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Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells.
Perea, Valerie; Baron, Kelsey R; Dolina, Vivian; Aviles, Giovanni; Kim, Grace; Rosarda, Jessica D; Guo, Xiaoyan; Kampmann, Martin; Wiseman, R Luke Cell chemical biology 2023 Oct;
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DELE1 oligomerization promotes integrated stress response activation.
Yang, Jie; Baron, Kelsey R; Pride, Daniel E; Schneemann, Anette; Guo, Xiaoyan; Chen, Wenqian; Song, Albert S; Aviles, Giovanni; Kampmann, Martin; Luke Wiseman, R; Lander, Gabriel C Nature structural & molecular biology 2023 Sep;30(9):1295-1302
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NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
Biebl, Maximilian M; Delhommel, Florent; Faust, Ofrah; Zak, Krzysztof M; Agam, Ganesh; Guo, Xiaoyan; Mühlhofer, Moritz; Dahiya, Vinay; Hillebrand, Daniela; Popowicz, Grzegorz M; Kampmann, Martin; Lamb, Don C; Rosenzweig, Rina; Sattler, Michael; Buchner, Johannes Molecular cell 2022 Feb;82(3):555-569.e7
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BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson, Avi J; Tran, Quang Dinh; Robinot, Rémy; Carrau, Lucia; Rezelj, Veronica V; Kain, Alice Mac; Chen, Merissa; Ramadoss, Gokul N; Guo, Xiaoyan; Lim, Shion A; Lui, Irene; Nuñez, James K; Rockwood, Sarah J; Wang, Jianhui; Liu, Na; Carlson-Stevermer, Jared; Oki, Jennifer; Maures, Travis; Holden, Kevin; Weissman, Jonathan S; Wells, James A; Conklin, Bruce R; TenOever, Benjamin R; Chakrabarti, Lisa A; Vignuzzi, Marco; Tian, Ruilin; Kampmann, Martin Nature cell biology 2022 Jan;24(1):24-34
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CRISPR-Based Screening for Stress Response Factors in Mammalian Cells.
Guo, Xiaoyan; Kampmann, Martin Methods in molecular biology (Clifton, N.J.) 2022 Jan;242819-40
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Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.
Goncalves, Jimmy; Wan, Yufeng; Guo, Xiaoyan; Rha, Kyoungsun; LeBoeuf, Brigitte; Zhang, Liusuo; Estler, Kerolayne; Garcia, L René iScience 2020 Apr;23(4):100990
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Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Guo, Xiaoyan; Aviles, Giovanni; Liu, Yi; Tian, Ruilin; Unger, Bret A; Lin, Yu-Hsiu T; Wiita, Arun P; Xu, Ke; Correia, M Almira; Kampmann, Martin Nature 2020 Mar;579(7799):427-432
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Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres, Sandra Elizabeth; Gallagher, Ciara M; Plate, Lars; Gupta, Meghna; Liem, Christina R; Guo, Xiaoyan; Tian, Ruilin; Stroud, Robert M; Kampmann, Martin; Weissman, Jonathan S; Walter, Peter eLife 2019 May;8
