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Rapid protein degradation systems to determine gene function in vivo.
Scott, Thomas G; Guertin, Michael J Lab animal 2025 Mar;54(3):66-67
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Classifying the molecular functions of transcription factors beyond activation and repression.
Dong, Jinhong; Guertin, Michael J Genes & development 2024 Nov;38(21-24):931-932
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The androgen receptor does not directly regulate the transcription of DNA damage response genes.
Hasterok, Sylwia; Scott, Thomas G; Roller, Devin G; Spencer, Adam; Dutta, Arun B; Sathyan, Kizhakke M; Frigo, Daniel E; Guertin, Michael J; Gioeli, Daniel Molecular cancer research : MCR 2023 Sep;
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ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation.
Przanowski, Piotr; Przanowska, Róza K; Guertin, Michael J Communications biology 2023 Mar;6(1):231
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Kinetic networks identify TWIST2 as a key regulatory node in adipogenesis.
Dutta, Arun B; Lank, Daniel S; Przanowska, Roza K; Przanowski, Piotr; Wang, Lixin; Nguyen, Bao; Walavalkar, Ninad M; Duarte, Fabiana M; Guertin, Michael J Genome research 2023 Feb;
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ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation
Przanowski P, Przanowska RK, Guertin MJ bioRXiv 2022 Dec;
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Kinetic networks identify Twist2 as a key regulatory node in adipogenesis
Dutta AB, Lank DS, Przanowska RK, Przanowski P, Wang L, Nguyen B, Walavalkar NM, Duarte FM, Guertin MJ bioRXiv 2022 Dec;
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Intrinsic bias estimation for improved analysis of bulk and single-cell chromatin accessibility profiles using SELMA.
Hu, Shengen Shawn; Liu, Lin; Li, Qi; Ma, Wenjing; Guertin, Michael J; Meyer, Clifford A; Deng, Ke; Zhang, Tingting; Zang, Chongzhi Nature communications 2022 Sep;13(1):5533
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Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.
Przanowska, Roza K; Weidmann, Chase A; Saha, Shekhar; Cichewicz, Magdalena A; Jensen, Kate N; Przanowski, Piotr; Irving, Patrick S; Janes, Kevin A; Guertin, Michael J; Weeks, Kevin M; Dutta, Anindya Cell reports 2022 Feb;38(7):110361
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PEPPRO: quality control and processing of nascent RNA profiling data.
Smith, Jason P; Dutta, Arun B; Sathyan, Kizhakke Mattada; Guertin, Michael J; Sheffield, Nathan C Genome biology 2021 May;22(1):155
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ARF-AID: A Rapidly Inducible Protein Degradation System That Preserves Basal Endogenous Protein Levels.
Sathyan, Kizhakke Mattada; Scott, Thomas G; Guertin, Michael J Current protocols in molecular biology 2020 Sep;132(1):e124
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Defining data-driven primary transcript annotations with primaryTranscriptAnnotation in R.
Anderson, Warren D; Duarte, Fabiana M; Civelek, Mete; Guertin, Michael J Bioinformatics (Oxford, England) 2020 May;36(9):2926-2928
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An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion.
Sathyan, Kizhakke Mattada; McKenna, Brian D; Anderson, Warren D; Duarte, Fabiana M; Core, Leighton; Guertin, Michael J Genes & development 2019 Oct;33(19-20):1441-1455
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Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Pincus, David; Anandhakumar, Jayamani; Thiru, Prathapan; Guertin, Michael J; Erkine, Alexander M; Gross, David S Molecular biology of the cell 2018 Dec;29(26):3168-3182
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BART: a transcription factor prediction tool with query gene sets or epigenomic profiles.
Wang, Zhenjia; Civelek, Mete; Miller, Clint L; Sheffield, Nathan C; Guertin, Michael J; Zang, Chongzhi Bioinformatics (Oxford, England) 2018 Aug;34(16):2867-2869
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Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq.
Guertin, Michael J; Cullen, Amy E; Markowetz, Florian; Holding, Andrew N Nucleic acids research 2018 Jul;46(12):e75
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Identification of Drivers of Aneuploidy in Breast Tumors.
Pfister, Katherine; Pipka, Justyna L; Chiang, Colby; Liu, Yunxian; Clark, Royden A; Keller, Ray; Skoglund, Paul; Guertin, Michael J; Hall, Ira M; Stukenberg, P Todd Cell reports 2018 May;23(9):2758-2769
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Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions.
Martins, André L; Walavalkar, Ninad M; Anderson, Warren D; Zang, Chongzhi; Guertin, Michael J Nucleic acids research 2018 Jan;46(2):e9
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Identification of breast cancer associated variants that modulate transcription factor binding.
Liu, Yunxian; Walavalkar, Ninad M; Dozmorov, Mikhail G; Rich, Stephen S; Civelek, Mete; Guertin, Michael J PLoS genetics 2017 Sep;13(9):e1006761
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Transcriptional response to stress is pre-wired by promoter and enhancer architecture.
Vihervaara, Anniina; Mahat, Dig Bijay; Guertin, Michael J; Chu, Tinyi; Danko, Charles G; Lis, John T; Sistonen, Lea Nature communications 2017 Aug;8(1):255
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Genome-Wide Identification of Basic Helix-Loop-Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus.
Pooley, John R; Flynn, Ben P; Grøntved, Lars; Baek, Songjoon; Guertin, Michael J; Kershaw, Yvonne M; Birnie, Matthew T; Pellatt, Annie; Rivers, Caroline A; Schiltz, R Louis; Hager, Gordon L; Lightman, Stafford L; Conway-Campbell, Becky L Endocrinology 2017 May;158(5):1486-1501
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Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation.
Duarte, Fabiana M; Fuda, Nicholas J; Mahat, Dig B; Core, Leighton J; Guertin, Michael J; Lis, John T Genes & development 2016 Aug;30(15):1731-46
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GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters.
Fuda, Nicholas J; Guertin, Michael J; Sharma, Sumeet; Danko, Charles G; Martins, André L; Siepel, Adam; Lis, John T PLoS genetics 2015 Mar;11(3):e1005108
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DNase footprint signatures are dictated by factor dynamics and DNA sequence.
Sung, Myong-Hee; Guertin, Michael J; Baek, Songjoon; Hager, Gordon L Molecular cell 2014 Oct;56(2):275-285
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Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure.
Guertin, Michael J; Zhang, Xuesen; Anguish, Lynne; Kim, Sohyoung; Varticovski, Lyuba; Lis, John T; Hager, Gordon L; Coonrod, Scott A PLoS genetics 2014 Sep;10(9):e1004613
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Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.
Guertin, Michael J; Zhang, Xuesen; Coonrod, Scott A; Hager, Gordon L Molecular endocrinology (Baltimore, Md.) 2014 Sep;28(9):1522-33
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Mechanisms by which transcription factors gain access to target sequence elements in chromatin.
Guertin, Michael J; Lis, John T Current opinion in genetics & development 2013 Apr;23(2):116-23
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Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation.
Zhang, Xuesen; Bolt, Michael; Guertin, Michael J; Chen, Wei; Zhang, Sheng; Cherrington, Brian D; Slade, Daniel J; Dreyton, Christina J; Subramanian, Venkataraman; Bicker, Kevin L; Thompson, Paul R; Mancini, Michael A; Lis, John T; Coonrod, Scott A Proceedings of the National Academy of Sciences of the United States of America 2012 Aug;109(33):13331-6
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Accurate prediction of inducible transcription factor binding intensities in vivo.
Guertin, Michael J; Martins, André L; Siepel, Adam; Lis, John T PLoS genetics 2012 Jan;8(3):e1002610
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Chromatin landscape dictates HSF binding to target DNA elements.
Guertin, Michael J; Lis, John T PLoS genetics 2010 Sep;6(9):e1001114
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A molecular analysis of mutations at the complex dumpy locus in Drosophila melanogaster.
Carmon, Amber; Guertin, Michael J; Grushko, Olga; Marshall, Brad; MacIntyre, Ross PloS one 2010 Aug;5(8):e12319
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Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation.
Burchfiel, Eileen T; Vihervaara, Anniina; Guertin, Michael J; Gomez-Pastor, Rocio; Thiele, Dennis J The Journal of biological chemistry 296100097
