Photo of Madison L. Doolittle, Ph.D.

Madison L. Doolittle, Ph.D.

Assistant Professor, Center for Regenerative Medicine and Skeletal Development
Academic Office Location:
Center for Regenerative Medicine and Skeletal Development
UConn School of Dental Medicine
263 Farmington Avenue
Farmington, CT 06030-3705
Phone: 860-679-1757
Education
DegreeInstitutionMajor
B.S.Rochester Institute of TechnologyBiomedical Sciences
Ph.D.University of RochesterPathology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralMayo ClinicAging & Endocrinology

Awards
Name of Award/HonorAwarding Organization
Raisz-Drezner JBMR First Paper AwardAmerican Society for Bone and Mineral Research
Top Abstract - 8th International Cell Senescence Association ConferenceICSA
Annual Meeting Poster AwardSenNet Consortium
John Haddad Young Investigator AwardAmerican Society for Bone and Mineral Research
Edward C. Kendall Fellowship in BiochemistryMayo Clinic
Innovation in Aging AwardMayo Clinic
Center for Biomedical Discovery Pilot AwardMayo Clinic
Annual Meeting Young Investigator AwardAmerican Society for Bone and Mineral Research
NIH Loan Repayment Grant in Clinical ResearchNational Institute on Aging
Glenn Foundation for Medical Research Fellowship in Aging ResearchAmerican Federation for Aging Research
Kogod Aging Center Early-Stage Career Development AwardMayo Clinic
Center for Professional Development Travel GrantUniversity of Rochester
Pathology Research Day Best Poster PresentationUniversity of Rochester
Travel Grant to the IFMRS Herbert Fleisch WorkshopAmerican Society for Bone and Mineral Research
Pathology Research Day Best Oral PresentationUniversity of Rochester
ORS Upstate NY & Northeast Regional Symposium Poster AwardUniversity of Rochester
Graduate Student Society Poster Competition Award WinnerUniversity of Rochester
Summer Undergraduate Research FellowshipRochester Institute of Technology
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Advances in Mineral Metabolism (AIMM)Professional/Scientific OrganizationMemberNational2023
NIH SenNet Consortium - Biomarkers Working GroupResearch CommitteeMemberNational2023
Gerontological Society of America (GSA)Professional/Scientific OrganizationMemberNational2022
American Aging Association (AGE)Professional/Scientific OrganizationMemberNational2020
American Society for Bone and Mineral Research (ASBMR)Professional/Scientific OrganizationMemberNational2016

We study mechanisms of musculoskeletal aging, specifically within the bone microenvironment. With age, a higher proportion of cells exhibit cellular senescence: a growth-arrested, yet inflammatory state that drives tissue dysfunction. A primary focus of our laboratory is to understand the paracrine effects of senescence with neighboring immune and mesenchymal cells, which may shed light on how senescent cells evade immune clearance and perpetuate age-related diseases.

We are accepting lab rotations starting in 2025

Journal Articles

Reviews