Faculty Directory > Gutstein, Howard
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Howard B. Gutstein, MD, FAAP, FASAProfessor and Chair, Department of Anesthesiology
Pronouns:
He/Him
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| BA | Washington University | Medicine |
| MD | Johns Hopkins University School of Medicine | Medicine |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Internship | University of California | General Surgery |
| Residency | University of California | General Surgery |
| Residency | University of California | Anesthesiology |
| Fellowship | University of California, San Francisco | Pediatric Anesthesiology |
| Postdoctoral | Mental Health Research Institute, University of Michigan | Research Investigator |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Invited Speaker | National Academy of Medicine Annual Meeting |
| Heavner Lectureship | Texas Pain Society |
| Faculty Leadership Academy, Houston, TX | MD Anderson Cancer Center |
| Castle Connolly Top Doctors in America |
Journal Articles
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Chronic Morphine Modulates PDGFR-β and PDGF-B Expression and Distribution in Dorsal Root Ganglia and Spinal Cord in Male Rats.
Puig, Stephanie; Gutstein, Howard B Neuroscience 2023 Mar;519147-161
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Preventing spread of aerosolized infectious particles during medical procedures: A lab-based analysis of an inexpensive plastic enclosure.
Monroe, Luke W; Johnson, Jack S; Gutstein, Howard B; Lawrence, John P; Lejeune, Keith; Sullivan, Ryan C; Jen, Coty N PloS one 2022 Jan;17(9):e0273194
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Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats.
Barker, Katherine E; Lecznar, Alynn J; Schumacher, Jill M; Morris, Jeffrey S; Gutstein, Howard B Journal of neuroscience research 2022 Jan;100(1):149-164
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Use of healthcare resources in patients with low back pain and comorbid depression or anxiety.
Bailes, Anna H; Navlani, Rohit; Koscumb, Stephen; Malecky, Amanda; Marroquin, Oscar C; Wasan, Ajay D; Gutstein, Howard B; Delitto, Anthony; Zigler, Christina; Vo, Nam; Sowa, Gwendolyn A The spine journal : official journal of the North American Spine Society 2021 Sep;21(9):1440-1449
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Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex.
Wang, Yao Q; Wang, Junshi; Xia, Sun-Hui; Gutstein, Howard B; Huang, Yanhua H; Schlüter, Oliver M; Cao, Jun-Li; Dong, Yan Pain 2021 May;162(5):1322-1333
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Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry.
Gaulton, Timothy G; Neuman, Mark D; US intubateCOVID Investigators British journal of anaesthesia 2021 May;126(5):e184-e186
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Artificial hyperventilation normalizes haemodynamics and arterial oxygen content in hypoxic rats.
de Villalobos, Diego; Laserna, Andres; Fowler, Cosmo; A Cuenca, John; Martin, Peyton; Guindani, Michele; Dong, Wenli; B Gutstein, Howard; J Price, Kristen; L Nates, Joseph Anaesthesiology intensive therapy 2021 Jan;53(3):223-231
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Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study.
El-Boghdadly, K; Wong, D J N; Owen, R; Neuman, M D; Pocock, S; Carlisle, J B; Johnstone, C; Andruszkiewicz, P; Baker, P A; Biccard, B M; Bryson, G L; Chan, M T V; Cheng, M H; Chin, K J; Coburn, M; Jonsson Fagerlund, M; Myatra, S N; Myles, P S; O'Sullivan, E; Pasin, L; Shamim, F; van Klei, W A; Ahmad, I Anaesthesia 2020 Nov;75(11):1437-1447
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Spinal Opioid Tolerance Depends upon Platelet-Derived Growth Factor Receptor-β Signaling, Not μ-Opioid Receptor Internalization.
Puig, S; Barker, K E; Szott, S R; Kann, P T; Morris, J S; Gutstein, H B Molecular pharmacology 2020 Oct;98(4):487-496
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EGFR Signaling Causes Morphine Tolerance and Mechanical Sensitization in Rats.
Puig, Stephanie; Donica, Courtney L; Gutstein, Howard B eNeuro 2020 Jan;7(2):
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An assay for chemical nociception in Drosophila larvae.
Lopez-Bellido, Roger; Himmel, Nathaniel J; Gutstein, Howard B; Cox, Daniel N; Galko, Michael J Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2019 Nov;374(1785):20190282
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Growth Factor Signaling Regulates Mechanical Nociception in Flies and Vertebrates.
Lopez-Bellido, Roger; Puig, Stephanie; Huang, Patrick J; Tsai, Chang-Ru; Turner, Heather N; Galko, Michael J; Gutstein, Howard B The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul;39(30):6012-6030
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Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain.
Barkai, Omer; Puig, Stephanie; Lev, Shaya; Title, Ben; Katz, Ben; Eli-Berchoer, Luba; Gutstein, Howard B; Binshtok, Alexander M Pain 2019 Jun;160(6):1281-1296
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A "tail" of opioid receptor variants.
Puig, Stephanie; Gutstein, Howard B The Journal of clinical investigation 2017 Apr;127(4):1221-1224
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Detection and Quantification of Protein Spots by Pinnacle.
Morris, Jeffrey S; Gutstein, Howard B Methods in molecular biology (Clifton, N.J.) 2016 Jan;1384185-201
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Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain.
Donica, Courtney L; Cui, Yan; Shi, Shanping; Gutstein, Howard B PloS one 2014 Jan;9(5):e97105
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Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
Wang, Yan; Barker, Katherine; Shi, Shanping; Diaz, Miguel; Mo, Bing; Gutstein, Howard B Nature medicine 2012 Feb;18(3):385-7
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Hedgehog signaling regulates nociceptive sensitization.
Babcock, Daniel T; Shi, Shanping; Jo, Juyeon; Shaw, Michael; Gutstein, Howard B; Galko, Michael J Current biology : CB 2011 Sep;21(18):1525-33
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AUTOMATED ANALYSIS OF QUANTITATIVE IMAGE DATA USING ISOMORPHIC FUNCTIONAL MIXED MODELS, WITH APPLICATION TO PROTEOMICS DATA.
Morris, Jeffrey S; Baladandayuthapani, Veerabhadran; Herrick, Richard C; Sanna, Pietro; Gutstein, Howard The annals of applied statistics 2011 Jan;5(2A):894-923
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Evaluating the performance of new approaches to spot quantification and differential expression in 2-dimensional gel electrophoresis studies.
Morris, Jeffrey S; Clark, Brittan N; Wei, Wei; Gutstein, Howard B Journal of proteome research 2010 Jan;9(1):595-604
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Informatics and statistics for analyzing 2-d gel electrophoresis images.
Dowsey, Andrew W; Morris, Jeffrey S; Gutstein, Howard B; Yang, Guang-Zhong Methods in molecular biology (Clifton, N.J.) 2010 Jan;604239-55
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SIMS and MALDI MS imaging of the spinal cord.
Monroe, Eric B; Annangudi, Suresh P; Hatcher, Nathan G; Gutstein, Howard B; Rubakhin, Stanislav S; Sweedler, Jonathan V Proteomics 2008 Sep;8(18):3746-54
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The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados.
Hamacher, Michael; Eisenacher, Martin; Tribl, Florian; Stephan, Christian; Marcus, Katrin; Hardt, Tanja; Wiltfang, Jens; Martens, Lennart; Desiderio, Dominic; Gutstein, Howard; Park, Young Mok; Meyer, Helmut E Proteomics 2008 Jun;8(11):2160-4
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The myth of automated, high-throughput two-dimensional gel analysis.
Clark, Brittan N; Gutstein, Howard B Proteomics 2008 Mar;8(6):1197-203
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Pinnacle: a fast, automatic and accurate method for detecting and quantifying protein spots in 2-dimensional gel electrophoresis data.
Morris, Jeffrey S; Clark, Brittan N; Gutstein, Howard B Bioinformatics (Oxford, England) 2008 Feb;24(4):529-36
Book Chapters
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Malignant Hyperthermia in Children
Edjiu N and Gutstein HB Advanced Anesthesiology Review 2023 Mar;683-686
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Anesthetic Management of patients with chronic alcohol or drug use.
Gutstein HB. Anesthetic Pharmacology: Basic Principles and Clinical Practice 2011 Apr;1106-1116
Letters
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Opioids: keeping the good, eliminating the bad.
Puig, Stephanie; Gutstein, Howard B Nature medicine 2017 Mar;23(3):272-273
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Guidelines for reporting the use of gel electrophoresis in proteomics.
Gibson, Frank; Anderson, Leigh; Babnigg, Gyorgy; Baker, Mark; Berth, Matthias; Binz, Pierre-Alain; Borthwick, Andy; Cash, Phil; Day, Billy W; Friedman, David B; Garland, Donita; Gutstein, Howard B; Hoogland, Christine; Jones, Neil A; Khan, Alamgir; Klose, Joachim; Lamond, Angus I; Lemkin, Peter F; Lilley, Kathryn S; Minden, Jonathan; Morris, Nicholas J; Paton, Norman W; Pisano, Michael R; Prime, John E; Rabilloud, Thierry; Stead, David A; Taylor, Chris F; Voshol, Hans; Wipat, Anil; Jones, Andrew R Nature biotechnology 2008 Aug;26(8):863-4
Reviews
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Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics.
Trang, Tuan; Al-Hasani, Ream; Salvemini, Daniela; Salter, Michael W; Gutstein, Howard; Cahill, Catherine M The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct;35(41):13879-88
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Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain.
Shurman, Joseph; Koob, George F; Gutstein, Howard B Pain medicine (Malden, Mass.) 2010 Jul;11(7):1092-8
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Microproteomics: analysis of protein diversity in small samples.
Gutstein, Howard B; Morris, Jeffrey S; Annangudi, Suresh P; Sweedler, Jonathan V Mass spectrometry reviews 2008 Jan;27(4):316-30
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| The opioid epidemic-causes and treatment strategies - Grand Rounds speaker | Talk | Departments of ENT, OMFS, and Plastic Surgery, University of Pittsburgh | 2019 | Pittsburgh, PA |
| Invited speaker, Ohio State University Center for Clinical and Translational Science Annual Scientific Meeting | Talk | Ohio State University | 2018 | Columbus, OH |
| Molecular approaches to eliminating opioid tolerance - Invited speaker | Talk | International Society for Anesthetic Pharmacology | 2018 | San Francisco, CA |
| Keynote speaker, Behavioral and Biomedical Sciences Spring Symposium | Talk | West Virginia University | 2018 | Morgantown, WV |