Stephen J. Crocker, Ph.D.Associate Professor, Neuroscience
Director, Neuroscience Graduate Program
- Education & Training
- Committees & Organizations
- Research Opportunities
- Lab Rotations
|B.Sc.||University of King's College||Biology|
|Ph.D.||University of Ottawa||Pharmacology|
|Postdoc||Ottawa Hospital Research Institute||Neurodegeneration|
|Postdoc||The Scripps Research Institute||Neuropharmacology|
|Postdoc||The Scripps Research Institute||Immunology|
|Fellowship||Ontario Neurotrauma Foundation||Postdoctoral Fellowship|
|Fellowship||National Multiple Sclerosis||Advanced Postdoctoral Fellowship|
|Postdoctoral||Neuroscience Research Institute||Neuroscience|
|Postdoctoral||The Scripps Research Institute||Neuropharmacology|
|Postdoctoral||The Scripps Research Institute||Immunology|
|Name of Award/Honor||Awarding Organization|
|Osborn Award for Excellence in Graduate Teaching in Biomedical Science||The Graduate School, UConn Health|
|National Multiple Sclerosis Society Career Transition Award (2007-2011)||National Multiple Sclerosis Society|
|Dale McFarlin Travel Award||National Multiple Sclerosis Society|
|International Outstanding Young Investigator Award||ICCP|
|Bronze Medal||Ottawa Life Sciences Conference|
|Jock Cleghorn Award.||Canadian College of Neuropsychopharmacology (CCNP)|
|Summer Studentship||Parkinson’s Disease Foundation|
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|Congressionally Directed Medical Research Fund (CDMRF) Study Panel for research on Multiple Sclerosis (a.k.a. "DoD")||Study Section||Chair||External||International||2022|
|Animal Services Advisory Committee||Advisory Committee||Chair||UConn Health||University||2022|
|National Multiple Sclerosis Society Biomedical Research Committee A||Study Section||Chair||External||International||2021||2022|
|Student Behavioral Health Committee||Education Committee||Member||UConn Health||University||2021|
|Neuroscience Graduate Program||Education Committee||Director||UConn Health||University||2020|
|Medical School Admissions Committee||Advisory Committee||Committee Member/Reviewer||UConn Health||University||2019|
|Graduate Programs Committee||Education Committee||Member - Neuroscience AoC Representative||UConn Health||Local||2018|
|Health Center Faculty Review Board||Advisory Committee||Member||UConn Health||Local||2018||2022|
|Journal of Neuroscience Research||Professional/Scientific Journal||Associate Editor||External||International||2018||2022|
|Curriculum Committee - UCHC Graduate School||Education Committee||Member||UConn Health||University||2018|
|Neurochemistry International||Editorial Board||Editorial Advisory Board Member||External||International||2017||2022|
|Institutional Animal Care and Use Committee (IACUC)||Other||Vice-Chair||UConn Health||Local||2016||2025|
|Government Relations Committee (GRC) NMSS||Community Service||Member||External||State||2016||2025|
|Representative of Connecticut at National Multiple Sclerosis Public Policy Conference||Community Service||Member/Representative||External||National||2016|
|American Association of Neuropathologists||Professional/Scientific Organization||Member||External||National||2005|
|American Society of Neurochemistry||Professional/Scientific Organization||Member||External||National||2003|
|Society for Neuroscience||Professional/Scientific Organization||Member||External||National||1999|
My lab is interested in how the immune and nervous systems interact and how this balance is disrupted by disease.
Specifically, my research program has centered around the role of glia in the context of immunity and myelin physiology during development and disease. Several recent studies provide an overview of current research projects in my lab, namely understanding human disease using induced pluripotent stem cells a a disease model (Nicaise et al. 2019 Proc. Natl. Acad. Sci USA), exploring the function of extracellular vesicles in CNS pathophysiology (Willis et al. 2020 Sci Rep; Willis et al. 2019 Proc. Natl. Acad Sci. USA).
We have several projects now exploring the role of cellular senescence, a process associated with aging, on myelin and remyelination in models of multiple sclerosis.
We also also actively studying the contributions of glia and immune cell types to a genetic demyelinating disease, Globoid cell leukodystrophy (Krabbe disease), with a focus on the role of CD8 T cells. We have determined that this fatal genetic disease elicits a profound yet previously undescribed neuroimmunological component, which could lead to novel treatment options for GLD patients.
Most of our studies are translational as we seek to identify fundamental processes related to glial functions and how these may impact the disease and physiology. For instance, we have an active project examining how CNS myelin controls bladder function as the vast majority of MS patients suffer from incontinence and bladder infections are a leading cause of hospitalization in this patient population.
There are research opportunities to study and learn about our projects (as described above), for PhD, MS, MD and MD/PhD candidates.
Accepting Lab Rotation Students: Spring 2023, Summer 2023, and Fall 2023