Photo of I-Ping  Chen, D.D.S., Ph.D.

I-Ping Chen, D.D.S., Ph.D.

Professor, Endodontics
Academic Office Location:
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-1030


Skeletal Biology and Regeneration Graduate Program

M.S.University of PennsylvaniaMaster of Science in Oral Biology
CertificateUniversity of PennsylvaniaEndodontics
Ph.D.University of Connecticut HealthBiomedical Sciences

Name of Award/HonorAwarding Organization
Outstanding Researcher Faculty Award
P.J. Robinson Award
Young Investigator AwardRare Bone Disease Research Summit
Harold M. Frost Young Investigator AwardThe American Society of Bone and Mineral Research (ASBMR)
Dentist Scientist Pathway to Independence Award (K99/R00)NIDCR

In the Chen laboratory, we mainly focus on the investigation of pathogenic mechanisms of craniometaphyseal dysplasia (CMD) using multiple genetic and molecular biology approaches including a knock-in mouse model for CMD and induced pluripotent stem cells (iPSCs) from CMD patients. We have characterized the CMD mouse model replicating many features of human CMD and identified abnormal properties of osteoclasts and osteoblasts in CMD. Subsequently, I have generated integration-free induced pluripotent stem (iPS) cells from peripheral blood of CMD patients and control subjects. These hiPSCs will be differentiated into osteoclasts to study osteoclast defects in CMD. My long-term goal is to develop therapeutic strategies that can benefit patients with CMD and similar rare bone disorders.

As an endodontist, I am also interested in dental research. In collaboration with Dr. Chon, a biomedical engineer, we aim to develop a quantitative and objective measurement for dental pain. We examine the use of electrodermal activity to assist pulpal diagnosis and assess dental pain. My laboratory has been funded by the American Association of Endodontists to establish a 3D culture modeling system that can be easily analyzed and improve or complement the current assays for testing new dental materials. 

Accepting Lab Rotation Students: Fall 2022 and Spring 2023

Journal Articles