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Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics.
Al-Naggar, Iman M; Antony, Maria; Baker, Dylan; Wang, Lichao; Godoy, Lucas Da Cunha; Kuo, Chia-Ling; Fraser, Matthew O; Smith, Phillip P; Xu, Ming; Kuchel, George A Aging Cell. 2024 Dec;e14399
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Bringing Geroscience into the Mainstream: From Education to Clinical Practice, What Will It Take?
Al-Naggar, Iman M; Campellone, Kenneth G; Espinoza, Sara E; Justice, Jamie N; Orr, Miranda E; Kozikowski, Chester; van der Willik, Odette; Thatcher, Christine; Schmader, Kenneth; Pignolo, Robert J; Newman, John C; Kuchel, George A. The Journals of Gerontology. Series A, Biological sciences and medical sciences. 2024 Sep;79(9):
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Role of the National Institute on Aging in Transforming Aging Research Through Geroscience and Gerotherapeutics-50 Years of Innovation.
Newman, John C; Al-Naggar, Iman M; Kuchel, George A JAMA Internal Medicine. 2024 Aug;
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SenNet recommendations for detecting senescent cells in different tissues.
Suryadevara, Vidyani; Hudgins, Adam D; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M; Aguayo-Mazzucato, Cristina; Baker, Darren J; Bernlohr, David A; Jurk, Diana; Mangarova, Dilyana B; Quardokus, Ellen M; Enninga, Elizabeth Ann L; Schmidt, Elizabeth L; Chen, Feng; Duncan, Francesca E; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A; Lee, Gung; Daldrup-Link, Heike E; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M; Rahman, Irfan; Nie, Jia; Passos, João F; Silverstein, Jonathan C; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J; Ding, Li; Wang, Lichao; Adams, Lisa C; Ruiyang, Liu; Doolittle, Madison L; Teneche, Marcos G; Schafer, Marissa J; Xu, Ming; Hajipour, Mohammadjavad; Boroumand, Mozhgan; Basisty, Nathan; Sloan, Nicholas; Slavov, Nikolai; Kuksenko, Olena; Robson, Paul; Gomez, Paul T; Vasilikos, Periklis; Adams, Peter D; Carapeto, Priscila; Zhu, Quan; Ramasamy, Ramalakshmi; Perez-Lorenzo, Rolando; Fan, Rong; Dong, Runze; Montgomery, Ruth R; Shaikh, Sadiya; Vickovic, Sanja; Yin, Shanshan; Kang, Shoukai; Suvakov, Sonja; Khosla, Sundeep; Garovic, Vesna D; Menon, Vilas; Xu, Yanxin; Song, Yizhe; Suh, Yousin; Dou, Zhixun; Neretti, Nicola. Nature Reviews Molecular Cell Biology. 2024 Jun;
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Loss of resilience contributes to detrusor underactivity in advanced age.
Ramasamy, Ramalakshmi; Baker, Dylan S; Lemtiri-Chlieh, Fouad; Rosenberg, Dawn A; Woon, Eric; Al-Naggar, Iman M; Hardy, Cara C; Levine, Eric S; Kuchel, George A; Bartley, Jenna M; Smith, Phillip P Biogerontology 2023 Jan;
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Healthy Eating Patterns: A Stealthy Geroscience-Guided Approach to Enhancing the Human Healthspan.
Al-Naggar, I M; Newman, J C; Kuchel, G A. The Journal of Nutrition, Health & Aging. 2023 Jan;27(3):238-239
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The Hyperpolarization Activated, Cyclic Nucleotide Gated Channel Resides on Myocytes in Mouse Bladders and Contributes to Adrenergic-Induced Detrusor Relaxation.
Lemtiri-Chlieh, Fouad; Baker, Dylan S; Al-Naggar, Iman M; Ramasamy, Ramalakshmi; Kuchel, George A; Levine, Eric S; Robson, Paul; Smith, Phillip P American Journal of Physiology. Regulatory, integrative and comparative physiology. 2022 May;
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Senescence-induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics.
Lorenzo, Erica C; Torrance, Blake L; Keilich, Spencer R; Al-Naggar, Iman; Harrison, Andrew; Xu, Ming; Bartley, Jenna M; Haynes, Laura Aging cell 2022 Jan;e13525
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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Wang, Lichao; Wang, Binsheng; Gasek, Nathan S; Zhou, Yueying; Cohn, Rachel L; Martin, Dominique E; Zuo, Wulin; Flynn, William F; Guo, Chun; Jellison, Evan R; Kim, Taewan; Prata, Larissa G P Langhi; Palmer, Allyson K; Li, Ming; Inman, Christina L; Barber, Lauren S; Al-Naggar, Iman M A; Zhou, Yanjiao; Kuchel, George A; Meves, Alexander; Tchkonia, Tamar; Kirkland, James L; Robson, Paul; Xu, Ming. Cell Metabolism. 2021 Nov;
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Senolytics alleviate the degenerative disorders of temporomandibular joint in old age.
Zhou, Yueying; Al-Naggar, Iman M A; Chen, Po-Jung; Gasek, Nathan S; Wang, Ke; Mehta, Shivam; Kuchel, George A; Yadav, Sumit; Xu, Ming Aging Cell. 2021 Jun;e13394
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Aging changes in bladder HCN are associated with increasing heterogeneity of adrenergic/mucosal influence on detrusor control in the mouse.
Hardy, Cara C; Al-Naggar, Iman M; Kuo, Chia-Ling; Kuchel, George A; Smith, Phillip P The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Mar;
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Surgical care of the geriatric patient.
Katz, Marilyn; Silverstein, Nicole; Coll, Patrick; Sullivan, Gail; Mortensen, Eric M; Sachs, Adam; Gross, Jeffrey B; Girard, Eric; Liang, Joy; Ristau, Benjamin T; Stevenson, Christina; Smith, Phillip P; Shames, Brian D; Millea, Ryan; Ali, Irfan; Poulos, Constantine M; Ramaraj, Akila B; Otukoya, Azuka Onye; Nolan, James; Wahla, Zulara; Hardy, Cara; Al-Naggar, Iman; Bliss, Lindsay A; McFadden, David W Current problems in surgery 2019 Jul;56(7):260-329
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HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation.
Al-Naggar, Iman M; Hardy, Cara C; Taweh, Omar G; Grabauskas, Titas; Mulkey, Daniel K; Kuchel, George A; Smith, Phillip P The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Aug;
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Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.
Alhamdi JR, Peng T, Al-Naggar IM, Hawley KL, Spiller KL, and Kuhn LT. Biomaterials 2018 Jul;
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Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.
Bartley, Jenna M; Pan, Sarah J; Keilich, Spencer R; Hopkins, Jacob W; Al-Naggar, Iman M; Kuche, George A; Haynes, Laura Aging 2016 Feb;8620-35
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Identification of single and double sites of phosphorylation by ECD FT-ICR/MS in peptides related to the phosphorylation site domain of the myristoylated alanine-rich C kinase protein.
Woodling, Kellie A; Eyler, John R; Tsybin, Yury O; Nilsson, Carol L; Marshall, Alan G; Edison, Arthur S; Al-Naggar, Iman M; Bubb, Michael R Journal of the American Society for Mass Spectrometry 2007 Dec;18(12):2137-45
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MARCKS is a natively unfolded protein with an inaccessible actin-binding site: evidence for long-range intramolecular interactions.
Tapp, Hazel; Al-Naggar, Iman M; Yarmola, Elena G; Harrison, Alexis; Shaw, Gerry; Edison, Arthur S; Bubb, Michael R The Journal of biological chemistry 2005 Mar;280(11):9946-56
