Faculty Directory › UConn Health

Elisa Barbarese, Ph.D.

Professor of Neuroscience


Academic Office Location: Neuroscience UConn Health 263 Farmington Avenue Farmington, CT 06030-3401
Phone:	860-679-3495
Fax:	860-679-8766
Website(s):	Barbarese Lab Page Neuroscience Graduate Program

Education & Training
Committees & Organizations
Research
Lab Rotations
Publications

Education

Degree	Institution	Major
B.A.	College Jesus-Marie	Chemistry
B.S.	University of Montreal	Biochemistry
M.S.	University of Montreal	Biochemistry
Ph.D.	McGill University	Biochemistry

Degree

Institution

Major

B.A.

College Jesus-Marie

Chemistry

B.S.

University of Montreal

Biochemistry

M.S.

University of Montreal

Biochemistry

Ph.D.

McGill University

Biochemistry

Post-Graduate Training

Training	Institution	Specialty
Fellowship	EMBO	Fellowship Summer Course in Virology
Fellowship	NATO	Fellowship Summer Course in Mammalian Genetics
Fellowship	Cancer Research Society	Graduate Student Fellowship
Fellowship	Canadian Federation of University Women	Margaret McWilliams Traveling Fellowship
Fellowship	Conseil de la Recherche en Sante du Quebec	Post-doctoral Fellowship
Postdoctoral	University of Connecticut	Cell & Mol. Biology

Training

Institution

Specialty

Fellowship

EMBO

Fellowship Summer Course in Virology

Fellowship

NATO

Fellowship Summer Course in Mammalian Genetics

Fellowship

Cancer Research Society

Graduate Student Fellowship

Fellowship

Canadian Federation of University Women

Margaret McWilliams Traveling Fellowship

Fellowship

Conseil de la Recherche en Sante du Quebec

Post-doctoral Fellowship

Postdoctoral

University of Connecticut

Cell & Mol. Biology

Awards

Name of Award/Honor	Awarding Organization
Jacob K. Javits Neuroscience Investigator Award, 1993-2000.

Name of Award/Honor

Awarding Organization

Jacob K. Javits Neuroscience Investigator Award, 1993-2000.

Name & Description	Category	Role	Type	Scope	Start Year	End Year
NMSS scientific advisory committee	Advisory Committee	member	External	National	2009	2012
NDGB/SRG (NIH)	Professional/Scientific Organization	temporary member	External	National	2006	2008
Fonds zur Forderung, Austria,	Professional/Scientific Organization	ad hoc reviewer	External	International	2006
National Science Foundation	Professional/Scientific Organization	Ad hoc Grants Reviewer	External	National	2005	2006
National Multiple Sclerosis Society	Professional/Scientific Organization	ad hoc grant reviewer	External	National	2005	2006
Fondazione Telethon (Italy)	Professional/Scientific Organization	ad hoc grant reviewer	External	International	2004
Israel Science Foundation	Professional/Scientific Organization	ad hoc grant reviewer	External	International	2004
Graduate Program in Neuroscience	Education Committee	Director	UConn Health	University	1996	1998
NIH Reviewers Reserve	Professional/Scientific Organization	Reviewer	External	National	1995	1999
NIH Special Review Committee	Advisory Committee	Ad hoc reviewer	External	National	1994
NIH Neurological Science Study Section 1	Study Section	Member	External	National	1991	1995
MD/Ph.D. Combined Degree Program Steering Committee	Education Committee	Committee member	UConn Health	University	1990	2002
NIH Neurological Science Study Section I	Study Section	Ad hoc reviewer	External	National	1990
Member of the Graduate Program in Neuroscience; Member of the Executive Committee	Advisory Committee	Member	UConn Health	University	1982
Member of the Graduate Program in Neuroscience; Admission Committee	Advisory Committee	Member	Other	University	1982
Member of the Graduate Program in Neuroscience; Student Progress Committee	Education Committee	Member	UConn Health	University	1982
Member of the Graduate Program in Neuroscience; Chair of the Curriculum Committee.	Education Committee	Chair	UConn Health	University	1982

Name & Description

Journal Articles

Conditional knockout of TOG results in CNS hypomyelination.
Maggipinto, Michael J; Ford, Joshay; Le, Kristine H; Tutolo, Jessica W; Furusho, Miki; Wizeman, John W; Bansal, Rashmi; Barbarese, Elisa Glia 2017 Mar;65(3):489-501
CGG Repeats in the 5'UTR of FMR1 RNA Regulate Translation of Other RNAs Localized in the Same RNA Granules.
Rovozzo, René; Korza, George; Baker, Mei W; Li, Meng; Bhattacharyya, Anita; Barbarese, Elisa; Carson, John H PloS one 2016 Jan;11(12):e0168204
CNS myelination is inhibited in the absence of the tumor overexpressed gene protein in oligodendrocytes.
Maggipinto, M J; Ford, J; Le, H; Weyman-Tutolo, J; Barbarese, E International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec;47(Pt A):101
New mechanism for CGG repeat expansion disorders.
Norman, Rene; Barbarese, Elisa; Carson, John H International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec;47(Pt A):101
Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions.
Claycomb, Kumiko I; Winokur, Paige N; Johnson, Kasey M; Nicaise, Alexandra M; Giampetruzzi, Anthony W; Sacino, Anthony V; Snyder, Evan Y; Barbarese, Elisa; Bongarzone, Ernesto R; Crocker, Stephen J Journal of neuropathology and experimental neurology 2014 Sep;73(10):964-74
FMRP and myelin protein expression in oligodendrocytes.
Giampetruzzi, Anthony; Carson, John H; Barbarese, Elisa Molecular and cellular neurosciences 2013 Sep;56333-41
Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation.
Barbarese, Elisa; Ifrim, Marius F; Hsieh, Lawrence; Guo, Caiying; Tatavarty, Vedakumar; Maggipinto, Michael J; Korza, George; Tutolo, Jessica W; Giampetruzzi, Anthony; Le, Hien; Ma, Xin-Ming; Levine, Eric; Bishop, Brian; Kim, Duck O; Kuwada, Shigeyuki; Carson, John H PloS one 2013 Jan;8(8):e69989
Single-molecule imaging of translational output from individual RNA granules in neurons.
Tatavarty, Vedakumar; Ifrim, Marius F; Levin, Mikhail; Korza, George; Barbarese, Elisa; Yu, Ji; Carson, John H Molecular biology of the cell 2012 Mar;23(5):918-29
Differential subcellular distributions and trafficking functions of hnRNP A2/B1 spliceoforms.
Han, Siew Ping; Friend, Lexie R; Carson, John H; Korza, George; Barbarese, Elisa; Maggipinto, Michael; Hatfield, Jodie T; Rothnagel, Joseph A; Smith, Ross Traffic (Copenhagen, Denmark) 2010 Jul;11(7):886-98
The microtubule-associated protein tumor overexpressed gene/cytoskeleton-associated protein 5 is necessary for myelin basic protein expression in oligodendrocytes.
Francone, Victor P; Maggipinto, Michael J; Kosturko, Linda D; Barbarese, Elisa The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Jul;27(29):7654-62
Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs.
Kosturko, Linda D; Maggipinto, Michael J; Korza, George; Lee, Joo Won; Carson, John H; Barbarese, Elisa Molecular biology of the cell 2006 Aug;17(8):3521-33
The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.
Kosturko, Linda D; Maggipinto, Michael J; D'Sa, Chrystal; Carson, John H; Barbarese, Elisa Molecular biology of the cell 2005 Apr;16(4):1938-47
Increased expression of the MBP mRNA binding protein HnRNP A2 during oligodendrocyte differentiation.
Maggipinto, M; Rabiner, C; Kidd, G J; Hawkins, A J; Smith, R; Barbarese, E Journal of neuroscience research 2004 Mar;75(5):614-23
RNA transport in oligodendrocytes from the taiep mutant rat.
Song, Jonathan; Carson, John H; Barbarese, Elisa; Li, Fang-Yuan; Duncan, Ian D Molecular and cellular neurosciences 2003 Dec;24(4):926-38
A molecular mechanism for mRNA trafficking in neuronal dendrites.
Shan, Jianguo; Munro, Trent P; Barbarese, Elisa; Carson, John H; Smith, Ross The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Oct;23(26):8859-66
Facilitation of dendritic mRNA transport by CPEB.
Huang, Yi-Shuian; Carson, John H; Barbarese, Elisa; Richter, Joel D Genes & development 2003 Mar;17(5):638-53
Anterograde RNA transport is inhibited in microtubule defective oligodendrocytes.
Song, J., Carson, J.H., Barbarese, E., Li, F-Y., Duncan, I.D. Mol. Cell Neurosci. 2003 Jan;24926-38
Intracellular trafficking of hnRNP A2 in oligodendrocytes.
Brumwell, C; Antolik, C; Carson, J H; Barbarese, E Experimental cell research 2002 Oct;279(2):310-20
Structural dynamics of oligodendrocyte lysis by perforin in culture: relevance to multiple sclerosis.
Zeine, R; Cammer, W; Barbarese, E; Liu, C C; Raine, C S Journal of neuroscience research 2001 May;64(4):380-91
Myelin basic protein gene dosage effects in the PNS.
Smith-Slatas, C; Barbarese, E Molecular and cellular neurosciences 2000 Apr;15(4):343-54
Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.
Munro, T P; Magee, R J; Kidd, G J; Carson, J H; Barbarese, E; Smith, L M; Smith, R The Journal of biological chemistry 1999 Nov;274(48):34389-95
Myelin-associated oligodendrocytic basic protein mRNAs reside at different subcellular locations.
Gould, R M; Freund, C M; Barbarese, E Journal of neurochemistry 1999 Nov;73(5):1913-24
The cis-acting RNA trafficking signal from myelin basic protein mRNA and its cognate trans-acting ligand hnRNP A2 enhance cap-dependent translation.
Kwon, S; Barbarese, E; Carson, J H The Journal of cell biology 1999 Oct;147(2):247-56
Concurrent loss and proliferation of astrocytes following lateral fluid percussion brain injury in the adult rat.
Hill-Felberg, S J; McIntosh, T K; Oliver, D L; Raghupathi, R; Barbarese, E Journal of neuroscience research 1999 Jul;57(2):271-9
RNA on the road to myelin
Barbarese E., Brumwell C., Kwon S., Cui H., Carson J.H. Brain Cell Biology 1999 Jan;28(5-Apr):263-270
RNA on the road to myelin.
Barbarese, E; Brumwell, C; Kwon, S; Cui, H; Carson, J H Journal of neurocytology 1999 Jan;28(4-5):263-70
Cytoplasmic dynein contains a family of differentially expressed light chains.
King, S M; Barbarese, E; Dillman, J F; Benashski, S E; Do, K T; Patel-King, R S; Pfister, K K Biochemistry 1998 Oct;37(43):15033-41
Transport and localization elements in myelin basic protein mRNA.
Ainger, K; Avossa, D; Diana, A S; Barry, C; Barbarese, E; Carson, J H The Journal of cell biology 1997 Sep;138(5):1077-87
Evaluation of lipid-coated microbubbles as a delivery vehicle for Taxol in brain tumor therapy.
Ho, S Y; Barbarese, E; D'Arrigo, J S; Smith-Slatas, C; Simon, R H Neurosurgery 1997 Jun;40(6):1260-6; discussion 1266-8
Rearrangement and reactivation of the myelin basic protein locus in myelin-deficient (mld) mouse brain.
Sun, Y; Xu, J; Barbarese, E; Carson, J H Journal of neurochemistry 1997 Feb;68(2):457-68
The affinity of lipid-coated microbubbles for maturing brain injury sites.
Ho, S Y; Li, X G; Wakefield, A; Barbarese, E; D'Arrigo, J S; Simon, R H Brain research bulletin 1997 Jan;43(6):543-9
Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesin.
Carson, J H; Worboys, K; Ainger, K; Barbarese, E Cell motility and the cytoskeleton 1997 Jan;38(4):318-28
Regional heterogeneity in the response of astrocytes following traumatic brain injury in the adult rat.
Hill, S J; Barbarese, E; McIntosh, T K Journal of neuropathology and experimental neurology 1996 Dec;55(12):1221-9
Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain.
King, S M; Barbarese, E; Dillman, J F; Patel-King, R S; Carson, J H; Pfister, K K The Journal of biological chemistry 1996 Aug;271(32):19358-66
Internalization of microbubbles by tumor cells in vivo and in vitro.
Barbarese, E; Ho, S Y; D'Arrigo, J S; Simon, R H Journal of neuro-oncology 1995 Oct;26(1):25-34
Protein translation components are colocalized in granules in oligodendrocytes.
Barbarese, E; Koppel, D E; Deutscher, M P; Smith, C L; Ainger, K; Morgan, F; Carson, J H Journal of cell science 1995 Aug;108 ( Pt 8)(8):2781-90
The number of Schmidt-Lanterman incisures is more than doubled in shiverer PNS myelin sheaths.
Gould, R M; Byrd, A L; Barbarese, E Journal of neurocytology 1995 Feb;24(2):85-98
Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes.
Ainger, K; Avossa, D; Morgan, F; Hill, S J; Barry, C; Barbarese, E; Carson, J H The Journal of cell biology 1993 Oct;123(2):431-41
Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts.
Warrington, A E; Barbarese, E; Pfeiffer, S E Journal of neuroscience research 1993 Jan;34(1):1-13
Comparison of CNS homing pattern among murine TH cell lines responsive to myelin basic protein.
Barbarese, E; Soares, H; Yang, S; Clark, R B Journal of neuroimmunology 1992 Jul;39(1-2):151-62
Visualizing cells in three dimensions using confocal microscopy, image reconstruction and isosurface rendering: application to glial cells in mouse central nervous system.
Morgan, F; Barbarese, E; Carson, J H Scanning microscopy 1992 Jun;6(2):345-56; discussion 356-7
Molecular genetic analysis of the mldr mouse: a spontaneous revertant at the mld locus containing a recombinant myelin basic protein gene.
Ainger, K; Barbarese, E; Berman, L; Carson, J H Genetics 1992 Feb;130(2):367-75
Stage specific, (O4+GalC-) isolated oligodendrocyte progenitors produce MBP+ myelin in vivo.
Warrington, A E; Barbarese, E; Pfeiffer, S E Developmental neuroscience 1992 Jan;14(2):93-7
Spatial distribution of myelin basic protein mRNA and polypeptide in quaking oligodendrocytes in culture.
Barbarese, E Journal of neuroscience research 1991 Jul;29(3):271-81
Diversification of glial lineages: a novel method to clone brain cells in vitro on nitrocellulose substratum.
Carnow, T B; Barbarese, E; Carson, J H Glia 1991 Jan;4(3):256-68
Radiation sensitivity of glial cells in primary culture.
Barbarese, E; Barry, C Journal of the neurological sciences 1989 Jun;91(1-2):97-107
Expression and localization of myelin basic protein in oligodendrocytes and transfected fibroblasts.
Barbarese, E; Barry, C; Chou, C H; Goldstein, D J; Nakos, G A; Hyde-DeRuyscher, R; Scheld, K; Carson, J H Journal of neurochemistry 1988 Dec;51(6):1737-45
Expression of myelin basic protein mRNA and polypeptides in mouse oligodendrocytes in culture: differential regulation by genetic and epigenetic factors.
Barbarese, E; Barry, C; D'Occhio, C; Edgar, S; Akowitz, A; Carson, J H Brain research 1988 Apr;467(2):183-91
Structure and expression of myelin basic protein gene sequences in the mld mutant mouse: reiteration and rearrangement of the MBP gene.
Akowitz, A A; Barbarese, E; Scheld, K; Carson, J H Genetics 1987 Jul;116(3):447-64
Myelin basic protein-specific protein methylase I activity in shiverer mutant mouse brain.
Kim, S; Tuck, M; Ho, L L; Campagnoni, A T; Barbarese, E; Knobler, R L; Lublin, F D; Chanderkar, L P; Paik, W K Journal of neuroscience research 1986 Jan;16(2):357-65
The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain.
Barbarese, E; Nielson, M L; Carson, J H Journal of neurochemistry 1983 Jun;40(6):1680-6
Developmental regulation of myelin basic protein expression in mouse brain.
Carson, J H; Nielson, M L; Barbarese, E Developmental biology 1983 Apr;96(2):485-92
Progenitors of oligodendrocytes: limiting dilution analysis in fetal rat brain culture.
Barbarese, E; Pfeiffer, S E; Carson, J H Developmental biology 1983 Mar;96(1):84-8
Antibody-independent complement activation by myelin via the classical complement pathway.
Cyong, J C; Witkin, S S; Rieger, B; Barbarese, E; Good, R A; Day, N K The Journal of experimental medicine 1982 Feb;155(2):587-98
Developmental regulation of myelin basic protein in dispersed cultures.
Barbarese, E; Pfeiffer, S E Proceedings of the National Academy of Sciences of the United States of America 1981 Mar;78(3):1953-7
Requirement for nonoligodendrocyte cell signals for enhanced myelinogenic gene expression in long-term cultures of purified rat oligodendrocytes.
Bhat, S; Barbarese, E; Pfeiffer, S E Proceedings of the National Academy of Sciences of the United States of America 1981 Feb;78(2):1283-7
Noncoordinate regulation of myelinogenic parameters in primary cultures of dissociated fetal rat brain.
Pfeiffer, S E; Barbarese, E; Bhat, S Journal of neuroscience research 1981 Jan;6(3):369-80
Subcellular distribution and structural polymorphism of myelin basic protein in normal and Jimpy mouse brain.
Barbarese, E; Carson, J H; Braun, P E Journal of neurochemistry 1979 May;32(5):1437-46
Accumulation of the four myelin basic proteins in mouse brain during development.
Barbarese, E; Carson, J H; Braun, P E Journal of neurochemistry 1978 Oct;31(4):779-82
Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein.
Carson, J H; Barbarese, E; Braun, P E; McPherson, T A Proceedings of the National Academy of Sciences of the United States of America 1978 Apr;75(4):1976-8
Identification of prelarge and presmall basic proteins in mouse myelin and their structural relationship to large and small basic proteins.
Barbarese, E; Braun, P E; Carson, J H Proceedings of the National Academy of Sciences of the United States of America 1977 Aug;74(8):3360-4
Alterations in the surface glycoproteins of chicken erythrocytes following transformation with erythroblastosis strain R virus.
Barbarese, E; Sauerwein, H; Simpkins, H The Journal of membrane biology 1973 Jan;13(2):129-42

Book Chapters

Oligodendrocyte differentiation: Quantitative studies in primary cultures of dissociated fetal rat brain
Bansal R, Barbarese E, Bhat S, Carson J, Edgar A, Friederich V, Macklin W, Pfeiffer SE, Singh H, Woodiel F Glial-Neuronal Communication in Development and Regeneration, 1986 Jan;737-754
Regulation of early myelinogenesis in primary cultures of dissociated rat brain
Barbarese E, Bhat S, Bansal R, Carson J, Edgar A, Pfeiffer SE, Singh H, Woodiel F Neuroscience Approached Through Cell Culture. Vol. II. 1983 Jan;167-176

Conference Papers

Introduction - Conference Paper
Barbarese E., Pfeiffer S. Developmental Neuroscience 1996 Jan;18(4):232
Morphological organization of oligodendrocyte processes during development in culture and in vivo.
Barry, C; Pearson, C; Barbarese, E Developmental neuroscience 1996 Jan;18(4):233-42

Reviews

Multiplexed RNA trafficking in oligodendrocytes and neurons.
Carson, John H; Gao, Yuanzheng; Tatavarty, Vedakumar; Levin, Mikhail K; Korza, George; Francone, Victor P; Kosturko, Linda D; Maggipinto, Michael J; Barbarese, Elisa Biochimica et biophysica acta 2008 Aug;1779(8):453-8
Systems analysis of RNA trafficking in neural cells.
Carson, John H; Barbarese, Elisa Biology of the cell / under the auspices of the European Cell Biology Organization 2005 Jan;97(1):51-62
The balance of power in RNA trafficking.
Carson, J H; Cui, H; Barbarese, E Current opinion in neurobiology 2001 Oct;11(5):558-63
RNA trafficking in oligodendrocytes.
Carson, J H; Cui, H; Krueger, W; Schlepchenko, B; Brumwell, C; Barbarese, E Results and problems in cell differentiation 2001 Jan;3469-81
RNA trafficking in myelinating cells.
Carson, J H; Kwon, S; Barbarese, E Current opinion in neurobiology 1998 Oct;8(5):607-12