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Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase.
Egbert, Jeremy R*; Silbern, Ivan; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Urlaub, Henning*; Jaffe, Laurinda A* Biology of reproduction 2023 Sep;
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Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases.
Egbert, Jeremy R*; Uliasz, Tracy F; Lowther, Katie M; Kaback, Deborah; Wagner, Brandon M; Healy, Chastity L; O'Connell, Timothy D; Potter, Lincoln R; Jaffe, Laurinda A*; Yee, Siu-Pok* Frontiers in molecular neuroscience 2022 Oct;151007026
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A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.
Lusk, Savannah J; McKinney, Andrew; Hunt, Patrick J; Fahey, Paul G; Patel, Jay; Chang, Andersen; Sun, Jenny J; Martinez, Vena K; Zhu, Ping Jun; Egbert, Jeremy R; Allen, Genevera; Jiang, Xiaolong; Arenkiel, Benjamin R; Tolias, Andreas S; Costa-Mattioli, Mauro; Ray, Russell S BMC biology 2022 Jan;20(1):28
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
Shuhaibar, Leia C; Kaci, Nabil; Egbert, Jeremy R; Horville, Thibault; Loisay, Léa; Vigone, Giulia; Uliasz, Tracy F; Dambroise, Emilie; Swingle, Mark R; Honkanen, Richard E; Biosse Duplan, Martin; Jaffe, Laurinda A; Legeai-Mallet, Laurence JCI insight 2021 May;6(9):e141426
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Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles.
Egbert, Jeremy R; Robinson, Jerid W; Uliasz, Tracy F; Potter, Lincoln R; Jaffe, Laurinda A Biology of reproduction 2021 Feb;104(5):939-941
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Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles.
Baena, Valentina; Owen, Corie M; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Terasaki, Mark; Egbert, Jeremy R; Jaffe, Laurinda A Endocrinology 2020 May;161(7)bgaa074
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Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles.
Egbert, Jeremy R; Fahey, Paul G; Reimer, Jacob; Owen, Corie M; Evsikov, Alexei V; Nikolaev, Viacheslav O; Griesbeck, Oliver; Ray, Russell S; Tolias, Andreas S; Jaffe, Laurinda A Biology of Reproduction 2019 Aug;101(2)433-444
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Multiple cAMP phosphodiesterases act together to prevent premature oocyte meiosis and ovulation.
Vigone, Giulia; Shuhaibar, Leia C; Egbert, Jeremy R; Uliasz, Tracy F; Movsesian, Matthew A; Jaffe, Laurinda A Endocrinology 2018 Mar;1592142-2152
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Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.
Egbert, Jeremy R; Yee, Siu-Pok; Jaffe, Laurinda A Developmental biology 2018 Mar;435(1):6-14
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
Shuhaibar, Leia C; Robinson, Jerid W; Vigone, Giulia; Shuhaibar, Ninna P; Egbert, Jeremy R; Baena, Valentina; Uliasz, Tracy F; Kaback, Deborah; Yee, Siu-Pok; Feil, Robert; Fisher, Melanie C; Dealy, Caroline N; Potter, Lincoln R; Jaffe, Laurinda A eLife 2017 Dec;6
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Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Robinson, Jerid W; Egbert, Jeremy R; Davydova, Julia; Schmidt, Hannes; Jaffe, Laurinda A; Potter, Lincoln R Cellular signalling 2017 Sep;40222-229
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Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.
Jaffe, Laurinda; Egbert, Jeremy R Annual review of physiology 2017 Jan;79237-260
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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Egbert, Jeremy R; Uliasz, Tracy F; Shuhaibar, Leia C; Geerts, Andreas; Wunder, Frank; Kleiman, Robin J; Humphrey, John M; Lampe, Paul D; Artemyev, Nikolai O; Rybalkin, Sergei D; Beavo, Joseph A; Movsesian, Matthew A; Jaffe, Laurinda A Biology of reproduction 2016 May;94(5):110
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Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Shuhaibar, Leia C; Egbert, Jeremy R; Edmund, Aaron B; Uliasz, Tracy F; Dickey, Deborah M; Yee, Siu-Pok; Potter, Lincoln R; Jaffe, Laurinda A Developmental biology 2015 Oct;409194-201
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Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Shuhaibar, Leia C; Egbert, Jeremy R; Norris, Rachael P; Lampe, Paul D; Nikolaev, Viacheslav O; Thunemann, Martin; Wen, Lai; Feil, Robert; Jaffe, Laurinda A Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(17):5527-32
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Egbert, Jeremy R; Shuhaibar, Leia C; Edmund, Aaron B; Van Helden, Dusty A; Robinson, Jerid W; Uliasz, Tracy F; Baena, Valentina; Geerts, Andreas; Wunder, Frank; Potter, Lincoln R; Jaffe, Laurinda A Development (Cambridge, England) 2014 Sep;141(18):3594-604