Srdjan D. Antic, MDProfessor of Neuroscience
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- Overview
- Education & Training
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Electrophysiology and optical imaging of calcium and voltage from dendrites in brain slices, cell culture of human neurons, spontaneous electrical activity, immunolabeling of human and mouse brain sections, computational modeling of CNS neurons and genetically-encoded voltage indicators.
Degree | Institution | Major |
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MD | Belgrade University | Medicine |
MS | Belgrade University | Biophysics |
Post-Graduate Training
Training | Institution | Specialty |
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Professional Training | Marine Biological Laboratory | Summer Course "Neural Systems & Behavior" |
Professional Training | Supercomputer Center | "Neuron Simulation Environment" Summer Course |
Postdoctoral | Yale University | Advisors: Dejan P. Zecevic & Lawrence B. Cohen |
Postdoctoral | Yale University | Advisor: Patricia Goldman-Rakic |
Professional Training | University College London | Dendritic Patching Workshop |
Awards
Name of Award/Honor | Awarding Organization |
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Alzheimer’s disease pathophysiology alters the level of electrical and chemical synapse coupling in the network of GABAergic PV+ interneurons | Cure Alzheimer's Fund |
Pharmacological Agents Capable of Alleviating Alcohol-mediated Changes in Synaptic Physiology | Kasowitz Medical Research Fund |
Population Network Responses in AD Model Animals | NIH |
Population Network Responses in AD Model Animals | NIH |
Physiological method for early detection of synaptic vulnerability in AD model animals | Cure Alzheimer's Fund |
Automated Functional Screening of IgGs for Diagnostics of Neurodegenerative Diseases | European Council |
Near Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology(U01) | NIH |
Embedded Ensemble Encoding (R01) | NIH |
MBL Whitman Center Research Award 2016 | MBL, Woods Hole, MA |
Sparse, strong and large area targeting of genetically encoded indicators (U01) | NIH |
Connexin channels in human neurons (R21) | NIH |
MBL Whitman Center Research Award 2015 | MBL, Woods Hole MA |
First Year Teaching Award | UConn Health |
Stem Cell Physiology and Chemistry Core | The Connecticut Stem Cell Research |
NARSAD Young Investigator Award | NARSAD |
Can Natural Neuromodulators Improve the Generation of Nerve Cells From Human Embryonic Stem Cells? | The Connecticut Stem Cell Research |
Ichiji Tasaki Prize for an outstanding presentation at the Marine Biological Laboratory, Woods Hole, MA | Merocyanine-540 Thirtieth Anniversary Celebration |
Dopaminergic Modulation of Dendritic Excitability (R01) | NIH |
Associate Fellowship, Woods Hole, MA. | Marine Biological Laboratory |
National Research Service Award | National Institute of Mental Health (NIH) |
Scholarship Award - International School of Biophysics "A. Borsalino", Erice, Sicily, 1997. | Ettore Majorana Foundation |
Financial Award for Neural Systems & Behavior - summer course, Woods Hole. | Marine Biological Laboratory |
8th Sardinian Conference of Neuroscience - Travel grant - Cagliary, Italy | Conference Organizors |
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
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Associate Editor, Frontiers in Cellular Neuroscience | Professional/Scientific Journal | Associate Editor | External | International | 2020 | 2025 |
Topic editor - Frontiers in Cellular Neuroscience | Editorial Board | Topic editor | External | International | 2018 | 2019 |
Committee on Undergraduate Medical Education (CUME) | Education Committee | Member | UConn Health | University | 2016 | 2022 |
Neuroscience Executive Committee | Research Committee | Member-at-large | UConn Health | University | 2015 | 2016 |
The Public Issues Council (PIC) | Advisory Committee | member | UConn Health | University | 2015 | 2018 |
Neuroscience Executive Committee | Education Committee | member | UConn Health | University | 2015 | |
The Wellcome Trust/DBT India Alliance | Other | reviewer | External | International | 2015 | |
PhD Admission Committee | Education Committee | Member | UConn Health | University | 2014 | 2016 |
The Neurophotonics SPIE | Other | Reviewer | External | International | 2014 | 2019 |
Stem Cell Research | Other | reviewer | External | International | 2012 | |
Stem Cell and Development, Journal | Other | Reviewer | External | International | 2011 | |
Neuroscience Letters, Journal | Other | Reviewer | External | International | 2011 | |
Frontiers in Neuroscience, Journal | Other | Reviewer | External | International | 2011 | |
NSERC, National Science Engineering and research Council of Canada. | Other | Reviewer | External | International | 2010 | |
Agence Nacionale De Recherce ANG), France | Other | Reviewer | External | International | 2010 | |
Neurochemistry Research, Journal | Other | Reviewer | External | International | 2010 | |
Medical Research Council (MRC) | Other | Reviewer | External | International | 2010 | 2010 |
Dental Senate Stirring Committee | Other | Member | UConn Health | University | 2009 | 2010 |
Brain Research | Other | Reviewer | External | International | 2009 | |
Journal of Neurophysiology | Other | Reviewer | External | International | 2009 | 2025 |
PAWS, Post-Approval Animal Welfare Support | Research Committee | Member | UConn Health | University | 2009 | 2010 |
American Physiological Society (APS) | Professional/Scientific Organization | Member | UConn Health | International | 2009 | |
Dental Senate | Other | Member | UConn Health | University | 2008 | |
Journal of Physiology - London | Other | Member | External | International | 2008 | |
European Journal of Neuroscience | Other | Reviewer | External | International | 2008 | |
PSC-CUNY Awards (Health Sciences grants program at City University of New York). | Other | Reviewer | External | Regional | 2008 | 2008 |
Journal of Neuroscience Methods | Other | Reviewer | External | International | 2007 | |
The United States-Israel Binational Science Foundation (BSF) | Other | Reviewer | External | International | 2007 | |
Journal of Biophysics | Other | Reviewer | External | International | 2006 | |
Animal Care Committee (IACUC) | Research Committee | Member | UConn Health | University | 2005 | 2015 |
Journal of Neuroscience | Other | Reviewer | External | International | 2005 | |
Cerebral Cortex, Journal | Other | Reviewer | External | International | 2004 | |
Journal of Neuroscience Research | Other | Reviewer | External | International | 2004 | 2005 |
Society for Neuroscience (SFN) | Professional/Scientific Organization | Member | UConn Health | International | 1996 | |
European Neuroscience Association (ENA) | Professional/Scientific Organization | Member | UConn Health | International | 1993 | 1995 |
Research in our laboratory is primarily directed towards understanding the cellular and molecular mechanisms of synaptic integration, synaptic plasticity, neuronal excitability and how dopamine modulates these fundamental processes. We have focused our attention on neurons and synapses in the prefrontal cortex, an area of the brain that plays an important role in working memory, planning and emotions. Prefrontal cortex is also of interest because this brain region and its interaction with the neurotransmitter dopamine are strongly implicated in some psychiatric diseases (e.g. schizophrenia). Our experimental methods include local and rapid application of neurotransmitters (glutamate & dopamine), electrophysiology (patch-clamp recordings), fast simultaneous multi-site imaging of the dendritic tree (calcium-sensitive dyes & voltage-sensitive dyes), calcium imaging using genetically-encoded calcium indicators (e.g. GCaMP6), genetically-encoded voltage indicators (VSFP Butterfly, Arclight, ASAP1-3 and Archon1) computer simulations (NEURON), neuron tracing and immunolabeling.
Dopamine drugs that block dopaminergic receptors have been shown to alleviate some symptoms in schizophrenia. On the other hand, drugs that stimulate dopamine receptors produce schizophrenic symptoms in healthy people. These two facts have prompted scientist to postulate that neurotransmitter dopamine is intimately related to higher psychic functions (understanding, planning, and interacting with others). Several decades ago experiments in non-human primates have shown that optimal dopaminergic transmission is absolutely necessary for normal cognitive function (Brozoski et al., 1979). In spite an extensive research effort that lasted for over 25 years, it is still not clear how exactly the release of dopamine affects neuronal networks and individual nerve cells. We are investigating the cellular effects of dopamine-receptor activation in the mammalian cortex. We have recently used fluorescence imaging techniques and patch-clamp recordings to analyze AP-evoked and glutamate-evoked influx of calcium ions into different parts of the pyramidal dendritic tree. We are currently measuring how dopamine receptor stimulations change dendritic calcium concentration. Calcium ions are important messengers that link electrical and biochemical processes in the central nervous system. We hope that these investigations will enhance our understanding of the brain function and explain disturbances in brain function which lead to schizophrenia.
Accepting Lab Rotation Students: Fall Block 2024, Spring 1 Block 2025
Potential projects:
Dendritic excitability. We use whole-cell patch electrode recording from cell body at the same time as optical voltage imaging from dendrite to measure backpropagating action potentials and locally generated dendritic spikes. We feed data into computational models to arrive at comprehensive descriptions of dendritic functional organization and signal transfer from dendrite to axon in different cell types.
Genetically-encoded voltage indicators (GEVIs). GEVIs such as (VSFP Butterfly 1.2, Arclight, ASAP1-3, Archon1 and other) are promising experimental tools for studying brain circuits in health and diseases. We have used GEVIs in HEK293 cells, primary culture neurons and brain slices.
Dopaminergic modulation of neuronal excitability. Dopamine is synthesized in neurons whose cell bodies are located in the brain stem. One group of dopamine-producing neurons (ventral tegmental area) sends their long axons to the prefrontal cortex. Electron microscope studies in monkey and human clearly demonstrate that dopamine synaptic contacts onto cortical neurons are located almost exclusively on the distal dendrites and spines of distal dendrites. What is the functional significance of glutamate-dopamine ultrastructural juxtaposition? Why is it necessary to have a dopamine release site right next to the glutamate release site, on the same dendritic spine? Is dopamine involved in the precise control of the excitatory glutamatergic synapse? The level of prefrontal cortex dopamine is critical for modulating normal cognitive/behavioral processes. One important hypothesis is that deviations from the critical levels can severely disrupt cognitive processes and result in mental disorders such as schizophrenia. At present, it is not known how dopamine interacts with prefrontal cortex neural circuits. We are using in vitro experimental methods to study how dopamine affects glutamate-evoked dendritic membrane potentials. Distal dendritic regions of thin dendrites, where the interaction between glutamatergic and dopaminergic signals actually takes place, are difficult to probe with glass electrodes. In order to measure directly the dendritic response to glutamatergic excitation we use optical recording techniques. Optical methods adopted in our laboratory are based on intracellularly applied calcium-sensitive and voltage-sensitive dyes.
Journal Articles
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Plateau Depolarizations in Spontaneously Active Neurons Detected by Calcium or Voltage Imaging (In Press)
Scientific Reports (https://www.nature.com/srep/) 2024 Sep;
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Characterization of two near-infrared genetically encoded voltage indicators.
Neurophotonics 2024 Apr;11(2):024201
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Imaging of Evoked Cortical Depolarizations Using Either ASAP2s, or chi-VSFP, or Di-4-Anepps, or Autofluorescence Optical Signals.
Journal of integrative neuroscience 2023 Nov;22(6):160
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Simulations predict differing phase responses to excitation vs. inhibition in theta-resonant pyramidal neurons.
Journal of neurophysiology 2023 Aug;
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Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study.
Journal of Alzheimer's disease : JAD 2022 Jan;88(4):1443-1458
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Studying Synaptically Evoked Cortical Responses ex vivo With Combination of a Single Neuron Recording (Whole-Cell) and Population Voltage Imaging (Genetically Encoded Voltage Indicator).
Frontiers in neuroscience 2021 Oct;15773883
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Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons.
Journal of neurophysiology 2021 Apr;125(4):1501-1516
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Population imaging discrepancies between a genetically-encoded calcium indicator (GECI) versus a genetically-encoded voltage indicator (GEVI).
Scientific reports 2021 Mar;11(1):5295
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Local Glutamate-Mediated Dendritic Plateau Potentials Change the State of the Cortical Pyramidal Neuron.
Journal of neurophysiology 2021 Jan;
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Screening and Cellular Characterization of Genetically Encoded Voltage Indicators Based on Near-Infrared Fluorescent Proteins.
ACS chemical neuroscience 2020 Nov;11(21):3523-3531
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In Vitro Testing of Voltage Indicators: Archon1, ArcLightD, ASAP1, ASAP2s, ASAP3b, Bongwoori-Pos6, BeRST1, FlicR1, and Chi-VSFP-Butterfly
eNeuro 2020 Sep;
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Cadmium versus Lanthanum Effects on Spontaneous Electrical Activity and Expression of Connexin Isoforms Cx26, Cx36, and Cx45 in the Human Fetal Cortex.
Cerebral cortex (New York, N.Y.) 2020 Mar;
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Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex-Mouse Subplate Zone.
Cerebral cortex (New York, NY) 2019 Jul;
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Single-Neuron Level One-Photon Voltage Imaging With Sparsely Targeted Genetically Encoded Voltage Indicators.
Frontiers in cellular neuroscience 2019 Feb;1339
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Embedded ensemble encoding hypothesis: The role of the "Prepared" cell.
Journal of Neuroscience Research 2018 Apr;961543-1559
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The stochastic nature of action potential backpropagation in apical tuft dendrites.
J Neurophysiol. 2017 Aug;118(2):1394-1414
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Transgenic Strategies for Sparse but Strong Expression of Genetically Encoded Voltage and Calcium Indicators.
International journal of molecular sciences 2017 Jul;18(7):
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Simultaneous recordings of voltage and current waveforms from dendrites.
The Journal of physiology 2016 May;594(10):2557-8
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Voltage imaging to understand connections and functions of neuronal circuits.
Journal of neurophysiology 2016 Apr;116135-52
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Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines.
Adv Exp Med Biol. 2015 Oct;85957-101
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Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2015 May;370(1672):
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Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons.
Neurophotonics 2014 Dec;2(2):021006
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Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states.
Frontiers in cellular neuroscience 2014 Sep;8292
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Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex.
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep;111(37):E3919-28
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Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons.
Stem cell research 2014 Jan;12(1):101-18
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Mild hypothermia inhibits differentiation of human embryonic and induced pluripotent stem cells.
BioTechniques 2013 Aug;55(2):79-82
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Neurogenic potential of hESC-derived human radial glia is amplified by human fetal cells.
Stem cell research 2013 Jul;11(1):587-600
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Dopamine receptors in human embryonic stem cell neurodifferentiation.
Stem cells and development 2013 May;22(10):1522-40
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Dopaminergic regulation of dendritic calcium: fast multisite calcium imaging.
Methods in molecular biology (Clifton, N.J.) 2013 Jan;964123-38
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Palette of fluorinated voltage-sensitive hemicyanine dyes.
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec;109(50):20443-8
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Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons.
The Journal of physiology 2012 Aug;590(Pt 16):3891-911
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Extrasynaptic glutamate receptor activation as cellular bases for dynamic range compression in pyramidal neurons.
Frontiers in physiology 2012 Jan;3334
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Physiological properties of neurons derived from human embryonic stem cells using a dibutyryl cyclic AMP-based protocol.
Stem cells and development 2011 Oct;20(10):1733-46
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Spontaneous electrical activity in the human fetal cortex in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb;31(7):2391-8
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The decade of the dendritic NMDA spike.
Journal of neuroscience research 2010 Nov;88(14):2991-3001
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Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation.
Cerebral cortex (New York, N.Y. : 1991) 2009 Aug;19(8):1795-805
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Quantitative assessment of the distributions of membrane conductances involved in action potential backpropagation along basal dendrites.
Journal of neurophysiology 2009 Mar;101(3):1524-41
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Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons.
The European journal of neuroscience 2008 Feb;27(4):923-36
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Voltage and calcium transients in basal dendrites of the rat prefrontal cortex.
The Journal of physiology 2007 Dec;585(Pt 2):447-68
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Intracellular long-wavelength voltage-sensitive dyes for studying the dynamics of action potentials in axons and thin dendrites.
Journal of neuroscience methods 2007 Aug;164(2):225-39
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Human cortical neurons originate from radial glia and neuron-restricted progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr;27(15):4132-45
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Initiation of sodium spikelets in basal dendrites of neocortical pyramidal neurons.
The Journal of membrane biology 2005 Nov;208(2):155-69
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Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Jul;25(29):6857-68
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A strict correlation between dendritic and somatic plateau depolarizations in the rat prefrontal cortex pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Apr;25(15):3940-51
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Voltage imaging from dendrites of mitral cells: EPSP attenuation and spike trigger zones.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jul;24(30):6703-14
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Burst generation in rat pyramidal neurones by regenerative potentials elicited in a restricted part of the basilar dendritic tree.
The Journal of physiology 2004 Jul;558(Pt 1):193-211
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Action potentials in basal and oblique dendrites of rat neocortical pyramidal neurons.
The Journal of physiology 2003 Jul;550(Pt 1):35-50
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Imaging nervous system activity with voltage-sensitive dyes.
Curr Protoc Neurosci 2003 Jan;August 2003(Chapter 6):Unit 6.17
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Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ.
The Journal of physiology 2000 Aug;527 Pt 1(1):55-69
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Imaging membrane potential with voltage-sensitive dyes.
The Biological bulletin 2000 Feb;198(1):1-21
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Fast multisite optical measurement of membrane potential: three examples.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999 Dec;13 Suppl 2S271-6
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Fast optical recordings of membrane potential changes from dendrites of pyramidal neurons.
Journal of neurophysiology 1999 Sep;82(3):1615-21
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Fast optical measurement of membrane potential changes at multiple sites on an individual nerve cell.
The Histochemical journal 1998 Mar;30(3):197-216
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Fast voltage-sensitive dye recording of membrane potential changes at multiple sites on an individual nerve cell in the rat cortical slice.
The Biological bulletin 1997 Oct;193(2):261
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Optical signals from neurons with internally applied voltage-sensitive dyes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Feb;15(2):1392-405
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Voltage-sensitive dyes for intracellular application.
Biological Bulletin 1992 Jan;183(2):350-351
Book Chapters
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Temporal Dynamics of Spontaneous Ca2+ Transients, ERBB4, vGLUT1, GAD1, Connexin, and Pannexin Genes in Early Stages of Human Stem Cell Neurodifferentiation
Pluripotent Stem Cells - From the Bench to the Clinic 2016 Dec;
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Intracellular Voltage-Sensitive Dyes for Studying Dendritic Excitability and Synaptic Integration
Patch-Clam Analysis: Advanced Techniques 2016 2016 Jan;
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Intracellular voltage-sensitive dyes for studying dendritic excitability and synaptic integration
Neuromethods: Advanced Patch-Clamp Analysis for Neuroscientists 2016 Jan;
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Dopamine Receptors in Human Embryonic Stem Cell Differentiation
Dopamine Receptor Technologies, Neuromethods 2015 Jun;
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Chapter 3: Physiological Properties of Human Fetal Cortex In Vitro.
Isolated Central Nervous System Circuits 2012 Jan;
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Chapter 3: Imaging submillisecond membrane potential changes from individual regions of single axons, dendrites and spines
The Voltage Imaging Book 2010 Jan;
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The role of dendrites in the maintenance of UP state
Mechanisms of spontaneous active states in neocortex 2007 Jan;
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Dendritic voltage imaging
Imaging in Neuroscience and Development: A Laboratory Manual 2005 Jan;457 – 461
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Imaging nervous system activity with voltage-sensitive dyes.
Current Protocols in Neuroscience 2001 Jan;
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Imaging membrane potential changes in individual neurons.
Fluorescent and Luminescent Probes for Biological Activity 1999 Jan;238-247
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Imaging membrane potential changes with intracellular voltage-sensitive dyes.
Imaging Living Cells: A Laboratory Manual. 1999 Jan;51.1 – 51.12
Editorials
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Editorial: New Insights on Neuron and Astrocyte Function From Cutting-Edge Optical Techniques.
Frontiers in cellular neuroscience 2019 Oct;13463
Reviews
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Radial glia cells in the developing human brain.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2008 Oct;14(5):459-73
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Photonics Toolkit for Studying Alzheimer’s Disease | Lecture | Institute of Physics | 2024 | Kopaonik, Serbia |
Glutamate-Mediated Dendritic UP States in Cortical Pyramidal Neurons - Voltage Imaging and Biophysical Model | Plenary Lecture | Croatian Biophysical Society | 2024 | Split, Croatia |
Induced Pluripotent Stem Cells - Neuronal Activity In Vitro | Lecture | ICGEB, Trieste, Italy | 2024 | Kotor, Montenegro |
Detecting Physiological Abnormalities in Alzheimer’s Disease | Lecture | European Council | 2023 | Petnica, Serbia |
The Role of Physics in Modern Neuroscience | Talk | Institute of Physics | 2023 | Kopaonik, Serbia |
Ex Vivo Gamma Frequency (40 Hz) Entrainment in the Mouse Model of Alzheimer’s Disease | Poster | NIH Brain Investigator Meeting | 2023 | Washington, DC |
Imaging of evoked cortical depolarizations using either ASAP2s, or chi-VSFP, or Di-4-Anepps, or intrinsic optical signals | Poster | Society for Neuroscience | 2023 | Washington, DC |
Simulation of dendritic plateau potentials in striatal spiny neurons | Poster | Society for Neuroscience | 2023 | Washington, DC |
Gamma Frequency (40 Hz) Entrainment in the Mouse Model of Alzheimer’s Disease | Poster | Department of Neuroscience | 2023 | Hartford, CT |
Ampyra Potently Modulates Ethanol-Induced Effects on the Neuronal Spontaneous Electrical Activity | Poster | Department of Neuroscience | 2023 | Hartford, CT |
Studying Cortical Circuitry with GEVI Voltage Imaging | Poster | Health Research Program, UConn | 2022 | Storrs, CT |
Spiny Neurons Enter the “Prepared” State” | Talk | The Kim Family Fund | 2022 | UConn Health |
Genetically Encoded Voltage Indicators for Studying Neuronal and Network Functions | Talk | SUNY Downstate | 2022 | Brooklyn, NY |
Evoked population signals in brain slices of transgenic GEVI animals | Talk | Marine Biological Laboratory (MBL) | 2022 | Woods Hole, MA |
The Effects of the ALS Patient’s Immunoglobulins on the Spontaneous Neuronal Activity – Optical Imaging Study | Talk | Yeditepe University, Turkey | 2022 | Sile, Turkey |
Photonics Experiments in the Mouse Model of Alzheimer’s Disease | Talk | Institute of Physics | 2022 | Kopaonik, Serbia |
Contributions of L-Type Calcium, NMDA and AMPA channels to Synaptically-Evoked Depolarizations in the Mouse Neocortex Layer 2/3 – GEVI voltage imaging | Poster | Society for Neuroscience | 2022 | San Diego, CA |
Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation | Poster | NIH BRAIN Initiative | 2022 | Washington, DC |
Studying Canonical Cortical Circuitry – Ex Vivo Voltage Imaging – Genetically Encoded Indicators | Poster | Department of Neuroscience | 2022 | Farmington, CT |
Physiological determinants of Alzheimer’s disease | Poster | Capstone, School of Medicine | 2022 | Farmington, CT |
Genetically-Encoded Calcium Indicator (GECI) versus a Genetically-Encoded Voltage Indicator (GEVI) | Talk | NIH, Cure Alzheimer's Fund | 2021 | Photonics Workshop - Kopaonik |
Glutamate-Mediated Dendritic Conductances | Talk | IBRO | 2021 | Kotor, Montenegro |
Glutamate-mediated dendritic plateau potentials in CNS neurons | Talk | UTSA | 2021 | San Antonio, Texas |
Studying synaptically evoked cortical responses with combination of a single neuron recording (whole-cell) and population voltage imaging (GEVI) | Poster | NIH | 2021 | NIH BRAIN Investigators Meeting |
Genetically Encoded Calcium and Voltage Indicators – Cortical Population Signals | Poster | NIH, Cure Alzheimer's Fund | 2021 | ISG Virtual Networking Event |
Faculty Spotlight Fall 2020: Easwar Natarajan, D.M.Sc. and Srdjan Antic, M.D. | Other | UConn Health | 2020 | https://www.youtube.com/watch?v=tQo68pRWLFw&feature=emb_title |
Testing the Fluorescent Proteins That Light Up the Brain, UConn Today | Other | UConn Today | 2020 | https://today.uconn.edu/2020/10/testing-fluorescent-proteins-light-brain/ |
Excellent Properties of Genetically Encoded Voltage Indicators | Talk | Kim Family Fund | 2020 | Neuroscience Department, Seminar Series, Farmington, CT |
Optical properties of genetically-encoded voltage indicators | Talk | Institute of Physics Belgrade | 2020 | 13th Photonics Workshop, Institute of Physics Belgrade, Serbia |
"Voltage Imaging in Brain Slices Using Several Variants of Genetically Encoded Voltage Indicators". | Poster | NIH | 2019 | Washington, DC |
Glutamate mediated dendritic and somatic plateau potentials in cortical pyramidal neurons | Talk | FENS | 2019 | Belgrade, Serbia |
Spontaneous Electrical Activity of Developing Neurons in the Cerebral Cortex | Talk | Karadeniz Technical University | 2019 | Trabzon, Turkey |
Voltage imaging in brain slices using dyes and protein indicators | Talk | Yale University | 2019 | New Haven, CT |
Voltage imaging in cortical pyramidal neurons with and without single action potential resolution | Talk | Okinawa Institute of Technology | 2018 | Okinawa, Japan |
Voltage imaging in brain slices | Talk | Marine Biological Laboratory (MBL) | 2018 | Woods Hole, MA |
Physiology of The Human Fetal Cortex (Brain Research Symposium) | Talk | UConn Health | 2018 | Hartford, CT |
Embedded Ensemble Encoding Hypothesis: The Role of the "Prepared" Cell | Talk | Biophysical society of Serbia | 2018 | Belgrade, Serbia |
Automated Functional Screening of IgGs for Diagnostics of Neurodegenerative Diseases - Functional Imaging of Cultured Neurons at UConn Health | Talk | European Union - Horizon 2020 | 2018 | Belgrade, Serbia |
Transgenic sparse expression of genetically encoded voltage indicators (437.25 / WW54) | Poster | Society for Neuroscience | 2017 | Washington, DC |
Engineering of near-infrared genetically encoded voltage indicators (437.10 / WW39) | Poster | Society for Neuroscience | 2017 | Washington, DC |
Dendritic plateau generation model in cortical pyramidal neurons: A link to cortical ensembles (380.14 / L10) | Poster | Society for Neuroscience | 2017 | Washington, DC |
Light-induced activation of dopamine, glutamate and GABA release on striatal medium spiny neurons in brain slices (378.18 / I5) | Poster | Society of Neuroscience | 2017 | Washington, DC |
Glutamate Mediated Dendritic Regenerative Potentials - Thomas Knopfel Lab Meeting | Talk | Imperial College London | 2017 | London, UK |
Voltage imaging of dendritic membrane potentials | Other | NIH -The BRAIN Initiative | 2017 | Internet |
Action Potential Backpropagation in Cortical Pyramidal Neurons | Lecture | Kim Family Fund | 2017 | Farmington, CT |
Sparse Labeling with Genetically Encoded Voltage Indicators | Poster | NIH | 2017 | Bethesda, MD |
Silencing of the Connexin Genes in Developing Human Neurons by Antisense Oligonucleotides | Poster | StemConn 2017 | 2017 | New Haven, CT |
Embedded Ensemble Encoding | Talk | NIH | 2016 | Bethesda, MD |
Sparse, Strong, and Large Area Targeting of Genetically Encoded Indicators for Functional Cortical Connectomics | Poster | NIH | 2016 | Bethesda. MD |
Near-Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology (AOE) | Poster | NIH | 2016 | Bethesda, MD |
Mechanisms of spontaneous electrical activity in the developing cerebral cortex - subplate zone | Poster | Society for Neuroscience | 2016 | San Diego |
Glutamate-mediated plateau potentials studied by simultaneous multi-site dendritic sodium and calcium imaging | Poster | Society for Neuroscience | 2016 | San Diego |
PLENARY SPEAKER: Antic Srdjan, UConn Health, Farmington, CT (USA)Biophysical Properties of Dendrites of Cortical Pyramidal Neurons - Simultaneous Sodium and Calcium Imaging | Plenary Lecture | Italian Society for Pure and Applied Biophysics | 2016 | Trieste, Italy |
Brown Bag Lunch Seminar (Whitman Center Awardees), Srdjan Antic, University of Connecticut, “Glutamate-mediated dendritic spikes in cortical neurons” | Talk | Marine Biological Laboratory | 2016 | Woods Hole, MA |
The best application for genetically-encoded voltage sensors and intracellular voltage-sensitive dyes with currently available methods. | Talk | HHMI - Janelia | 2016 | Janelia Farm, VA |
Extra IoN Seminar, Dendritic Spikes and Dendritic UP states in Cortical Pyramidal Neurons – Voltage-sensitive dye Imaging | Talk | Newcastle Univ. Institute of Neuroscience | 2015 | Newcastle, UK |
Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons. | Talk | Ministry of Science, Serbia | 2015 | Eight Photonics Workshop 2015 (Kopaonik) |
Dendritic Mechanisms for Detecting Strong Glutamatergic Inputs | Talk | Department of Neuroscience, UConn Health | 2015 | Farmington, CT |
Sodium-calcium imaging of glutamate-mediated dendritic spikes | Talk | MBL, Woods Hole, MA | 2015 | MBL, Woods Hole, MA |
NeuroImaging Seminar Series: “Glutamate-mediated Plateau Potentials in thin Dendritic Branches: Dendritic UP States” | Lecture | MBL, Woods Hole, MA | 2015 | MBL, Woods Hole, MA |
Dendritic spikes and dendritic UP states. | Talk | Computational Neuroscience | 2015 | Brandeis University |
Neuroscience Journal Club - Responsible Research Conduct | Talk | Neuroscience Department | 2015 | |
Sparse, Strong and Large Area Targeting of Genetically Encoded Indicators | Poster | NIH Investigator Meeting | 2015 | Bethesda, MD |
Extrasynaptic receptors and dentritic spikes. See more at: https://royalsociety.org/events/2015/01/chemical-transmitters/ | Talk | The Royal Society, London | 2015 | London, UK |
NMDA Spikes and Plateau Potentials in Thin Dendrites of Cortical Pyramidal Neurons - Voltage-sensitive Dye Imaging - See more at: http://www.gc.cuny.edu/Public-Programming/Calendar/Detail?id=22817#sthash.6B8BHEaz.dpuf | Talk | CUNY | 2014 | The Graduate Center 365 Fifth Avenue, New York |
The use of lasers for functional dendritic imaging-voltage-sensitive and calcium-sensitive dye recordings from dendritic branches.See more at: http://www.scribd.com/doc/237736432/IBRO-NERKA-School-on-Neurophotonics-2014-Program#scribd | Lecture | International Brain Research Organisation (IBRO) | 2014 | IBRO NERKA School on Neurophotonics 2014 |
Branch-specific and Spike order-specific Action Potential Backpropagation in Basal, Oblique and Apical Tuft Dendrites of Cortical Pyramidal Neurons. | Talk | Neuroplex Workshop | 2014 | Hamilton Crowne Plaza Hotel, 1001 14th St NW, Washington, D.C. |
Optical recordings of dendritic membrane potential and calcium transients. | Talk | Ministry of Science, Serbia | 2014 | Seventh Photonics Workshop 2014 (Kopaonik) |
Synapse discussion | Other | CT science festival neuroscience | 2014 | The Richard D. Berlin Center for Cell Analysis and Modeling (CCAM) |
Inconsistent Efficacy of the Action Potential Back-propagation Observed in Rat Prefrontal Cortex Layer 5 Pyramidal Neurons. | Talk | Marine Biological Laboratory | 2013 | Woods Hole, MA |
The use of lasers and voltage sensitive-dyes in neurobiology | Talk | Photonics Workshop 2013 | 2013 | Institute of Physics, Serbia |
The Physiology and Genetics of Human Neurodifferentiation Inspire Some Ideas about Mental Diseases | Talk | Department of Neuroscience | 2013 | Farmington, CT |
Studying Human Embryonic Stem Cells with the RedShirtImaging Camera | Talk | SFN Satellite Event | 2012 | New Orleans, LO |
Glutamate Evoked Potentials in Dendrites of Pyramidal Neurons | Talk | Southern Illinois University | 2012 | Carbondale, IL |
Integration of Glutamatergic Inputs in Thin and Spiny Dendrites - Voltage-Sensitive Dye Imaging | Talk | Rutgers University | 2012 | Newark, NJ |
Dendritic Spine Group, Dendrites Swim in Glutamate | Talk | CCAM and Dept of Neuroscience | 2012 | CCAM, 400 Farmington Ave. |
Stem Cell Physiology and Chemistry Core | Talk | 2012 Connecticut Stem Cell Research Retreat | 2012 | Yale University School of Medicine |
Voltage spikes in thin dendrites of pyramidal neurons | Talk | Janelia Voltage Imaging Workshop | 2012 | Janelia Farm |
Dopamine Potentiates Differentiation of Human Embryonic Stem Cells into Neurons, Glenn S. Belinsky, Shaina M. Short, Anna R. Moore, Matthew T. Rich and Srdjan D. Antic | Poster | Connecticut Innovations, Department of Public Health | 2011 | Farmington, CT |
AP Propagation in Oblique and Apical Tuft Dendrites of CA1 Pyramidal Cells, Wen-Liang Zhou and Srdjan D. Antic | Poster | Gordon Research Conference | 2011 | Ventura, CA |
Physiology of the Human Fetal Cortex in Health and Disease; Srdjan D. Antic, Seminar, Neuroscience Retreat 2011 | Talk | Department of Neuroscience | 2011 | Farmington, CT |
Dopaminergic and GABAergic Modulation of Dendritic Calcium Transients in the Rat Prefrontal Cortex, Wen-Liang Zhou and Srdjan D. Antic | Poster | Neuroscience at Storrs | 2011 | Storrs, CT |
Dopaminergic and GABAergic Modulation of Dendritic Calcium Transients in the Rat Prefrontal Cortex, Wen-Liang Zhou and Srdjan D. Antic | Poster | Society for Neuroscience | 2011 | Washington, DC |
CCAM Seminar: "Dendritic Spines for Students" | Talk | Richard D. Berlin Center for Cell Analysis & Modeling | 2010 | CCAM, 400 Farmington Ave. |
NeuroPlex Workshop, Satellite Society of Neuroscience Meeting, San Diego, CA. | Talk | RedShirtImaging | 2010 | Hilton San Diego Gaslight Quarter. |
Seminar Speaker: Srdjan D. Antic, Cell and Genome Sciences Inaugural Symposium. | Talk | Cell and Genome Sciences | 2010 | 400 Farmington Ave, Farmington CT. |
International Symposium - 100 Years of Belgrade School of Physiology | Talk | University of Belgrade | 2010 | Belgrade, Serbia |
AP Propagation in Oblique Dendrites of CA1 Pyramidal Cells, Wenliang Zhou and Srdjan Antic | Poster | Society for Neuroscience | 2010 | San Diego, CA, USA |
Neuroscience Journal Club Faculty Presentation; Publication presented: /Science/ 325(5941):756-60. | Talk | Department of Neuroscience | 2009 | UCHC Room E-4036 |
Microelectrode Techniques for Cell Physiology Workshop | Talk | Marine Biological Association of the UK | 2009 | Plymouth, England |
NeuroPlex Workshop, Satellite Society of Neuroscience Meeting, Chicago, IL. | Talk | RedShirtImaging | 2009 | Chicago, IL |
Transient stimulation of somatic dopamine receptors on layer 5 pyramidal neurons of the rat prefrontal cortex Anna R. Moore, Wen-Liang Zhou and Srdjan D. Antic | Poster | Society for Neuroscience, Chicago, IL. | 2009 | Chicago, IL |
Heterogeneity among individual dendritic branches belonging to the same pyramidal cell, Wenliang Zhou and Srdjan Antic | Poster | Gordon Research Conference, Italy | 2009 | Toscany, Italy |
Glutamate-evoked Plateau Potentials in Thin Dendrites | Talk | University of Bonn | 2009 | Bonn, Germany |
Invited Seminar, Department of Physiology and Biophysics | Talk | Dalhousie University | 2008 | Halifax, Canada |
Voltage-Sensitive Dye Workshop | Talk | FASEB (European Society for Neuroscience) | 2008 | Geneva, Switzerland |