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Noelle Germain, Ph.D.Assistant Professor, Genetics and Genome Sciences
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.S. | Roger Williams University | Biology |
| B.A. | Roger Williams University | Chemistry |
| Ph.D. | Wesleyan University | Stem Cell Biology |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Connecticut Health Center | Research Fellowship Investigating the Cellular and Molecular Mechanisms of Angelman Syndrome and Dup15q Syndrome Using Induced Pluripotent Stem Cell Models |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Dr. Joseph E. Wagstaff Postdoctoral Research Fellowship | Angelman Syndrome Foundation |
| NIH Loan Repayment Program in Pediatric Research, Renewal | National Center for Advancing Translational Sciences |
| Barry Kiefer Prize for Graduate Research in Biology | Wesleyan University |
| Chris Meyer Senior Award in Biology for Academic Excellence in the College of Arts and Sciences | Roger Williams University |
Journal Articles
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A protein regulated by UBE3A PEGs a potential biomarker.
Cell reports. Medicine 2021 Aug;2(8):100377
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Specific ZNF274 binding interference at SNORD116 activates the maternal transcripts in Prader-Willi syndrome neurons.
Human molecular genetics 2020 Sep;
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Abundance and localization of human UBE3A protein isoforms.
Human molecular genetics 2020 Aug;
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A bipartite boundary element restricts UBE3A imprinting to mature neurons.
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan;
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Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells.
Nature communications 2017 Apr;815038
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Cell polarity and neurogenesis in embryonic stem cell-derived neural rosettes.
Stem cells and development 2015 Apr;24(8):1022-33
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Modeling Genomic Imprinting Disorders Using Induced Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.) 2014 Dec;135345-64
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Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1.
Molecular autism 2014 Aug;5(44):44
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Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.
Human molecular genetics 2014 Apr;23(17):4674-85
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Derivation and isolation of NKX2.1-positive basal forebrain progenitors from human embryonic stem cells.
Stem cells and development 2013 May;22(10):1477-89
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Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants.
Cell transplantation 2012 Jan;21(8):1603-11
Reviews
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Embryonic stem cell neurogenesis and neural specification.
Journal of cellular biochemistry 2010 Oct;111(3):535-42
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Investigating the efficacy of novel therapeutic approaches for restoring UBE3A expression in human Angelman syndrome neurons | Lecture | New England Regional Genetics Group Annual Education Conference | 2019 | Portsmouth, NH |
| Investigating the efficacy of novel therapeutic approaches for restoring UBE3A expression in human Angelman syndrome neurons | Talk | Angelman Syndrome Foundation Research Symposium | 2019 | Louisville, KY |
| Investigating novel therapeutic approaches for restoring UBE3A expression in human Angelman syndrome neurons | Talk | Organizzazione Sindrome di Angelman | 2018 | Assisi, Italy |
| Investigating the efficacy of novel therapeutic approaches for restoring UBE3A expression in human Angelman syndrome neurons | Poster | UCONN Postdoc Research Day | 2017 | Farmington, CT |
| Human Induced Pluripotent Stem Cell (iPSC) Models of Angelman Syndrome | Talk | 4th European Angelman Syndrome Scientific Conference / ASSERT | 2015 | Liverpool, United Kingdom |
| Human Induced Pluripotent Stem Cell Models of Chromosome 15q Duplication Syndrome | Poster | StemCONN | 2015 | Hartford, CT |
| Human Induced Pluripotent Stem Cell Models of Chromosome 15q Duplication Syndrome | Poster | Keystone Symposium “Pathways of Neurodevelopmental Disorders” | 2015 | Tahoe City, CA |
| Induced Pluripotent Stem Cell Models of 15q Duplication Syndrome | Poster | Miami Winter Symposium “The Molecular Basis of Brain Disorders” | 2014 | Miami, FL |
| Induced Pluripotent Stem Cell Models of 15q Duplication Syndrome | Talk | 6th Annual New Jersey Stem Cell Research Symposium | 2012 | Bridgewater, NJ |
| From Embryonic Stem Cell to Neuron | Talk | Connecticut Stem Cell Retreat at Wesleyan University | 2012 | Middletown, CT |
| Induced Pluripotent Stem Cell Models of 15q Duplication Syndrome | Poster | 6th Annual New Jersey Stem Cell Research Symposium | 2012 | Bridgewater, NJ |
| Morphogenesis, Patterning, and Differentiation of ESC-derived Neural Rosettes | Poster | 9th Annual International Society for Stem Cell Research Meeting | 2011 | Toronto, Canada |
| Morphogenesis, Patterning, and Differentiation of ESC-derived Neural Rosettes | Poster | StemCONN | 2011 | Farmington, CT |
| Derivation and Isolation of Human Embryonic Stem Cell-Derived Forse1+ Neural Stem Cells | Poster | 8th Annual International Society for Stem Cell Research Meeting | 2010 | San Francisco, CA |
| Human Embryonic Stem Cell-Derived Neural Stem Cells Migrate and Differentiate Following Transplantation to the Mouse Hippocampus | Poster | 7th Annual International Society for Stem Cell Research Meeting | 2009 | Barcelona, Spain |
| Enrichment of Embryonic Stem Cell Derived Neural Stem Cells and Transplantation into the Mouse Hippocampus | Poster | StemCONN | 2009 | Farmington, CT |
| A Role for Sonic Hedgehog in Embryonic Stem Cell Neurogenesis in vitro and Following Transplant to the Mouse Hippocampus | Poster | 6th Annual International Society for Stem Cell Research Meeting | 2008 | Philadelphia, PA |
| The Growth and Adhesion of Two Mouse Mesothelial Cell Lines are Related to their Rates of Tumor Formation | Poster | 45th Annual American Society for Cell Biology Meeting | 2005 | San Francisco, CA |