGFs and BMPs in chick mandibular morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Mar;223(3):333-52
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Col1a1-GFP transgene expression in developing incisors.
Connective tissue research 2002 Jan;43(2-3):216-9
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Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme.
Developmental dynamics : an official publication of the American Association of Anatomists 1999 Dec;216(4-5):320-35
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Odontogenic epithelium induces similar molecular responses in chick and mouse mandibular mesenchyme.
Developmental dynamics : an official publication of the American Association of Anatomists 1998 Dec;213(4):386-97
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Functional and morphologic evidence of the presence of tissue-plasminogen activator in vascular nerves: implications for a neurologic control of vessel wall fibrinolysis and rigidity.
Journal of neuroscience research 1998 Aug;53(4):443-53
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EGF does not induce Msx-1 and Msx-2 in dental mesenchyme.
European journal of oral sciences 1998 Jan;106 Suppl 1(1 SUPPL.):100-3
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Downregulation of Msx-2 expression results in chondrogenesis in the medial region of the avian mandible.
Connective tissue research 1996 Jan;35(1-4):79-84
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Tenascin-C is associated with early stages of chondrogenesis by chick mandibular ectomesenchymal cells in vivo and in vitro.
Developmental dynamics : an official publication of the American Association of Anatomists 1996 Jan;205(1):24-40
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Experimental analysis of Msx-1 and Msx-2 gene expression during chick mandibular morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1995 Feb;202(2):195-214
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Enhancement of avian mandibular chondrogenesis in vitro in the absence of epithelium.
Archives of oral biology 1994 Jul;39(7):551-62
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Stage-related chondrogenic potential of avian mandibular ectomesenchymal cells.
Differentiation; research in biological diversity 1991 Sep;48(1):9-16
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Temporal and spatial expression of genes for cartilage extracellular matrix proteins during avian mandibular arch development.
Differentiation; research in biological diversity 1991 Sep;48(1):17-24
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Assay of ATP-sulfurylase activity from rat liver by high-performance liquid chromatography.
Journal of chromatography 1988 Dec;43363-72
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An evaluation of the morphogenic and anatomic effects of the functional regulator utilizing the counterpart analysis.
European journal of orthodontics 1988 Aug;10(3):192-202
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The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium.
Archives of oral biology 1987 Jan;32(2):123-7
Abstracts
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Varying PLA functionality and texture to influence osteoprogenitors.
Academy of Dental Materials 2010 Oct;
Conference Papers
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Mineralization and expression of Col1a1-3.6GFP transgene in primary dental pulp culture.
Cells, tissues, organs 2009 Jan;189(1-4):163-8
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New insight into progenitor/stem cells in dental pulp using Col1a1-GFP transgenes.
Cells, tissues, organs 2004 Jan;176(1-3):120-33
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Morphogenesis of the medial region of the developing mandible is regulated by multiple signaling pathways.
Cells, tissues, organs 2001 Jan;169(3):295-301
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Role of the early epithelium in the patterning of the teeth and Meckel's cartilage.
Journal of craniofacial genetics and developmental biology 1991 Jan;11(4):223-8
Editorials
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Introduction to the special issue on the 14th International conference on the chemistry and biology of mineralized tissues.
Journal of structural biology 2024 Oct;216(4):108146
Reviews
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Regulation of mandibular growth and morphogenesis.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2001 Jan;12(4):276-300
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Interaction between the neural crest and extracellular matrix proteins in craniofacial skeletogenesis.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1990 Jan;1(2):79-87