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Molecular basis for sortase-catalyzed pilus tip assembly.
Bhat, Aadil H; Chang, Chungyu; Das, Asis; Ton-That, Hung mBio 2024 Sep;15(9):e0148424
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Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase.
Chang, Chungyu; Ton-That, HyLam; Osipiuk, Jerzy; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung The Journal of biological chemistry 2024 Apr;107329
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Single-Copy Gene Editing of a Cell Wall-Anchored Pilin in Actinomyces oris.
Bhat, Aadil H; Das, Asis; Ton-That, Hung Methods in molecular biology (Clifton, N.J.) 2024 Jan;2727125-134
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The respiratory enzyme complex Rnf is vital for metabolic adaptation and virulence in Fusobacterium nucleatum.
Britton, Timmie A; Wu, Chenggang; Chen, Yi-Wei; Franklin, Dana; Chen, Yimin; Camacho, Martha I; Luong, Truc T; Das, Asis; Ton-That, Hung mBio 2023 Dec;e0175123
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A cryptic oxidoreductase safeguards oxidative protein folding in Corynebacterium diphtheriae.
Reardon-Robinson, Melissa E; Nguyen, Minh Tan; Sanchez, Belkys C; Osipiuk, Jerzy; Rückert, Christian; Chang, Chungyu; Chen, Bo; Nagvekar, Rahul; Joachimiak, Andrzej; Tauch, Andreas; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2023 Feb;120(8):e2208675120
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Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence.
Chen, Yi-Wei; Camacho, Martha I; Chen, Yimin; Bhat, Aadil H; Chang, Chungyu; Peluso, Emily A; Wu, Chenggang; Das, Asis; Ton-That, Hung mBio 2022 Oct;13(5):e0193622
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A conserved signal-peptidase antagonist modulates membrane homeostasis of actinobacterial sortase critical for surface morphogenesis.
Ramirez, Nicholas A; Wu, Chenggang; Chang, Chungyu; Siegel, Sara D; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2022 Jul;119(28):e2203114119
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The Fused Methionine Sulfoxide Reductase MsrAB Promotes Oxidative Stress Defense and Bacterial Virulence in Fusobacterium nucleatum.
Scheible, Matthew; Nguyen, Cuong T; Luong, Truc Thanh; Lee, Ju Huck; Chen, Yi-Wei; Chang, Chungyu; Wittchen, Manuel; Camacho, Martha I; Tiner, Bethany L; Wu, Chenggang; Tauch, Andreas; Das, Asis; Ton-That, Hung mBio 2022 Jun;13(3):e0302221
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A cell wall anchored glycoprotein confers resistance to cation stress in Actinomyces oris biofilms.
Mamun, Abu Amar M Al; Wu, Chenggang; Chang, Chungyu; Sanchez, Belkys C; Das, Asis; Ton-That, Hung Molecular oral microbiology 2022 Mar;
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Genetic and molecular determinants of polymicrobial interactions in Fusobacterium nucleatum.
Wu, Chenggang; Chen, Yi-Wei; Scheible, Matthew; Chang, Chungyu; Wittchen, Manuel; Lee, Ju Huck; Luong, Truc T; Tiner, Bethany L; Tauch, Andreas; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2021 Jun;118(23):
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Ribonuclease J-Mediated mRNA Turnover Modulates Cell Shape, Metabolism and Virulence in Corynebacterium diphtheriae.
Luong, Truc Thanh; Nguyen, Minh Tan; Chen, Yi-Wei; Chang, Chungyu; Lee, Ju Huck; Wittchen, Manuel; Ton-That, HyLam; Cruz, Melissa; Garsin, Danielle A; Das, Asis; Tauch, Andreas; Ton-That, Hung Microorganisms 2021 Feb;9(2):
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Cell-to-cell interaction requires optimal positioning of a pilus tip adhesin modulated by gram-positive transpeptidase enzymes.
Chang, Chungyu; Wu, Chenggang; Osipiuk, Jerzy; Siegel, Sara D; Zhu, Shiwei; Liu, Xiangan; Joachimiak, Andrzej; Clubb, Robert T; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 116(36):18041-18049 (2019). 2019 Aug;
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In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.
Chang, Chungyu; Amer, Brendan R; Osipiuk, Jerzy; McConnell, Scott A; Huang, I-Hsiu; Hsieh, Van; Fu, Janine; Nguyen, Hong H; Muroski, John; Flores, Erika; Ogorzalek Loo, Rachel R; Loo, Joseph A; Putkey, John A; Joachimiak, Andrzej; Das, Asis; Clubb, Robert T; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2018 May;115E5477-E5486
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Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC.
Wu, Chenggang; Al Mamun, Abu Amar Mohamed; Luong, Truc Thanh; Hu, Bo; Gu, Jianhua; Lee, Ju Huck; D'Amore, Melissa; Das, Asis; Ton-That, Hung mBio 2018 Apr;9(2):
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A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence.
Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Jooya, Neda; Chang, Chungyu; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung Molecular microbiology 2015 Aug;981037-50
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A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris.
Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Chang, Chungyu; Wu, Chenggang; Jooya, Neda; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung The Journal of biological chemistry 2015 Jul;290(35):21393-405
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Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development.
Mishra, Arunima; Devarajan, Bharanidharan; Reardon, Melissa E; Dwivedi, Prabhat; Krishnan, Vengadesan; Cisar, John O; Das, Asis; Narayana, Sthanam V L; Ton-That, Hung Molecular microbiology 2011 Sep;81(5):1205-20
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Cell surface display of minor pilin adhesins in the form of a simple heterodimeric assembly in Corynebacterium diphtheriae.
Chang, Chungyu; Mandlik, Anjali; Das, Asis; Ton-That, Hung Molecular microbiology 2011 Mar;79(5):1236-47
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Adhesion by pathogenic corynebacteria.
Rogers, Elizabeth A; Das, Asis; Ton-That, Hung Advances in experimental medicine and biology 2011 Jan;71591-103
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The Actinomyces oris type 2 fimbrial shaft FimA mediates co-aggregation with oral streptococci, adherence to red blood cells and biofilm development.
Mishra, Arunima; Wu, Chenggang; Yang, Jinghua; Cisar, John O; Das, Asis; Ton-That, Hung Molecular microbiology 2010 Jun;77(4):841-54
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Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria.
Guttilla, Irene K; Gaspar, Andrew H; Swierczynski, Arlene; Swaminathan, Anu; Dwivedi, Prabhat; Das, Asis; Ton-That, Hung Journal of bacteriology 2009 Sep;191(18):5603-12
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The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria.
Mandlik, Anjali; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2008 Sep;105(37):14147-52
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Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae.
Swaminathan, Anu; Mandlik, Anjali; Swierczynski, Arlene; Gaspar, Andrew; Das, Asis; Ton-That, Hung Molecular microbiology 2007 Nov;66(4):961-74
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ADAR editing wobbles the microRNA world.
Das, Asis K; Carmichael, Gordon G ACS chemical biology 2007 Apr;2(4):217-20
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Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells.
Mandlik, Anjali; Swierczynski, Arlene; Das, Asis; Ton-That, Hung Molecular microbiology 2007 Apr;64(1):111-24
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Sortase-catalyzed assembly of distinct heteromeric fimbriae in Actinomyces naeslundii.
Mishra, Arunima; Das, Asis; Cisar, John O; Ton-That, Hung Journal of bacteriology 2007 Apr;189(8):3156-65
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GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming.
Toulmé, F; Mosrin-Huaman, C; Sparkowski, J; Das, A; Leng, M; Rahmouni, A R The EMBO journal 2000 Dec;19(24):6853-9
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The structure of the transcriptional antiterminator NusB from Escherichia coli.
Altieri, A S; Mazzulla, M J; Horita, D A; Coats, R H; Wingfield, P T; Das, A; Court, D L; Byrd, R A Nature structural biology 2000 Jun;7(6):470-4
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The functional role of basic patch, a structural element of Escherichia coli transcript cleavage factors GreA and GreB.
Kulish, D; Lee, J; Lomakin, I; Nowicka, B; Das, A; Darst, S; Normet, K; Borukhov, S The Journal of biological chemistry 2000 Apr;275(17):12789-98
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A novel mutation in the KH domain of polynucleotide phosphorylase affects autoregulation and mRNA decay in Escherichia coli.
García-Mena, J; Das, A; Sánchez-Trujillo, A; Portier, C; Montañez, C Molecular microbiology 1999 Jul;33(2):235-48
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Regulation of the elongation-termination decision at intrinsic terminators by antitermination protein N of phage lambda.
Rees, W A; Weitzel, S E; Das, A; von Hippel, P H Journal of molecular biology 1997 Nov;273(4):797-813
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Complexes of N antitermination protein of phage lambda with specific and nonspecific RNA target sites on the nascent transcript.
Van Gilst, M R; Rees, W A; Das, A; von Hippel, P H Biochemistry 1997 Feb;36(6):1514-24
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Bacteriophage lambda N protein alone can induce transcription antitermination in vitro.
Rees, W A; Weitzel, S E; Yager, T D; Das, A; von Hippel, P H Proceedings of the National Academy of Sciences of the United States of America 1996 Jan;93(1):342-6
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Role of Escherichia coli RNA polymerase alpha subunit in modulation of pausing, termination and anti-termination by the transcription elongation factor NusA.
Liu, K; Zhang, Y; Severinov, K; Das, A; Hanna, M M The EMBO journal 1996 Jan;15(1):150-61
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Components of multiprotein-RNA complex that controls transcription elongation in Escherichia coli phage lambda.
Das, A; Pal, M; Mena, J G; Whalen, W; Wolska, K; Crossley, R; Rees, W; von Hippel, P H; Costantino, N; Court, D; Mazzulla, M; Altieri, A S; Byrd, R A; Chattopadhyay, S; DeVito, J; Ghosh, B Methods in enzymology 1996 Jan;274374-402
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Immunoprinting: a technique used to study dynamic protein-nucleic acid interactions within transcription elongation complex.
Das, A; Barik, S; Ghosh, B; Whalen, W Methods in enzymology 1996 Jan;274363-74
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Modulation of pausing, termination and antitermination in E. coli by the transcription elongation factor NusA: Role of RNA polymerase alpha subunit
Liu K, Zhang Y, Severinov K, Das A, Hanna M EMBO J 1996 Jan;15(1):150-161
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Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda.
Chattopadhyay, S; Hung, S C; Stuart, A C; Palmer, A G; Garcia-Mena, J; Das, A; Gottesman, M E Proceedings of the National Academy of Sciences of the United States of America 1995 Dec;92(26):12131-5
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Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda.
Chattopadhyay, S; Garcia-Mena, J; DeVito, J; Wolska, K; Das, A Proceedings of the National Academy of Sciences of the United States of America 1995 Apr;92(9):4061-5
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Control of transcription processivity in phage lambda: Nus factors strengthen the termination-resistant state of RNA polymerase induced by N antiterminator.
DeVito, J; Das, A Proceedings of the National Academy of Sciences of the United States of America 1994 Aug;91(18):8660-4
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Identification of several rod loci and cloning of the rodD locus of Streptococcus mutans.
Tao, L; Tanzer, J M; Kuramitsu, H K; Das, A Gene 1993 Apr;126(1):123-8
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Electrophysiological abnormalities of the atrial muscle in patients with manifest Wolff-Parkinson-White syndrome associated with paroxysmal atrial fibrillation.
Konoe, A; Fukatani, M; Tanigawa, M; Isomoto, S; Kadena, M; Sakamoto, T; Mori, M; Shimizu, A; Hashiba, K Pacing and clinical electrophysiology : PACE 1992 Jul;15(7):1040-52
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Simultaneous gain and loss of functions caused by a single amino acid substitution in the beta subunit of Escherichia coli RNA polymerase: suppression of nusA and rho mutations and conditional lethality.
Sparkowski, J; Das, A Genetics 1992 Mar;130(3):411-28
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Specificity of antitermination mechanisms. Suppression of the terminator cluster T1-T2 of Escherichia coli ribosomal RNA operon, rrnB, by phage lambda antiterminators.
Ghosh, B; Grzadzielska, E; Bhattacharya, P; Peralta, E; DeVito, J; Das, A Journal of molecular biology 1991 Nov;222(1):59-66
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Action of an RNA site at a distance: role of the nut genetic signal in transcription antitermination by phage-lambda N gene product.
Whalen, W A; Das, A The New biologist 1990 Nov;2(11):975-91
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Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.
Rubinstein, L V; Shoemaker, R H; Paull, K D; Simon, R M; Tosini, S; Skehan, P; Scudiero, D A; Monks, A; Boyd, M R Journal of the National Cancer Institute 1990 Jul;82(13):1113-8
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An analysis of the role of host factors in transcription antitermination in vitro by the Q protein of coliphage lambda.
Barik, S; Das, A Molecular & general genetics : MGG 1990 Jun;222(1):152-6
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Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif.
Lazinski, D; Grzadzielska, E; Das, A Cell 1989 Oct;59(1):207-18
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NusA protein is necessary and sufficient in vitro for phage lambda N gene product to suppress a rho-independent terminator placed downstream of nutL.
Whalen, W; Ghosh, B; Das, A Proceedings of the National Academy of Sciences of the United States of America 1988 Apr;85(8):2494-8
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Rapid sequencing of cloned DNA using a transposon for bidirectional priming: sequence of the Escherichia coli K-12 avtA gene.
Liu, L; Whalen, W; Das, A; Berg, C M Nucleic acids research 1987 Nov;15(22):9461-9
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An antitermination protein engages the elongating transcription apparatus at a promoter-proximal recognition site.
Barik, S; Ghosh, B; Whalen, W; Lazinski, D; Das, A Cell 1987 Sep;50(6):885-99
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Evidence that ribosomal protein S10 itself is a cellular component necessary for transcription antitermination by phage lambda N protein.
Das, A; Ghosh, B; Barik, S; Wolska, K Proceedings of the National Academy of Sciences of the United States of America 1985 Jun;82(12):4070-4
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Autogenous regulation of transcription termination factor Rho.
Barik, S; Bhattacharya, P; Das, A Journal of molecular biology 1985 Apr;182(4):495-508
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nusB: a protein factor necessary for transcription antitermination in vitro by phage lambda N gene product.
Ghosh, B; Das, A Proceedings of the National Academy of Sciences of the United States of America 1984 Oct;81(20):6305-9
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Transcription antitermination in vitro by lambda N gene product: requirement for a phage nut site and the products of host nusA, nusB, and nusE genes.
Das, A; Wolska, K Cell 1984 Aug;38(1):165-73
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Formation of termination-resistant transcription complex at phage lambda nut locus: effects of altered translation and a ribosomal mutation.
Warren, F; Das, A Proceedings of the National Academy of Sciences of the United States of America 1984 Jun;81(12):3612-6
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Mutagenesis and mutation transfer induced by ultraviolet light in plasmid-cloned DNA.
Chattoraj, D K; Cordes, K; Berman, M L; Das, A Gene 1984 Feb;27(2):213-22
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The pleiotropic ts15 mutation of E. coli is an IS1 insertion in the rho structural gene.
Gulletta, E; Das, A; Adhya, S Genetics 1983 Oct;105(2):265-80
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Control of phage lambda development by stability and synthesis of cII protein: role of the viral cIII and host hflA, himA and himD genes.
Hoyt, M A; Knight, D M; Das, A; Miller, H I; Echols, H Cell 1982 Dec;31(3 Pt 2):565-73
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Transcription anti-termination by bacteriophage lambda N gene product
Gottesman M, Adhya S, Das A J Mol Biol 1980 Jan;14057-65
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Utilization of exogenous fuel substrates in shock.
Daniel, A M; Maclean, L D Surgical forum 1979 Jan;30(10):5-7
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Expression of a bacterial gene turned on by a potent carcinogen.
Levine, A; Moreau, P L; Sedgwick, S G; Devoret, R Mutation research 1978 Jan;50(1):29-35
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Interaction of Rna-Polymerase and Rho in Transcription Termination - Coupled Atpase
Das, A.,Merril, C.,Adhya, S. Proc Natl Acad Sci U S A 1978 Jan;75(10):4828-4832
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Role of Rho in transcription termination
Gottesman M, Adhya S, Court D, Das A FEBS Letts 1977 Jan;43163-169
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Isolation and characterization of conditional lethal mutants of Escherichia coli defective in transcription termination factor rho.
Das, A; Court, D; Adhya, S Proceedings of the National Academy of Sciences of the United States of America 1976 Jun;73(6):1959-63
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Microassay for UDP-galactose 4-epimerase activity.
Merril, C R; Das, A K; LaPolla, R J; Prissovsky, I Analytical biochemistry 1976 May;72606-13
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Molecular weight and subunit structure of RNA polymerase I and initiation factor from chromatin of plant cell nuclei.
Ganguly, A; Das, A; Mondal, H; Mandal, R K; Biswas, B B FEBS letters 1973 Aug;34(1):27-30
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Ribonucleic acid polymerase from eukaryotic cells. Effects of factors and rifampicin on the activity of RNA polymerase from chromatin of coconut nuclei.
Mondal, H; Ganguly, A; Das, A; Mandal, R K; Biswas, B B European journal of biochemistry / FEBS 1972 Jun;28(1):143-50
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Ribonuclease J-Mediated mRNA Turnover Modulates Cell Shape, Metabolism and Virulence in Corynebacterium diphtheriae.
Luong TT, Nguyen MT, Chen YW, Chang C, Lee JH, Wittchen M, Ton-That H, Cruz M, Garsin DA, Das A, Tauch A, Ton-That H. Microorganisms. 9(2):389 (2021).
