Education

Degree	Institution	Major
BA	University of Colorado	Molecular, Cellular, and Developmental Biology
PhD	University of Vermont	Microbiology and Molecular Genetics

Post-Graduate Training

Training	Institution	Specialty
Fellowship	American Cancer Society	Undergraduate Fellowship
Fellowship	Howard Hughes Medical Institute	Undergraduate Fellowship
Fellowship	Colorado Commission on Higher Education
Fellowship		Undergraduate Research Opportunity Fellowship
Postdoctoral	Department of Molecular and Cellular Biology, Harvard University, Laboratory of Tom Maniatis	Postdoctoral Fellow
Fellowship	Jane Coffin Childs Memorial Fund	Medical Research Postdoctoral Fellowship

Awards

Name of Award/Honor	Awarding Organization
Elected Member	Connecticut Academy of Science and Engineering

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Strategic Plan, Implementation Committee	Advisory Committee	Co-Chair	UConn-Storrs	University	2023
NIH RNome Group	Workshop/Conference	Member, Executive Committee	External	National	2022	2022
NHGRI Advisory Council, Presentation on RNomics Meeting Report	Advisory Committee	Presenter	External	National	2022	2022
NHGRI National Advisory Council for Human Genome Research	Advisory Committee	Member	External	National	2015
ZRG1 MDCN-E Study Section, "Molecular and Cellular Neuroscience"	Study Section	Chair	External	National	2014	2014
ZRG1 GGG-A Study Section, "Defining a Comprehensive Reference Profile of Circulating Human Extracellular RNA"	Study Section	Ad-hoc member	External	National	2014	2014
NIGMS National Advisory General Medical Sciences Council	Advisory Committee	Ad-hoc member	External	National	2014	2014
Scientific Data	Editorial Board	Member	External	International	2013
NIMG PsychENCODE Study Section	Study Section	ad-hoc member	External	National	2013	2013
Grant Reviews, NIH	Study Section	AD-hoc Member	External	National	2012
Grant Reviews, NIH GCAT	Study Section	AD-hoc Member	External	National	2012
RNA	Editorial Board	Editor	External	International	2011
The Biology of Genomes	Other	Session Chair	External	International	2010	2010
Art Committee for the 400 Farmington Building	Community Service	Member	UConn Health	Local	2010	2012
National Cancer Institute of Canada	Advisory Committee	Ad Hoc Reviewer	External	National	2009
Genome Biology	Editorial Board	Editorial Board	External	International	2009
CSHL Eukaryotic mRNA Processing	Other	Session Chair	External	Regional	2009	2009
Bioinformatics section of the CTSA Proposal	Advisory Committee	Co-Director	UConn Health	Local	2009	2009
Planning and Design Committee for the 400 Farmington Building	Community Service	Member	UConn Health	Local	2009	2009
Translational Genomics Core Facility	Advisory Committee	Senior Advisor	UConn Health	Local	2009	2012
BMC Genomics	Editorial Board	Member	External	International	2009	2011
NIH MG-A Study Section	Study Section	Member	External	National	2006	2010
Translational Genomics Core Facility	Advisory Committee	Director	UConn Health	Local	2006	2009
Genetics and Developmental Biology Faculty Search Committee	Education Committee	Member	UConn Health	Local	2006
Grant Reviews, NIH Molecular Genetics	Study Section	Member	External	National	2006	2010
RNA	Editorial Board	Editorial Board	External	International	2005	2011
NIH MG-A Study Section	Study Section	Ad Hoc Reviewer	External	National	2005	2006
Splicing Regulation Session, RNA 2005, 10th Annual Meeting of the RNA Society	Other	SciChair	External	International	2005	2005
Research Recruitment Committee	Education Committee	Member	UConn Health	Local	2005
Neuroscience Faculty Search Committee	Education Committee	Member	UConn Health	Local	2005	2005
Immunology Faculty Search Committee	Education Committee	Member	UConn Health	Local	2005	2006
MMSB Faculty Search Committee	Education Committee	Member	UConn Health	Local	2005	2006
BMC Molecular Biology	Editorial Board	Editorial Board	External	International	2004
First Year Advisory Committee	Advisory Committee	Chair	UConn Health	Local	2004	2005
Ph.D. Curriculum Strategic Plan Committee	Advisory Committee	Member	UConn Health	Local	2004	2006
Education 20/20 Vision Committee	Education Committee	Member	UConn Health	Local	2004	2005
Grant Reviews, NIH Molecular Genetics	Study Section	AD-hoc Member	External	National	2004	2006
Library Advisory Committee	Advisory Committee	Member	UConn Health	Local	2003	2005
Management Negotiating Team for Postdoctoral Fellow Union Contract	Advisory Committee	Member	UConn Health	Local	2003	2004
First Year Graduate Advisory Committee	Advisory Committee	Member	UConn Health	Local	2002	2004
Graduate Admissions Committee	Education Committee	Member	UConn Health	Local	2002	2005
MD/Ph.D. Admissions Committee	Education Committee	Member	UConn Health	Local	2002
Summer Undergraduate Research Fellowship Committee	Education Committee	Member	UConn Health	Local	2002
Genetics and Developmental Biology Seminar Series	Other	Director	UConn Health	Local	2002
American Society for Microbiology	Professional/Scientific Organization	Member	External	National	2001	2002
Graduate Programs Committee	Education Committee	Member	UConn Health	Local	2001	2006
Genetics and Developmental Biology Faculty Search Committee	Education Committee	Member	UConn Health	Local	2001	2002
HSEC committee	Education Committee	Member	UConn Health	Local	2001	2005
Faculty Mentor Committee for the GMBB program	Education Committee	Member	UConn Health	Local	2001	2002
Genetics and Developmental Biology Graduate Program	Education Committee	Co-Director	UConn Health	Local	2001	2002
American Association for the Advancement of Science	Professional/Scientific Organization	Member	External	National	1996
RNA Society	Professional/Scientific Organization	Board of Directors	External	International	1995
Science	Professional/Scientific Journal	Reviewer	External	International
Nature; Structure and Molecular Biology, Reviews Genetics	Professional/Scientific Journal	Reviewer	External	National
Cell; Molecular Cell, Developmental Cell	Professional/Scientific Journal	Reviewer	External	National
PNAS	Professional/Scientific Journal	Reviewer	External	National
Genes and Development	Professional/Scientific Journal	Reviewer	External	National
RNA	Professional/Scientific Journal	Reviewer	External	National
PLoS Genetics	Professional/Scientific Journal	Reviewer	External	National
EMBO	Professional/Scientific Journal	Reviewer	External	International
Molecular and Cellular Biology	Professional/Scientific Journal	Reviewer	External	National
Trends in Genetics	Professional/Scientific Journal	Reviewer	External	National
Trends in Biochemical Sciences	Professional/Scientific Journal	Reviewer	External	National
Genome Research	Professional/Scientific Journal	Reviewer	External	National
Genome Biology	Professional/Scientific Journal	Reviewer	External	National
Journal of Biological Chemistry	Professional/Scientific Journal	Reviewer	External	National
Journal of Cell Biology	Professional/Scientific Journal	Reviewer	External	National
Journal of Molecular Biology	Professional/Scientific Journal	Reviewer	External	National
Molecular Biology and Evolution	Professional/Scientific Journal	Reviewer	External	National
Gene	Professional/Scientific Journal	Reviewer	External	National
Nucleic Acids Research	Professional/Scientific Journal	Reviewer	External	National
BMC Genomics	Professional/Scientific Journal	Reviewer	External	National
Biochemistry	Professional/Scientific Journal	Reviewer	External	National
Genomics	Professional/Scientific Journal	Reviewer	External	National
Journal of Proteome Research	Professional/Scientific Journal	Reviewer	External	National
Mechanisms of Development	Professional/Scientific Journal	Reviewer	External	National
Molecular Therapy	Professional/Scientific Journal	Reviewer	External	National
Biological Psychiatry	Professional/Scientific Journal	Reviewer	External	National

My laboratory studies a wide variety of experiments that can be grouped into five broad areas:

Alternative Splicing Regulatory Networks in Drosophila In eukaryotes, genes are organized into segments referred to as exons and introns. When genes are transcribed into messenger RNA (mRNA), the exons are joined together and the introns are spliced out. The majority of eukaryotic genes contain multiple exons and introns. In such cases, the exons can be joined together in different patterns in a process called alternative splicing to generate multiple mRNAs from a single gene, each of which can encode a protein with a distinct function. Alternative splicing is a common means by which eukaryotes regulate gene expression and is the primary means of enhancing the diversity of proteins encoded in the genome. In addition, defects in alternative splicing can result in the onset of many human diseases including cancer, Alzheimer’s disease, and myotonic dystrophy. Thus, understanding the mechanisms by which alternative splicing is regulated is of tremendous importance to human health.My laboratory is interested in all aspects of the regulation of alternative splicing in Drosophila melanogaster. Drosophila is an excellent system in which to study alternative splicing due to the ability to use cutting-edge genetic, biochemical, tissue culture, and genomic technologies. In addition, the majority of the genes involved in the regulation of alternative splicing are shared between humans and flies. Thus, the principals we learn by studying this process in Drosophila are directly applicable to the regulation of alternative splicing in humans.

Alternative Splicing in Human Embryonic Stem Cells Cells and organisms function based on the expression patterns, actions, and interactions of thousands of genes and their products. A tremendous amount of work has gone into dissecting the transcriptional regulatory and protein interaction networks that drive cell function. However, one important aspect of gene regulation is often overlooked in these studies - alternative splicing. Alternative splicing is the process by which exons can be joined together in different patterns to generate multiple mRNAs from a single gene. Alternative splicing is a tremendously important mechanism by which eukaryotes regulate gene expression and is the primary means of enhancing the diversity of proteins encoded by the genome. It is currently estimated that as many as 75 percent of human genes encode pre-mRNAs that are alternative spliced to generate multiple mRNAs, each of which can potentially encode a protein with a distinct function. Thus, just like transcription regulation, alternative splicing can function as a developmental switch.A number of microarray studies have been conducted to identify a set of stemness genes - genes that are expressed in and define the core gene regulatory program for all types of stem cells. While these studies have led to the identification of a number of genes that play important roles in controlling various aspects of stem cell biology, they have not examined alternative splicing in stem cells. Thus, a crucial aspect of the gene regulatory programs of all types of human stem cells has been overlooked.The goal of our work is to fill this gap by performing expression profiling experiments of hES cells in their undifferentiated state and as they differentiate down different lineage pathways using microarrays that can monitor alternative splicing and to elucidate the role of specific RNA binding proteins in controlling alternative splicing in hES cells. These experiments should lead to a more complete understanding of the gene expression programs of hES cells which is critical to our ability to guide stem cells down different lineage pathways and to realizing the full therapeutic potential of hES cells.

Alternative Splicing of the Drosophila Dscam Pre-mRNA A major project in the laboratory is to determine the mechanisms involved in controlling alternative splicing of the Drosophila Down Syndrome Cell Adhesion Molecule (Dscam) gene. The Dscam gene, which was discovered in Larry Zipurskys lab, encodes an axon guidance receptor that is most similar to one of the human genes implicated in causing Down Syndrome. Perhaps the most interesting aspect of this gene is that it is the most extensively alternatively spliced gene that we know of in any organism. This single gene can generate over 38,000 different isoforms by virtue of extensive alternative splicing. In fact, the number of proteins generated by this gene is two to three times the number of genes in the entire Drosophila genome! It is thought that the diversity of Dscam isoforms contributes to the specificity of neuronal wiring. We have found that the alternative splicing of Dscam transcripts is regulated throughout development and in a tissue-specific manner. Moreover, this regulated alternative splicing is evolutionarily conserved. We are now using RNAi, genetics, evolutionary, and biochemical approaches to identify trans-acting factors and cis-acting RNA sequences that participate in controlling this extraordinarily complex alternative splicing event.By performing an RNAi screen in which we depleted hundreds of RNA binding proteins in the Drosophila genome, we have identified about 40 different proteins that regulate the splicing of various Dscam exons. We have also identified several splicing regulatory elements that are required for the inclusion of any alternative exons and we are currently working to identify the mechanisms by which these elements act. In addition, we are using a variety of techniques to determine the role of the different Dscam isoforms in specifying axon guidance in the fly. Although there are differences in the properties of the human and Drosophila Dscam proteins, these studies may lead to insights regarding the role of this gene in the development of Down syndrome in humans.

The Drosophila modENCODE Project The goal of this project is to generate a comprehensive list of all the sequence-based functional elements in the Drosophila genome. This will be done by generating a set of developmentally staged and tissue- and cell-specific RNAs for expression profiling using high-density genome tiling microarrays and 454 pyrosequencing of small RNAs. These expression data will be used for sophisticated transcript modeling that integrates extant EST and cDNA sequence and comparative data from the 12 sequenced Drosophila genomes. These gene models will be experimentally validated and functionally analyzed in RNAi assays. The final product of these efforts will include comprehensive annotations of transcription start sites, exon/intron structures, polyadenylation sites and the cis-elements required for splicing.

The Role of microRNAs in Planarian Regeneration Planarians are free-living flat worms that are best known for their regenerative capacity. For example, after surgical bisection of the animal in either the vertical or horizontal plane each half of the animal will regenerate the missing structures. In fact, a fragment as small as 1/279th the size of the original individual has the capacity to regenerate into an entire animal. The key to the amazing regenerative prowess of these creatures is a population of cells known as neoblasts that are distributed throughout the body of the animal. Neoblasts are totipotent cells that are the only dividing cells in the animal. The division progeny of neoblasts replace cells lost during normal cellular turnover in the animal. After injury, however, neoblasts migrate to the wound site, divide, and their progeny eventually replace the missing structures. Thus, neoblasts are the planarian equivalent of stem cells making these unique organisms an excellent model system for studying stem cell biology.

Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025

A wide variety of potential rotation projects in the general areas of post-transcriptional gene regulation (i.e., the RNA world) are available to highly motivated students. Please contact me to discuss potential projects or even better, to suggest a project of your own.

Journal Articles

Books

Book Chapters

Conference Papers

Editorials

Erratums

Other

Reviews

Short Surveys

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Facilitating Technology Dissemination and Adoption	Plenary Lecture	NIH	2022	Virtual
Insights into RNA Biology in Drosophila from Genome-Wide Studies	Talk	Dept. Biochemistry & Biophysics, UPenn School of Medicine	2013	Philadelphia, PA
Insights into RNA Biology in Drosophila from Genome-Wide Studies	Talk	Dept. of Molecular Genetics and Microbiology, University of Florida	2013	Gainesville, FL
Insights into RNA Biology in Drosophila from Genome-Wide Studies	Talk	Department of Molecular Biology and Genetics, Cornell University	2013	Ithica, NY
Why are flies so weird?	Lecture		2013	Biochemistry and Molecular Pharmacology. UMass Medical School
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	NIH, NIDDK	2012	Bethesda, MD
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	MIT, Department of Biology.	2012	Cambridge, MA
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	UMDNJ, Department of Biology	2012	Newark, NJ
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	Case Western Reserve University, RNA Center	2012	Cleveland, OH
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	Brown University, Department of Biology	2012	Providence, RI
Genomic Approaches to Studying Alternative Splicing in Drosophila.	Talk	John Hopkins University, Department of Biology.	2012	Baltimore, MD
Post Transcriptional Regulation of Gene Expression.	Talk	Gordon Conference	2012	Newport, RI
ModENCODE Symposium	Talk	NHGRI/NIH	2012	Bethesda, MD
Genome-wide Analysis of Alternative Splicing in Drosophila.	Talk	RNA 2012	2012	Ann Arbor, MI
Genome-wide Analysis of Alternative Splicing in Drosophila.	Talk	Cold Spring Harbor Laboratories	2012	Cold Spring Harbor, NY
Genomic Approaches to Studying RNA Processing in Drosophila.	Talk	Drosophila 2012	2012	Chicago, IL
Genomic approaches to the study of RNA processing in Drosophila	Talk	Cell Press, Regulatory RNAs	2011	Chicago, IL
Genomic approaches to the study of RNA processing in Drosophila	Talk	John Hopkins University, Department of Biology	2011	John Hopkins University, Baltimore, MD
Genomic approaches to the study of RNA processing in Drosophila	Talk	University of Colorado, Boulder, MCDB Department	2011	Boulder, CO
Genome wide analysis of mRNA processing in Drosophila	Talk	Gordon Conference - Nucleic Acids	2011	Biddeford, ME
Genome wide analysis of mRNA processing in Drosophila	Talk	University of California, Irvine	2011	Irvine, CA
Genome wide analysis of mRNA processing in Drosophila	Talk	University of California, Los Angeles	2011	Los Angeles, CA
Alternative Splicing in Drosophila.	Talk	University of Colorado	2011	Colorado
Alternative Splicing in Drosophila.	Talk	University of California	2011	Los Angeles, California
Alternative Splicing in Drosophila.	Talk	University of California	2011	Irvine, California
Dynamics and Diversity of the Drosophila Transcriptome.	Talk	Nucleic Acids. Gordon Conference	2011	Biddeford, ME
The developmental transcriptome of Drosophila melanogaster	Talk	Genome Biology, Beyond the Genome	2010	Boston, MA
Alternative Splicing in Drosophila.	Talk	University of Vermont	2010	University of Vermont
Alternative Splicing in Drosophila.	Talk	Lawrence Berkeley National Labs	2010	Berkeley, CA
Alternative Splicing in Drosophila.	Talk	University of Connecticut Health Center	2010	Farmington, CT
MicroRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.	Poster	40th Annual Meeting of the Society for Neuroscience	2010	San Diego, CA
Deep Sequencing of Schmidtea mediterranea Reveals Strain-specific Transcript Expression.	Poster	Genome Informatics. Cold Spring Harbor Laboratory/Wellcome Trust.	2010	Hingston, UK
Using RNAi and RNA-Seq to Identify Alternative Exons Regulated by Individual RNA Binding Proteins and their Associated Regulatory Motifs.	Talk	ISMB	2010	Boston, MA
Using RNAi and RNA-Seq to identify alternative exons regulated by individual RNA binding proteins and their associated regulatory motifs.	Talk	Fifteenth Annual Meeting of the RNA Society.	2010	Seattle, Washington
Dynamics and Diversity of the Drosophila Transcriptome.	Talk	Beyond the Genome. International Conference	2010	Boston, MA
Dynamics and Diversity of the Drosophila Transcriptome.	Talk	Gordon Conference	2010	Newport, RI
The Regulation of Alternative Splicing.	Talk	Annual Meeting of the RNA Society	2010	Seattle, WA
Alternative Splicing in Human Embryonic Stem Cells.	Talk	State of Connecticut Stem Cell Retreat	2010	New Haven, CT
Dynamics and Diversity of the Drosophila Transcriptome.	Talk	Cold Spring Harbor Laboratories	2010	Cold Spring Harbor, NY
Dynamics and Diversity of the Drosophila Transcriptome.	Talk	Cold Spring Harbor Laboratories	2010	Cold Spring Harbor, NY
Alternative Splicing in Drosophila.	Talk	RNA Center, Case Western Reserve University	2009	Cleveland, OH
Alternative Splicing in Drosophila.	Talk	University of Massachusetts	2009	Amherst, Massachusetts
Alternative Splicing in Drosophila.	Talk	Wesleyan University	2009	Middletown, CT
Alternative Splicing in Drosophila.	Talk	University of Wisconsin	2009	Madison, Wisconsin
Alternative Splicing in Drosophila.	Talk	University of Kentucky	2009	Kentucky
Alternative Splicing in Drosophila.	Talk	University of Connecticut	2009	Storrs, Connecticut
Analysis of Dscam expression and mechanisms of alternative splicing. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2009	Cold Spring Harbor, NY
Drosophila development at single-nucleotide resolution. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2009	Cold Spring Harbor, NY
Using RNAi and RNA-Seq to identify alternative exons regulated by individual RNA binding proteins and their associated regulatory motifs. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	2009	Cold Spring Harbor , NY
Alternative Trans-Splicing in Drosophila. Eukaryotic mRNA Processing	Talk	Cold Spring Harbor Laboratory.	2009	Cold Spring Harbor , NY
Modencode Meeting	Talk		2009	Washington, DC
High Throughput Technologies for the Analysis of Alternative Splicing.	Talk	European Alternative Splicing Network (EURASNET) Conference	2009	Valencia, Spain
Alternative Splicing of Dscam.	Talk	ASBMB 2008 Annual Meeting	2008	San Diego, California
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	University of North Carolina	2008	North Carolina
Alternative Splicing in Drosophila.	Talk	16th Annual International Conference on Intelligent Systems for Molecular Biology	2008	Toronto, Canada
Alternative Splicing in Drosophila.	Talk	Crete XVI EMBO Conference	2008	Crete (Greece)
Alternative Splicing of Dscam: The Making of 38,000 Isoforms.	Talk	International Centre for Genetic Engineering and Biotechnology	2007	Bariloche, Argentina
Alternative Splicing of Dscam: The Making of 38,000 Isoforms.	Talk	VIII Symposium. IBMC,	2007	Porto, Portugal
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	University of Toronto	2007	Toronto, Caneda
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	University of Georgia	2007	Georgia
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	University of Illinois	2007	Illinois
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	Cold Spring Harbor Laboratory	2007	Cold Spring Harbor, NY
Pasilla, the Drosophila homolog of Nova-1 and -2 regulates sex-specific alternative trans-splicing. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2007	Cold Spring Harbor, NY
Musashi Regulates Dscam Alternative Splicing in Drosophila. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2007	Cold Spring Harbor, NY
Pasilla, Mub, and Bancal comprise a binary switch that regulated Dscam alternative splicing.	Talk	Cold Spring Harbor Laboratory	2007	Cold Spring , NY
A Regulator of Mutually Exclusive Splicing Fidelity in Dscam. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	2007	Cold Spring Harbor , NY
The Insect Down Syndrome Cell Adhesion Molecule (Dscam) Gene: The making and function of 38,000 isoforms.	Talk	Genome Canada, International Conference	2006	Quebec City, Canada
Alternative Splicing in Drosophila.	Talk	Gordon Conference	2006	Oxford, UK
Alternative Splicing in Drosophila.	Talk	Crete XV EMBO Conference	2006	Crete (Greece)
Alternative Splicing in Human Embryonic Stem Cells.	Talk	State of Connecticut Stem Cell Retreat	2006	New Haven, CT
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	EMBO Conference on Alternative Transcript Diversity II	2006	Heidelberg, Germany
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	Boston College	2006	Boston, MA
Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	Brandeis University	2006	Waltham, MA
“Alternative Splicing in Drosophila and miRNA-Mediated Gene Regulation in Planarians.	Talk	Johns Hopkins University	2006	Baltimore, MD
The microRNAs of the Planarian Schmidtea Mediterranea.	Poster	RNA 2006	2006	Seattle, WA
The microRNAs of the Planarian Schmidtea Mediterranea.	Poster	Cold Spring Harbor Symposium on Regulatory RNAs	2006	Cold Spring Harbor , NY
Alternative Splicing Regulators Identified in Drosophila Using High-Throughput Microarrays.	Talk	RNA 2006	2006	Seattle, WA
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	Nucleic Acids. Gordon Conference	2005	Newport, RI
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	University of Massachusetts Medical School	2005	Worcester, MA
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	Michigan State University	2005	Michigan
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	University of Pittsburgh	2005	Pittsburgh, PA
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	Massachusetts Institute of Technology	2005	Cambridge, MA
Alternative Splicing of the Drosophila Dscam gene: The making of 38,000 isoforms.	Talk	University of California	2005	San Diego, CA
Microarray, and Chemical Biology Tools Designed to Study Alternative Splicing.	Talk	A conference sponsored by Exon-Hit Therapeutics	2005	Baltimore, MD
Identification of Planarian micoRNAs Required for Regeneration. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2005	Cold Spring Harbor, NY
A Mechanism for the Mutually Exclusive Splicing of the Insect Dscam Gene. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	2005	Cold Spring Harbor , NY
The KH Domain Proteins PS and MUB Function to Regulated Alternative Splicing of the Drosophila Dscam Pre-mRNA.	Talk	Cold Spring Harbor Laboratory	2005	Cold Spring Harbor, NY
Global Identification of Alternative Splicing Regulators and their Regulatory Targets in Drosophila Using High-Throughput Microarrays. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	2005	Cold Spring Harbor, NY
A Mechanism for the Mutually Exclusive Splicing of the Insect Dscam Gene Deduced by Comparative Genomics.	Talk	RNA 2005	2005	Banff, Canada,
Global Identification of Alternative Splicing Regulators and their Regulatory Targets in Drosophila Using High-Throughput Microarrays.	Talk	Drosophila Conference	2005	San Diego, CA
Dscam: The making of 38,000 isoforms.	Talk	Gordon Conference	2004	Andover, NH
Wiring of the Drosophila nervous system and the regulation of Dscam alternative splicing.	Talk	Brandeis University	2004	Pikesville, MD
Wiring of the Drosophila nervous system and the regulation of Dscam alternative splicing.	Talk	University of Vermont	2004	Vermont
The Regulation of Alternative Splicing in Drosophila.	Talk	Universite de Sherbrooke	2004	Sherbrooke, QC, Canada
The Regulation of Alternative Splicing in Drosophila.	Talk	University of Texas	2004	Texas
The Regulation of Alternative Splicing in Drosophila.	Talk	Ohio State University	2004	Ohio
The Regulation of Alternative Splicing in Drosophila.	Talk	Case Western Reserve University	2004	Cleveland, OH
Alternative splicing of the Drosophila Dscam pre-mRNA.	Talk	Rockefeller University	2004	New York, NY
The Regulation of Alternative Splicing in Drosophila.	Talk	University of Connecticut Health Center	2004	Farmington, CT
TRA and TRA2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor.	Poster	RNA 2004	2004	Madison, WI
Identification of proteins participating in developmentally regulated alternative splicing of the Drosophila Dscam pre-mRNA.	Poster	RNA 2004	2004	Madison, WI
A combined computational and experimental approach towards a priori identification of alternative exons.	Talk	RNA 2004	2004	Madison, WI
A long-range secondary structure is required for exon inclusion in the Drosophila Dscam pre-mRNA.	Talk	RNA 2004	2004	Madison, WI
A genome wide RNAi screen for RNA binding proteins that affect alternative splicing in Drosophila.	Talk	RNA 2004	2004	Madison, WI
The Regulation of Alternative Splicing in Drosophila.	Talk	University of Maryland	2003	Marylan
The regulation of alternative splicing of the Dscam pre-mRNA and its role in specifying neural wiring in Drosophila.	Talk	Johns Hopkins University	2003	Baltimore, MD
Alternative Splicing of the Drosophila Dscam Pre-mRNA.	Talk	A conference sponsored by Exon-Hit Therapeutics	2003	Baltimore, MD
Evidence for multiple, recent exon duplication events in the insect Dscam genes. Eukaryotic mRNA processing.	Poster	Cold Spring Harbor Laboratory	2003	Cold Spring Harbor, NY
Recursive splicing is required for Dscam alternative splicing. Eukaryotic mRNA processing.	Poster	Cold Spring Harbor Laboratory	2003	Cold Spring Harbor, NY
Tra and Tra2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor.	Talk	RNA 2003	2003	Vienna, Austria
Comparing mechanisms of sex-specific 5’ and 3’ splice site activation.	Poster	RNA 2003	2003	Vienna, Austria
Exon-Specific RNAi: A Tool for Dissecting the Functional Relevance of Alternative Splicing.	Poster	Drosophila 2003	2003	Chicago, IL
The Identification of RNA Sequences Involved in the Regulation of Dscam Alternative Splicing.	Poster	Drosophila 2003	2003	Chicago, IL
Tra and Tra2 activate the female-specific 5’ splice site of the Drosophila fruitless pre-mRNA by counteracting a splicing repressor. Eukaryotic mRNA processing.	Talk	Cold Spring Harbor Laboratory	2003	Cold Spring Harbor, NY
Recursive splicing is required for Dscam alternative splicing.	Talk	RNA 2003	2003	Vienna, Austria
Regulation of Dscam alternative splicing by B52 and U2AF.	Talk	Drosophila 2003	2003	Chicago, IL
Alternative Splicing of the Drosophila Dscam Pre-mRNA.	Talk	Ohio State University	2002	Ohio
Exonic Splicing Enhancers – “Determining their mechanism of action and harnessing their awesome power.	Talk	Ohio State University	2002	Ohio
Alternative Splicing of the Drosophila Dscam pre-mRNA.	Talk	UCLA	2002	Los Angeles, California
Splicing and Dicing the Genome: Using Alternative Splicing to Create Extraordinary Protein Diversity.	Talk	New York Medical College	2002	Valhala, New York
Splicing and Dicing the Genome: Using Alternative Splicing to Create Extraordinary Protein Diversity.	Talk	Karolinska Institut	2002	Stockholm, Sweden
Analysis of the potential contribution of SR proteins to poly(A) site recognition.	Poster	RNA 2002	2002	Madison, WI
Alternative splicing of the Drosophila Dscam pre-mRNA.	Talk	RNA 2002	2002	Madison, WI
Analysis of the potential contribution of SR proteins to poly(A) site recognition.	Poster	Cold Spring Harbor Laboratory	2001	Cold Spring Harbor, New York
RS domain sequence requirements in enhancer-dependent splicing. Eukaryotic mRNA Processing.	Poster	Cold Spring Harbor Laboratory	2001	Cold Spring Harbor, New York
Alternative splicing of pre-mRNAs encoding the axon guidance receptor Dscam is temporally and spatially regulated.	Poster	Drosophila 2001	2001
Defining the mechanisms regulating Dscam alternative splicing in DrosophIla. Eukaryotic mRNA Processing	Talk	Cold Spring Harbor Laboratory	2001	Cold Spring Harbor, New York
Neurexins: A multigene family with really big introns. Genome sequencing and analysis.	Poster		2000
Defining the protein sequence requirements for RS domain function. RNA '00.	Poster	The Fifth Annual Meeting of the RNA Society. University of Wisconsin	2000	Wisconsin, Madison
Evidence for the recruitment model for splicing activator function. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	1999	Cold Spring Harbor, New York
The control of alternative pre-mRNA splicing with small molecule drugs.	Poster	RNA '99 The Fourth Annual Meeting of the RNA Society	1999	Edinburgh, Scottland
Parameters that influence the efficiency of splicing enhancers.	Poster	RNA '98. The Third Annual Meeting of the RNA Society.	1998	Wisconsin, Madison
Parameters that influence the efficiency of splicing enhancers.	Poster	Jane Coffin Childs Memorial Fund for Medical Research Fall Symposium	1998	Lakeville, Connecticut
An RS domain tethered to RNA can activate enhancer-dependent pre-mRNA splicing. Eukaryotic mRNA Processing.	Talk	Cold Spring Harbor Laboratory	1997	Cold Spring Harbor, New York
RS domains function as activators of enhancer-dependent pre-mRNA splicing.	Poster	Jane Coffin Childs Memorial Fund for Medical Research Fall Symposium	1997	Lakeville, Connecticut
An exploration of the sequence and structural requirements for poly(A) site recognition by in vitro selection.	Poster	RNA '96: The First Annual Meeting of the RNA Society. University of Wisconsin	1996	Wisconsin, Madison
Disruption of transcription initiation complexes during DNA replication in yeast.	Poster	Cold Spring Harbor Laboratory	1995	Cold Spring Harbor, New York
Identification of upstream sequences that enhance pre-mRNA 3' processing.	Poster	Cold Spring Harbor Laboratory	1995	Cold Spring Harbor, New York
CPSF recognition of an HIV-1 mRNA 3' processing enhancer: multiple sequence contacts involved in poly(A) site definition.	Talk	RNA Processing Meeting of the RNA Society.	1994	Madison, Wisconsin
The upstream element of the HIV-1 poly(A) site enhances processing efficiency through the stabilization of the interaction of CPSF with the core poly(A) site. RNA 3' Ends: Formation and Function.	Talk		1993	Oxford, UK