Dr. Choudhary is an Assistant Professor in the Department of Surgery since 2006. He joined the Schenkman laboratory in the Pharmacology Department as a Postdoctoral fellow in 2000 after successfully completing studies toward the Ph.D. in the field of toxicology. He was recipient of two Research Fellowship awards from University Grants Commission, India during his Ph.D. training. His Ph.D. was based on characterization of new physiological roles for the glyoxalase system. His work on describing the toxic effects of methylglyoxal on redox status (toxicol Lett, 1997) was been well received by the scientific community and has been cited at least 20 times in peer reviewed journals. Methylglyoxal, belongs to a class of cytotoxic compounds called a-oxoaldehydes and is metabolized into a non-toxic lactic acid by the two enzymes glyoxalase I and glyoxalase II. The a-oxoaldehydes are involved in free radical generation and cell killing. They are known to be associated in mutagenesis and cancer by modifying DNA/proteins and forming crosslinked adducts similar to advanced glycylation end products (AGE) which are known to contributing to several pathophysiological conditions, e.g., cancer, diabetes, arthritis. The glyoxalase system holds significant importance in regulating allowable levels of toxic oxoaldehydes.
Dr Choudhary has been working with Dr. Schenkman in a collaboration with Prof. Mansoor Sarfarazi, in studies focused on understanding the role of a cytochrome P450 hemoprotein, CYP1B1, in primary congenital glaucoma (PCG). PCG is a disease manifesting during neonatal and early infantile periods of development (0-3 yrs) and is characterized by high intraocular pressure (IOP), which if uncontrolled results to optic nerve damage and permanent loss of vision. It occurs due to abnormal development of the anterior chamber angle of the eye (especially the trabecular meshwork). This developmental anomaly in trabecular meshwork causes obstruction of the proper drainage of aqueous humor outflow resulting in high intraocular pressure (IOP), optic nerve damage, and blindness.