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Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates.
Maia, Mara A C; Bettin, Everton B; Barbosa, Liana N; de Oliveira, Natasha R; Bunde, Tiffany T; Pedra, Ana Carolina K; Rosa, Guilherme A; da Rosa, Elias E B; Seixas Neto, Amilton C P; Grassmann, André A; McFadden, Johnjoe; Dellagostin, Odir A; McBride, Alan J A Frontiers in cellular and infection microbiology 2022 Jan;12940966
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TonB-dependent receptor epitopes expressed in M. bovis BCG induced significant protection in the hamster model of leptospirosis.
Bettin, Everton B; Dorneles, Jessica; Hecktheuer, Amanda S; Madruga, Andriele B; Seixas Neto, Amilton C P; McBride, Alan J A; Oliveira, Thais L; Grassmann, André A; Dellagostin, Odir A Applied microbiology and biotechnology 2022 Jan;106(1):173-184
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The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
Grassmann, André A; Zavala-Alvarado, Crispin; Bettin, Everton B; Picardeau, Mathieu; Benaroudj, Nadia; Caimano, Melissa J PLoS pathogens 2021 Dec;17(12):e1009078
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PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
Groshong, Ashley M; Grassmann, André A; Luthra, Amit; McLain, Melissa A; Provatas, Anthony A; Radolf, Justin D; Caimano, Melissa J PLoS pathogens 2021 Jul;17(7):e1009725
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Role of glucosyltransferase R in biofilm interactions between Streptococcus oralis and Candida albicans.
Souza, João Gabriel Silva; Bertolini, Martinna; Thompson, Angela; Mansfield, Jillian M; Grassmann, André Alex; Maas, Kendra; Caimano, Melissa J; Barao, Valentim Adelino Ricardo; Vickerman, M Margaret; Dongari-Bagtzoglou, Anna The ISME journal 2020 Feb;
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Cultivation of Leptospira interrogans Within Rat Peritoneal Dialysis Membrane Chambers.
Grassmann, Andre Alex; Caimano, Melissa J Methods in molecular biology (Clifton, N.J.) 2020 Jan;2134229-242
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Discovery of Novel Leptospirosis Vaccine Candidates Using Reverse and Structural Vaccinology.
Grassmann, André Alex; Kremer, Frederico Schmitt; Dos Santos, Júlia Cougo; Souza, Jéssica Dias; Pinto, Luciano da Silva; McBride, Alan John Alexander Frontiers in immunology 2017 Jan;8463
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Pathogenic Leptospires Modulate Protein Expression and Post-translational Modifications in Response to Mammalian Host Signals.
Nally, Jarlath E; Grassmann, Andre A; Planchon, Sébastien; Sergeant, Kjell; Renaut, Jenny; Seshu, Janakiram; McBride, Alan J; Caimano, Melissa J Frontiers in cellular and infection microbiology 2017 Jan;7362
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Lectin I from Bauhinia variegata (BVL-I) expressed by Pichia pastoris inhibits initial adhesion of oral bacteria in vitro.
Klafke, Gabriel Baracy; Moreira, Gustavo Marçal Schmidt Garcia; Pereira, Juliano Lacava; Oliveira, Patrícia Diaz; Conceição, Fabricio Rochedo; Lund, Rafael Guerra; Grassmann, André Alex; Dellagostin, Odir Antonio; da Silva Pinto, Luciano International journal of biological macromolecules 2016 Dec;93(Pt A):913-918
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Draft genome of the Leptospira interrogans strains, Acegua, RCA, Prea, and Capivara, obtained from wildlife maintenance hosts and infected domestic animals.
Kremer, Frederico S; Eslabão, Marcus R; Jorge, Sérgio; Oliveira, Natasha R; Labonde, Julia; Santos, Monize N P; Monte, Leonardo G; Grassmann, André A; Cunha, Carlos E P; Forster, Karine M; Moreno, Luísa Z; Moreno, Andrea M; Campos, Vinicius F; McBride, Alan J A; Pinto, Luciano S; Dellagostin, Odir A Memorias do Instituto Oswaldo Cruz 2016 Apr;111(4):280-3
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Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Grassmann, André Alex; McBride, Alan John Alexander; Nally, Jarlath E; Caimano, Melissa J Bio-protocol 2015 Jul;5(14):
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Evaluation of the Leptospira interrogans Outer Membrane Protein OmpL37 as a Vaccine Candidate.
Oliveira, Thaís Larré; Grassmann, André Alex; Schuch, Rodrigo Andrade; Seixas Neto, Amilton Clair Pinto; Mendonça, Marcelo; Hartwig, Daiane Drawanz; McBride, Alan John Alexander; Dellagostin, Odir Antônio PloS one 2015 Jan;10(11):e0142821
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A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
Caimano, Melissa J; Sivasankaran, Sathesh K; Allard, Anna; Hurley, Daniel; Hokamp, Karsten; Grassmann, André A; Hinton, Jay C D; Nally, Jarlath E PLoS pathogens 2014 Mar;10(3):e1004004
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Protection against lethal leptospirosis after vaccination with LipL32 coupled or coadministered with the B subunit of Escherichia coli heat-labile enterotoxin.
Grassmann, André A; Félix, Samuel R; dos Santos, Carolina Ximendes; Amaral, Marta G; Seixas Neto, Amilton C P; Fagundes, Michel Q; Seixas, Fabiana K; da Silva, Everton F; Conceição, Fabricio R; Dellagostin, Odir A Clinical and vaccine immunology : CVI 2012 May;19(5):740-5
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Highly virulent Leptospira borgpetersenii strain characterized in the hamster model.
Diniz, Juliana Alcoforado; Félix, Samuel Rodrigues; Bonel-Raposo, Josiane; Seixas Neto, Amilton Clair Pinto; Vasconcellos, Flávia Aleixo; Grassmann, André Alex; Dellagostin, Odir Antônio; Aleixo, José Antonio Guimarães; da Silva, Everton Fagonde The American journal of tropical medicine and hygiene 2011 Aug;85(2):271-4
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Preliminary characterization of Mus musculus-derived pathogenic strains of Leptospira borgpetersenii serogroup Ballum in a hamster model.
da Silva, Everton F; Félix, Samuel R; Cerqueira, Gustavo M; Fagundes, Michel Q; Neto, Amilton C P S; Grassmann, André A; Amaral, Marta G; Gallina, Tiago; Dellagostin, Odir A The American journal of tropical medicine and hygiene 2010 Aug;83(2):336-7
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B subunit of Escherichia coli heat-labile enterotoxin as adjuvant of humoral immune response in recombinant BCG vaccination.
da Silva Ramos Rocha, Andréa; Conceição, Fabricio Rochedo; Grassmann, André Alex; Lagranha, Valeska Lizzi; Dellagostin, Odir Antônio Canadian journal of microbiology 2008 Aug;54(8):677-86
