Dr. Canalis is a Professor of Orthopedics and Medicine in the UConn Musculoskeletal Institute at UConn Health and Director of the Center for Skeletal Research. He is an internationally renowned expert in bone metabolism. Dr. Canalis’ clinical interests include osteoporosis and metabolic bone disorders. He sees patients at the Center for Osteoporosis in the UConn Musculoskeletal Institute.

Education

Degree	Institution	Major
MD	Universidad Peruana Cayetano Heredia	Medicine

Post-Graduate Training

Training	Institution	Specialty
Internship	UConn School of Medicine	Internal Medicine
Residency	Henry Ford Hospital	Internal Medicine
Residency	UConn School of Medicine	Internal Medicine
Fellowship	Tufts-New England Medical Center	Endocrinology

Awards

Name of Award/Honor	Awarding Organization
Lawrence G. Raisz Award for Outstanding Achievements in Preclinical Translational Research	American Society for Bone and Mineral Research
Distinguished Physician Award, Medical Staff	Saint Francis Hospital and Medical Center
Louis V. Avioli Founders Award for Fundamental Contributions to Bone and Mineral Basic Research	American Society for Bone and Mineral Research
Marshall Urist Award for Excellence in Tissue Regeneration Research	Orthopaedic Research Society
Gerald D. Aurbach Award for Outstanding Research in Endocrinology	Endocrine Society
MERIT Award	National Institute of Arthritis and Musculoskeletal and Skin Diseases
Ann Doner Vaughan Kappa Delta Award for Excellence in Orthopaedic Research	American Academy of Orthopaedic Surgeons

Name & Description	Category	Role	Type	Scope	Start Year	End Year
UConn Health Research Council	Research Committee	Member	UConn Health	University	2019
J. Clinical Densitometry	Editorial Board	Member	External	National	2019
Recruitment of Basic Scientist and of Director of MicroCT Core	Other	Chair	UConn Health	University	2018
National Institutes of Health	Study Section	Chair	External	International	2016	2018
Shriners Hospitals for Children Research Program	Other	Grant Reviewer	External	National	2015
NIH Center for Scientific Review, Skeletal Biology Development and Disease Study Section	Study Section	Appointed Member	External	International	2014	2018
European Journal of Endocrinology	Editorial Board	Associate Editor for North America	External	International	2012	2020
Calcified International	Editorial Board		External	International	1989

The Canalis laboratory is known for the discovery of skeletal growth factors and has pursued important investigations on the role of growth factors and their antagonists in skeletal function.  Dr. Canalis’ group has made seminal contributions to our understanding of the mechanisms of glucocorticoid action in bone in an effort to explain the pathogenesis of glucocorticoid induced osteoporosis and correct the disease.  The laboratory’s recent work has centered on factors determining osteoblast and osteoclast cell fate and function.  These investigations include studies on the role of Notch signaling and Nuclear factor of activated T cells (NFAT) in osteoblast and osteoclast cell differentiation.  Cellular and genetically engineered mouse models are used for the research conducted by the group.  The laboratory is particularly interested in translational research and has created genetically engineered mouse models of Hajdu Cheney Syndrome and Lateral Meningocele Syndrome, devastating diseases characterized by bone loss and fractures.  The studies have allowed the team to determine mechanisms of the bone loss and are exploring ways to prevent the skeletal disease.The laboratory has been funded continuously by the National Institutes of Health (NIH) since the 1981, and in 1990 received a MERIT Award from the National Institute of Musculoskeletal and Skin Disorders (NIAMS).  Currently, the laboratory is funded by NIAMS and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025

Projects available include

--Role of Hes1 in osteoclast differentiation and function
--Role of Nfat in osteoblast differentiation  and function; in vivo and in vitro studies
--Characterization of genetically engineered mice carrying Notch2 or Notch3 mutations
--Role of Notch in osteocyte function                                                                                          --Role of vascular Notch in skeletal homeostasis                                                                          --Targeting Notch mutations to reverse skeletal phenotypes 

Journal Articles

Book Chapters

Conference Papers

Erratums

Reviews

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Experimental Models of Hajdu Cheney Syndrome and Related Disorders	Lecture	Gordon Conference - Bone and Teeth	2018	Galveston, TX
Notch Signaling and Genetic Skeletal Disorders	Lecture	University of Pennsylvania	2018	Philadelphia, PA
Notch Signaling and Genetic Skeletal Disorders	Lecture	Brown University	2018	Providence, RI
Notch Signaling - Basic Science for Clinicans	Poster	2017 ASBMR Annual Meeting	2017	Denver, CO
Hajdu Cheney Syndrome - 3rd Translational European Society of Endocrinology (ESE) Bone Course	Lecture	8th Skeletal Endocrinology Meeting	2017	Mantova, Italy
Notch and Hajdu Cheney Syndrome - 2nd Translational European (ESE) Bone Course	Lecture	7th Skeletal Endocrinology	2015	Brescia, Italy
Señalización Notch	Lecture	XX Congreso de la Sociedad Española de Investigación Ósea y Metabolismo Min	2015	Bilbao, Spain
Osteoporosis por Glucocorticoides		XX Congreso de la Sociedad Española de Investigación Ósea y Metabolismo Min	2015	Bilbao, Spain
Hajdu Cheney Syndrome	Lecture	Skeletal Endocrinology	2014	Brescia, Italy
Notch and the Skeleton	Lecture	Louis Avioli Lecture	2014	St. Louis, MO
Mechanisms of Glucocorticoid Action in Bone		American Academy of Allergy, Asthma and Immunology	2014	San Diego, CA
Visiting Professor Universita di Brescia		Universita di Brescia	2014	Brescia, Italy
Notch Signaling and Skeletal Disorders (6th Skeletal Endorcrinology Meeting and First Translational European Society of Endocrinology Bone Course)			2014	Brescia, Italy
From Growth Factors to Glucocorticoids	Talk	NIDDK 60th Anniversary Symposium and Reception at ASBMR	2010	Toronto, Canada
Effects of Glucocorticoids on Bone Cells	Lecture	2010 Update on Bone Involvement in Arthritis	2010	Genova, Italy
Safety of Bisphosphonates with Particular Reference to Bone Quality, Fracture Healing and Implant Integration	Lecture	New York Academy of Medicine	2010	New York, NY
Glucocorticoid-Induced Osteoporosis: From Bench to Bedside	Lecture	New York Academy of Medicine	2010	New York, NY
New Treatment Modalities in Osteoporosis	Lecture	American Association of Clinical Endocrinologists	2010	Boston, MA
Notch and the Skeleton	Lecture	Maine Medical Center Research Institute	2010	Portland, ME
Mechanisms of Anabolic Agents in Bone	Lecture	The Lowell P. Weicker, Jr. General Clinical Research Center (GCRC) Seminar	2010	Farmington, CT
Notch, a Novel Signal Controlling Osteoblastic Cell Fate	Lecture	6th International Congress GIO	2009	Siena, Italy
Glucocorticoid Induced Osteoporosis	Lecture	Delaware Rheumatology Society	2009	Denver, CO
Clinical Management Decisions in Osteoporosis	Lecture	Clinical 411	2009	Denver, CO
Notch Signaling in Bone Development and Homeostasis	Lecture	The Endocrine Society’s 91st Annual Meeting – ENDO 09	2009	Washington, DC
Regulation of Osteoblastic Cell Differentiation and Function by CTGF	Lecture	3rd International Meeting on Skeletal Endocrinology	2009	Brescia, Italy
Actions of Glucocorticoids on the Osteoblast and Their Reversal by Anabolic Therapies	Lecture	5th International Congress on Glucocorticoid Induced Osteoporosis	2007	Napoli, Italy
A Novel BMP/Wnt Antagonist	Lecture	Gordon Research Conferences – Small Integrin-Binding Proteins	2007	Biddeford, Maine
Inhibitors of Osteoblast Differentiation	Lecture	2nd Conference on Skeletal Biology and Medicine	2007	New York, NY
Post Menopausal Osteoporosis	Lecture	Wyndham Hospital	2006	Wyndham, CT
Mechanisms of Glucorticoid Action in Bone: Relevance to Osteoporosis	Lecture	Hallet Center for Diabetes and Endocrinology – Rhode Island Hospital	2005	Providence, RI
Mechanism of Glucocorticoid Action in Bone	Lecture	University of Colorado Health Sciences Center	2005	Aurora, CO
Mechanisms of Glucocorticoid Action on Osteoblasts	Lecture	4th International Congress on Glucocorticoid Induced Osteoporosis	2005	Trieste, Italy
Mechanisms of Action of Glucocorticoids in Bone	Lecture	Third International Conference on Osteoporosis in Men	2005	Genoa, Italy
Signals Determining Osteoblastic Cell Fate and Function	Lecture	Third International Conference on Children’s Bone Health	2005	Sorrento, Italy
Glucocorticoid Induced Osteoporosis	Lecture	Endocrine Grand Rounds- Stanford University	2005	Palo Alto, CA
Glucocorticoid Induced Osteoporosis	Lecture	Medical Grand Rounds- Saint Francis Hospital and Medical Center	2005	Hartford, CT
Management of Post-Menopausal Osteoporosis	Lecture	Medical Grand Rounds- University of West Virginia	2005	Morgantown, WV
Mechanisms of Glucocorticoid Action In Bone	Lecture	Endocrinology Grand Rounds- Vanderbilt University	2005	Nashville, TN
Glucocorticoid Induced Osteoporosis	Lecture	Rheumatology Grand Rounds- Yale University	2005	New Haven, CT
Regulation of Osteoblastogenesis	Lecture	Skeletal Endocrinology 2004	2005	Arzaga, Italy
Mechanisms of Glucocorticoid Induced Osteoporosis	Lecture	4th Global Arthritis Research Network (GARN)	2004	Montreal, Canada
New Concepts in the Screening and Treatment of Osteoporosis	Lecture	Family Medicine Grand Rounds	2004	Bethesda, MD
Glucocorticoid Induced Osteoporosis	Lecture	Rheumatology Rounds	2004	Manhasset, NY
Mechanisms of Glucocorticoid Action in Bone	Lecture	Lupus 2004 - 7th International Congress SLE and Related Conditions	2004	New York, NY
Osteoporosis	Lecture	Medical Grand Rounds- Bryn Mawr Hospital	2004	Bryn Mawr,PA
Mechanisms of Glucocorticoid Action in Bone Relevance to Glucocorticoid Induced Osteoporosis	Lecture	Rheumatology Grand Rounds	2004	Mineola, NY
Current Approaches to the Management of Osteoporosis	Lecture	Medical Grand Rounds- Bridgeport Hospital	2004	Bridgeport, CT
Mechanisms of Glucocorticoid Action in Bone	Lecture	Rheumatology Grand Rounds	2003	Seattle, WA
Management of Osteoporosis in Light of the Women's Health Initiative	Lecture	Medical Grand Rounds	2003	Seattle, WA
A Scientific Approach to Glucocorticosteroid-Induced Osteoporosis	Lecture	The State of the Art in the Management of Osteoporosis	2003	Washington, DC
Mechanisms of Action of Glucocorticoids in Bone: Relevance to Osteoporosis in Men	Lecture	Second International Conference on Osteoporosis in Men	2003	Genoa, Italy
Mechanisms of Glucocorticoid Action and Relevance to Glucocorticoid Induced Osteoporosis Growth Factors as Determinants of Bone Mass	Lecture	VI Congreso Sociedad Iberoamericana de Osteologia y Metabolismo Mineral	2003	Quito, Ecuador
Post-Menopausal Osteoporosis	Lecture	Harrington Memorial Hospital Medical Grand Rounds	2003	Southbridge, MA
Glucocorticoid Induced Osteoporosis	Lecture	Hamot Medical Center Medical Grand Rounds	2002	Erie, PA
Glucocorticoid Steroid Induced Osteoporosis	Lecture	Pascack Valley Hospital Medical Grand Rounds	2002	Westwood, NJ
Controversies in Women's Health	Lecture	Center for Women's Health & Medicine at Mercy	2002	Baltimore, MD
Osteoporosis	Lecture	Riverside Regional Medical Center Medical Grand Rounds	2002	Newport News, VT
Skeletal Growth Factors	Lecture	24th Annual Meeting of the American Society for Bone and Mineral Research	2002	San Antonio, TX
Insulin Like Growth Factors and Future Therapies in Osteoporosis	Lecture	12 corso Nazionale sulle Malattie Metaboliche dell'Osso	2002	Turin, Italy
Glucocorticoid Induced Osteoporosis / Inflammatory Bowel Disease	Lecture	Lenox Hill Hospital Gastroenterology Grand Rounds	2002	New York, NY
Effect of Glucocorticoids on the Skeleton	Lecture	33rd Annual Symposium	2002	Barcelona, Spain
Glucocorticoid Induced Osteoporosis	Lecture	16th Annual Meeting of the Metabolic Bone Disease Society of Colorado	2002	Denver, CO
Selected Topics in Osteoporosis	Lecture	Baystate Medical Center Medical Grand Rounds	2002	Springfield, MA
Mechanisms of Glucocorticoid Action in Bone	Lecture	Rheumatology Grand Rounds - Massachusetts General Hospital	2001	Boston, MA
GH and Bone: GH/IGF and Osteoblast Function	Lecture	5th International HYPOCCS Symposium	2001	Antwerp, Belgium
Role of Bisphosphonates and Estrogens in the Therapy of Osteoporosis	Lecture	Annual Meeting of the Sociedad Peruana del Clinaterio	1999	Lima, Peru
Local Factors in the Regulation of Bone Remodeling	Lecture	7th Congress, Spanish Society for Bone Research and Mineral Metabolism	1999	Sitges, Spain
Basic Pathophysiology of Glucocorticoid Action on Bone	Lecture	81st Annual Meeting of the Endocrine Society	1999	San Diego, CA
Expression and Regulation of Hepatocyte Growth Factor/Scatter Factor in Osteoblast Cultures	Lecture	International Bone and Mineral Society	1999	Gallipoli, Italy
Effects of Glucocorticoids on Bone Formation and Coordinator	Lecture	1st International Congress, Glucocorticoid Induced Osteoporosis	1999	Lake Garda, Italy
Mechanisms of Glucocorticoid Action in Bone Relevance to Osteoporosis	Lecture	Keystone Symposia on Molecular & Cellular Biology	1999	Tahoe City, CA
Bone Matters: Current Clinical Research in the Management of Osteoporosis	Lecture	American Society for Bone and Mineral Research	1998	San Francisco, CA
Skeletal Growth Factors	Lecture	Women’s Health Symposium	1998	Santiago, Chile
Effects of IL-6 on Matrix Metalloproteinases: Implications to Bone Remodeling and the Insulin-Like Growth Factor Axis	Lecture	IV Workshop on Osteobiology	1997	Parma, Italy
Growth Factors and Bone	Lecture		1997	Singapore
Assessment of the Growth Hormone/IGF-I Axis in Aging	Lecture	Symposium Sponsored by the National Institute for Aging Bethesda, Maryland,	1997	Bethesda, MD
Effect of Glucocorticoids on Insulin-Like Growth Factors and Their Binding Proteins	Lecture	2nd International Conference on Steroids and Bone	1997	Siena, Italy
Osteoporosis: Etiology, Pathophysiology and Current Medical Management	Lecture	Symposium Sponsored by New York State Academy of Family Physicians	1997	Lake Placid, NY
In Vitro and In Vivo Actions of Growth Factors on the Skeleton	Lecture	VII International Conference on Bone Morphometry	1996	Sardinia, Italy
Growth Factors in Bone Metabolism	Lecture	IV Congreso Chileno de Osteologia y Metabolismo Mineral	1996	Santiago, Chile
Role of Insulin-Like Growth Factor in Bone Metabolism	Lecture	10th International Congress of Endocrinology	1996	San Francisco, CA
Skeletal Insulin-Like Growth Factors and Their Binding Proteins	Lecture	Symposium Pharmaco-Clinique Roussel Uclaf: Role of Growth Factors in Skelet	1996	Paris, France
Role of Insulin-Like Growth Factor I (IGFI) and IGF Binding Proteins in Bone	Lecture	20th Birthday of the Belgian Bone Club	1995	Brussels, Belgium
Actions of Deflazacort and Other Glucocorticoids on Osteoblasts	Lecture	Satellite of First International Conference on Steroids and Bone	1994	Florence, Italy
Steroids, Growth Factors and Bone Turnover	Lecture	First International Conference on Steroids and Bone	1994	Florence, Italy
Insulin-Like Growth Factor, An Autocrine Regulator of Skeletal Cells	Lecture	Third International Symposium on Insulin-Like Growth Factors	1994	Sydney, Australia
Biology of Cartilage and Bone	Lecture	European Research Conferences	1992	Obernai, France
Insulin-Like Growth Factor and the Local Regulation of Bone Formation	Lecture	The Sixth International Congress on Bone Morphometry	1992	Lexington, KY
Cytokines and Local Growth Factors in the Regulation of Bone Metabolism	Lecture	Effects of Space Travel on the Musculoskeletal System	1990	Bethesda, MD
Cultures of Fetal Rat Calvariae to Study Bone Formation	Lecture	American Society for Bone and Mineral Research	1984
Local Skeletal Growth Factors in Osteoporosis	Lecture	Consensus Development Conference in Osteoporosis-NIH	1984	Bethesda, MD
Bone Derived Growth Factor	Lecture	Workshop on Local Mechanisms Regulating Bone Formation, NIH	1983	Bethesda, MD
Local Regulation of Bone Growth	Lecture	Gordon Research Conferences - Bone and Teeth	1983	Meriden, NH