Photo of Corey  Acker

Corey Acker

Assistant Professor, Center for Cell Analysis and Modeling
Academic Office Location:

UConn Health
263 Farmington Avenue
Farmington, CT 06030
Website(s):

Systems Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.University of AlbertaElectrical Engineering
M.S.Boston UniversityBiomedical Engineering
Ph.D.Boston UniversityBiomedical Engineering

Areas of interest


Functional imaging of neural activity, synaptic physiology, cardiac electrophysiology, mechanisms and functional signatures of autism in model systems.


Research areas


Dr. Acker’s lab focuses on developing and applying advanced quantitative techniques from computational modeling to imaging to look at neurophysiology and cardiac electrophysiology in new, more direct and powerful ways. The lab’s goal is to help accelerate our understanding of fundamental human physiology in order to find improved strategies for the prevention or treatment of cardiac and neurological disorders.


Voltage sensor development: together with Dr. Yan and Dr. Loew, Dr. Acker’s lab is actively testing and improving existing voltage sensors, which can be used in studies of the heart or brain, including studies of single cells up to whole organs. At the same time, new sensors are being developed for improved performance, allowing higher resolution, more accurate, and reliable measurements.


Neurodevelopmental disorders: in disorders such as autism, many genetic variations involving components of synapses, the chemical connections between neurons (brain cells), have been implicated. The functional implications of these variations can be studied at the level of single synapses as well as the network level, where altered synaptic signals ultimately lead to changes in patterns of brain activity. Better understanding the connection between the molecular (proteins and receptors) level changes in autism and the network (neuronal firing patterns and synaptic plasticity) level changes will improve our understanding of this disorder and provide new platforms for searching for new treatments or interventions.

Not accepting students for Lab Rotations at this time

Journal Articles

Book Chapters

Reviews

  • Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.
    Müllenbroich, M Caroline; Kelly, Allen; Acker, Corey; Bub, Gil; Bruegmann, Tobias; Di Bona, Anna; Entcheva, Emilia; Ferrantini, Cecilia; Kohl, Peter; Lehnart, Stephan E; Mongillo, Marco; Parmeggiani, Camilla; Richter, Claudia; Sasse, Philipp; Zaglia, Tania; Sacconi, Leonardo; Smith, Godfrey L Frontiers in physiology 2021 Jan;12769586
Title or AbstractTypeSponsor/EventDate/YearLocation
Voltage-Sensitive Dyes and Techniques for Optical Voltage Recordings: From Single Cells to Whole HeartsTalkNovel Optics-Based Approaches to Cardiac Electrophysiology (NOtiCE)2018Florence, Italy
Current Voltage Imaging Efforts of the Loew Lab, Potentiometric Probes, and CollaboratorsTalkMercyanine 5402018MBL, Woods Hole