Brenton R. Graveley, PhDProfessor and Chair, Genetics and Genome SciencesHealth Net, Inc. Endowed Chair in Genetics and Developmental Biology Director, UConn Stem Cell Institute Associate Director, Institute for Systems Genomics
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Degree | Institution | Major |
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BA | University of Colorado | Molecular, Cellular, and Developmental Biology |
PhD | University of Vermont | Microbiology and Molecular Genetics |
Post-Graduate Training
Training | Institution | Specialty |
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Fellowship | American Cancer Society | Undergraduate Fellowship |
Fellowship | Howard Hughes Medical Institute | Undergraduate Fellowship |
Fellowship | Colorado Commission on Higher Education | |
Fellowship | Undergraduate Research Opportunity Fellowship | |
Postdoctoral | Department of Molecular and Cellular Biology, Harvard University, Laboratory of Tom Maniatis | Postdoctoral Fellow |
Fellowship | Jane Coffin Childs Memorial Fund | Medical Research Postdoctoral Fellowship |
Awards
Name of Award/Honor | Awarding Organization |
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Elected Member | Connecticut Academy of Science and Engineering |
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
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Strategic Plan, Implementation Committee | Advisory Committee | Co-Chair | UConn-Storrs | University | 2023 | |
NIH RNome Group | Workshop/Conference | Member, Executive Committee | External | National | 2022 | 2022 |
NHGRI Advisory Council, Presentation on RNomics Meeting Report | Advisory Committee | Presenter | External | National | 2022 | 2022 |
NHGRI National Advisory Council for Human Genome Research | Advisory Committee | Member | External | National | 2015 | |
ZRG1 MDCN-E Study Section, "Molecular and Cellular Neuroscience" | Study Section | Chair | External | National | 2014 | 2014 |
ZRG1 GGG-A Study Section, "Defining a Comprehensive Reference Profile of Circulating Human Extracellular RNA" | Study Section | Ad-hoc member | External | National | 2014 | 2014 |
NIGMS National Advisory General Medical Sciences Council | Advisory Committee | Ad-hoc member | External | National | 2014 | 2014 |
Scientific Data | Editorial Board | Member | External | International | 2013 | |
NIMG PsychENCODE Study Section | Study Section | ad-hoc member | External | National | 2013 | 2013 |
Grant Reviews, NIH | Study Section | AD-hoc Member | External | National | 2012 | |
Grant Reviews, NIH GCAT | Study Section | AD-hoc Member | External | National | 2012 | |
RNA | Editorial Board | Editor | External | International | 2011 | |
The Biology of Genomes | Other | Session Chair | External | International | 2010 | 2010 |
Art Committee for the 400 Farmington Building | Community Service | Member | UConn Health | Local | 2010 | 2012 |
National Cancer Institute of Canada | Advisory Committee | Ad Hoc Reviewer | External | National | 2009 | |
Genome Biology | Editorial Board | Editorial Board | External | International | 2009 | |
CSHL Eukaryotic mRNA Processing | Other | Session Chair | External | Regional | 2009 | 2009 |
Bioinformatics section of the CTSA Proposal | Advisory Committee | Co-Director | UConn Health | Local | 2009 | 2009 |
Planning and Design Committee for the 400 Farmington Building | Community Service | Member | UConn Health | Local | 2009 | 2009 |
Translational Genomics Core Facility | Advisory Committee | Senior Advisor | UConn Health | Local | 2009 | 2012 |
BMC Genomics | Editorial Board | Member | External | International | 2009 | 2011 |
NIH MG-A Study Section | Study Section | Member | External | National | 2006 | 2010 |
Translational Genomics Core Facility | Advisory Committee | Director | UConn Health | Local | 2006 | 2009 |
Genetics and Developmental Biology Faculty Search Committee | Education Committee | Member | UConn Health | Local | 2006 | |
Grant Reviews, NIH Molecular Genetics | Study Section | Member | External | National | 2006 | 2010 |
RNA | Editorial Board | Editorial Board | External | International | 2005 | 2011 |
NIH MG-A Study Section | Study Section | Ad Hoc Reviewer | External | National | 2005 | 2006 |
Splicing Regulation Session, RNA 2005, 10th Annual Meeting of the RNA Society | Other | SciChair | External | International | 2005 | 2005 |
Research Recruitment Committee | Education Committee | Member | UConn Health | Local | 2005 | |
Neuroscience Faculty Search Committee | Education Committee | Member | UConn Health | Local | 2005 | 2005 |
Immunology Faculty Search Committee | Education Committee | Member | UConn Health | Local | 2005 | 2006 |
MMSB Faculty Search Committee | Education Committee | Member | UConn Health | Local | 2005 | 2006 |
BMC Molecular Biology | Editorial Board | Editorial Board | External | International | 2004 | |
First Year Advisory Committee | Advisory Committee | Chair | UConn Health | Local | 2004 | 2005 |
Ph.D. Curriculum Strategic Plan Committee | Advisory Committee | Member | UConn Health | Local | 2004 | 2006 |
Education 20/20 Vision Committee | Education Committee | Member | UConn Health | Local | 2004 | 2005 |
Grant Reviews, NIH Molecular Genetics | Study Section | AD-hoc Member | External | National | 2004 | 2006 |
Library Advisory Committee | Advisory Committee | Member | UConn Health | Local | 2003 | 2005 |
Management Negotiating Team for Postdoctoral Fellow Union Contract | Advisory Committee | Member | UConn Health | Local | 2003 | 2004 |
First Year Graduate Advisory Committee | Advisory Committee | Member | UConn Health | Local | 2002 | 2004 |
Graduate Admissions Committee | Education Committee | Member | UConn Health | Local | 2002 | 2005 |
MD/Ph.D. Admissions Committee | Education Committee | Member | UConn Health | Local | 2002 | |
Summer Undergraduate Research Fellowship Committee | Education Committee | Member | UConn Health | Local | 2002 | |
Genetics and Developmental Biology Seminar Series | Other | Director | UConn Health | Local | 2002 | |
American Society for Microbiology | Professional/Scientific Organization | Member | External | National | 2001 | 2002 |
Graduate Programs Committee | Education Committee | Member | UConn Health | Local | 2001 | 2006 |
Genetics and Developmental Biology Faculty Search Committee | Education Committee | Member | UConn Health | Local | 2001 | 2002 |
HSEC committee | Education Committee | Member | UConn Health | Local | 2001 | 2005 |
Faculty Mentor Committee for the GMBB program | Education Committee | Member | UConn Health | Local | 2001 | 2002 |
Genetics and Developmental Biology Graduate Program | Education Committee | Co-Director | UConn Health | Local | 2001 | 2002 |
American Association for the Advancement of Science | Professional/Scientific Organization | Member | External | National | 1996 | |
RNA Society | Professional/Scientific Organization | Board of Directors | External | International | 1995 | |
Science | Professional/Scientific Journal | Reviewer | External | International | ||
Nature; Structure and Molecular Biology, Reviews Genetics | Professional/Scientific Journal | Reviewer | External | National | ||
Cell; Molecular Cell, Developmental Cell | Professional/Scientific Journal | Reviewer | External | National | ||
PNAS | Professional/Scientific Journal | Reviewer | External | National | ||
Genes and Development | Professional/Scientific Journal | Reviewer | External | National | ||
RNA | Professional/Scientific Journal | Reviewer | External | National | ||
PLoS Genetics | Professional/Scientific Journal | Reviewer | External | National | ||
EMBO | Professional/Scientific Journal | Reviewer | External | International | ||
Molecular and Cellular Biology | Professional/Scientific Journal | Reviewer | External | National | ||
Trends in Genetics | Professional/Scientific Journal | Reviewer | External | National | ||
Trends in Biochemical Sciences | Professional/Scientific Journal | Reviewer | External | National | ||
Genome Research | Professional/Scientific Journal | Reviewer | External | National | ||
Genome Biology | Professional/Scientific Journal | Reviewer | External | National | ||
Journal of Biological Chemistry | Professional/Scientific Journal | Reviewer | External | National | ||
Journal of Cell Biology | Professional/Scientific Journal | Reviewer | External | National | ||
Journal of Molecular Biology | Professional/Scientific Journal | Reviewer | External | National | ||
Molecular Biology and Evolution | Professional/Scientific Journal | Reviewer | External | National | ||
Gene | Professional/Scientific Journal | Reviewer | External | National | ||
Nucleic Acids Research | Professional/Scientific Journal | Reviewer | External | National | ||
BMC Genomics | Professional/Scientific Journal | Reviewer | External | National | ||
Biochemistry | Professional/Scientific Journal | Reviewer | External | National | ||
Genomics | Professional/Scientific Journal | Reviewer | External | National | ||
Journal of Proteome Research | Professional/Scientific Journal | Reviewer | External | National | ||
Mechanisms of Development | Professional/Scientific Journal | Reviewer | External | National | ||
Molecular Therapy | Professional/Scientific Journal | Reviewer | External | National | ||
Biological Psychiatry | Professional/Scientific Journal | Reviewer | External | National |
My laboratory studies a wide variety of experiments that can be grouped into five broad areas:
Alternative Splicing Regulatory Networks in Drosophila In eukaryotes, genes are organized into segments referred to as exons and introns. When genes are transcribed into messenger RNA (mRNA), the exons are joined together and the introns are spliced out. The majority of eukaryotic genes contain multiple exons and introns. In such cases, the exons can be joined together in different patterns in a process called alternative splicing to generate multiple mRNAs from a single gene, each of which can encode a protein with a distinct function. Alternative splicing is a common means by which eukaryotes regulate gene expression and is the primary means of enhancing the diversity of proteins encoded in the genome. In addition, defects in alternative splicing can result in the onset of many human diseases including cancer, Alzheimer’s disease, and myotonic dystrophy. Thus, understanding the mechanisms by which alternative splicing is regulated is of tremendous importance to human health.My laboratory is interested in all aspects of the regulation of alternative splicing in Drosophila melanogaster. Drosophila is an excellent system in which to study alternative splicing due to the ability to use cutting-edge genetic, biochemical, tissue culture, and genomic technologies. In addition, the majority of the genes involved in the regulation of alternative splicing are shared between humans and flies. Thus, the principals we learn by studying this process in Drosophila are directly applicable to the regulation of alternative splicing in humans.
Alternative Splicing in Human Embryonic Stem Cells Cells and organisms function based on the expression patterns, actions, and interactions of thousands of genes and their products. A tremendous amount of work has gone into dissecting the transcriptional regulatory and protein interaction networks that drive cell function. However, one important aspect of gene regulation is often overlooked in these studies - alternative splicing. Alternative splicing is the process by which exons can be joined together in different patterns to generate multiple mRNAs from a single gene. Alternative splicing is a tremendously important mechanism by which eukaryotes regulate gene expression and is the primary means of enhancing the diversity of proteins encoded by the genome. It is currently estimated that as many as 75 percent of human genes encode pre-mRNAs that are alternative spliced to generate multiple mRNAs, each of which can potentially encode a protein with a distinct function. Thus, just like transcription regulation, alternative splicing can function as a developmental switch.A number of microarray studies have been conducted to identify a set of stemness genes - genes that are expressed in and define the core gene regulatory program for all types of stem cells. While these studies have led to the identification of a number of genes that play important roles in controlling various aspects of stem cell biology, they have not examined alternative splicing in stem cells. Thus, a crucial aspect of the gene regulatory programs of all types of human stem cells has been overlooked.The goal of our work is to fill this gap by performing expression profiling experiments of hES cells in their undifferentiated state and as they differentiate down different lineage pathways using microarrays that can monitor alternative splicing and to elucidate the role of specific RNA binding proteins in controlling alternative splicing in hES cells. These experiments should lead to a more complete understanding of the gene expression programs of hES cells which is critical to our ability to guide stem cells down different lineage pathways and to realizing the full therapeutic potential of hES cells.
Alternative Splicing of the Drosophila Dscam Pre-mRNA A major project in the laboratory is to determine the mechanisms involved in controlling alternative splicing of the Drosophila Down Syndrome Cell Adhesion Molecule (Dscam) gene. The Dscam gene, which was discovered in Larry Zipurskys lab, encodes an axon guidance receptor that is most similar to one of the human genes implicated in causing Down Syndrome. Perhaps the most interesting aspect of this gene is that it is the most extensively alternatively spliced gene that we know of in any organism. This single gene can generate over 38,000 different isoforms by virtue of extensive alternative splicing. In fact, the number of proteins generated by this gene is two to three times the number of genes in the entire Drosophila genome! It is thought that the diversity of Dscam isoforms contributes to the specificity of neuronal wiring. We have found that the alternative splicing of Dscam transcripts is regulated throughout development and in a tissue-specific manner. Moreover, this regulated alternative splicing is evolutionarily conserved. We are now using RNAi, genetics, evolutionary, and biochemical approaches to identify trans-acting factors and cis-acting RNA sequences that participate in controlling this extraordinarily complex alternative splicing event.By performing an RNAi screen in which we depleted hundreds of RNA binding proteins in the Drosophila genome, we have identified about 40 different proteins that regulate the splicing of various Dscam exons. We have also identified several splicing regulatory elements that are required for the inclusion of any alternative exons and we are currently working to identify the mechanisms by which these elements act. In addition, we are using a variety of techniques to determine the role of the different Dscam isoforms in specifying axon guidance in the fly. Although there are differences in the properties of the human and Drosophila Dscam proteins, these studies may lead to insights regarding the role of this gene in the development of Down syndrome in humans.
The Drosophila modENCODE Project The goal of this project is to generate a comprehensive list of all the sequence-based functional elements in the Drosophila genome. This will be done by generating a set of developmentally staged and tissue- and cell-specific RNAs for expression profiling using high-density genome tiling microarrays and 454 pyrosequencing of small RNAs. These expression data will be used for sophisticated transcript modeling that integrates extant EST and cDNA sequence and comparative data from the 12 sequenced Drosophila genomes. These gene models will be experimentally validated and functionally analyzed in RNAi assays. The final product of these efforts will include comprehensive annotations of transcription start sites, exon/intron structures, polyadenylation sites and the cis-elements required for splicing.
The Role of microRNAs in Planarian Regeneration Planarians are free-living flat worms that are best known for their regenerative capacity. For example, after surgical bisection of the animal in either the vertical or horizontal plane each half of the animal will regenerate the missing structures. In fact, a fragment as small as 1/279th the size of the original individual has the capacity to regenerate into an entire animal. The key to the amazing regenerative prowess of these creatures is a population of cells known as neoblasts that are distributed throughout the body of the animal. Neoblasts are totipotent cells that are the only dividing cells in the animal. The division progeny of neoblasts replace cells lost during normal cellular turnover in the animal. After injury, however, neoblasts migrate to the wound site, divide, and their progeny eventually replace the missing structures. Thus, neoblasts are the planarian equivalent of stem cells making these unique organisms an excellent model system for studying stem cell biology.
Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025
A wide variety of potential rotation projects in the general areas of post-transcriptional gene regulation (i.e., the RNA world) are available to highly motivated students. Please contact me to discuss potential projects or even better, to suggest a project of your own.
Journal Articles
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Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-Seq.
RNA (New York, N.Y.) 2024 Aug;
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Late-life shift in caloric intake affects fly metabolism and longevity.
Proceedings of the National Academy of Sciences of the United States of America 2023 Dec;120(50):e2311019120
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Histones direct site-specific CRISPR spacer acquisition in model archaeon.
Nature microbiology 2023 Sep;8(9):1682-1694
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Investigation of CRISPR-Independent Phage Resistance Mechanisms Reveals a Role for FtsH in Phage Adsorption to Streptococcus thermophilus.
Journal of bacteriology 2023 May;e0048222
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Hyper-stimulation of Pyrococcus furiosus CRISPR DNA uptake by a self-transmissible plasmid.
Extremophiles : life under extreme conditions 2022 Nov;26(3):36
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RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins.
Nucleic acids research 2022 Nov;
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Type III-A CRISPR systems as a versatile gene knockdown technology.
RNA (New York, N.Y.) 2022 Aug;28(8):1074-1088
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Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules.
Nucleic acids research 2022 Jun;
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Unique properties of spacer acquisition by the type III-A CRISPR-Cas system.
Nucleic acids research 2021 Dec;
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Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis.
Molecular cell 2020 Nov;80(4):648-665.e9
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A large-scale binding and functional map of human RNA-binding proteins.
Nature 2020 Jul;583(7818):711-719
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Expanded encyclopaedias of DNA elements in the human and mouse genomes.
Nature 2020 Jul;583(7818):699-710
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Perspectives on ENCODE.
Nature 2020 Jul;583(7818):693-698
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Primed CRISPR DNA uptake in Pyrococcus furiosus.
Nucleic acids research 2020 Jun;48(11):6120-6135
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Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins.
Genome biology 2020 Apr;21(1):90
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Sequencing and Structure Probing of Long RNAs Using MarathonRT: A Next-Generation Reverse Transcriptase.
Journal of molecular biology 2020 Apr;
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Complete Genome Sequence of Streptococcus ratti JH145.
Microbiology resource announcements 2020 Mar;9(10):
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CRISPR DNA elements controlling site-specific spacer integration and proper repeat length by a Type II CRISPR-Cas system.
Nucleic acids research 2019 Aug;
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Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription.
Cell 2019 Jun;178(1):107-121.e18
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CRISPR repeat sequences and relative spacing specify DNA integration by Pyrococcus furiosus Cas1 and Cas2.
Nucleic acids research 2019 Jun;
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Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA.
Nature communications 2019 Mar;10(1):1338
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Correction to: DNA copy number evolution in Drosophila cell lines.
Genome biology 2019 Mar;20(1):53
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Regulation of RNA editing by RNA-binding proteins in human cells.
Communications biology 2019 Jan;219
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RBP-Maps enables robust generation of splicing regulatory maps.
RNA (New York, N.Y.) 2018 Nov;25193-204
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Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
bioRxiv 2018 Aug;
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mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases.
Molecular cell 2018 Jun;70(6):1089-1100.e8
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Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci.
Molecular cell 2018 Jun;70(5):814-824.e6
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Sequence, Structure, and Context Preferences of Human RNA Binding Proteins.
Molecular cell 2018 Jun;70(5):854-867.e9
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Vex-seq: high-throughput identification of the impact of genetic variation on pre-mRNA splicing efficiency.
Genome biology 2018 Jun;19(1):71
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Complete Genome Sequence of Industrial Dairy StrainStreptococcus thermophilusDGCC 7710.
Genome announcements 2018 Feb;6(6):
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Role of free DNA ends and protospacer adjacent motifs for CRISPR DNA uptake in Pyrococcus furiosus.
Nucleic acids research 2017 Nov;45(19):11281-11294
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Ccr4 And Pop2 Control Poly(A) Tail Length In Saccharomyces cerevisiae
bioRxiv 2017 May;
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Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors.
Stem cell reviews 2016 Aug;12744-756
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Resources for the Comprehensive Discovery of Functional RNA Elements.
Molecular cell 2016 Mar;61(6):903-13
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Distal Alternative Last Exons Localize mRNAs to Neural Projections.
Molecular cell 2016 Feb;61821-33
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A benchmark for RNA-seq quantification pipelines.
Genome biology 2016 Jan;17(1):74
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Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila.
Genome research 2015 Aug;25(11):1692-702
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Regulation of alternative splicing in Drosophila by 56 RNA binding proteins.
Genome research 2015 Aug;25(11):1771-80
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Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome.
Molecular biology and evolution 2015 Jun;32(10):2605-15
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Genome-wide identification of zero nucleotide recursive splicing in Drosophila.
Nature 2015 May;521(7552):376-9
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Three CRISPR-Cas immune effector complexes coexist in Pyrococcus furiosus.
RNA (New York, N.Y.) 2015 Apr;21(6):1147-58
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Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation.
eLife 2015 Apr;4
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Musings on 20 years of RNA.
RNA (New York, N.Y.) 2015 Apr;21(4):506-7
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Codon optimality is a major determinant of mRNA stability.
Cell 2015 Mar;160(6):1111-24
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Determining exon connectivity in complex mRNAs by nanopore sequencing.
Genome biology 2015 Jan;16(1):204
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The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing.
eLife 2015 Jan;4
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Comparative analysis of the transcriptome across distant species.
Nature 2014 Aug;512(7515):445-8
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Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1.
Molecular autism 2014 Aug;5(44):44
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Comparative validation of the D. melanogaster modENCODE transcriptome annotation.
Genome research 2014 Jul;24(7):1209-23
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Evolution of splicing regulatory networks in Drosophila.
Genome research 2014 Mar;24(5):786-96
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Diversity and dynamics of the Drosophila transcriptome.
Nature 2014 Mar;512(7515):393-9
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Probabilistic splicing of Dscam1 establishes identity at the level of single neurons.
Cell 2013 Nov;155(5):1166-77
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Identification of neoblast- and regeneration-specific miRNAs in the planarian Schmidtea mediterranea.
RNA (New York, N.Y.) 2013 Oct;19(10):1394-404
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Circuitous route to transcription regulation.
Molecular cell 2013 Sep;51(6):705-6
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The genome of Anopheles darlingi, the main neotropical malaria vector.
Nucleic acids research 2013 Aug;41(15):7387-400
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Programmable plasmid interference by the CRISPR-Cas system in Thermococcus kodakarensis.
RNA biology 2013 May;10(5):828-40
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Dynamic integration of splicing within gene regulatory pathways.
Cell 2013 Mar;152(6):1252-69
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Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genes, brain, and behavior 2013 Feb;12(1):21-33
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Genomic imprinting absent in Drosophila melanogaster adult females.
Cell reports 2012 Jul;2(1):69-75
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Global patterns of tissue-specific alternative polyadenylation in Drosophila.
Cell reports 2012 Mar;1(3):277-89
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Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs.
Molecular cell 2012 Feb;45(3):292-302
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Transcriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea.
PloS one 2012 Jan;7(4):e34447
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Splicing up pluripotency.
Cell 2011 Sep;147(1):22-4
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microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.
RNA (New York, N.Y.) 2011 Aug;17(8):1529-43
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RNA structure and the mechanisms of alternative splicing.
Current opinion in genetics & development 2011 Aug;21(4):373-9
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The developmental transcriptome of Drosophila melanogaster.
Nature 2011 Mar;471(7339):473-9
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Getting in the loop: new insights into the mechanism of poly(A) site recognition.
Structure (London, England : 1993) 2011 Mar;19(3):279-81
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Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster.
RNA (New York, N.Y.) 2011 Feb;17(2):222-9
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Conservation of an RNA regulatory map between Drosophila and mammals.
Genome research 2011 Feb;21(2):193-202
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Genome-wide analysis of promoter architecture in Drosophila melanogaster.
Genome research 2011 Feb;21(2):182-92
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The transcriptional diversity of 25 Drosophila cell lines.
Genome research 2011 Feb;21(2):301-14
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Genomewide characterization of non-polyadenylated RNAs.
Genome biology 2011 Jan;12(2):R16
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Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells.
PloS one 2011 Jan;6(7):e21808
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Identification of functional elements and regulatory circuits by Drosophila modENCODE.
Science (New York, N.Y.) 2010 Dec;330(6012):1787-97
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Global analysis of trans-splicing in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul;107(29):12975-9
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Regulatory divergence in Drosophila revealed by mRNA-seq.
Genome research 2010 Jun;20(6):816-25
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Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution.
RNA (New York, N.Y.) 2010 Jan;16(1):91-105
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RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex.
Cell 2009 Nov;139(5):945-56
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Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea.
RNA (New York, N.Y.) 2009 Aug;15(8):1483-91
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The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians.
RNA (New York, N.Y.) 2008 Jun;14(6):1174-86
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A regulator of Dscam mutually exclusive splicing fidelity.
Nature structural & molecular biology 2007 Dec;14(12):1134-40
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MicroRNAs from the Planarian Schmidtea mediterranea: a model system for stem cell biology.
RNA (New York, N.Y.) 2006 Sep;12(9):1640-9
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Coordinated control of splicing and translation.
Nature structural & molecular biology 2005 Dec;12(12):1022-3
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The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA.
Molecular and cellular biology 2005 Dec;25(23):10251-60
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Use of RNA interference to dissect the roles of trans-acting factors in alternative pre-mRNA splicing.
Methods (San Diego, Calif.) 2005 Dec;37(4):341-4
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Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures.
Cell 2005 Oct;123(1):65-73
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Small molecule control of pre-mRNA splicing.
RNA (New York, N.Y.) 2005 Mar;11(3):355-8
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Exon-specific RNA interference: a tool to determine the functional relevance of proteins encoded by alternatively spliced mRNAs.
Methods in molecular biology (Clifton, N.J.) 2005 Jan;309273-82
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A computational and experimental approach toward a priori identification of alternatively spliced exons.
RNA (New York, N.Y.) 2004 Dec;10(12):1838-44
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Identification of alternative splicing regulators by RNA interference in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov;101(45):15974-9
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The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes.
RNA (New York, N.Y.) 2004 Oct;10(10):1499-506
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RNA interference of mRNA processing factors in Drosophila S2 cells.
Methods in molecular biology (Clifton, N.J.) 2004 Jan;257245-54
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Using single-strand conformational polymorphism gel electrophoresis to analyze mutually exclusive alternative splicing.
Methods in molecular biology (Clifton, N.J.) 2004 Jan;25765-74
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Arginine/serine repeats are sufficient to constitute a splicing activation domain.
Nucleic acids research 2003 Nov;31(22):6502-8
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Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing.
The Journal of biological chemistry 2003 Jun;278(25):22740-7
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Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing.
Genes & development 2003 Feb;17(4):461-75
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Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing.
RNA (New York, N.Y.) 2002 Jun;8(6):718-24
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Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.
Genomics 2002 Apr;79(4):587-97
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Characterization of U2AF(6), a splicing factor related to U2AF(35).
Molecular and cellular biology 2002 Jan;22(1):221-30
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Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated.
Genetics 2001 Oct;159(2):599-608
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The role of U2AF35 and U2AF65 in enhancer-dependent splicing.
RNA (New York, N.Y.) 2001 Jun;7(6):806-18
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A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers.
The EMBO journal 1998 Nov;17(22):6747-56
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Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing.
Molecular cell 1998 Apr;1(5):765-71
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Restoration of both structure and function to a defective poly(A) site by in vitro selection.
The Journal of biological chemistry 1996 Dec;271(52):33654-63
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TFIIS binds to mouse RNA polymerase I and stimulates transcript elongation and hydrolytic cleavage of nascent rRNA.
Molecular & general genetics : MGG 1996 Sep;252(4):412-9
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RNA structure is a critical determinant of poly(A) site recognition by cleavage and polyadenylation specificity factor.
Molecular and cellular biology 1996 Sep;16(9):4942-51
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A common mechanism for the enhancement of mRNA 3' processing by U3 sequences in two distantly related lentiviruses.
Journal of virology 1996 Mar;70(3):1612-7
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CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition.
Genes & development 1995 Jan;9(1):72-83
Books
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Alternative Splicing in the Postgenomic Era 2008 Jan;
Book Chapters
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One Gene, Many Products.
The Implicit Genome 2006 Jan;385 p.
Conference Papers
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Splicing bioinformatics to biology.
Genome biology 2006 Jan;7(5):317
Editorials
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RNAs: dynamic and mutable.
Genome biology 2017 Nov;18(1):226
Erratums
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Erratum to: A benchmark for RNA-seq quantification pipelines.
Genome biology 2016 Sep;17(1):203
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Erratum to: A benchmark for RNA-seq quantification pipelines.
Genome biology 17(1):107
Other
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Evolution of genes and genomes on the Drosophila phylogeny.
Nature 2007 Nov;450(7167):203-18
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Sex, AGility, and the regulation of alternative splicing.
Cell 2002 May;109(4):409-12
Reviews
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RNA Matchmaking: Finding Cellular Pairing Partners.
Molecular cell 2016 Jul;63(2):186-9
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New insights from existing sequence data: generating breakthroughs without a pipette.
Molecular cell 2013 Feb;49(4):605-17
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Expansion of the eukaryotic proteome by alternative splicing.
Nature 2010 Jan;463(7280):457-63
-
Complex alternative splicing.
Advances in experimental medicine and biology 2007 Jan;62350-63
-
RS domains contact the pre-mRNA throughout spliceosome assembly.
Trends in biochemical sciences 2005 Mar;30(3):115-8
-
The origins and implications of Aluternative splicing.
Trends in genetics : TIG 2004 Jan;20(1):1-4
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Alternative splicing: increasing diversity in the proteomic world.
Trends in genetics : TIG 2001 Feb;17(2):100-7
-
Alternative splicing: Through the proteome jungle [L'épissage alternatif: Diversifier le protéome]
Biofutur 2001 Jan;(216):39-43
-
L'Èpissage alternatif: diversifier le protÈome.
Biofutur 2001 Jan;(216):39-43
-
Sorting out the complexity of SR protein functions.
RNA (New York, N.Y.) 2000 Sep;6(9):1197-211
-
SR proteins are 'locators' of the RNA splicing machinery.
Current biology : CB 1999 Jan;9(1):R6-7
Short Surveys
-
Alternative splicing: regulation without regulators.
Nature structural & molecular biology 2009 Jan;16(1):13-5
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Getting the message out.
Molecular cell 2008 Jul;31(1):4-6
-
Molecular biology: power sequencing.
Nature 2008 Jun;453(7199):1197-8
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The haplo-spliceo-transcriptome: common variations in alternative splicing in the human population.
Trends in genetics : TIG 2008 Jan;24(1):5-7
-
Splicing from the outside in.
Molecular cell 2007 Sep;27(6):861-2
-
A protein interaction domain contacts RNA in the prespliceosome.
Molecular cell 2004 Feb;13(3):302-4
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
---|---|---|---|---|
Facilitating Technology Dissemination and Adoption | Plenary Lecture | NIH | 2022 | Virtual |
Insights into RNA Biology in Drosophila from Genome-Wide Studies | Talk | Dept. Biochemistry & Biophysics, UPenn School of Medicine | 2013 | Philadelphia, PA |
Insights into RNA Biology in Drosophila from Genome-Wide Studies | Talk | Dept. of Molecular Genetics and Microbiology, University of Florida | 2013 | Gainesville, FL |
Insights into RNA Biology in Drosophila from Genome-Wide Studies | Talk | Department of Molecular Biology and Genetics, Cornell University | 2013 | Ithica, NY |
Why are flies so weird? | Lecture | 2013 | Biochemistry and Molecular Pharmacology. UMass Medical School | |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | NIH, NIDDK | 2012 | Bethesda, MD |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | MIT, Department of Biology. | 2012 | Cambridge, MA |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | UMDNJ, Department of Biology | 2012 | Newark, NJ |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | Case Western Reserve University, RNA Center | 2012 | Cleveland, OH |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | Brown University, Department of Biology | 2012 | Providence, RI |
Genomic Approaches to Studying Alternative Splicing in Drosophila. | Talk | John Hopkins University, Department of Biology. | 2012 | Baltimore, MD |
Post Transcriptional Regulation of Gene Expression. | Talk | Gordon Conference | 2012 | Newport, RI |
ModENCODE Symposium | Talk | NHGRI/NIH | 2012 | Bethesda, MD |
Genome-wide Analysis of Alternative Splicing in Drosophila. | Talk | RNA 2012 | 2012 | Ann Arbor, MI |
Genome-wide Analysis of Alternative Splicing in Drosophila. | Talk | Cold Spring Harbor Laboratories | 2012 | Cold Spring Harbor, NY |
Genomic Approaches to Studying RNA Processing in Drosophila. | Talk | Drosophila 2012 | 2012 | Chicago, IL |
Genomic approaches to the study of RNA processing in Drosophila | Talk | Cell Press, Regulatory RNAs | 2011 | Chicago, IL |
Genomic approaches to the study of RNA processing in Drosophila | Talk | John Hopkins University, Department of Biology | 2011 | John Hopkins University, Baltimore, MD |
Genomic approaches to the study of RNA processing in Drosophila | Talk | University of Colorado, Boulder, MCDB Department | 2011 | Boulder, CO |
Genome wide analysis of mRNA processing in Drosophila | Talk | Gordon Conference - Nucleic Acids | 2011 | Biddeford, ME |
Genome wide analysis of mRNA processing in Drosophila | Talk | University of California, Irvine | 2011 | Irvine, CA |
Genome wide analysis of mRNA processing in Drosophila | Talk | University of California, Los Angeles | 2011 | Los Angeles, CA |
Alternative Splicing in Drosophila. | Talk | University of Colorado | 2011 | Colorado |
Alternative Splicing in Drosophila. | Talk | University of California | 2011 | Los Angeles, California |
Alternative Splicing in Drosophila. | Talk | University of California | 2011 | Irvine, California |
Dynamics and Diversity of the Drosophila Transcriptome. | Talk | Nucleic Acids. Gordon Conference | 2011 | Biddeford, ME |
The developmental transcriptome of Drosophila melanogaster | Talk | Genome Biology, Beyond the Genome | 2010 | Boston, MA |
Alternative Splicing in Drosophila. | Talk | University of Vermont | 2010 | University of Vermont |
Alternative Splicing in Drosophila. | Talk | Lawrence Berkeley National Labs | 2010 | Berkeley, CA |
Alternative Splicing in Drosophila. | Talk | University of Connecticut Health Center | 2010 | Farmington, CT |
MicroRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. | Poster | 40th Annual Meeting of the Society for Neuroscience | 2010 | San Diego, CA |
Deep Sequencing of Schmidtea mediterranea Reveals Strain-specific Transcript Expression. | Poster | Genome Informatics. Cold Spring Harbor Laboratory/Wellcome Trust. | 2010 | Hingston, UK |
Using RNAi and RNA-Seq to Identify Alternative Exons Regulated by Individual RNA Binding Proteins and their Associated Regulatory Motifs. | Talk | ISMB | 2010 | Boston, MA |
Using RNAi and RNA-Seq to identify alternative exons regulated by individual RNA binding proteins and their associated regulatory motifs. | Talk | Fifteenth Annual Meeting of the RNA Society. | 2010 | Seattle, Washington |
Dynamics and Diversity of the Drosophila Transcriptome. | Talk | Beyond the Genome. International Conference | 2010 | Boston, MA |
Dynamics and Diversity of the Drosophila Transcriptome. | Talk | Gordon Conference | 2010 | Newport, RI |
The Regulation of Alternative Splicing. | Talk | Annual Meeting of the RNA Society | 2010 | Seattle, WA |
Alternative Splicing in Human Embryonic Stem Cells. | Talk | State of Connecticut Stem Cell Retreat | 2010 | New Haven, CT |
Dynamics and Diversity of the Drosophila Transcriptome. | Talk | Cold Spring Harbor Laboratories | 2010 | Cold Spring Harbor, NY |
Dynamics and Diversity of the Drosophila Transcriptome. | Talk | Cold Spring Harbor Laboratories | 2010 | Cold Spring Harbor, NY |
Alternative Splicing in Drosophila. | Talk | RNA Center, Case Western Reserve University | 2009 | Cleveland, OH |
Alternative Splicing in Drosophila. | Talk | University of Massachusetts | 2009 | Amherst, Massachusetts |
Alternative Splicing in Drosophila. | Talk | Wesleyan University | 2009 | Middletown, CT |
Alternative Splicing in Drosophila. | Talk | University of Wisconsin | 2009 | Madison, Wisconsin |
Alternative Splicing in Drosophila. | Talk | University of Kentucky | 2009 | Kentucky |
Alternative Splicing in Drosophila. | Talk | University of Connecticut | 2009 | Storrs, Connecticut |
Analysis of Dscam expression and mechanisms of alternative splicing. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2009 | Cold Spring Harbor, NY |
Drosophila development at single-nucleotide resolution. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2009 | Cold Spring Harbor, NY |
Using RNAi and RNA-Seq to identify alternative exons regulated by individual RNA binding proteins and their associated regulatory motifs. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 2009 | Cold Spring Harbor , NY |
Alternative Trans-Splicing in Drosophila. Eukaryotic mRNA Processing | Talk | Cold Spring Harbor Laboratory. | 2009 | Cold Spring Harbor , NY |
Modencode Meeting | Talk | 2009 | Washington, DC | |
High Throughput Technologies for the Analysis of Alternative Splicing. | Talk | European Alternative Splicing Network (EURASNET) Conference | 2009 | Valencia, Spain |
Alternative Splicing of Dscam. | Talk | ASBMB 2008 Annual Meeting | 2008 | San Diego, California |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | University of North Carolina | 2008 | North Carolina |
Alternative Splicing in Drosophila. | Talk | 16th Annual International Conference on Intelligent Systems for Molecular Biology | 2008 | Toronto, Canada |
Alternative Splicing in Drosophila. | Talk | Crete XVI EMBO Conference | 2008 | Crete (Greece) |
Alternative Splicing of Dscam: The Making of 38,000 Isoforms. | Talk | International Centre for Genetic Engineering and Biotechnology | 2007 | Bariloche, Argentina |
Alternative Splicing of Dscam: The Making of 38,000 Isoforms. | Talk | VIII Symposium. IBMC, | 2007 | Porto, Portugal |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | University of Toronto | 2007 | Toronto, Caneda |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | University of Georgia | 2007 | Georgia |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | University of Illinois | 2007 | Illinois |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | Cold Spring Harbor Laboratory | 2007 | Cold Spring Harbor, NY |
Pasilla, the Drosophila homolog of Nova-1 and -2 regulates sex-specific alternative trans-splicing. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2007 | Cold Spring Harbor, NY |
Musashi Regulates Dscam Alternative Splicing in Drosophila. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2007 | Cold Spring Harbor, NY |
Pasilla, Mub, and Bancal comprise a binary switch that regulated Dscam alternative splicing. | Talk | Cold Spring Harbor Laboratory | 2007 | Cold Spring , NY |
A Regulator of Mutually Exclusive Splicing Fidelity in Dscam. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 2007 | Cold Spring Harbor , NY |
The Insect Down Syndrome Cell Adhesion Molecule (Dscam) Gene: The making and function of 38,000 isoforms. | Talk | Genome Canada, International Conference | 2006 | Quebec City, Canada |
Alternative Splicing in Drosophila. | Talk | Gordon Conference | 2006 | Oxford, UK |
Alternative Splicing in Drosophila. | Talk | Crete XV EMBO Conference | 2006 | Crete (Greece) |
Alternative Splicing in Human Embryonic Stem Cells. | Talk | State of Connecticut Stem Cell Retreat | 2006 | New Haven, CT |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | EMBO Conference on Alternative Transcript Diversity II | 2006 | Heidelberg, Germany |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | Boston College | 2006 | Boston, MA |
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | Brandeis University | 2006 | Waltham, MA |
“Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians. | Talk | Johns Hopkins University | 2006 | Baltimore, MD |
The microRNAs of the Planarian Schmidtea Mediterranea. | Poster | RNA 2006 | 2006 | Seattle, WA |
The microRNAs of the Planarian Schmidtea Mediterranea. | Poster | Cold Spring Harbor Symposium on Regulatory RNAs | 2006 | Cold Spring Harbor , NY |
Alternative Splicing Regulators Identified in Drosophila Using High-Throughput Microarrays. | Talk | RNA 2006 | 2006 | Seattle, WA |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | Nucleic Acids. Gordon Conference | 2005 | Newport, RI |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | University of Massachusetts Medical School | 2005 | Worcester, MA |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | Michigan State University | 2005 | Michigan |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | University of Pittsburgh | 2005 | Pittsburgh, PA |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | Massachusetts Institute of Technology | 2005 | Cambridge, MA |
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms. | Talk | University of California | 2005 | San Diego, CA |
Microarray, and Chemical Biology Tools Designed to Study Alternative Splicing. | Talk | A conference sponsored by Exon-Hit Therapeutics | 2005 | Baltimore, MD |
Identification of Planarian micoRNAs Required for Regeneration. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2005 | Cold Spring Harbor, NY |
A Mechanism for the Mutually Exclusive Splicing of the Insect Dscam Gene. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 2005 | Cold Spring Harbor , NY |
The KH Domain Proteins PS and MUB Function to Regulated Alternative Splicing of the Drosophila Dscam Pre-mRNA. | Talk | Cold Spring Harbor Laboratory | 2005 | Cold Spring Harbor, NY |
Global Identification of Alternative Splicing Regulators and their Regulatory Targets in Drosophila Using High-Throughput Microarrays. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 2005 | Cold Spring Harbor, NY |
A Mechanism for the Mutually Exclusive Splicing of the Insect Dscam Gene Deduced by Comparative Genomics. | Talk | RNA 2005 | 2005 | Banff, Canada, |
Global Identification of Alternative Splicing Regulators and their Regulatory Targets in Drosophila Using High-Throughput Microarrays. | Talk | Drosophila Conference | 2005 | San Diego, CA |
Dscam: The making of 38,000 isoforms. | Talk | Gordon Conference | 2004 | Andover, NH |
Wiring of the Drosophila nervous system and the regulation of Dscam alternative splicing. | Talk | Brandeis University | 2004 | Pikesville, MD |
Wiring of the Drosophila nervous system and the regulation of Dscam alternative splicing. | Talk | University of Vermont | 2004 | Vermont |
The Regulation of Alternative Splicing in Drosophila. | Talk | Universite de Sherbrooke | 2004 | Sherbrooke, QC, Canada |
The Regulation of Alternative Splicing in Drosophila. | Talk | University of Texas | 2004 | Texas |
The Regulation of Alternative Splicing in Drosophila. | Talk | Ohio State University | 2004 | Ohio |
The Regulation of Alternative Splicing in Drosophila. | Talk | Case Western Reserve University | 2004 | Cleveland, OH |
Alternative splicing of the Drosophila Dscam pre-mRNA. | Talk | Rockefeller University | 2004 | New York, NY |
The Regulation of Alternative Splicing in Drosophila. | Talk | University of Connecticut Health Center | 2004 | Farmington, CT |
TRA and TRA2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor. | Poster | RNA 2004 | 2004 | Madison, WI |
Identification of proteins participating in developmentally regulated alternative splicing of the Drosophila Dscam pre-mRNA. | Poster | RNA 2004 | 2004 | Madison, WI |
A combined computational and experimental approach towards a priori identification of alternative exons. | Talk | RNA 2004 | 2004 | Madison, WI |
A long-range secondary structure is required for exon inclusion in the Drosophila Dscam pre-mRNA. | Talk | RNA 2004 | 2004 | Madison, WI |
A genome wide RNAi screen for RNA binding proteins that affect alternative splicing in Drosophila. | Talk | RNA 2004 | 2004 | Madison, WI |
The Regulation of Alternative Splicing in Drosophila. | Talk | University of Maryland | 2003 | Marylan |
The regulation of alternative splicing of the Dscam pre-mRNA and its role in specifying neural wiring in Drosophila. | Talk | Johns Hopkins University | 2003 | Baltimore, MD |
Alternative Splicing of the Drosophila Dscam Pre-mRNA. | Talk | A conference sponsored by Exon-Hit Therapeutics | 2003 | Baltimore, MD |
Evidence for multiple, recent exon duplication events in the insect Dscam genes. Eukaryotic mRNA processing. | Poster | Cold Spring Harbor Laboratory | 2003 | Cold Spring Harbor, NY |
Recursive splicing is required for Dscam alternative splicing. Eukaryotic mRNA processing. | Poster | Cold Spring Harbor Laboratory | 2003 | Cold Spring Harbor, NY |
Tra and Tra2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor. | Talk | RNA 2003 | 2003 | Vienna, Austria |
Comparing mechanisms of sex-specific 5’ and 3’ splice site activation. | Poster | RNA 2003 | 2003 | Vienna, Austria |
Exon-Specific RNAi: A Tool for Dissecting the Functional Relevance of Alternative Splicing. | Poster | Drosophila 2003 | 2003 | Chicago, IL |
The Identification of RNA Sequences Involved in the Regulation of Dscam Alternative Splicing. | Poster | Drosophila 2003 | 2003 | Chicago, IL |
Tra and Tra2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor. Eukaryotic mRNA processing. | Talk | Cold Spring Harbor Laboratory | 2003 | Cold Spring Harbor, NY |
Recursive splicing is required for Dscam alternative splicing. | Talk | RNA 2003 | 2003 | Vienna, Austria |
Regulation of Dscam alternative splicing by B52 and U2AF. | Talk | Drosophila 2003 | 2003 | Chicago, IL |
Alternative Splicing of the Drosophila Dscam Pre-mRNA. | Talk | Ohio State University | 2002 | Ohio |
Exonic Splicing Enhancers – “Determining their mechanism of action and harnessing their awesome power. | Talk | Ohio State University | 2002 | Ohio |
Alternative Splicing of the Drosophila Dscam pre-mRNA. | Talk | UCLA | 2002 | Los Angeles, California |
Splicing and Dicing the Genome: Using Alternative Splicing to Create Extraordinary Protein Diversity. | Talk | New York Medical College | 2002 | Valhala, New York |
Splicing and Dicing the Genome: Using Alternative Splicing to Create Extraordinary Protein Diversity. | Talk | Karolinska Institut | 2002 | Stockholm, Sweden |
Analysis of the potential contribution of SR proteins to poly(A) site recognition. | Poster | RNA 2002 | 2002 | Madison, WI |
Alternative splicing of the Drosophila Dscam pre-mRNA. | Talk | RNA 2002 | 2002 | Madison, WI |
Analysis of the potential contribution of SR proteins to poly(A) site recognition. | Poster | Cold Spring Harbor Laboratory | 2001 | Cold Spring Harbor, New York |
RS domain sequence requirements in enhancer-dependent splicing. Eukaryotic mRNA Processing. | Poster | Cold Spring Harbor Laboratory | 2001 | Cold Spring Harbor, New York |
Alternative splicing of pre-mRNAs encoding the axon guidance receptor Dscam is temporally and spatially regulated. | Poster | Drosophila 2001 | 2001 | |
Defining the mechanisms regulating Dscam alternative splicing in DrosophIla. Eukaryotic mRNA Processing | Talk | Cold Spring Harbor Laboratory | 2001 | Cold Spring Harbor, New York |
Neurexins: A multigene family with really big introns. Genome sequencing and analysis. | Poster | 2000 | ||
Defining the protein sequence requirements for RS domain function. RNA '00. | Poster | The Fifth Annual Meeting of the RNA Society. University of Wisconsin | 2000 | Wisconsin, Madison |
Evidence for the recruitment model for splicing activator function. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 1999 | Cold Spring Harbor, New York |
The control of alternative pre-mRNA splicing with small molecule drugs. | Poster | RNA '99 The Fourth Annual Meeting of the RNA Society | 1999 | Edinburgh, Scottland |
Parameters that influence the efficiency of splicing enhancers. | Poster | RNA '98. The Third Annual Meeting of the RNA Society. | 1998 | Wisconsin, Madison |
Parameters that influence the efficiency of splicing enhancers. | Poster | Jane Coffin Childs Memorial Fund for Medical Research Fall Symposium | 1998 | Lakeville, Connecticut |
An RS domain tethered to RNA can activate enhancer-dependent pre-mRNA splicing. Eukaryotic mRNA Processing. | Talk | Cold Spring Harbor Laboratory | 1997 | Cold Spring Harbor, New York |
RS domains function as activators of enhancer-dependent pre-mRNA splicing. | Poster | Jane Coffin Childs Memorial Fund for Medical Research Fall Symposium | 1997 | Lakeville, Connecticut |
An exploration of the sequence and structural requirements for poly(A) site recognition by in vitro selection. | Poster | RNA '96: The First Annual Meeting of the RNA Society. University of Wisconsin | 1996 | Wisconsin, Madison |
Disruption of transcription initiation complexes during DNA replication in yeast. | Poster | Cold Spring Harbor Laboratory | 1995 | Cold Spring Harbor, New York |
Identification of upstream sequences that enhance pre-mRNA 3' processing. | Poster | Cold Spring Harbor Laboratory | 1995 | Cold Spring Harbor, New York |
CPSF recognition of an HIV-1 mRNA 3' processing enhancer: multiple sequence contacts involved in poly(A) site definition. | Talk | RNA Processing Meeting of the RNA Society. | 1994 | Madison, Wisconsin |
The upstream element of the HIV-1 poly(A) site enhances processing efficiency through the stabilization of the interaction of CPSF with the core poly(A) site. RNA 3' Ends: Formation and Function. | Talk | 1993 | Oxford, UK |