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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.
Farr, Joshua N; Atkinson, Elizabeth J; Achenbach, Sara J; Volkman, Tammie L; Tweed, Amanda J; Vos, Stephanie J; Ruan, Ming; Sfeir, Jad; Drake, Matthew T; Saul, Dominik; Doolittle, Madison L; Bancos, Irina; Yu, Kai; Tchkonia, Tamara; LeBrasseur, Nathan K; Kirkland, James L; Monroe, David G; Khosla, Sundeep Nature Medicine 2024 Sep;30(9):2605-2612
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SenNet recommendations for detecting senescent cells in different tissues.
Suryadevara, Vidyani; Hudgins, Adam D; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M; Aguayo-Mazzucato, Cristina; Baker, Darren J; Bernlohr, David A; Jurk, Diana; Mangarova, Dilyana B; Quardokus, Ellen M; Enninga, Elizabeth Ann L; Schmidt, Elizabeth L; Chen, Feng; Duncan, Francesca E; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A; Lee, Gung; Daldrup-Link, Heike E; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M; Rahman, Irfan; Nie, Jia; Passos, João F; Silverstein, Jonathan C; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J; Ding, Li; Wang, Lichao; Adams, Lisa C; Ruiyang, Liu; Doolittle, Madison L; Teneche, Marcos G; Schafer, Marissa J; Xu, Ming; Hajipour, Mohammadjavad; Boroumand, Mozhgan; Basisty, Nathan; Sloan, Nicholas; Slavov, Nikolai; Kuksenko, Olena; Robson, Paul; Gomez, Paul T; Vasilikos, Periklis; Adams, Peter D; Carapeto, Priscila; Zhu, Quan; Ramasamy, Ramalakshmi; Perez-Lorenzo, Rolando; Fan, Rong; Dong, Runze; Montgomery, Ruth R; Shaikh, Sadiya; Vickovic, Sanja; Yin, Shanshan; Kang, Shoukai; Suvakov, Sonja; Khosla, Sundeep; Garovic, Vesna D; Menon, Vilas; Xu, Yanxin; Song, Yizhe; Suh, Yousin; Dou, Zhixun; Neretti, Nicola. Nature Reviews Molecular Cell Biology. 2024 Jun;
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Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
Saul, Dominik; Doolittle, Madison L; Rowsey, Jennifer L; Froemming, Mitchell N; Kosinsky, Robyn L; Vos, Stephanie J; Ruan, Ming; LeBrasseur, Nathan K; Chandra, Abhishek; Pignolo, Robert J; Passos, João F; Farr, Joshua N; Monroe, David G; Khosla, Sundeep The Journal of Clinical Investigation 2024 May;
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Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages.
Zhang, Xu; Ng, Yan Er; Chini, Lucas C S; Heeren, Amanda A; White, Thomas A; Li, Hao; Huang, Haojie; Doolittle, Madison L; Khosla, Sundeep; LeBrasseur, Nathan K Aging Cell 2024 Mar;23(3):e14069
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Modest Effects of Osteoclast-Specific ERα Deletion after Skeletal Maturity.
Doolittle, Madison L; Eckhardt, Brittany A; Vos, Stephanie J; Grain, Sarah; Rowsey, Jennifer L; Ruan, Ming; Saul, Dominik; Farr, Joshua N; Weivoda, Megan M; Khosla, Sundeep; Monroe, David G JBMR Plus 2023 Oct;7(10):e10797
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Single-Cell Integration of BMD GWAS Results Prioritize Candidate Genes Influencing Age-Related Bone Loss.
Doolittle, Madison L; Khosla, Sundeep; Saul, Dominik JBMR Plus 2023 Oct;7(10):e10795
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Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton.
Doolittle, Madison L; Saul, Dominik; Kaur, Japneet; Rowsey, Jennifer L; Vos, Stephanie J; Pavelko, Kevin D; Farr, Joshua N; Monroe, David G; Khosla, Sundeep Nature Communications 2023 Jul;14(1):4587
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MicroRNA-19a-3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence.
Kaur, Japneet; Saul, Dominik; Doolittle, Madison L; Farr, Joshua N; Khosla, Sundeep; Monroe, David G JBMR Plus 2023 Jun;7(6):e10745
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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Samakkarnthai, Parinya; Saul, Dominik; Zhang, Lei; Aversa, Zaira; Doolittle, Madison L; Sfeir, Jad G; Kaur, Japneet; Atkinson, Elizabeth J; Edwards, James R; Russell, Graham G; Pignolo, Robert J; Kirkland, James L; Tchkonia, Tamar; Niedernhofer, Laura J; Monroe, David G; Lebrasseur, Nathan K; Farr, Joshua N; Robbins, Paul D; Khosla, Sundeep Aging 2023 May;15(9):3331-3355
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr, Joshua N; Saul, Dominik; Doolittle, Madison L; Kaur, Japneet; Rowsey, Jennifer L; Vos, Stephanie J; Froemming, Mitchell N; Lagnado, Anthony B; Zhu, Yi; Weivoda, Megan; Ikeno, Yuji; Pignolo, Robert J; Niedernhofer, Laura J; Robbins, Paul D; Jurk, Diana; Passos, João F; LeBrasseur, Nathan K; Tchkonia, Tamara; Kirkland, James L; Monroe, David G; Khosla, Sundeep The Journal of Clinical Investigation 2023 Apr;133(8):
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Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice.
Doolittle, Madison L; Saul, Dominik; Kaur, Japneet; Rowsey, Jennifer L; Eckhardt, Brittany; Vos, Stephanie; Grain, Sarah; Kroupova, Kveta; Ruan, Ming; Weivoda, Megan; Oursler, Merry Jo; Farr, Joshua N; Monroe, David G; Khosla, Sundeep Journal of Bone and Mineral Research 2022 Sep;37(9):1750-1760
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
Saul, Dominik; Kosinsky, Robyn Laura; Atkinson, Elizabeth J; Doolittle, Madison L; Zhang, Xu; LeBrasseur, Nathan K; Pignolo, Robert J; Robbins, Paul D; Niedernhofer, Laura J; Ikeno, Yuji; Jurk, Diana; Passos, João F; Hickson, LaTonya J; Xue, Ailing; Monroe, David G; Tchkonia, Tamara; Kirkland, James L; Farr, Joshua N; Khosla, Sundeep Nature Communications 2022 Aug;13(1):4827
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Identification of a suitable endogenous control miRNA in bone aging and senescence.
Kaur, Japneet; Saul, Dominik; Doolittle, Madison L; Rowsey, Jennifer L; Vos, Stephanie J; Farr, Joshua N; Khosla, Sundeep; Monroe, David G Gene 2022 Aug;835146642
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Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
Chandra, Abhishek; Lagnado, Anthony B; Farr, Joshua N; Doolittle, Madison; Tchkonia, Tamara; Kirkland, James L; LeBrasseur, Nathan K; Robbins, Paul D; Niedernhofer, Laura J; Ikeno, Yuji; Passos, João F; Monroe, David G; Pignolo, Robert J; Khosla, Sundeep Aging Cell 2022 May;21(5):e13602
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Modulation of fracture healing by the transient accumulation of senescent cells.
Saul, Dominik; Monroe, David G; Rowsey, Jennifer L; Kosinsky, Robyn Laura; Vos, Stephanie J; Doolittle, Madison L; Farr, Joshua N; Khosla, Sundeep eLife 2021 Oct;10
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Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D; Dolan, David; Reeves, Helen L; Grellscheid, Sushma; Wilson, Colin H; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L; Jurk, Diana; Mann, Derek A; Passos, João F The EMBO Journal 2021 May;40(9):e106048
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Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts.
Doolittle, Madison L; Ackert-Bicknell, Cheryl L; Jonason, Jennifer H Methods in Molecular Biology (Clifton, N.J.) 2021 Jan;2230425-436
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Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.
Doolittle, Madison L; Calabrese, Gina M; Mesner, Larry D; Godfrey, Dana A; Maynard, Robert D; Ackert-Bicknell, Cheryl L; Farber, Charles R PLoS genetics 2020 Jun;16(6):e1008805
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Targeting the gut microbiome to treat the osteoarthritis of obesity.
Schott, Eric M; Farnsworth, Christopher W; Grier, Alex; Lillis, Jacquelyn A; Soniwala, Sarah; Dadourian, Gregory H; Bell, Richard D; Doolittle, Madison L; Villani, David A; Awad, Hani; Ketz, John P; Kamal, Fadia; Ackert-Bicknell, Cheryl; Ashton, John M; Gill, Steven R; Mooney, Robert A; Zuscik, Michael J JCI Insight 2018 Apr;3(8):
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A nondestructive, reproducible method of measuring joint reaction force at the distal radioulnar joint.
Canham, Colin D; Schreck, Michael J; Maqsoodi, Noorullah; Doolittle, Madison; Olles, Mark; Elfar, John C The Journal of Hand Surgery 2015 Jun;40(6):1138-44
