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Scalable topic modelling decodes spatial tissue architecture for large-scale multiplexed imaging analysis.
Peng, Xiyu; Smithy, James W; Yosofvand, Mohammad; Kostrzewa, Caroline E; Bleile, MaryLena; Ehrich, Fiona D; Lee, Jasme; Postow, Michael A; Callahan, Margaret K; Panageas, Katherine S; Shen, Ronglai Nature communications 2025 Jul;16(1):6619
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Quantitatively defined stromal B cell aggregates are associated with response to checkpoint inhibitors in unresectable melanoma.
Smithy, James W; Peng, Xiyu; Ehrich, Fiona D; Moy, Andrea P; Yosofvand, Mohammad; Maher, Colleen; Aleynick, Nathaniel; Vanguri, Rami; Zhuang, Mingqiang; Lee, Jasme; Bleile, MaryLena; Li, Yanyun; Postow, Michael A; Panageas, Katherine S; Hollmann, Travis J; Callahan, Margaret K; Shen, Ronglai Cell reports 2025 Apr;44(4):115554
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The response to anti-PD-1 and anti-LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming.
Rolig, Annah S; Peng, Xiyu; Sturgill, Elizabeth R; Holay, Nisha; Kasiewicz, Melissa; Mick, Courtney; Mcgee, Grace Helen; Miller, William; Koguchi, Yoshinobu; Kaufmann, Johanna; Yanamandra, Niranjan; Griffin, Sue; Smothers, James; Adamow, Matthew; Lee, Jasme; Shen, Ronglai; Callahan, Margaret K; Redmond, William L Science translational medicine 2025 Apr;17(793):eadk3702
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Decoding Spatial Tissue Architecture: A Scalable Bayesian Topic Model for Multiplexed Imaging Analysis.
Peng, Xiyu; Smithy, James W; Yosofvand, Mohammad; Kostrzewa, Caroline E; Bleile, MaryLena; Ehrich, Fiona D; Lee, Jasme; Postow, Michael A; Callahan, Margaret K; Panageas, Katherine S; Shen, Ronglai bioRxiv : the preprint server for biology 2024 Nov;
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Durable complete response in a patient with leptomeningeal melanoma after treatment with dabrafenib, trametinib, and nivolumab.
Lochrin, Sarah E; Buonocore, Darren J; Young, Robert J; Kaley, Thomas J; Postow, Michael A; Wolchok, Jedd D; Shoushtari, Alexander N; Momtaz, Parisa; Betof Warner, Allison S; Callahan, Margaret K Pigment cell & melanoma research 2024 Nov;37(6):801-807
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Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study.
Smithy, James W; Kalvin, Hannah L; Ehrich, Fiona D; Shah, Ronak; Adamow, Matthew; Raber, Vladislav; Maher, Collen A; Kleman, Jenna; McIntyre, Deborah A G; Shoushtari, Alexander N; Betof Warner, Allison; Callahan, Margaret K; Momtaz, Parisa; Eton, Omar; Nair, Suresh; Wolchok, Jedd D; Chapman, Paul B; Berger, Michael F; Panageas, Katherine S; Postow, Michael A Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Aug;30(16):3407-3415
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Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.
Widman, Adam J; Shah, Minita; Frydendahl, Amanda; Halmos, Daniel; Khamnei, Cole C; Øgaard, Nadia; Rajagopalan, Srinivas; Arora, Anushri; Deshpande, Aditya; Hooper, William F; Quentin, Jean; Bass, Jake; Zhang, Mingxuan; Langanay, Theophile; Andersen, Laura; Steinsnyder, Zoe; Liao, Will; Rasmussen, Mads Heilskov; Henriksen, Tenna Vesterman; Jensen, Sarah Østrup; Nors, Jesper; Therkildsen, Christina; Sotelo, Jesus; Brand, Ryan; Schiffman, Joshua S; Shah, Ronak H; Cheng, Alexandre Pellan; Maher, Colleen; Spain, Lavinia; Krause, Kate; Frederick, Dennie T; den Brok, Wendie; Lohrisch, Caroline; Shenkier, Tamara; Simmons, Christine; Villa, Diego; Mungall, Andrew J; Moore, Richard; Zaikova, Elena; Cerda, Viviana; Kong, Esther; Lai, Daniel; Malbari, Murtaza S; Marton, Melissa; Manaa, Dina; Winterkorn, Lara; Gelmon, Karen; Callahan, Margaret K; Boland, Genevieve; Potenski, Catherine; Wolchok, Jedd D; Saxena, Ashish; Turajlic, Samra; Imielinski, Marcin; Berger, Michael F; Aparicio, Sam; Altorki, Nasser K; Postow, Michael A; Robine, Nicolas; Andersen, Claus Lindbjerg; Landau, Dan A Nature medicine 2024 Jun;30(6):1655-1666
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Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032).
Callahan, Margaret; Amin, Asim; Kaye, Frederic J; Morse, Michael A; Taylor, Matthew H; Peltola, Katriina J; Sharma, Padmanee; O'Reilly, Eileen M; Meadows Shropshire, Stephanie; O'Brien, Shaun; Tschaika, Marina; Le, Dung T Journal for immunotherapy of cancer 2024 Feb;12(2):
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Phase Ib Trial of Phenformin in Patients with V600-mutated Melanoma Receiving Dabrafenib and Trametinib.
Chapman, Paul B; Klang, Mark; Postow, Michael A; Shoushtari, Alexander Noor; Sullivan, Ryan J; Wolchok, Jedd D; Merghoub, Taha; Budhu, Sadna; Wong, Phillip; Callahan, Margaret K; Zheng, Bin; Zippin, Jonathan Cancer research communications 2023 Dec;3(12):2447-2454
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Integration of peripheral blood- and tissue-based biomarkers of response to immune checkpoint blockade in urothelial carcinoma.
Vanguri, Rami S; Smithy, James W; Li, Yanyun; Zhuang, Mingqiang; Maher, Colleen A; Aleynick, Nathaniel; Peng, Xiyu; Al-Ahmadie, Hikmat; Funt, Samuel A; Rosenberg, Jonathan E; Iyer, Gopa; Bajorin, Dean; Mathews, James C; Nadeem, Saad; Panageas, Katherine S; Shen, Ronglai; Callahan, Margaret K; Hollmann, Travis J The Journal of pathology 2023 Nov;261(3):349-360
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A topic modeling approach reveals the dynamic T cell composition of peripheral blood during cancer immunotherapy.
Peng, Xiyu; Lee, Jasme; Adamow, Matthew; Maher, Colleen; Postow, Michael A; Callahan, Margaret K; Panageas, Katherine S; Shen, Ronglai Cell reports methods 2023 Aug;3(8):100546
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Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial.
Ascierto, Paolo Antonio; Lipson, Evan J; Dummer, Reinhard; Larkin, James; Long, Georgina V; Sanborn, Rachel E; Chiarion-Sileni, Vanna; Dréno, Brigitte; Dalle, Stéphane; Schadendorf, Dirk; Callahan, Margaret K; Nyakas, Marta; Atkinson, Victoria; Gomez-Roca, Carlos Alberto; Yamazaki, Naoya; Tawbi, Hussein A; Sarkis, Naomey; Warad, Deepti; Dolfi, Sonia; Mitra, Priyam; Suryawanshi, Satyendra; Grob, Jean-Jacques Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 May;41(15):2724-2735
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Decision-Making and Health-Related Quality of Life in Patients with Melanoma Considering Adjuvant Immunotherapy.
Atkinson, Thomas M; Hay, Jennifer L; Young Kim, Soo; Schofield, Elizabeth; Postow, Michael A; Momtaz, Parisa; Warner, Allison Betof; Shoushtari, Alexander N; Callahan, Margaret K; Wolchok, Jedd D; Li, Yuelin; Chapman, Paul B The oncologist 2023 Apr;28(4):351-357
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Beyond the 5-year milestone: Long-term survivorship of melanoma patients treated off-trial with anti-PD-1.
Loo, Kimberly; Kalvin, Hannah L; Panageas, Katherine S; Callahan, Margaret K; Chapman, Paul B; Momtaz, Parisa; Shoushtari, Alexander N; Wolchok, Jedd D; Postow, Michael A; Warner, Allison Betof Pigment cell & melanoma research 2023 Jan;36(3-4):314-320
