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A corneo-retinal hypercitrullination axis underlies ocular injury to nitrogen mustard.
Umejiego, Ezigbobiara; Paramo, Ricky; Zafiris, Alexander; Mullane, Elias; Bargagna-Mohan, Paola; Mohan, Royce Experimental eye research 2023 Jun;231109485
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Peptidyl arginine deiminase 4 deficiency protects against subretinal fibrosis by inhibiting Müller glial hypercitrullination.
Palko, Sarah I; Saba, Nicholas J; Bargagna-Mohan, Paola; Mohan, Royce Journal of Neuroscience Research. 10.1002/jnr.25158. 2022 Dec;
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Compartmentalized citrullination in Muller glial endfeet during retinal degeneration.
Palko, Sarah I; Saba, Nicholas J; Mullane, Elias; Nicholas, Benjamin D; Nagasaka, Yosuke; Ambati, Jayakrishna; Gelfand, Bradley D; Ishigami, Akihito; Bargagna-Mohan, Paola; Mohan, Royce Proceedings of the National Academy of Sciences of the United States of America. 2022 Mar 1;119(9):e2121875119. 2022 Jan;119(9):
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Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers.
Bargagna-Mohan, P., Schultz, G., Rheaume, B., Trakhtenberg, E.F., Robson, P., Pal-Ghosh, S., Stepp, M.A., Given, K.S., Macklin, W.B., and Mohan, R. Journal of Neuroscience Research 2021 Jan;99(3):731-749
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Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis.
Bargagna-Mohan, Paola; Lei, Ling; Thompson, Alexis; Shaw, Camille; Kasahara, Kousuke; Inagaki, Masaki; Mohan, Royce PloS one 2015 Jan;10(7):e0133399
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Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.
Bargagna-Mohan, Paola; Deokule, Sunil P; Thompson, Kyle; Wizeman, John; Srinivasan, Cidambi; Vooturi, Sunil; Kompella, Uday B; Mohan, Royce PloS one 2013 Jan;8(5):e63881
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Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin.
Bargagna-Mohan, Paola; Paranthan, Riya R; Hamza, Adel; Zhan, Chang-Guo; Lee, Do-Min; Kim, Kyung Bo; Lau, Daniel L; Srinivasan, Cidambi; Nakayama, Keiko; Nakayama, Keiichi I; Herrmann, Harald; Mohan, Royce The Journal of biological chemistry 2012 Jan;287(2):989-1006
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The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin.
Bargagna-Mohan, Paola; Hamza, Adel; Kim, Yang-eon; Khuan Abby Ho, Yik; Mor-Vaknin, Nirit; Wendschlag, Nicole; Liu, Junjun; Evans, Robert M; Markovitz, David M; Zhan, Chang-Guo; Kim, Kyung Bo; Mohan, Royce Chemistry & biology 2007 Jun;14(6):623-34
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Development of withaferin A analogs as probes of angiogenesis.
Yokota, Yasuno; Bargagna-Mohan, Paola; Ravindranath, Padma P; Kim, Kyung B; Mohan, Royce Bioorganic & medicinal chemistry letters 2006 May;16(10):2603-7
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Withaferin A is a potent inhibitor of angiogenesis.
Mohan, Royce; Hammers, Hans J; Bargagna-Mohan, Paola; Zhan, Xiaoguo H; Herbstritt, Christopher J; Ruiz, Antonio; Zhang, Li; Hanson, Art D; Conner, Barry P; Rougas, John; Pribluda, Victor S Angiogenesis 2004 Jan;7(2):115-22
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Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling.
Mohan, R; Rinehart, W B; Bargagna-Mohan, P; Fini, M E The Journal of biological chemistry 1998 Oct;273(40):25903-14
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Desmin deficiency is not sufficient to prevent corneal fibrosis.
Pietraszkiewicz, Alexandra; Hampton, Christopher; Caplash, Sonny; Lei, Ling; Cepetanaki, Yassemi; Tadvalkar, Gauri; Pal-Ghosh, Sonali; Stepp, Mary Ann; Bargagna-Mohan, Paola; Mohan, Royce Experimental Eye Research 180155-163
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LMP2-specific inhibitors: chemical genetic tools for proteasome biology.
Ho, Yik Khuan; Bargagna-Mohan, Paola; Wehenkel, Marie; Mohan, Royce; Kim, Kyung-Bo Chemistry & Biology 14(4):419-30
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Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization.
Bargagna-Mohan, Paola; Ravindranath, Padma Priya; Mohan, Royce Investigative ophthalmology & visual science 47(9):4138-45
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Sustained activation of ERK1/2 MAPK in Schwann cells causes corneal neurofibroma.
Bargagna-Mohan, Paola; Ishii, Akihiro; Lei, Ling; Sheehy, Daniel; Pandit, Saagar; Chan, Grace; Bansal, Rashmi; Mohan, Royce Journal of Neuroscience Research 95(9):1712-1729
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Use of PROTACS as molecular probes of angiogenesis.
Bargagna-Mohan, Paola; Baek, Sun-Hee; Lee, Hyosung; Kim, Kyungbo; Mohan, Royce Bioorganic & medicinal chemistry letters 15(11):2724-7
