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Melissa J. Caimano, PhDAssociate Professor
Pronouns:
She/Her
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- Overview
- Education & Training
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Melissa Caimano received a B.S. degree from the University of Rhode Island in 1989. She attended graduate school at the University of Alabama at Birmingham doing her thesis work on the genetic elements involved in Streptococcus pneumoniae capsule biosynthesis. In 1996, Caimano began a post-doctoral fellowship with Dr. Justin Radolf at the University of Texas Southwestern Medical Center in Dallas, relocating to the University of Connecticut in 1999. Her work has focused primarily on the regulatory pathways and molecular mechanisms underlying mammalian host adaptation and maintenance of Borrelia burgdorferi within its natural enzootic cycle. Most notably, these studies have led to the discovery that the alternate sigma factor RpoS plays a critical role in the down-regulation, as well as up-regulation, of borrelial genes specifically in response to mammalian host signals. She has published more than 46 peer-reviewed articles on microbial pathogenesis and related areas in high impact journals. Her work examining the interaction between the Lyme disease spirochete and its arthropod vector is supported by grants awarded to her by the National Research Fund for Tick-Borne Diseases (NRFTD) and the National Institutes of Health (NIH/NIAID). Caimano currently is an Assistant Professor in the UConn Health Department of Medicine and holds a secondary appointments in the Departments of Pediatrics and Molecular Biology and Biophysics. She has served on the Editorial Board of Infection and Immunity since 2006 and PLoS Neglected Tropical Diseases since 2015.
Degree | Institution | Major |
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BS | University of Rhode Island | Microbiology |
PhD | University of Alabama at Birmingham | Microbiology |
Post-Graduate Training
Training | Institution | Specialty |
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Postdoctoral | UT Southwestern Medical Center | Post-doctoral fellow |
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
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NIH/NIAID Bacterial Pathogenesis Study Section (BACP); Feb 2020 | Study Section | Ad Hoc reviewer | External | National | 2020 | |
PLoS Neglected Tropical Diseases | Editorial Board | Deputy Editor | External | International | 2019 | 2021 |
Biomedical Sciences PhD Program Graduate Admissions Committee | Advisory Committee | Chair/C-Chair | UConn Health | University | 2019 | 2020 |
PLoS Neglected Tropical Diseases | Editorial Board | Deputy Editor | External | International | 2019 | |
Graduate Program Admissions Committee | Advisory Committee | Chair | UConn Health | University | 2019 | 2020 |
Medical Student Coaching | Education Committee | Coach | UConn Health | University | 2019 | |
NIH/NIAID Special Emphasis Panel ZRG1 IDM-B (March, 2019) | Study Section | Ad Hoc reviewer | External | National | 2019 | 2019 |
NIH/NIAID P01 Special Emphasis Panel (SEP) | Study Section | Reviewer | External | National | 2018 | 2019 |
Cellular Signaling | Editorial Board | Editorial Board Member | External | International | 2018 | |
BMC Infectious Diseases | Editorial Board | Associate Editor | External | International | 2018 | |
NIH/NIAID Special Emphasis Panel ZRG1 IDM-B | Study Section | Member | External | National | 2018 | |
Junior Science and Humanities Symposium (Mar, 2019) | Workshop/Conference | Oral Presentation Judge | External | Regional | 2017 | 2019 |
NIH/NIAID, Special Emphasis Panel ZRG1 IDM-B(81) | Study Section | Reviewer | External | National | 2017 | 2017 |
PLoS Neglected Tropical Diseases | Editorial Board | Associate Editor | External | International | 2017 | |
Cellular Microbiology - special issue | Editorial Board | Guest Editor | External | International | 2017 | 2018 |
National Science Foundation | Study Section | Ad hoc reviewer | External | International | 2017 | 2017 |
Frontiers in Immunology - Research Topic: Spirochetes and immune evasion: infection, persistence and clearance. | Editorial Board | Special Topic Co-Editor | External | International | 2016 | 2017 |
Frontiers in Microbiology, section Microbial Immunology | Editorial Board | Guest Editor | External | International | 2016 | 2017 |
Frontiers in Microbiology - Research Topic: Borrelia Pathogenesis, Immunity and Vaccines. | Editorial Board | Special Topic Co-Editor | External | International | 2016 | 2018 |
Czech Science Foundation | Study Section | Ad hoc grant reviewer | External | International | 2016 | 2017 |
Stanford Synchrotron Radiation Lightsource (SSRL), SLAC National Accelerator Laboratory | Study Section | Ad hoc grant reviewer | External | Regional | 2016 | 2016 |
Committee on Biohazards | Research Committee | Vice-Chair | UConn Health | University | 2015 | |
IACUC | Research Committee | Member | UConn Health | Local | 2010 | |
Infection and Immunity | Editorial Board | Associate Editor | External | International | 2006 | 2020 |
ASM | Professional/Scientific Organization | Member | External | National | 1993 |
Her work has focused primarily on the regulatory pathways and molecular mechanisms underlying mammalian host adaptation and maintenance of Borrelia burgdorferi within its natural enzootic cycle. Most notably, these studies have led to the discovery that the alternate sigma factor RpoS plays a critical role in the down-regulation, as well as up-regulation, of borrelial genes specifically in response to mammalian host signals. More recently, Dr. Caimano has identified a central role for the small nucleotide second messenger, c-di-GMP, for maintenance of B. burgdorferi in its arthropod vector. She has published more than 60 peer-reviewed articles on microbial pathogenesis and related areas in high impact journals
Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025
Journal Articles
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Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities.
PLoS pathogens 2024 Dec;20(12):e1012443
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Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research.
Scientific data 2024 Dec;11(1):1313
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
mBio 2024 Nov;e0325324
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Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study.
The Lancet. Microbe 2024 Sep;5(9):100871
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Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs.
Scientific reports 2024 Aug;14(1):19958
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An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms.
Cell 2024 Jul;187(15):4113-4127.e13
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Clinical presentation of early syphilis and genomic sequences of Treponema pallidum strains in patient specimens and isolates obtained by rabbit inoculation.
The Journal of infectious diseases 2024 Jun;
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Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.
PloS one 2024 Jan;19(7):e0307600
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A unique borrelial protein facilitates microbial immune evasion.
mBio 2023 Oct;e0213523
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High-resolution microbiome analysis reveals exclusionary Klebsiella species competition in preterm infants at risk for necrotizing enterocolitis.
Scientific reports 2023 May;13(1):7893
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BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals.
The Journal of clinical investigation 2023 Jan;
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Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326).
Frontiers in immunology 2023 Jan;141222267
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Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis.
mBio 2022 Aug;13(4):e0163922
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Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.
mBio 2022 Jan;e0375221
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The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
PLoS pathogens 2021 Dec;17(12):e1009078
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PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
PLoS pathogens 2021 Jul;17(7):e1009725
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Levels and Characteristics of mRNAs in Spores of Firmicute Species.
Journal of bacteriology 2021 May;
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Structural modeling of the Treponema pallidum OMPeome: a roadmap for deconvolution of syphilis pathogenesis and development of a syphilis vaccine.
Journal of bacteriology 2021 May;
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High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon.
mBio 2021 Feb;12(1):
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Gene Regulation and Transcriptomics.
Current issues in molecular biology 2021 Jan;42223-266
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Cytotoxin-producing Klebsiella oxytoca in the preterm gut and its association with necrotizing enterocolitis.
Emerging microbes & infections 2020 Dec;9(1):1321-1329
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The BB0345 hypothetical protein of Borrelia burgdorferi is essential for mammalian infection.
Infection and immunity 2020 Sep;
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Analysis of 5'-NAD capping of mRNAs in dormant spores of Bacillus subtilis.
FEMS microbiology letters 2020 Sep;367(17):
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Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.*Shared First Authorship
PLoS pathogens 2020 Sep;16(9):e1008871
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Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres.
The Journal of Infectious Diseases (in press) 2020 Jul;
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Role of glucosyltransferase R in biofilm interactions between Streptococcus oralis and Candida albicans.
The ISME journal 2020 Feb;
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The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.
Frontiers in microbiology 2019 Sep;101923
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Properties of Aged Spores of Bacillus subtilis.
Journal of bacteriology 2019 May;
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Fecal Microbiomes in Premature Infants With and Without Parenteral Nutrition-Associated Cholestasis.
Journal of pediatric gastroenterology and nutrition 2019 Apr;
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Analysis of the Messenger RNAs in Spores of Bacillus subtilis.
Journal of bacteriology 2019 Feb;
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Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2018 Jun;1-10
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Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.
mBio 2018 Jun;9(3):
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Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Methods in molecular biology (Clifton, N.J.) 2018 Jan;169035-45
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Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.
mBio 2017 Dec;8(6):
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The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola.
Scientific reports 2017 Oct;7(1):13260
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Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.
mBio 2017 Aug;8(4):
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IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.
Frontiers in immunology 2017 Jan;81227
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The Treponema denticola FhbB protein is a dominant early antigen that elicits FhbB variant specific antibodies that block factor H binding and cleavage by dentilisin.
Infection and immunity 2016 Apr;842051-2058
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Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Nature Communications 2016 Jan;710507
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Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding.
Journal of structural biology 2015 Aug;192(1):48-58
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Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Bio-protocol 2015 Jul;5(14):
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Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission.
Infection and immunity 2015 May;83(8):3043-60
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A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.
Journal of bacteriology 2015 Mar;197(11):1906-20
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Correction for Anand et al., The Major Outer Sheath Protein (Msp) of Treponema denticola Has a Bipartite Domain Architecture and Exists as Periplasmic and Outer Membrane-Spanning Conformers.
Journal of bacteriology 2014 Sep;196(18):3361
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Correction for Anand et al., TprC/D (Tp0117/131), a Trimeric, Pore-Forming Rare Outer Membrane Protein of Treponema pallidum, Has a Bipartite Domain Structure.
Journal of bacteriology 2014 Sep;196(18):3360
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A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
PLoS pathogens 2014 Mar;10(3):e1004004
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Initial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferi.
PloS one 2014 Jan;9(5):e98338
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HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.
PLoS pathogens 2013 Dec;9(12):e1003841
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Sequence divergence in the Treponema denticola FhbB protein and its impact on factor H binding.
Molecular oral microbiology 2013 Aug;28(4):316-30
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The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers.
Journal of bacteriology 2013 May;195(9):2060-71
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The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks.
Molecular microbiology 2012 Sep;85(6):1105-18
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TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure.
Journal of bacteriology 2012 May;194(9):2321-33
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The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb;109(8):3059-64
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Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.
PLoS pathogens 2012 Feb;8(2):e1002532
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CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan;109(4):1228-32
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The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.
The Journal of biological chemistry 2011 Dec;286(48):41656-68
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The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.
Molecular microbiology 2011 Nov;82(3):679-97
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The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.
Infection and immunity 2011 Aug;79(8):3117-30
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Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.
PLoS pathogens 2011 Jul;7(7):e1002102
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TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.
Molecular microbiology 2011 Jun;80(6):1496-515
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BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle.
Infection and immunity 2011 Mar;79(3):1208-17
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Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum.
Infection and immunity 2010 Dec;78(12):5178-94
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Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars.
Bone 2010 Jun;46(6):1639-51
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Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi.
PLoS pathogens 2010 Jan;6(9):e1001104
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Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.
The Journal of clinical investigation 2009 Dec;119(12):3652-65
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Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.
PLoS pathogens 2009 May;5(5):e1000444
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Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals.
Journal of bacteriology 2009 Apr;191(8):2783-94
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NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec;105(50):19863-8
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MicroCommentary: The long strange trip of Borrelia burgdorferi OspC.
Mol Micro 2008 Jan;69(1):1-4
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Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.
Molecular microbiology 2007 Sep;65(5):1193-217
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Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties.
Journal of bacteriology 2007 Mar;189(5):2063-8
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Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the -10 region.
Molecular microbiology 2006 Mar;59(6):1859-75
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Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes.
Journal of bacteriology 2005 Nov;187(22):7845-52
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Cultivation of Borrelia burgdorferi in dialysis membrane chambers in rat peritonea.
Current protocols in microbiology 2005 Jul;Chapter 12Unit 12C.3
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Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 2005 Feb;174(3):1539-48
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Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes.
Journal of bacteriology 2004 Nov;186(21):7390-402
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RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.
Infection and immunity 2004 Nov;72(11):6433-45
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Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.
Infection and immunity 2004 Oct;72(10):5938-46
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The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.
Infection and immunity 2004 Aug;72(8):4864-7
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Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA.
Microbial pathogenesis 2004 Jul;37(1):35-40
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Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans.
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep;171(5):2660-70
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Molecular characterization of the presence of Eubacterium spp and Streptococcus spp in endodontic infections.
Oral microbiology and immunology 2003 Aug;18(4):249-55
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A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.
Molecular microbiology 2003 May;48(3):753-64
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Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays.
Infection and immunity 2003 Apr;71(4):1689-705
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Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.
Molecular microbiology 2003 Mar;47(5):1433-44
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Characterization of the stringent response and rel(Bbu) expression in Borrelia burgdorferi.
Journal of bacteriology 2003 Feb;185(3):957-65
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Environmental regulation and differential production of members of the Bdr protein family of Borrelia burgdorferi.
Infection and immunity 2002 Dec;70(12):7033-41
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PCR-based identification of bacteria associated with endodontic infections.
Journal of clinical microbiology 2002 Sep;40(9):3223-31
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Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.
Infection and immunity 2002 Apr;70(4):2139-50
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Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete.
Molecular microbiology 2002 Jan;43(2):281-95
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Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals.
Infection and immunity 2001 Jun;69(6):3618-27
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The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity.
The Journal of experimental medicine 2001 May;193(9):1015-26
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Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks.
Infection and immunity 2000 Aug;68(8):4759-64
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Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland.
The Journal of parasitology 2000 Jun;86(3):516-25
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Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase.
Journal of bacteriology 2000 Apr;182(7):1854-63
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Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.
Infection and immunity 2000 Mar;68(3):1574-86
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Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family.
Infection and immunity 1999 Nov;67(11):6008-18
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Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins.
Journal of immunology (Baltimore, Md. : 1950) 1999 Aug;163(4):2049-56
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The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure.
Infection and immunity 1999 Aug;67(8):4072-83
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Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides.
Infection and immunity 1999 Mar;67(3):1526-32
Book Chapters
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Gene Regulation and Transcriptomics.
Current issues in molecular biology 2020 Dec;223-266
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Generation of mammalian host-adapted Borrelia burgdorferi by cultivation in in dialysis membrane chamber implantation in rats.
Methods in Molecular Biology. Borrelia burgdorferi: Methods and Protocols. 2017 Mar;
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The Prokaryotes: An Evolving Electronic Resource for the Microbiological Community
The Genus Borrelia. 2002 Jan;
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Cultivation of Leptospira interrogans within rat peritoneal dialysis membrane chambers. (Chapter 21)
Methods in Molecular Biology: Leptospira spp. - Methods and Protocols.
Notes
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The long strange trip of Borrelia burgdorferi outer-surface protein C.
Molecular microbiology 2008 Jul;69(1):1-4
Reviews
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Systematic Review of the Human Milk Microbiota.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2016 Sep;32354-364
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Interaction of the Lyme disease spirochete with its tick vector.
Cellular microbiology 2016 May;18919-27
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Borrelia burgdorferi gene expression profiling with membrane-based arrays.
Methods in enzymology 2002 Jan;358165-77
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Deciphering the RpoS Regulon and Regulatory Crosstalk throughout the Enzootic Cycle | Talk | Gordon Research Conference | 2022 | Ventura, CA |
Diverse Environment Related (Der) protein is a novel OMP85 subfamily present in free-living bacteria and pathogenic Leptospira spp.Everton Bettin, André Grassmann and Melissa Caimano | Poster | NESS | 2020 | UConn Storrs (virtual) |
Persistence of B. burgdorferi: What's RpoS got to do with it? | Talk | Springtime for Lyme (Jan. 22, 2019) | 2019 | Hartford, CT |
Physiology, Membrane Biology and Structural Biology | Other | Gordon Research Conference-Biology of Spirochetes | 2016 | Ventura, CA |
How does the Lyme disease spirochete know whether it's coming or going? | Talk | Bates College | 2016 | Lewiston, MA |
Environmental sensing by Borrelia burgdorferi “Bringing the Outside -> In” | Other | Umea University | 2015 | Umea, Sweden |
Environmental sensing by the Lyme disease spirochete, Borrelia burgdorferi | Talk | UConn Storrs | 2015 | Storrs, CT |
Prolonged Rupture of Membranes Impacts Early Intestinal Microbiome of Premature Infants | Poster | Pediatric Academic Societies | 2015 | San Diego, CA |
Comparison of the Gastric Fluid Microbiome of Children with and without Eosinophilic Esophagitis | Poster | North Amer. Soc. of Ped, Gastro. Hep. and Nutr. | 2015 | Washington, DC |
Environmental sensing by Borrelia burgdorferi: How does the Lyme disease spirochete know whether it's coming or going? | Talk | Gordon Research Conferences | 2014 | Ventura, CA |
Cultivation of Leptospira interrogans serovar Copenhageni within dialysis membrane chambers provides a model system for studying the transcriptional and physiological adaptation of pathogenic leptospires within the mammalian host. | Poster | Gordon Research Conferences | 2014 | Ventura, CA |
Role of Two-Component Systems for maintenance of the Lyme disease spirochetes in its enzootic cycle. | Talk | General Microbiology | 2014 | Dublin, Ireland |
Environmental sensing by Borrelia burgdorferi: How do Lyme disease spirochetes know if they are coming or going? | Talk | Pasteur Institute | 2014 | Paris, France |
Springtime for Lyme:Hk1/Rrp1-mediated environmental sensing by Borrelia burgdorferi | Talk | Linda Bockenstedt, Yale University | 2014 | New Haven |
Maintenance of Borrelia burgdorferi within its Enzootic Cycle Requires Both Hk1/Rrp1 and RpoS Regulatory Pathways | Talk | International Conference on Lyme Borreliosis | 2013 | Boston, MA |