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Lazar John Greenfield, MD, PhDProfessor of NeurologyChair, Department of Neurology
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| BA | Yale University | History |
| PhD | University of Virginia | Neuroscience |
| MD | University of Virginia | Medicine |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Virginia | Physiology Department (Laboratory of John Hackett, Ph.D.) |
| Internship | University of Michigan Hospitals | Department of Internal Medicine |
| Residency | University of Michigan Hospitals | Department of Neurology |
| Fellowship | University of Michigan Medical Center | EEG and Epilepsy, Department of Neurology |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Top Doctor Award | Castle Connolly |
| Top Doctor Award | Castle Connoly |
| Palatucci Advocacy Leadership Forum Graduate | American Academy of Neurology |
| Top Doctor Award | Castle Connolly |
| Top Doctor Award - Annually since 2016 | Castle Connolly |
| Faculty of the Year, Dept. of Neurology Resident Teaching Award | University of Arkansas for Medical Sciences |
| Fellow | American Epilepsy Soceity |
| Top Doctor Award | Castle Connolly |
| Fellow | American Association of Neurology |
| Elected to American Neurological Association 2010; Fellow status in 2012 | American Neurological Association |
| Lamplighter Award | Epilepsy Center of Northwest Ohio |
| Robert Wilson Award | Epilepsy Center of Northwest Ohio |
| American Epilepsy Society Junior Investigator Award | American Epilepsy Society |
| American Academy of Neurology Research Fellowship in Neuropharmacology | American Academy of Neurology |
| Whitfield Randolph Scholarship in Neuroscience | University of Virginia |
| Alpha Omega Alpha | University of Virginia |
| Seymour Prize in Humanities, Berkeley College | Yale University |
| Phi Beta Kappa | Yale Univesity |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Epilepsy Foundation of Connecticut - Board of Trustees | Community Service | Board Member | External | State | 2022 | |
| Patterson Trust Mentored Research Award in Clinical Health Services and Policy Research, Medical Foundation for Health Resources in Action. | Study Section | Grant Reviewer | External | Regional | 2020 | 2020 |
| American Brain Coalition - Board of Directors | Professional/Scientific Organization | Board of Directors | External | National | 2017 | |
| American Epilepsy Society | Professional/Scientific Organization | Merrit Putnam Symposium Planning Committee | External | National | 2017 | |
| Academic Merit Program Executive Committee | Advisory Committee | Member | UConn Health | University | 2017 | |
| American Board of Psychiatry and Neurology Research Award Committee | Study Section | Grant reviewer | External | National | 2016 | |
| Clinical Council | Advisory Committee | Member | UConn Health | University | 2016 | |
| Clinical Chairs and Center Directors | Advisory Committee | Member | UConn Health | University | 2016 | |
| Association of University Professors of Neurology Councilor 2014 - 2018, 1st Vice President 2019 - 20 President-Elect, 2020 - 2022 President, 2022 - 2024 National organization of Neurology Department Chairs and Residency Program Directors | Professional/Scientific Organization | President | External | National | 2014 |
Journal Articles
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The AUPN: Past, Present, and Future.
Annals of neurology 2023 Feb;93(2):216-219
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Network analysis of preictal iEEG reveals changes in network structure preceding seizure onset.
Scientific reports 2022 Jul;12(1):12526
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Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy.
Experimental neurology 2021 Apr;342113724
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The critical role of persistent sodium current in hippocampal gamma oscillations.
Neuropharmacology 2019 Sep;107787
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Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons.
Neuropharmacology 2018 Jun;139150-162
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Cell Type-specific Intrinsic Perithreshold Oscillations in Hippocampal GABAergic Interneurons.
Neuroscience 2018 Feb;37680-93
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Commentary: Forced thinking about hypercognitive seizures.
Epilepsy research 2017 Aug;13462
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Telemedicine Interest for Routine Follow-Up Care Among Neurology Patients in Arkansas.
Telemedicine journal and e-health : the official journal of the American Telemedicine Association 2016 Jun;22(6):514-8
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Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale.
Epilepsy research 2015 Nov;11790-6
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Ictal asystole in epilepsy patients undergoing inpatient video-EEG monitoring.
Neurosciences (Riyadh, Saudi Arabia) 2014 Oct;19(4):317-21
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Role of neural stem cell activity in postweaning development of the sexually dimorphic nucleus of the preoptic area in rats.
PloS one 2013 Jan;8(1):e54927
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Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated with blood brain barrier permeability: effect of age.
ACS chemical neuroscience 2012 Jun;3(6):428-32
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Hypoxia enhances high-voltage-activated calcium currents in rat primary cortical neurons via calcineurin.
Epilepsy research 2012 May;99(3):293-305
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Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration.
Molecular pharmacology 2012 Mar;81(3):384-92
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Post-hypoxic changes in rat cortical neuron GABA A receptor function require L-type voltage-gated calcium channel activation.
Neuropharmacology 2009 Jan;56(1):198-207
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Chronic benzodiazepine administration potentiates high voltage-activated calcium currents in hippocampal CA1 neurons.
The Journal of pharmacology and experimental therapeutics 2008 Dec;327(3):872-83
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Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.
The Journal of pharmacology and experimental therapeutics 2007 Aug;322(2):569-81
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Neurologic complications after surgery for obesity.
Muscle & nerve 2006 Feb;33(2):166-76
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Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons.
Brain research. Molecular brain research 2005 Aug;138(2):105-15
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Activation of protein kinase C reduces benzodiazepine potency at GABAA receptors in NT2-N neurons.
Neuropharmacology 2005 Mar;48(3):333-42
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Hypoxia alters GABAA receptor function and subunit expression in NT2-N neurons.
Neuropharmacology 2004 Mar;46(3):318-30
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Chronic benzodiazepine administration alters hippocampal CA1 neuron excitability: NMDA receptor function and expression(1).
Neuropharmacology 2002 Sep;43(4):595-606
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Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.
Neuropharmacology 2002 Mar;42(4):502-21
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GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Jul;18(13):4993-5007
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Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation.
Neuropharmacology 1997 Jan;36(1):63-73
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Whole-cell and single-channel alpha1 beta1 gamma2S GABAA receptor currents elicited by a "multipuffer" drug application device.
Pflugers Archiv : European journal of physiology 1996 Oct;432(6):1080-90
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Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor.
The Journal of pharmacology and experimental therapeutics 1996 Jun;277(3):1784-92
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Contralateral reperfusion injury after carotid endarterectomy.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 1994 Jan;4(4):203-6
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Xenopus oocyte K+ current. I. FSH and adenosine stimulate follicle cell-dependent currents.
The American journal of physiology 1990 Nov;259(5 Pt 1):C775-83
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Xenopus oocyte K+ current. II. Adenylyl cyclase-linked receptors on follicle cells.
The American journal of physiology 1990 Nov;259(5 Pt 1):C784-91
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Xenopus oocyte K+ current. III. Phorbol esters and pH regulate current at gap junctions.
The American journal of physiology 1990 Nov;259(5 Pt 1):C792-800
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Synapsin I injected presynaptically into goldfish mauthner axons reduces quantal synaptic transmission.
Journal of neurophysiology 1990 Apr;63(4):701-6
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Quantal transmission at Mauthner axon target synapses in the goldfish brainstem.
Neuroscience 1989 Jan;32(1):49-64
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Blockade of long-term potentiation by phencyclidine and sigma opiates in the hippocampus in vivo and in vitro.
Brain research 1983 Nov;280(1):127-38
Books
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Reading EEGs: A Practical Approach 2021 Jan;
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Reading EEGs: A Practical Approach, 2nd Edition
Book Chapters
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"Recording the EEG"
Reading EEGs: A Practical Approach, 2nd Edition 2020 Jun;
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“Approaching the EEG: An Introduction to Visual Analysis,”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Artifacts and Noise,”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Basic Neuroscience of EEG”
Reading EEGs: A Practical Approach, 2nd Edition 2020 Jun;
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“Electronics of EEG”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Genetics of EEG and Epilepsy
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Neonatal and Pediatric Epilepsy Syndromes,”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Pathophysiology of Epileptiform Activity"
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“Seizure Semiology: Signs of the Seizure,”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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“The Normal EEG in Adults,”
“Reading EEGs: A Practical Approach, 2nd Edition” 2020 Jun;
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Physiologic Basis of Epileptic EEG Patterns
Understanding Epilepsy: A Study Guide for the Boards 2019 Oct;19-38
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“Physiologic Basis of Epileptic EEG Patterns”
Understanding Epilepsy- A Study Guide for the Boards 2019 Jun;
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Benzodiazepines
The Treatment of Epilepsy: Principles and Practice, 7th Ed 2019 Jun;
Case Reports
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De novo status epilepticus due to multiple cerebral hamartomas.
Neurology 1999 Jul;53(1):237-8
Editorials
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Commentary.
Journal of neurosciences in rural practice 2014 Apr;5(2):149-50
Letters
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"The slow code".
The New England journal of medicine 1998 Jun;338(26):1921-2; author reply 1922-3
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Nitric oxide and motor neuron disease.
The New England journal of medicine 1995 Aug;333(8):522-3
Reviews
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Molecular mechanisms of antiseizure drug activity at GABAA receptors.
Seizure 2013 Oct;22(8):589-600
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Mechanisms of action of new antiepileptic drugs.
Current opinion in neurology 1997 Apr;10(2):121-8
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Sumsky S, Greenfield LJ. Network Analysis of Focal Seizure Dynamics Suggests a Possible Mechanism of Seizure Termination. American Academy of Neurology Annual meeting, 2022, Session S7.009. 2022 American Academy of Neurology Abstract Website (mirasmart.com) | Poster | American Academy of Neurology Annual Meeting 2022 | 2022 | Seattle, WA |
| Sumsky S, Greenfield LJ. Accurate Identification of the Epileptogenic Zone from Intracranial EEG Data Using Effective Connectivity MISO Models. American Epilepsy Society 2022 Annual Meeting, Abstract number : 2.071 www.aesnet.org Presentation date : 12/4/2022 12:00:00 PM. | Poster | American Epilepsy Society Annual Meeting | 2022 | Nashville, TN |
| LJ Greenfield Jr, D Higgins: “Keeping Your Sanity Through Delegation.” AUPN Leadership Minute, Episode 18, February 2022, on line https://vimeo.com/672981111 . | Other | Association of University Professors of Neurology | 2022 | on line |
| "Alterations in iEEG network connectivity predicts seizure onset in temporal lobe epilepsy patients." Stefan Sumsky and L. John Greenfield | Poster | American Epilepsy Society Annual Meeting | 2020 | On Line |
| Neurology on the Hill - AAN sponsored lobbying of Congress for Neurology | Other | American Academy of Neurology | 2019 | Washington DC |
| Epilepsy Update | Lecture | Current Clinical Medicine CME series, Dept. Internal Medicine, UConn Health | 2019 | UConn Health, Farmington CT |
| High Frequency Oscillations in Epilepsy. | Lecture | University of Toledo Grand Rounds | 2019 | Toledo, OH |
| Faculty Wellness and Burnout at UConn Health | Lecture | UConn Health Leadership Group | 2019 | Farmington, CT |
| High Frequency Oscillations in Epilepsy | Lecture | Neurology Grand Rounds, Hartford Hospital | 2018 | Hartford, CT |
| Faculty Wellness and Burnout | Lecture | AUPN Chair’s Course, ANA | 2018 | Atlanta, GA |
| Driving and Epilepsy | Lecture | Epilepsy Foundation of Connecticut Webinar | 2018 | Webcast (statewide) |
| Altered States: Causes of Confusion | Lecture | UConn Internal Medicine CME course lecture | 2018 | UConn Health, Farmington CT |
| Impact of Driving Restriction on People with Epilepsy (IDRoPS). | Poster | American Epilepsy Society Annual Meeting | 2017 | |
| Eating Epilepsy: What the Reflex Epilepsies Teach Us About Seizures | Lecture | UConn/Hartford Hospital Neurology Grand Rounds | 2017 | Hartford Hospital, Hartford, CT |
| High Frequency Oscillations in Epilepsy | Lecture | University of Arkansas for Medical Sciences Neurology Grand Rounds | 2017 | UAMS, Little Rock, AR |
| Transverse Myelitis after Spinal Cord Contusion | Poster | American Academy of Neurology | 2016 | Vancouver, BC |
| Eating epilepsy, a rare and under-recognized reflex epilepsy. | Poster | American Academy of Neurology | 2016 | Vancouver BC |
| Electrophysiological properties of channelrhodopsin2 channels differ when expressed in NT2 neurons and HEK293 cells | Poster | Society for Neuroscience | 2013 | Washington DC |
| Transfected NT2N cells express channelrhodopsin-2 after grafting into organotypic hippocampal slices. | Poster | Society for Neuroscience | 2013 | Washington DC |