Photo of Michael R. Gryk, Ph.D.

Michael R. Gryk, Ph.D.

Associate Professor, Department of Molecular Biology and Biophysics
Academic Office Location:
Molecular Biology and Biophysics
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3305
Phone: 860-679-4785
Fax: 860-679-3408

Molecular Biology & Biochemistry Graduate Program

B.S.University of ConnecticutBiophysics
M.S.University of ConnecticutChemistry
Ph.D.Stanford UniversityBiophysics

Post-Graduate Training
PostdoctoralEuropean Molecular Biology LaboratoryPostdoctoral Research Assistant in the Laboratory of Dr. Hartmut Oschkinat.
PostdoctoralUniversity of Connecticut Health CenterPostdoctoral Research Assistant in the Laboratory of Dr. Gregory P. Mullen

Name of Award/HonorAwarding Organization
DAAD post-doctoral fellowship (declined)Deutscher Akademischer Austausch Dienst
Who's Who Among Students in American Universities Who's Who Among Students in American Universities
Training Grant 1990-1994NIH
Who's Who Among Students in American UniversitiesWho's Who Among Students in American Universities
MemberGolden Key National Honor Society
Biophysics Award for Distinguished Undergraduate Research Honors Scholar Phi Beta Kappa Honor Society
Who's Who Among Students in American UniversitiesWho's Who Among Students in American Universities
University ScholarUCONN Phi Kappa Phi Honor Society
MemberAlpha Lambda Delta Honor Society
Bruce Mahon Scholarship 1986-1990
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
IT LiaisonAdvisory CommitteeMemberUConn HealthUniversity2012

The focus of our laboratory is structural bioinformatics. We are currently involved in several projects on this topic, mainly the use of NMR spectroscopy as a tool for macromolecular characterization and molecular structure as an aid to bioinformatics.

Particular projects include the development of CONNJUR ( – an open source integration platform for biomolecular NMR data processing; utilizing non-uniform sampling techniques and the use of maximum entropy methods for spectral reconstruction; and the development of a database of short linear motifs which confer specific functions to proteins ( NMR studies involve DNA repair proteins of relatively large molecular weight for NMR spectroscopy (20-70 kDa). Current methods to overcome the difficulties inherent in studying these large systems include extensive labeling using stable isotopes and the use of TROSY-based pulse sequences. A critical mission of the lab is the facility approach to NMR, such that as advancements are made, they are tailored for ease-of-use both internally and externally when possible.

--CONNJUR NMR Software Integration
--MiniMotif Miner
--Structural Biology Facility
--Structural Biology Tools

Accepting Lab Rotation Students: Fall 2022 and Spring 2023

Journal Articles


Conference Papers





Title or AbstractTypeSponsor/EventDate/YearLocation
Data, Meet ComputationPosterExperimental NMR Conference2022Orlando, FL
Storied Past, Bright Future: A Provenance Jam Session.Panel DiscussionAssociation for Information Science and Technology2022Pittsburgh, PA
Curating Scientific Workflows for Biomolecular Nuclear Magnetic Resonance Spectroscopy.TalkInternational Digital Curation Conference2018Barcelona, Spain
Semantic Mediation to Improve Reproducibility for Biomolecular NMR Analysis.TalkiConference 20182018Sheffield, UK