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Mallika Ghosh, PhDAssistant Professor, Department of Cell BiologyCenter for Vascular Biology
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| BSc | Calcutta University | Chemistry |
| MSc | Calcutta University | Biochemistry |
| PhD | Indian Institute of Chemical Biology | Biochemistry |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Fellowship | Council of Scientific and Industrial Research (CSIR) | Junior Research Fellowship |
| Fellowship | Council of Scientific and Industrial Research | Senior Research Fellowship |
| Postdoctoral | Wayne State University School of Medicine | Postdoctoral Fellow |
| Postdoctoral | Wayne State University | Molecular Biology |
| Postdoctoral | Center for Microbial Pathogenesis, University of Connecticut Health Center | Postdoctoral Fellow |
| Postdoctoral | University of Connecticut Health Center | Cell Biology |
| Postdoctoral | Center for Vascular Biology, University of Connecticut Health Center | Postdoctoral Fellow |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Recipient of 2023 AAI Early Career Faculty Travel Grant | American Association for Immunologists |
| My manuscript entitled "The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins” was selected by the Editors as a Top Read for the February 15, 2024, issue of The Journal of Immunology | Journal of Immunology |
| Selected and invited for joining the PAIR-UP workshop as a PAIR-UP Affiliate hosted by Rockefeller University, part of the American Society for Cell Biology. The role of an Affiliate is to support the goals of PAIR-UP to advance imaging research, imaging workshops; research funds for novel, collaborative research projects using advanced imaging techniques; and professional development workshops to improve the work environment for Black research scientists. | American Society for Cell Biology |
| Selected and invited for joining the PAIR-UP workshop as a PAIR-UP Affiliate hosted by Rockefeller University, part of the American Society for Cell Biology. The role of an Affiliate is to support the goals of PAIR-UP to advance imaging research, imaging workshops; research funds for novel, collaborative research projects using advanced imaging techniques; and professional development workshops to improve the work environment for Black research scientists. | American Society for Cell Biology |
| Invention disclosure- Therapeutic agents for the treatment of cell-cell fusion-related pathologies. Inventors- Mallika Ghosh, Ivo Kalajzic, Linda Shapiro Submitted in 2021. | Technology Commercialization Services Internship Program,UCONN |
| The 20 Most-Frequently Read Articles in The Journal of Immunology December 2020 thru November 2021 Based on full-text and pdf views. Coronavirus Receptors as Immune ModulatorsCharan Kumar V. Devarakonda, Emily Meredith, Mallika Ghosh and Linda H. Shapiro J Immunol 206 (5) 923-929; March 1, 2021 | Journal of Immunology |
| Research Excellance Program- CD13 as a target for controlling myeloid cell fusion for AY2021-2022. Multi-PI. Mallika Ghosh, Joseph Lorenzo, Ivo Kalajzic,Alix Deymier and Linda Shapiro. | OVPR-UCONN |
| Invention disclosure application- submitted in October 2020. Results awaited. Title of invention-Regulation of osteoclast fusion events through modulation of CD13/Aminopeptidase N Inventors- Mallika Ghosh, Ivo Kalajzic and Linda Shapiro | TCS and OVPR-UCONN |
| Ms. Emily Meredith, a graduate student in Dr. Linda Shapiro's lab, whom I co-supervise/mentor won the outstanding Poster award at NAVBO, 2020. | North American Vascular Biology Organization |
| My summer undergraduate student Reileigh Fleeher was awarded first prize for the best overall poster at the Innovation Research Day, UCONN Health Center, 2019 | Partnership in Innovation and Education |
| My recent publication in Science Signaling journal describing CD13’s role in molecular movement was highlighted in The UConn Today. The story is published here: https://today.uconn.edu/2019/05/missing-molecule-hobbles-cell-movement/ | UCONN Today |
| Early career faculty travel award-2012-2018 | American Association of Immunogists |
| Travel award for Gordon Research Conference | Athersclerosis |
| Travel Award for the 9th Annual Winter Eicosanoid Conference | NIEHS/NIH |
| Judge for Best Poster Award | 9th Annual Winter Eicosanoid Conference |
| Travel Award for the 8th Annual Winter Eicosanoid Conference | NIEHS/NIH |
| Outstanding Research Award | Wayne State University |
| Ray K. Brown Award | Wayne State University |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Network for Enriched Mentorship (NEM) , University of Connecticut | Other | Mentor | UConn-Storrs | University | 2024 | |
| North American Vascular Biology Organization (NAVBO)- Education Committee | Education Committee | Journal Club Organizer | External | National | 2023 | |
| Review Editor on the Editorial Board of Inflammation specialty section of Frontiers in Immunology) | Editorial Board | Review Editor | External | International | 2023 | |
| Aetna Health Professions Partnership Initiative, Summer Research Fellowship Program, UCONN Health | Other | Mentor and Supervisor | UConn Health | University | 2023 | |
| International Journal of Molecular Sciences | Editorial Board | Guest Editor | External | International | 2022 | |
| 2022-2023 -Biomedical Sciences PhD program Admissions Committe. Review applications for the 2022 Biomedical Sciences PhD program. Interview and evaluate applicants and attend meetings with other members of the committee. | Education Committee | Committee member, advisor and reviewer | UConn Health | University | 2020 | |
| Journal Editor- Oxidative Medicine and Cellular Longevity | Editorial Board | Editor | External | International | 2019 | |
| USMLE item writing and review committees to review, revise, and help develop questions across the COrE courses within Stage 1 of the curriculum with Dr. Thomas M Manger | Education Committee | Reviewer | UConn Health | University | 2018 | |
| Supervisor and Mentor for UCONN Undergraduates (PIE/TIP program)-University of Saint Joseph, West Hartford, CT | Research Committee | Advisor and Mentor | External | Regional | 2018 | 2018 |
| American Society for Cell Biology | Professional/Scientific Journal | Member | External | National | 2018 | |
| Drop-in Editor with Dr. Caroline Dealy | Education Committee | Editor | UConn Health | University | 2018 | 2019 |
| Research Histology and Molecular Core Facility Advisory Committee | Advisory Committee | Advisor | UConn Health | University | 2018 | |
| Student Research Task Force Member, American Heart Association Founders Committee for medical and undergraduate fellowships with FDA Research Engagement Committee and Chairperson, Dr. Elizabeth Harrington, Professor of Medicine at Brown University, Student Research Task Force. | Education Committee | Reviewer | External | National | 2017 | |
| Supervisor and Mentor for UCONN Undergraduates (Health Research Program, Summer Innovation Fellows partnership programs | Research Committee | Advisor and Mentor | UConn-Storrs | University | 2017 | 2019 |
| Mentor for High school student research apprentice program | Research Committee | Advisor and Mentor | External | Regional | 2017 | 2017 |
| Graduate student thesis committee advisor and mentor in the Center for Vascular Biology and Biomedical Engineering | Advisory Committee | Advisor and Mentor | UConn Health | University | 2017 | |
| American Association of Immunology | Professional/Scientific Journal | Member | External | National | 2014 | |
| Manuscript reviewer for peer reviewed journals- Journal of Pathology, PLOS ONE, Frontiers in Immunology, JOVE, Molecular and Cellular Oncology, Communications Biology, Journal of Experimental Cell Research, Arthritis & Rheumatology, Prostaglandins and other lipid mediators. | Professional/Scientific Journal | Reviewer | External | International | 2008 |
Accepting Lab Rotation Students: Fall Block 2024, Spring 1 Block 2025
Journal Articles
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Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection.
mBio 2024 Oct;e0156124
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The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins.
Journal of immunology (Baltimore, Md. : 1950) 2024 Feb;
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A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843.
Experimental eye research 2023 Oct;235109643
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PDGF inhibits BMP2-induced bone healing.
NPJ Regenerative medicine 2023 Jan;8(1):3
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Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.
International journal of molecular sciences 2022 Oct;23(21):
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Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.
Experimental eye research 2021 Jul;208108628
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
Scientific reports 2021 May;11(1):10736
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Proteoglycan 4 (PRG4) expression and function under dry eye associated inflammation,
BioRxiv Experimental Eye Research (under revision) 2020 Oct;
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
BioRxiv 2020 Jun;
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CD13 Regulation of Membrane Recycling: Implications for Cancer Dissemination.
Mol. Cell. Oncol. 2019 Aug;
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CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.
Atherosclerosis 2019 Jun;28770-80
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CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.
Science signaling 2019 Apr;12(579):
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Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
PloS one 2018 Jan;13(3):e0194053
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Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.
Angiogenesis 2016 Jul;19487-500
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CD13 restricts TLR4 endocytic signal transduction in inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar;194(9):4466-76
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Molecular mechanisms regulating CD13-mediated adhesion.
Immunology 2014 Mar;142(4):636-47
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CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle.
Frontiers in physiology 2014 Jan;4402
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CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury.
Stem cells (Dayton, Ohio) 2013 Dec;32(6):1564-77
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CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.
Cardiovascular research 2013 Oct;100(1):74-83
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Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug;191(7):3905-12
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Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.
The Journal of biological chemistry 2013 Feb;288(7):4908-21
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CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun;188(11):5489-99
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Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.
The Journal of biological chemistry 2010 Aug;285(35):26825-31
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Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.
The Journal of clinical investigation 2009 Dec;119(12):3530-43
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PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer.
Prostaglandins & other lipid mediators 2009 Apr;88(3-4):97-100
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Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C.
Hepatology (Baltimore, Md.) 2008 Mar;47(3):789-98
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COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation.
The Journal of experimental medicine 2007 Sep;204(9):2053-61
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Families of soft-metal-ion-transporting ATPases.
Journal of bacteriology 1999 Oct;181(19):5891-7
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Molecular cloning and expression of adenosine kinase from Leishmania donovani: identification of unconventional P-loop motif.
The Biochemical journal 1999 May;339 ( Pt 3)667-73
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Pathways of As(III) Detoxification in Saccharomyces cerevisiae
Proc Natl Acad Sci USA 1999 Jan;965001-5006
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Two conformationally vicinal thiols at the active site of Leishmania donovani adenosine kinase.
The Biochemical journal 1996 Jun;316 ( Pt 2)439-45
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Probing the function(s) of active-site arginine residue in Leishmania donovani adenosine kinase.
The Biochemical journal 1994 Mar;298 ( Pt 2)295-301
Book Chapters
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Microbial resistance mechanisms for heavy metals and metalloids
Heavy Metals in the Environment 2002 Jan;531-548
Reviews
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Coronavirus Receptors as Immune Modulators.
Journal of Immunology 2021 Mar;206(5):923-929
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Coronavirus Receptors as Immune Modulators.
Journal of immunology (Baltimore, Md. : 1950) 2020 Dec;
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| CD13 is a critical regulator of macrophage giant cell fusion and foreign body response Presenter- Mallika Ghosh Authors- Mallika Ghosh, Fraser McGurk, Rachael Norris and Linda Shapiro | Poster | Cold Spring Harbor Laboratory | 2024 | Cold Spring Harbor, NY |
| CD13 Mediates Spontaneous Fusion of Kaposi Sarcoma Endothelial Cells to M2 Macrophages. Presenter- Maximillian D. Shlafstein. Authors- Maximillian D. Shlafstein, Linda Shapiro and Mallika Ghosh | Poster | Cold Spring Harbor Laboratory | 2024 | Cold Spring Harbor, NY |
| CD13 controls myeloid cell- cell fusion cd13 controls myeloid cell- cell fusion Authors- Mallika Ghosh, F. Mcgurk and L. Shapiro Presenter-Mallika Ghosh | Poster | American Association of Immunologists | 2023 | Washington D.C |
| The Role of CD13 in the Foreign Body Response in Implantable Biological Devices. Authors- Selinam Dzisi, Andy Dong, Fraser Mcgurk, Yi Ciao, Donald Kreutzer, Linda Shapiro, Mallika Ghosh | Poster | Aetna Health Professions Partnership Initiative | 2023 | UCONN Health |
| Contribution of Foreign Body Giant Cells in Foreign Body Reaction to Implantable Devices in CD13KO Mouse Model. Fraser McGurk, Andy Dong and Mallika Ghosh | Poster | UCONN, SURF | 2023 | UCONN Health |
| Contribution of Foreign Body Giant Cells in Foreign Body Reaction to Implantable Devices in CD13KO Mouse Model. Authors- Fraser McGurk, Andy Dong and Mallika Ghosh | Poster | UCONN, SURF, Fall Frontiers | 2023 | UCONN |
| Visualizing the CD13-Dependent Implant Foreign Body Response. Andy Dong, Fraser McGurk and Mallika Ghosh | Poster | UCONN, HRP | 2023 | UCONN Health |
| The role of CD13 in macrophage giant cell fusion. Author- Fraser Mcgurk and Mallika Ghosh | Poster | Big East Symposium | 2023 | NY |
| Investigating the Macrophage-to-Myofibroblast Transition in Implant-Induced Foreign Body Response Presenter- Fraser McGurk Authors- Fraser McGurk, Linda Shapiro and Mallika Ghosh | Poster | Cell Biology/Vascular Biology Retreat | 2023 | Hillstead Museum, Farmington, CT |
| Visualizing the CD13-Dependent Implant Foreign Body Response. Presenter- Fraser McGurk. Authors- Fraser McGurk and Mallika Ghosh | Poster | University of Connecticut | 2023 | UCONN, Storrs |
| Role of CD13 in Macrophage Giant Cell Fusion Authors- Fraser Mcgurk and Mallika Ghosh | Poster | Fall Frontiers, University of Connecticut | 2022 | UCONN, STORRS |
| Proteoglycan 4 (PRG4) regulates NF-?B activation in human corneal epithelial cells through suppression of ubiquitin-like modifier: HLA-F Adjacent transcript number 10 (FAT10). Authors- Nikhil G Menon; Yasir Suhail; Kshitiz Gupta; Gregory Jay; Linda Shapiro; Rachel Redfern; Mallika Ghosh; Tannin A Schmidt | Talk | Association for Research in Vision and Ophthalmology | 2022 | Denver, Colorado |
| The role of CD13 in macrophage giant cell fusion. Author- Fraser Mcgurk and Mallika Ghosh | Poster | HRP research presentation | 2022 | UCONN Health |
| CD13 differentially regulates the formation of cellular protrusions. Contributors-Emily Meredith, Mallika Ghosh and Linda Shapiro | Talk | WesUAGro | 2021 | Wesleyan University |
| CD13 is a Critical Regulator of Cell-cell Communication via Tunneling Nanotubes. Contributors- Emily Meredith, Mallika Ghosh and Linda Shapiro. | Poster | The American Society for Cell Biology | 2021 | Virtual |
| CD13 is a Critical Regulator of Cell-cell Communication via Tunneling Nanotubes. Contributors- Emily Meredith, Mallika Ghosh and Linda Shapiro | Poster | North American Vascular Biology Organization | 2021 | Virtual |
| CD13 is a negative regulator of myeloid cell fusion. Contributors- Mallika Ghosh and Linda Shapiro | Poster | The American Society for Cell Biology | 2021 | Virtual |
| CD13 differentially regulates the formation of cellular protrusions. Contributors- Emily Meredith, Mallika Ghosh and Linda Shapiro | Poster | North American Vascular Biology Organization | 2020 | Virtual |
| CD13 differentially regulates the formation of cellular protrusions. Contributors- Emily Meredith, Mallika Ghosh and Linda Shapiro | Poster | American Society of Cell Biology | 2020 | Virtual |
| Transmembrane peptidase CD13 is a negative regulator of cell-cell fusion in osteoclastogenesis. Contributors- Mallika Ghosh, Ivo Kalajzic, Hector L Aguila and Linda Shapiro | Poster | American Society for Cell Biology | 2020 | Virtual |
| Proteoglycan 4 expression and function under dry eye associated conditions. Association for Research in Vision and Ophthalmology. Contributors- Schmidt, Tannin ; Mennon, Nikhil ; Lema, Carolina ; Goyal, Ruchi ; Jay, Gregory ; Shapiro, Linda ; Ghosh, Mallika ; Redfern, Rachel | Poster | Association for Research in Vision and Opthalmology | 2020 | Virtual |
| CD13 in cell-cell and cell-ECM communication and signaling. Presenter- Mallika Ghosh | Talk | Vascular Biology Retreat | 2019 | Farmington, Connecticut |
| Mechanism of CD13 Mediated Tunneling Nanotube Formation in Endothelial Cells. Contributors- Reileigh Fleeher, Linda Shapiro and Mallika Ghosh | Poster | UCONN Summer 2019 Health Research Program | 2019 | UCONN Health Center |
| CD13 is a Critical Regulator of Cell-cell Communication via Tunneling Nanotubes. Contributors- Meredith Emily, Ghosh Mallika, Shapiro Linda | Poster | American Society for Cell Biology | 2019 | Washington D.C |
| CD13 in cell-cell communication and signaling Mallika Ghosh | Talk | Center for Vascular Biology Research Retreat | 2019 | Farmington, CT |
| CD13 Promotes Tunneling Nanotube Formation and Cell-cell Communication in Human Endothelial Cells and Mouse Primary Macrophages Brian Aguilera, Linda Shapiro and Mallika Ghosh | Talk | 17th Annual New England Science Symposium & Harvard Medical School | 2019 | Harvard Medical School, Boston, MA |
| Regulation of b1 Integrin Recycling, Cell Migration and Focal Adhesion Turnover by Cell Adhesion molecule- CD13 Ghosh M, Thangada S, Devarakonda C and Shapiro LH | Talk | American Association of Immunology | 2018 | Austin, Tx |
| Role of CD13 in Renal Proximal Tubular Handling of Albumin Lo R, Gerber C, Shearier E, Ghosh M, Shapiro LH | Poster | American Society of Nephrology | 2018 | San Diego, CA |
| A Novel Role for CD13 in Mediating Intercellular Transfer via Tunneling nanotubes Alexa Taylor and Mallika Ghosh Innovation Fellows Research Day | Talk | PIE (Partnership in Innovation & Education) | 2018 | UCONN Health Center |
| CD13 is a critical regulator of beta1 Integrin recycling, cell migration and focal adhesion turnover Ghosh M and Shapiro LH | Poster | American Society for Cell Biology | 2017 | Philadelphia, PA |
| Focal Adhesion Dynamics and beta1 Integrin Signal Transduction, Endocytosis and Recycling are Regulated by CD13 Ghosh M and Shapiro LH | Poster | Gordon Research Conference | 2016 | Andover, NH |
| CD13 Restricts TLR4 Endocytic Signal Transduction in Inflammation Ghosh M, Rahman MM, Subramani J and Shapiro LH | Talk | American Association of Immunology | 2015 | New Orleans, LA |
| CD13 Restricts TLR4 Endocytic Signal Transduction in Inflammation Ghosh M, Subramani J, Rahman MM and Shapiro LH | Poster | Keystone Conference on Dendritic Cell Biology | 2014 | Keystone CO |
| CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake Ghosh M, McAuliffe B, Subramani J, Basu S, Shapiro LH | Talk | American Association of Immunology | 2012 | Boston, MA |
| Trafficking and functional roles of myeloid cells lacking CD13 in inflammatory diseases Ghosh M, Vernier K, Rahman MM, Subramani J, McAuliffe B, Basu S, Shapiro LH | Poster | Gordon Research Conference | 2011 | Newport, RI |