Caroline N. Dealy, PhDProfessor, Orthodontics, School of Dental MedicineDepartment of Biomedical Engineering, School of Dental Medicine Department of Orthopedic Surgery, School of Medicine Department of Cell Biology, School of Medicine
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- Education & Training
- Teaching
- Committees & Organizations
- Research
- Research Opportunities
- Lab Rotations
- Publications
- Presentations
Degree | Institution | Major |
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BS | University of New Hampshire | Animal Science / Pre-Veterinary |
PhD | University of Connecticut | Molecular Cell Biology / Developmental Biology |
Postdoc | UConn Health | Cartilage Biology |
Awards
Name of Award/Honor | Awarding Organization |
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Connecticut Academy of Science and Engineering, Elected Member (2024) | Connecticut Academy of Science and Engineering |
ELAM (Executive Leadership in Academic Medicine) National Training Program Selected Participant (2024-2025 Cohort) | Executive Leadership in Academic Medicine Program |
Provost's Award for Outstanding Service (2024) | University of Connecticut Office of the Provost |
Connecticut Women of Innovation: Academic Innovation and Leadership, Finalist (2024) | Connecticut Technology Council |
Connecticut Women of Innovation: Innovation in Post-Secondary Education, Nominee (2019) | Connecticut Technology Council |
Osborn Teaching Award, First Place Runner Up (2017) | UConn Graduate School |
Excellence in Mentorship, Young Innovative Investigator Program (2016) | UConn Center for Clinical and Translational Sciences |
Connecticut Women of Innovation: Academic Innovation and Leadership, Semifinalist | Connecticut Technology Council |
Outstanding Research and Service, Nominee | UConn School of Dental Medicine |
UConn School of Dental Medicine Outstanding Research and Service, Nominee (2015) | UConn School of Dental Medicine |
Connecticut Women of Innovation, Entrepreneurial Innovation and Leadership, Nominee (2012) | Connecticut Technology Council |
Basil O’Connor Research Scholar Award (1993) | March of Dimes Foundation |
Donaghue Foundation New Investigator Award (1992) | Patrick and Catherine Weldon Donaghue Medical Research Foundation |
Eli Lilly Research Award (1990) | Eli Lilly Corporation and the American Teratology Society |
James Wilson Award for Research Excellence (1990) | American Teratology Society |
Dr. Dealy teaches courses on Clinical Innovation for medical and dental students, as well as Skeletal Biology, Developmental Biology, Stem Cells, and Scientific Writing for graduate students.
She is the former director of UConn Health’s PhD program in Skeletal Biology and the founder and former director of Eggsperiencing Biology, a middle school STEM outreach program.
Dr. Dealy has mentored 47 trainees in her research laboratory, from junior faculty to undergraduate students; 50% of her mentees are underrepresented, and 70% are women.
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
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Research Histology Core Advisory Committee | Advisory Committee | Advisory member | UConn Health | University | 2024 | |
Dental Senate, Department Representative | Education Committee | Representative | UConn Health | University | 2024 | |
QuantumCT Workforce and Education Committee | Other | Chair | Other | State | 2023 | |
QuantumCT Communications Committee | Other | co-Chair | Other | State | 2023 | |
Skeletal Biology and Regeneration program Fall Symposium | Education Committee | co-organizer | UConn Health | University | 2022 | |
Connecticut Chapter: Women in Bio | Professional/Scientific Organization | founding member | External | National | 2020 | |
Connecticut Women in Bio Mentors and Advisors Committee | Professional/Scientific Organization | co-Chair | External | State | 2020 | |
Graduate Faculty Council | Education Committee | Elected Institutional Representative | UConn Health | University | 2020 | 2022 |
Accelerate UConn i-Corps training site | Other | faculty liaision | UConn-Storrs | University | 2020 | |
Institutional Stem Cell Research Oversight Committee | Other | member | UConn-Storrs | University | 2019 | |
Skeletal Biology and Regeneration Program Alumni & Awards Committee | Education Committee | Chair | UConn Health | University | 2018 | |
Institutional Financial Conflict of Interest Committee | Other | Chair | UConn-Storrs | University | 2017 | |
Connecticut PIE (Partnership in Innovation and Education) program | Education Committee | Program Founder and Director | External | State | 2017 | 2020 |
Dental Faculty Assessment Committee | Education Committee | co-Chair | UConn Health | University | 2017 | 2018 |
EggsPeriencing Biology STEM Outreach Program | Community Service | Program Founder and Director | External | Local | 2015 | 2018 |
Young Innovative Investigator Program | Advisory Committee | Advisory member | UConn-Storrs | University | 2014 | |
StemCONN Scientific Conference | Professional/Scientific Organization | Organizing Chair; co-Chair | External | State | 2013 | 2021 |
NSF Organismal Systems Grant Review Panels | Research Committee | Reviewer | External | National | 2013 | 2016 |
Skeletal Biology and Regeneration Program | Education Committee | Program Director, Assoc Director, ex officio Director | UConn Health | University | 2012 | 2018 |
TIP Innovation Fellows Program | Education Committee | Program Founder and Director | UConn-Storrs | University | 2012 | |
Dept of Defense Grant Review Panels (17 different panels over 12 years) | Research Committee | Reviewer (17 times) or Chair (4 times) | External | National | 2011 | |
NIH Developmental Biology Grant Review Panel | Research Committee | reviewer | External | National | 2008 | 2010 |
Biomedical Sciences Admissions Committee | Education Committee | member and reviewer | UConn Health | University | 2006 | 2018 |
NIH Aging and Geriatrics Grant Review Panel | Research Committee | reviewer | External | National | 2003 | 2003 |
Research, Innovation, Leadership, and Major Service Roles:
Research: Dr. Dealy’s research is based on her long-standing interest in the human skeleton. Her research is exploring the cells and signals that control cartilage development and growth, as well as the response of adult cartilage to injury and aging that lead to disabling conditions like osteoarthritis. Her current studies are identifying agents that activate latent regenerative capacity by articular cartilage tissue. These agents offer clinical utility for improving cartilage repair outcomes or as treatments for osteoarthritis.
Innovation: Dr. Dealy is committed to translating the results of her research toward clinical benefit through research commercialization. She is an inventor with two issued patents and a serial startup founder. She is an alumnus of the NSF-iCorps Accelerate UConn entrepreneurship training program and the ABCT Accelerator for Biosciences in Connecticut program.
Leadership: Dr. Dealy is active in the innovation ecosystem at UConn and in the State and serves as faculty liaison for UConn’s flagship entrepreneurship training program, Accelerate UConn. She is also founder and director of the TIP Innovation Fellows program, a student internship program that places UConn students with UConn-affiliated startup companies for mentored entrepreneurship experience (220 student and 70 companies have participated to date). She is also prior founder and director of the Connecticut Partnership for Innovation and Education (PIE), a consortium 9 Connecticut institutions of higher education that engaged 188 students in bioscience research and career development. Currently, Dr. Dealy is leading a state-wide workforce development and education initiative for QuantumCT, Connectiut’s quantum technology engine.
Community Service: Dr. Dealy is a founding member of the Connecticut Chapter of Women in Bio, a professional leadership organization, and co-chairs its mentorship and advising committee. Dr. Dealy is also a former chair and co-chair of StemCONN, Connecticut’s biannual bioscience and stem cell conference.
Ongoing projects include:
• Identifying growth factor signals that promote regenerative responses in injured articular cartilage
• Developing translatable therapeutic approaches for osteoarthritis
Not Accepting Lab Rotation Students at this time.
Please see Dr. Dealy for more information on research opportunities.
Ongoing projects include:
• Identifying growth factor signals that promote regenerative responses in injured articular cartilage
• Developing translatable therapeutic approaches for osteoarthritis
Journal Articles
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Anabolic Response of Intermittent Parathyroid Hormone and Alendronate on the Osteochondral Tissue of TMJ
Cartilage 2022 Oct;19476035221109229
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Cross-talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification.
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Nov;
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Chondrocytes respond both anabolically and catabolically to impact loading generally considered non-injurious.
Journal of the mechanical behavior of biomedical materials 2020 Dec;115104252
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
eLife 2017 Dec;6
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Harnessing External Cues: Development and Evaluation of an In Vitro Culture System for Osteochondral Tissue Engineering.
Tissue engineering. Part A 2017 Mar;23719-737
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FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Endocrinology 2016 Oct;1574602-4614
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Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia.
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Mar;243(7):875-93
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Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
PLoS genetics 2014 Mar;5(10):e1000691
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Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo.
Arthritis research & therapy 2013 May;15(3):R60
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The potential of human embryonic stem cells for articular cartilage repair and osteoarthritis
Rheumatology Curr Res 2012 Jan;Accepted(s3-004):
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Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge.
Developmental dynamics : an official publication of the American Association of Anatomists 2011 May;240(5):1289-302
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Direct and progressive differentiation of human embryonic stem cells into the chondrogenic lineage.
Journal of cellular physiology 2010 Sep;224(3):664-71
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Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb.
Development (Cambridge, England) 2009 Aug;136(16):2825-35
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Requirement for ErbB2/ErbB signaling in developing cartilage and bone.
Development, growth & differentiation 2007 Aug;49(6):503-13
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Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limb.
Development, growth & differentiation 2007 Aug;49(6):515-21
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Hyaluronan in limb morphogenesis.
Developmental biology 2007 May;305(2):411-20
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Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.
Matrix biology : journal of the International Society for Matrix Biology 2006 Jan;25(1):27-39
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Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth.
Bone 2005 Dec;37(6):741-50
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Function of BMPs in the apical ectoderm of the developing mouse limb.
Developmental biology 2004 May;269(1):109-22
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Beta-catenin-dependent Wnt signaling in apical ectodermal ridge induction and FGF8 expression in normal and limbless mutant chick limbs.
Development, growth & differentiation 2002 Aug;44(4):315-25
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Roles of insulin-like growth factor-I (IGF-I) and IGF-I binding protein-2 (IGFBP2) and -5 (IGFBP5) in developing chick limbs.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001 Dec;11(6):346-63
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Dlx-5 in limb initiation in the chick embryo.
Developmental dynamics : an official publication of the American Association of Anatomists 1999 Sep;216(1):10-5
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A novel human gene encoding an F-box/WD40 containing protein maps in the SHFM3 critical region on 10q24.
Biochemical and biophysical research communications 1999 Jul;261(1):64-70
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FGFR2 signaling in normal and limbless chick limb buds.
Developmental genetics 1999 Jan;25(4):331-8
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Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development.
Developmental biology 1998 Oct;202(1):43-55
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Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.
Developmental biology 1998 May;197(1):12-24
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Hensen's node provides an endogenous limb-forming signal.
Developmental biology 1997 Aug;188(2):216-23
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FGF-stimulated outgrowth and proliferation of limb mesoderm is dependent on syndecan-3.
Developmental biology 1997 Apr;184(2):343-50
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Ability of FGFs to promote the outgrowth and proliferation of limb mesoderm is dependent on IGF-I activity.
Developmental dynamics : an official publication of the American Association of Anatomists 1996 Aug;206(4):463-9
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IGF-I and insulin in the acquisition of limb-forming ability by the embryonic lateral plate.
Developmental biology 1996 Jul;177(1):291-9
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IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos.
Development (Cambridge, England) 1996 Apr;122(4):1323-30
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Studies on insulin-like growth factor-I and insulin in chick limb morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1995 Jan;202(1):67-79
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Limb mesenchymal cells inhibited from undergoing cartilage differentiation by a tumor promoting phorbol ester maintain expression of the homeobox-containing gene Msx1 and fail to exhibit gap junctional communication.
Biochemical and biophysical research communications 1994 Nov;205(1):429-34
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Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature.
Developmental dynamics : an official publication of the American Association of Anatomists 1994 Feb;199(2):156-67
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Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.
Mechanisms of development 1993 Oct;43(2-3):175-86
Conference Papers
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Studies on epidermal growth factor receptor signaling in vertebrate limb patterning.
Developmental dynamics : an official publication of the American Association of Anatomists 2005 Jun;233(2):288-300
Reviews
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The potential of human embryonic stem cell for articular cartilage repair and osteoarthritis treatment
Rheumatology Current Research 2012 Jan;((S3)):
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Women Technology Pioneers in Connecticut | Panel Discussion | Jackson Laboratories for Genomic Medicine and Women in Bio professional leadership organization | 2023 | Jackson Laboratories for Genomic Medicine, Farmington CT |
Education for Connecticut's Quantum Workforce | Panel Discussion | QuantumCT | 2023 | Hartford, CT |
Directed Cell Migration by Articular Cartilage Superficial Zone Cells | Talk | ICRS: International Cartilage Repair Society | 2022 | Berlin, Germany |
Biologic Approach for Articular Cartilage Repair | Lecture | AOSSM: American Orthopedic Society for Sports Medicine | 2022 | remote |
Strategies to reactivate limb regenerative potential in higher vertebrates: | Panel Discussion | NICHD National Strategic Plan on Human Limb Regeneration Working Group | 2021 | remote |
Innovation in Cartilage Repair and Regeneration Strategies | Lecture | Sema4 Incorporated | 2019 | Branford, CT |
ErbB Signaling in Mammalian Digit Regeneration | Talk | 14th International Limb Development Conference | 2019 | Barcelona, Spain |
Characteristics for Entrepreneurship Success | Lecture | Healthcare Innovation and Entrepreneurship Essentials Workshop | 2019 | School of Nursing, Storrs CT |
Stem Cells and Cartilage Repair | Panel Discussion | AdvanceCT: Select USA International Investor Forum Japan | 2019 | remote |
Balancing Articular Cartilage Homeostasis in Joint Health and Aging | Talk | UConn-Jackson Conference on Aging | 2014 | Storrs, CT |
Developing a Therapy for Osteoarthritic Cartilage Damage using hESC-derived Chondrogenic Cells | Talk | Therapeutics Discovery Symposium | 2013 | Boston, MA |
The Future of Stem Cells | Panel Discussion | Colin McEnroe Show, National Public Radio | 2013 | Hartford, CT |
Developmental, Molecular and Cellular Strategies in Cartilage Repair | Talk | Lehigh University Dept of Biology | 2013 | Bethlehem PA |
Opportunity at the Interface of Academics and Biotechnology | Talk | UConn School of Dental Medicine Dean’s Seminar | 2012 | UConn Health, Farmington, CT |
Genetic and Cellular Strategies in Cartilage Disease | Talk | 2011 Howard Hughes Lecture Series | 2011 | Wesleyan University, Middletown, CT |
Stem Cells for Profit? | Panel Discussion | StemConn 2011 | 2011 | Farmington, CT |
Genetic and Cellular Strategies in Cartilage Disease | Lecture | Howard Hughes Lecture Series | 2011 | Wesleyan University, Middletown CT |
ErbB Signaling in Cartilage and Bone | Talk | 10th International Limb Development Conference | 2006 | Awaji, Japan |
Patterning of the Vertebrate Limb | Talk | National Institute of Child Health and Development | 1999 | Bethesda, MD |