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Rosaria Guzzo, Ph.D.Assistant ProfessorDepartment of Neuroscience Investigator, Stem Cell Institute Program Director, Skeletal Biology and Regeneration Graduate Program
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- Overview
- Education & Training
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Dr. Rosaria Guzzo is an assistant professor in the Department of Neuroscience and an investigator in the Stem Cell Institute. Her research has focused on understanding the underlying mechanisms that dictate differentiation of stem cells to musculoskeletal lineages.
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.Sc. | University of Ottawa | Biochemistry-Nutrition |
| Ph.D. | University of Ottawa | Pharmacology |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | Sanford-Burnham Medical Research Institute | Research fellow, Development, Aging and Regeneration Program |
| Postdoctoral | UConn School of Medicine | Research fellow, Department of Orthopaedic Surgery |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Mid-Career Faculty Travel Grant | American Society for Bone and Mineral Research |
| Basic Research Poster Award-Aging Research Day | Univeristy of Connecticut |
| Postdoctoral Fellowship Award | American Heart Association |
| Excellence Scholarship | University of Ottawa |
| Doctoral Fellowship Award | Canadian Institutes of Health Research |
| Entrance Scholarship | University of Ottawa |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| PhD Qualifying Exam Committee - Hui Sun (Skeletal Biology and Regeneration) | Education Committee | Examiner | UConn Health | University | 2023 | |
| PhD Qualifying Exam Committee - Steven Toro (Skeletal Biology and Regeneration) | Education Committee | Examiner | UConn Health | University | 2023 | 2023 |
| PhD Qualifying Exam Committee - Justin King (Skeletal Biology and Regeneration) | Education Committee | Examiner | UConn Health | University | 2023 | 2023 |
| Biomedical Science Graduate School Admissions Committee | Advisory Committee | Reviewer | UConn Health | University | 2023 | 2023 |
| Skeletal Biology and Regeneration Graduate Program | Education Committee | Program Director | UConn Health | University | 2022 | |
| PhD Student General Exam Committee (Qinfang Liu) | Education Committee | Examiner | UConn Health | University | 2022 | |
| Natural Sciences and Engineering Research Council of Canada, Discovery Grants Program | Study Section | Reviewer | External | International | 2022 | |
| American Society for Bone and Mineral Research Membership Engagement Committee | Professional/Scientific Organization | Committee Member | External | International | 2022 | 2025 |
| Graduate Program, Skeletal Biology and Regeneration Area of Concentration | Education Committee | Associate Director | UConn Health | University | 2020 | 2021 |
| Skeletal Biology and Regeneration (SBR) Graduate Program | Education Committee | Associate Director | UConn Health | University | 2020 | 2020 |
| Ad Hoc Reviewer | Professional/Scientific Journal | Manuscript Reviewer | External | International | 2019 | 2019 |
| Biomedical Sciences, Graduate School, 1st year student advisor | Education Committee | Advisor | University | 2019 | ||
| Curriculum Committee, Skeletal Biology and Regeneration Graduate Program | Chair | UConn Health | University | 2018 | 2019 | |
| Graduate School General Exam Committee, Skeletal Biology and Regeneration Area of Concentration (Laura Doherty) | Education Committee | Examiner | UConn Health | University | 2018 | 2018 |
| Medical School Research Day | Research Committee | Examiner, oral presentations | UConn Health | University | 2018 | 2018 |
| MD/PHD Admissions | Education Committee | Interviewer | UConn Health | University | 2017 | |
| Scientific Review Panel, Medical Student Research | Education Committee | Reviewer | UConn Health | University | 2017 | 2017 |
| Biomedical Science Graduate School Admissions | Education Committee | Interviewer | UConn Health | University | 2016 | |
| Scientific Review Panel, Medical student summer research proposals | Education Committee | Reviewer | UConn Health | University | 2016 | |
| Curriculum Committee, Skeletal Biology and Regeneration Graduate Program | Education Committee | Vice Chair | UConn Health | University | 2016 | 2017 |
| PHD Thesis Advisory (Alexandra Nicaise, Neuroscience) | Research Committee | Committee member | UConn Health | University | 2016 | 2018 |
| Graduate School General Exam Committee, Skeletal Biology and Regeneration Area of Concentration (Patience Mao-Burt) | Education Committee | Examiner | UConn Health | University | 2015 | 2015 |
| Graduate School General Exam Committee, Skeletal Biology and Regeneration Area of Concentration (Spencer Smith) | Education Committee | Examiner | UConn Health | University | 2015 | 2016 |
| Musculoskeletal Program “Work in Progress” Seminar Series | Other | Seminar Series Coordinator | UConn Health | University | 2009 | 2013 |
| Let’s Talk Science -Volunteer Outreach Program Promoting Science Among High School Students | Community Service | External | Local | 2001 | 2001 | |
| American Society for Cell Biology | Professional/Scientific Organization | External | National | 1999 | ||
| Pharmacology Graduate Program Student Council | Advisory Committee | External | University | 1999 | 2000 | |
| American Society for Bone and Mineral Research | Professional/Scientific Organization | Member | External | International | ||
| NIH - Center for Scientific Review Special Emphasis Panel ZRG1 MCST-U (80) Training in Veterinary and Comparative Medicine June 2023 | Study Section | Reviewer | External | National | ||
| NIH - Center for Scientific Review Special Emphasis Panel ZRG1 MSOS-L (03) Musculoskeletal, Dental and Oral Sciences December 2023 | Study Section | Reviewer | External | National | ||
| Graduate Programs Committee | Advisory Committee | Members - Skeletal Biology and Regeneration AoC Representative | UConn Health | University |
My independent research focuses on novel molecular and epigenetic mechanisms in the transcriptional regulation of musculoskeletal and how these mechanisms control physiological processes in homeostasis and degeneration. This research bears significance to clinically relevant problems related to regenerative therapies.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
Journal Articles
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Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures.
eLife 2023 Jan;12
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Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.
Bone 2021 Jan;142115677
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TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.
Molecular neurobiology 2018 Aug;
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iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response.
Experimental neurology 2016 Nov;288114-121
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Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially With BMP-2 and Wnt5a
Stem Cells Translational Medicine 2016 Aug;241639-41
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Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially With BMP-2 and Wnt5a.
Stem cells translational medicine 2016 Aug;
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Aberrant expression of Twist1 in diseased articular cartilage and a potential role in the modulation of osteoarthritis severity
Genes and Diseases 2016 Mar;3(1):88-99
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Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential.
Stem cell reviews 2014 Jun;10(6):820-9
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PDGF-BB inhibits intervertebral disc cell apoptosis in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014 May;32(9):1181-8
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Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.
Genes & development 2013 Nov;27(21):2332-44
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PDLA/PCL nanofiber-thermogelling chitosan gel composite scaffolds for osteochondral tissue regeneration in a
rat model.
J Bioactive Compatible Polymers 2013 Feb;28(2):115-125
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Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells.
Journal of cellular biochemistry 2013 Feb;114(2):480-90
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A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis.
Circulation research 2012 Sep;111(7):876-81
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Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1585-97
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Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice.
The International journal of developmental biology 2011 Jan;55(6):641-7
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Hydrophobic profiles of the tail anchors in SLMAP dictate subcellular targeting.
BMC cell biology 2009 Jan;1048
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Embryonic heart induction.
Annals of the New York Academy of Sciences 2006 Oct;108085-96
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Molecular properties of cardiac tail-anchored membrane protein SLMAP are consistent with structural role in arrangement of excitation-contraction coupling apparatus.
American journal of physiology. Heart and circulatory physiology 2005 Apr;288(4):H1810-9
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Regulated expression and temporal induction of the tail-anchored sarcolemmal-membrane-associated protein is critical for myoblast fusion.
The Biochemical journal 2004 Aug;381(Pt 3):599-608
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A novel isoform of sarcolemmal membrane-associated protein (SLMAP) is a component of the microtubule organizing centre.
Journal of cell science 2004 May;117(Pt 11):2271-81
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Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins.
The Journal of biological chemistry 2000 Dec;275(49):38474-81
Book Chapters
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Human Pluripotent Stem Cells: Advances in Chondrogenic Differentiation and Articular Cartilage Regeneration
Current Molecular Biology Reports 2016 Jul;Stem/Progenitor Cells Biology and Regeneration1-10
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Cardiac development in the frog.
Heart Development and Regeneration 2008 Jan;87-102
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Signaling pathways in embryonic heart
induction.
Advances in Developmental Biology: Cardiovascular Development 2007 Jan;117-151
Abstracts
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Control of cartilage maintenance and degeneration by Twist1 and Runx1 transcription factors.
American Society for Bone and Mineral Research Annual Meeting: Baltimore, MD 2013 Oct;
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Defining the chondrogenic potential of iPSC-derived
mesenchymal stem cells.
StemConn 2013 Symposium: New Haven, CT 2013 Apr;
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Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages.
BMC developmental biology 2013 Apr;51
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Incremental loss of Runx1 function temporally impairs fracture healing.
2010 Annual Meeting of the Orthopaedic Research Society: Long Beach, CA 2010 Jan;
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Heart Induction in mouse embryonic stem cells by
Nodal/Cripto involves Cerberus.
15th Weinstein Cardiovascular Development Conference: San Francisco, CA 2009 Jan;
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Twist1 overexpression in
chondrocytes leads to aberrant growth plate organization in vivo.
American Society of Bone and Mineral Research 2009 Jan;
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Paracrine factors promote embryonic
stem cell-derived cardiomyocyte specification.
14th Weinstein Cardiovascular Development Conference: Indianapolis, IN, USA 2007 Jan;
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Endoderm-derived signals promote cardiogenesis in embryonic stem cell cultures.
13th Annual Weinstein Cardiovascular Development Conference 2006 Jan;
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Expression of the tail-anchored protein SLMAP in developing myocardium and during remodeling after myocardial infarction.
Canadian Cardiovascular Congress: Vancouver, AB, Canada. 2006 Jan;
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Developmental expression and a potential role for sarcolemmal membrane-associated proteins (SLMAPs) in muscle differentiation.
42nd Annual Meeting of the American Society of Cell Biology: San Francisco, CA 2002 Jan;
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Sarcolemmal Associated Proteins
(SLMAPs) comprise a novel family of alpha-helical coiled-coil membrane proteins associated with the
Golgi apparatus.
Canadian Society of Biochemistry and Molecular and Cellular Biology 11th Winternational Conference 2001 Jan;
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Targeting of Sarcolemmal Associated Proteins (SLMAPs) to cellular membranes and the microtubule organizing
centre.
39th Annual Meeting of the American Society of Cell Biology: Washington, DC 1999 Jan;
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SLMAP: A coiled-coil protein associated
with membranes exhibits changes during the cell cycle that are suggestive of a role in cleavage.
Signaling in Normal and Cancer Cells: Banff, AB, Canada 1998 Jan;
Conference Papers
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Non-catalytic functions of Dot1L histone methyltransferase regulate endochondral bone growth and development | Talk | American Society for Bone and Mineral Research Annual Meeting | 2022 | Austin, Texas |
| Developmental models to study skeletal growth | Talk | 8th Annual Developmental Biology Day, University of Hartford | 2022 | Hartford, CT |
| Understanding the role of the Disruptor of Telomeric Silencing-1 like in Skeletal Growth and Development | Talk | 16th Annual Musculoskeletal Institute Research Day: The Future of the MSI | 2022 | UConn Health, Farmington, CT |
| Postnatal inactivation of Dot1L histone methyltransferase in growth plate cartilage impairs longitudinal bone growth | Poster | ASBMR Annual Meeting | 2018 | Montreal, PQ Canada |
| Postnatal inactivation of Dot1L histone methyltransferase in growth plate cartilage impairs longitudinal bone growth | Poster | Mechanistic and Therapeutic Advances in Rare Skeletal Diseases | 2018 | Montreal, PQ Canada |
| Growth plate characterization in Dot1L conditional knockout mice | Poster | UConn Health, Summer Student Research Day | 2018 | Farmington, CT |
| Efficacy of pharmacological and genetic inhibition of Dot1L in chondrocytes | Talk | UConn Health, Summer Student Research Day | 2018 | Farmington, CT |
| Establishing the chondrogenic potential of human iPS cells: tissue and disease-specific effects | Talk | Connecticut Stem Cell Retreat | 2014 | Wesleyan, University |
| Interrogating the epigenetic control of skeletal growth and development | Talk | University of Connecticut Health Center | 2014 | |
| Twist1 is Differentially Regulated in Normal and Osteoarthritic Articular Cartilage | Lecture | Orthopaedic Research Society | 2012 | San Francisco, CA |
| Differentiation of Induced Pluripotent Stem Cells Into an Articular Cartilage-like Phenotype | Lecture | University of Connecticut Health Center | 2011 | Farmington, CT |
| In vivo Role of Twist1 During Cartilage Development | Lecture | Orthopaedic Research Society | 2009 | Las Vegas, NV |
| The San Diego Consortium for Regenerative Medicine: “The Stem Cell Meeting on the Mesa” | Lecture | The Salk Institute | 2006 | La Jolla, CA |