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Caroline N. Dealy, Ph.D.Associate ProfessorDepartment of Craniofacial Sciences, School of Dental Medicine Department of Biomedical Engineering, School of Dental Medicine Department of Orthopedic Surgery, School of Medicine Department of Cell Biology, School of Medicine
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Education
Awards
| Degree | Institution | Major |
|---|---|---|
| B.S. | University of New Hampshire | Animal Science / preVeterinary |
| Ph.D. | University of Connecticut | Molecular Cell Biology / Developmental Biology |
| Postdoc | UConn Health | Cartilage Biology |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| 2012 Finalist, Connecticut Women of Innovation Award In Entrepreneurial Innovation and Leadership | Connecticut Technology Council |
| Basil O’Connor Research Scholar Award: 1993-1996 | March of Dimes Foundation |
| New Investigator Award: 1992-1995 | Donaghue Medical Research Foundation |
| Eli Lilly Award | Eli Lilly Corporation and the American Teratology Society |
| James G. Wilson Award for Research Excellence | American Teratology Society |
Dr. Dealy’s research is based on her long standing interest in the human skeleton. Her research is exploring the cells and signals that control cartilage development and growth, as well as the response of adult cartilage to injury and aging that lead to disabling conditions like osteoarthritis.
Not accepting students for Lab Rotations at this time
Lab Rotation Projects
Ongoing projects include:
• Identifying growth factor signals that promote regenerative responses in injured articular cartilage
• Developing translatable therapeutic aproaches for osteoarthritis
Journal Articles
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Cross-talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification.
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Nov;
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Chondrocytes respond both anabolically and catabolically to impact loading generally considered non-injurious.
Journal of the mechanical behavior of biomedical materials 2020 Dec;115104252
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
eLife 2017 Dec;6
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Harnessing External Cues: Development and Evaluation of an In Vitro Culture System for Osteochondral Tissue Engineering.
Tissue engineering. Part A 2017 Mar;23719-737
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FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Endocrinology 2016 Oct;1574602-4614
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Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia.
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Mar;243(7):875-93
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Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
PLoS genetics 2014 Mar;5(10):e1000691
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Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo.
Arthritis research & therapy 2013 May;15(3):R60
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The potential of human embryonic stem cells for articular cartilage repair and osteoarthritis
Rheumatology Curr Res 2012 Jan;Accepted(s3-004):
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Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge.
Developmental dynamics : an official publication of the American Association of Anatomists 2011 May;240(5):1289-302
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Direct and progressive differentiation of human embryonic stem cells into the chondrogenic lineage.
Journal of cellular physiology 2010 Sep;224(3):664-71
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Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb.
Development (Cambridge, England) 2009 Aug;136(16):2825-35
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Requirement for ErbB2/ErbB signaling in developing cartilage and bone.
Development, growth & differentiation 2007 Aug;49(6):503-13
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Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limb.
Development, growth & differentiation 2007 Aug;49(6):515-21
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Hyaluronan in limb morphogenesis.
Developmental biology 2007 May;305(2):411-20
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Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.
Matrix biology : journal of the International Society for Matrix Biology 2006 Jan;25(1):27-39
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Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth.
Bone 2005 Dec;37(6):741-50
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Function of BMPs in the apical ectoderm of the developing mouse limb.
Developmental biology 2004 May;269(1):109-22
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Beta-catenin-dependent Wnt signaling in apical ectodermal ridge induction and FGF8 expression in normal and limbless mutant chick limbs.
Development, growth & differentiation 2002 Aug;44(4):315-25
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Roles of insulin-like growth factor-I (IGF-I) and IGF-I binding protein-2 (IGFBP2) and -5 (IGFBP5) in developing chick limbs.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001 Dec;11(6):346-63
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Dlx-5 in limb initiation in the chick embryo.
Developmental dynamics : an official publication of the American Association of Anatomists 1999 Sep;216(1):10-5
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A novel human gene encoding an F-box/WD40 containing protein maps in the SHFM3 critical region on 10q24.
Biochemical and biophysical research communications 1999 Jul;261(1):64-70
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FGFR2 signaling in normal and limbless chick limb buds.
Developmental genetics 1999 Jan;25(4):331-8
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Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development.
Developmental biology 1998 Oct;202(1):43-55
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Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.
Developmental biology 1998 May;197(1):12-24
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Hensen's node provides an endogenous limb-forming signal.
Developmental biology 1997 Aug;188(2):216-23
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FGF-stimulated outgrowth and proliferation of limb mesoderm is dependent on syndecan-3.
Developmental biology 1997 Apr;184(2):343-50
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Ability of FGFs to promote the outgrowth and proliferation of limb mesoderm is dependent on IGF-I activity.
Developmental dynamics : an official publication of the American Association of Anatomists 1996 Aug;206(4):463-9
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IGF-I and insulin in the acquisition of limb-forming ability by the embryonic lateral plate.
Developmental biology 1996 Jul;177(1):291-9
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IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos.
Development (Cambridge, England) 1996 Apr;122(4):1323-30
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Studies on insulin-like growth factor-I and insulin in chick limb morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1995 Jan;202(1):67-79
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Limb mesenchymal cells inhibited from undergoing cartilage differentiation by a tumor promoting phorbol ester maintain expression of the homeobox-containing gene Msx1 and fail to exhibit gap junctional communication.
Biochemical and biophysical research communications 1994 Nov;205(1):429-34
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Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature.
Developmental dynamics : an official publication of the American Association of Anatomists 1994 Feb;199(2):156-67
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Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.
Mechanisms of development 1993 Oct;43(2-3):175-86
Conference Papers
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Studies on epidermal growth factor receptor signaling in vertebrate limb patterning.
Developmental dynamics : an official publication of the American Association of Anatomists 2005 Jun;233(2):288-300
Reviews
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The potential of human embryonic stem cell for articular cartilage repair and osteoarthritis treatment
Rheumatology Current Research 2012 Jan;((S3)):
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Balancing Articular Cartilage Homeostasis in Joint Health and Aging | Talk | UConn-Jackson Conference on Aging | 2014 | Storrs, CT |
| Developing a Therapy for Osteoarthritic Cartilage Damage using hESC-derived Chondrogenic Cells | Talk | Therapeutics Discovery Symposium | 2013 | Boston, MA |
| The Future of Stem Cells | Other | Colin McEnroe Show, National Public Radio | 2013 | Hartford, CT |
| Developmental, Molecular and Cellular Strategies in Cartilage Repair | Talk | Lehigh University Dept of Biology | 2013 | Bethlehem PA |
| Opportunity at the Interface of Academics and Biotechnology | Talk | UCHC School of Dental Medicine Dean’s Seminar | 2012 | UConn Health Center, Farmington, CT |
| Genetic and Cellular Strategies in Cartilage Disease | Talk | 2011 Howard Hughes Lecture Series | 2011 | Wesleyan University, Middletown, CT |
| Stem Cells for Profit? | Panel Discussion | StemConn 2011 | 2011 | Farmington, CT |