Faculty Directory › UConn Health

I-Ping Chen, DDS, PhD

Professor, Endodontics


Academic Office Location: Endodontics UConn Health 263 Farmington Avenue Farmington, CT 06030
Phone:	860-679-1030
Website(s):	Endodontics Skeletal Biology and Regeneration Graduate Program

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Education & Training
Research
Lab Rotations
Publications

Education

Degree	Institution	Major
MS	University of Pennsylvania	Master of Science in Oral Biology
Certificate	University of Pennsylvania	Endodontics
PhD	University of Connecticut Health	Biomedical Sciences

Degree

Institution

Major

University of Pennsylvania

Master of Science in Oral Biology

Certificate

University of Pennsylvania

Endodontics

PhD

University of Connecticut Health

Biomedical Sciences

Awards

Name of Award/Honor	Awarding Organization
Outstanding Researcher Faculty Award
P.J. Robinson Award
Young Investigator Award	Rare Bone Disease Research Summit
Harold M. Frost Young Investigator Award	The American Society of Bone and Mineral Research (ASBMR)
Dentist Scientist Pathway to Independence Award (K99/R00)	NIDCR

Name of Award/Honor

Awarding Organization

Outstanding Researcher Faculty Award

P.J. Robinson Award

Young Investigator Award

Rare Bone Disease Research Summit

Harold M. Frost Young Investigator Award

The American Society of Bone and Mineral Research (ASBMR)

Dentist Scientist Pathway to Independence Award (K99/R00)

NIDCR

In the Chen laboratory, we mainly focus on the investigation of pathogenic mechanisms of craniometaphyseal dysplasia (CMD) using multiple genetic and molecular biology approaches including a knock-in mouse model for CMD and induced pluripotent stem cells (iPSCs) from CMD patients. We have characterized the CMD mouse model replicating many features of human CMD and identified abnormal properties of osteoclasts and osteoblasts in CMD. Subsequently, I have generated integration-free induced pluripotent stem (iPS) cells from peripheral blood of CMD patients and control subjects. These hiPSCs will be differentiated into osteoclasts to study osteoclast defects in CMD. My long-term goal is to develop therapeutic strategies that can benefit patients with CMD and similar rare bone disorders.

As an endodontist, I am also interested in dental research. In collaboration with Dr. Chon, a biomedical engineer, we aim to develop a quantitative and objective measurement for dental pain. We examine the use of electrodermal activity to assist pulpal diagnosis and assess dental pain. My laboratory has been funded by the American Association of Endodontists to establish a 3D culture modeling system that can be easily analyzed and improve or complement the current assays for testing new dental materials.

Not Accepting Lab Rotation Students at this time

Journal Articles

ENPP1 enzyme replacement therapy improves ectopic calcification but does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia.
Reichenberger, Ernst J; O'Brien, Kevin; Hatori, Ayano; Carpenter, Thomas O; van de Wetering, Koen; Flaman, Lisa; Howe, Jennifer; Ortiz, Daniel; Sabbagh, Yves; Chen, I-Ping JBMR plus 2024 Sep;8(9):ziae103
Differentiating between stress- and EPT-induced electrodermal activity during dental examination.
Kong, Youngsun; Posada-Quintero, Hugo F; Tran, Hanh; Talati, Ankur; Acquista, Thomas J; Chen, I-Ping; Chon, Ki H Computers in biology and medicine 2023 Mar;155106695
The use of electrodermal activity in pulpal diagnosis and dental pain assessment.
Tran, Hanh T; Kong, Youngsun; Talati, Ankur; Posada-Quintero, Hugo; Chon, Ki H; Chen, I-Ping International endodontic journal 2023 Mar;56(3):356-368
Design and Validation of a Multimodal Wearable Device for Simultaneous Collection of Electrocardiogram, Electromyogram, and Electrodermal Activity.
McNaboe, Riley; Beardslee, Luke; Kong, Youngsun; Smith, Brittany N; Chen, I-Ping; Posada-Quintero, Hugo F; Chon, Ki H Sensors (Basel, Switzerland) 2022 Nov;22(22):
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.
Riaz, Muhammad; Park, Jinkyu; Sewanan, Lorenzo R; Ren, Yongming; Schwan, Jonas; Das, Subhash K; Pomianowski, Pawel T; Huang, Yan; Ellis, Matthew W; Luo, Jiesi; Liu, Juli; Song, Loujin; Chen, I-Ping; Qiu, Caihong; Yazawa, Masayuki; Tellides, George; Hwa, John; Young, Lawrence H; Yang, Lei; Marboe, Charles C; Jacoby, Daniel L; Campbell, Stuart G; Qyang, Yibing Circulation 2022 Apr;145(16):1238-1253
Tlr2/4-Mediated Hyperinflammation Promotes Cherubism-Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice.
Fujii, Yasuyuki; Monteiro, Nelson; Sah, Shyam Kishor; Javaheri, Homan; Ueki, Yasuyoshi; Fan, Zhichao; Reichenberger, Ernst J; Chen, I-Ping JBMR plus 2022 Jan;6(1):e10562
Sensitive Physiological Indices of Pain Based on Differential Characteristics of Electrodermal Activity.
Kong, Youngsun; Posada-Quintero, Hugo F; Chon, Ki H IEEE transactions on bio-medical engineering 2021 Oct;68(10):3122-3130
Real-Time High-Level Acute Pain Detection Using a Smartphone and a Wrist-Worn Electrodermal Activity Sensor.
Kong, Youngsun; Posada-Quintero, Hugo F; Chon, Ki H Sensors (Basel, Switzerland) 2021 Jun;21(12):
Generation of Keratinocytes from Human Induced Pluripotent Stem Cells Under Defined Culture Conditions.
Sah, Shyam Kishor; Kanaujiya, Jitendra K; Chen, I-Ping; Reichenberger, Ernst J Cellular reprogramming 2020 Dec;
Use of 3D-Printed Guide in Hemisection and Autotransplantation of a Fusion Tooth: a Case Report.
Sato, Manuel; Garcia-Sanchez, Alvaro; Sanchez, Sergio; Chen, I-Ping Journal of endodontics 2020 Dec;
Biodegradable nanofiber-based piezoelectric transducer.
Curry, Eli J; Le, Thinh T; Das, Ritopa; Ke, Kai; Santorella, Elise M; Paul, Debayon; Chorsi, Meysam T; Tran, Khanh T M; Baroody, Jeffrey; Borges, Emily R; Ko, Brian; Golabchi, Asiyeh; Xin, Xiaonan; Rowe, David; Yue, Lixia; Feng, Jianlin; Morales-Acosta, M Daniela; Wu, Qian; Chen, I-Ping; Cui, X Tracy; Pachter, Joel; Nguyen, Thanh D Proceedings of the National Academy of Sciences of the United States of America 2020 Jan;
Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia.
Kanaujiya, Jitendra; Bastow, Edward; Luxmi, Raj; Hao, Zhifang; Zattas, Dimitrios; Hochstrasser, Mark; Reichenberger, Ernst J; Chen, I-Ping Scientific reports 2018 Oct;8(1):15710
Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling.
Liu, Yaling; Sharma, Tulika; Chen, I-Ping; Reichenberger, Ernst; Ueki, Yasuyoshi; Arif, Yumna; Parisi, Daniel; Maye, Peter Bone 2018 Mar;11128-35
Craniometaphyseal Dysplasia Mutations in ANKH Negatively Affect Human Induced Pluripotent Stem Cell Differentiation into Osteoclasts.
Chen, I-Ping; Luxmi, Raj; Kanaujiya, Jitendra; Hao, Zhifang; Reichenberger, Ernst J Stem cell reports 2017 Oct;91369-1376
Human Dendritic Cell-Derived Induced Pluripotent Stem Cell Lines Are Not Immunogenic.
Chhabra, Arvind; Chen, I-Ping; Batra, Deepika Journal of immunology (Baltimore, Md. : 1950) 2017 Jan;1981875-1886
Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia.
Liu, Yaling; Dutra, Eliane H; Reichenberger, Ernst J; Chen, I-Ping Journal of negative results in biomedicine 2016 Oct;15(1):18
Comparison of the Osteogenic Potential of Mineral Trioxide Aggregate and Endosequence Root Repair Material in a 3-dimensional Culture System.
Rifaey, Hisham S; Villa, Max; Zhu, Qiang; Wang, Yu-Hsiung; Safavi, Kamran; Chen, I-Ping Journal of endodontics 2016 Mar;42(5):760-765
Dental Anomalies Associated with Craniometaphyseal Dysplasia.
Chen, I-P; Tadinada, A; Dutra, E H; Utreja, A; Uribe, F; Reichenberger, E J Journal of dental research 2014 Mar;93(6):553-558
Induced pluripotent stem cell reprogramming by integration-free Sendai virus vectors from peripheral blood of patients with craniometaphyseal dysplasia.
Chen, I-Ping; Fukuda, Keiichi; Fusaki, Noemi; Iida, Akihiro; Hasegawa, Mamoru; Lichtler, Alexander; Reichenberger, Ernst J Cellular reprogramming 2013 Dec;15(6):503-13
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.
Wang, Tao; Wu, Hao; Li, Yujing; Szulwach, Keith E; Lin, Li; Li, Xuekun; Chen, I-Ping; Goldlust, Ian S; Chamberlain, Stormy J; Dodd, Ann; Gong, He; Ananiev, Gene; Han, Ji Woong; Yoon, Young-sup; Rudd, M Katharine; Yu, Miao; Song, Chun-Xiao; He, Chuan; Chang, Qiang; Warren, Stephen T; Jin, Peng Nature cell biology 2013 Jun;15(6):700-11
Dental abnormalities in a mouse model for craniometaphyseal dysplasia.
Dutra, E H; Chen, I-P; Reichenberger, E J Journal of dental research 2013 Feb;92(2):173-9
A novel autosomal recessive GJA1 missense mutation linked to Craniometaphyseal dysplasia.
Hu, Ying; Chen, I-Ping; de Almeida, Salome; Tiziani, Valdenize; Do Amaral, Cassio M Raposo; Gowrishankar, Kalpana; Passos-Bueno, Maria Rita; Reichenberger, Ernst J PloS one 2013 Jan;8(8):e73576
Oculofaciocardiodental syndrome: a rare case and review of the literature.
Davoody, Amirparviz; Chen, I-Ping; Nanda, Ravindra; Uribe, Flavio; Reichenberger, Ernst J The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2012 Sep;49(5):e55-60
Two novel large ANKH deletion mutations in sporadic cases with craniometaphyseal dysplasia.
Dutra, E H; Chen, I-P; McGregor, T L; Ranells, J D; Reichenberger, E J Clinical genetics 2012 Jan;81(1):93-5
A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).
Chen, I-Ping; Wang, Liping; Jiang, Xi; Aguila, Hector Leonardo; Reichenberger, Ernst J Human molecular genetics 2011 Mar;20(5):948-61
Inhibitory activities of omega-3 Fatty acids and traditional african remedies on keloid fibroblasts.
Olaitan, Peter B; Chen, I-Ping; Norris, James E C; Feinn, Richard; Oluwatosin, Odunayo M; Reichenberger, Ernst J Wounds : a compendium of clinical research and practice 2011 Jan;23(4):97-106
Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function.
Mukherjee, Padma M; Wang, Chiachien J; Chen, I-Ping; Jafarov, Toghrul; Olsen, Bjorn R; Ueki, Yasuyoshi; Reichenberger, Ernst J American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2010 Aug;138(2):140.e1-140.e11; discussion 140-1
Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties.
Wang CJ, Chen IP, Koczon-Jaremko B, Boskey AL, Ueki Y, Kuhn LT, and Reichenberger EJ. Bone 2010 May;46(5):1306-1315
Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia.
Chen, I-Ping; Wang, Chiachien J; Strecker, Sara; Koczon-Jaremko, Boguslawa; Boskey, Adele; Reichenberger, Ernst J Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Jul;24(7):1206-15
Conventional and surgical endodontic retreatment of a maxillary first molar: unusual anatomy.
Chen, I-Ping; Karabucak, Bekir Journal of endodontics 2006 Mar;32(3):228-30

Reviews

Dental abnormalities in rare genetic bone diseases: Literature review.
Iwata, Eiji; Sah, Shyam Kishor; Chen, I-Ping; Reichenberger, Ernst Clinical anatomy (New York, N.Y.) 2023 Sep;
The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders.
Chen, I-Ping Journal of clinical medicine 2014 Dec;3(4):1490-510
GeneReviews(®)
Pagon, Roberta A; Adam, Margaret P; Ardinger, Holly H; Wallace, Stephanie E; Amemiya, Anne; Bean, Lora JH; Bird, Thomas D; Fong, Chin-To; Mefford, Heather C; Smith, Richard JH; Stephens, Karen 1993 Jan;