Photo of Dharamainder  Choudhary, Ph.D.

Dharamainder Choudhary, Ph.D.

Assistant Professor of Surgery
Academic Office Location:
UConn Health
263 Farmington Avenue
Farmington, CT 06030-6125
Phone: 860-679-4997
Fax: 860-679-2473

Dr. Choudhary is an Assistant Professor in the Department of Surgery since 2006. He joined the Schenkman laboratory in the Pharmacology Department as a Postdoctoral fellow in 2000 after successfully completing studies toward the Ph.D. in the field of toxicology. He was recipient of two Research Fellowship awards from University Grants Commission, India during his Ph.D. training. His Ph.D. was based on characterization of new physiological roles for the glyoxalase system. His work on describing the toxic effects of methylglyoxal on redox status (toxicol Lett, 1997) was been well received by the scientific community and has been cited at least 20 times in peer reviewed journals. Methylglyoxal, belongs to a class of cytotoxic compounds called a-oxoaldehydes and is metabolized into a non-toxic lactic acid by the two enzymes glyoxalase I and glyoxalase II. The a-oxoaldehydes are involved in free radical generation and cell killing. They are known to be associated in mutagenesis and cancer by modifying DNA/proteins and forming crosslinked adducts similar to advanced glycylation end products (AGE) which are known to contributing to several pathophysiological conditions, e.g., cancer, diabetes, arthritis. The glyoxalase system holds significant importance in regulating allowable levels of toxic oxoaldehydes.

No data available

Name of Award/HonorAwarding Organization
Charles N. Loeser AwardUConn School of Medicine
Star ReviewerUrologic Oncology Journal
First Year Teaching Appreciation Award, UConn Health, CTUConn School of Medicine
Charles N. Loeser Honorable Mention Award, UConn Health, CTUConn School of Medicine
First Year Teaching Appreciation Award, UConn Health, CTDepartment of Medicine, UConn Health
C.A.M.E.L. Award - Anatomy teaching faculty group, UConn Health, CTDepartment of Medicine, UConn Health
Best Poster AwardAmerican Urological Association
Dean's award (Student's research day)UConn Health
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Curriculum Evaluation Committee, School of MedicineEducation CommitteeChairmanUConn HealthUniversity2020
Committee on Undergraduate Medical Education (CUME), School of MedicineAdvisory CommitteeMemberUConn HealthUniversity2020
Education CouncilAdvisory CommitteeDelegate from CUMEUConn HealthUniversity2020
DEI Committee, Department of SurgeryAdvisory CommitteeMemberUConn HealthLocal2020
Course Grading Committee of Fabric of Anatomy LabEducation CommitteeMemberUConn HealthUniversity2019
Admissions CommitteeEducation CommitteeMemberUConn HealthUniversity2018
Department of Defense, US Army, CDMRP, Bladder Cancer Review PanelStudy SectionReviewerExternalInternational20182018
Reviewer for grant proposals (Research Excellence Program)ReviewerUConn-StorrsNational2016
FABLab CommitteeEducation CommitteeMemberUConn HealthUniversity2015

Dr Choudhary has been working with Dr. Schenkman in a collaboration with Prof. Mansoor Sarfarazi, in studies focused on understanding the role of a cytochrome P450 hemoprotein, CYP1B1, in primary congenital glaucoma (PCG). PCG is a disease manifesting during neonatal and early infantile periods of development (0-3 yrs) and is characterized by high intraocular pressure (IOP), which if uncontrolled results to optic nerve damage and permanent loss of vision. It occurs due to abnormal development of the anterior chamber angle of the eye (especially the trabecular meshwork). This developmental anomaly in trabecular meshwork causes obstruction of the proper drainage of aqueous humor outflow resulting in high intraocular pressure (IOP), optic nerve damage, and blindness.

Journal Articles