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Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326).
Ferguson, Mary R; Delgado, Kristina N; McBride, Shannon; Orbe, Isabel C; La Vake, Carson J; Caimano, Melissa J; Mendez, Qiana; Moraes, Trevor F; Schryvers, Anthony B; Moody, M Anthony; Radolf, Justin D; Weiner, Michael P; Hawley, Kelly L Frontiers in immunology 2023 Jan;141222267
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Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis.
Delgado, Kristina N; Montezuma-Rusca, Jairo M; Orbe, Isabel C; Caimano, Melissa J; La Vake, Carson J; Luthra, Amit; Hennelly, Christopher M; Nindo, Fredrick N; Meyer, Jacob W; Jones, Letitia D; Parr, Jonathan B; Salazar, Juan C; Moody, M Anthony; Radolf, Justin D; Hawley, Kelly L mBio 2022 Aug;13(4):e0163922
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A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples.
Chen, Wentao; Luo, Hao; Zeng, Lihong; Pan, Yuying; Parr, Jonathan B; Jiang, Yinbo; Cunningham, Clark H; Hawley, Kelly L; Radolf, Justin D; Ke, Wujian; Ou, Jiangli; Yang, Jianjiang; Yang, Bin; Zheng, Heping Nature communications 2022 Aug;13(1):4671
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High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny.
Lieberman, Nicole A P; Armstrong, Thaddeus D; Chung, Benjamin; Pfalmer, Daniel; Hennelly, Christopher M; Haynes, Austin; Romeis, Emily; Wang, Qian-Qiu; Zhang, Rui-Li; Kou, Cai-Xia; Ciccarese, Giulia; Conte, Ivano Dal; Cusini, Marco; Drago, Francesco; Nakayama, Shu-Ichi; Lee, Kenichi; Ohnishi, Makoto; Konda, Kelika A; Vargas, Silver K; Eguiluz, Maria; Caceres, Carlos F; Klausner, Jeffrey D; Mitja, Oriol; Rompalo, Anne; Mulcahy, Fiona; Hook, Edward W; Hoffman, Irving F; Matoga, Mitch M; Zheng, Heping; Yang, Bin; Lopez-Medina, Eduardo; Ramirez, Lady G; Radolf, Justin D; Hawley, Kelly L; Salazar, Juan C; Lukehart, Sheila A; Seña, Arlene C; Parr, Jonathan B; Giacani, Lorenzo; Greninger, Alexander L Frontiers in microbiology 2022 Jan;131007056
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Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation.
Benjamin, Sarah J; Hawley, Kelly L; Vera-Licona, Paola; La Vake, Carson J; Cervantes, Jorge L; Ruan, Yijun; Radolf, Justin D; Salazar, Juan C BMC immunology 2021 May;22(1):32
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Structural modeling of the Treponema pallidum OMPeome: a roadmap for deconvolution of syphilis pathogenesis and development of a syphilis vaccine.
Hawley, Kelly L; Montezuma-Rusca, Jairo M; Delgado, Kristina N; Singh, Navreeta; Uversky, Vladimir N; Caimano, Melissa J; Radolf, Justin D; Luthra, Amit Journal of bacteriology 2021 May;
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Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.*Shared First Authorship
Luthra, Amit; Montezuma-Rusca, Jairo M* ; La Vake, Carson J; LeDoyt, Morgan; Delgado, Kristina N; Davenport, Timothy C; Fiel-Gan, Mary; Caimano, Melissa J; Radolf, Justin D; Hawley, Kelly L. PLoS pathogens 2020 Sep;16(9):e1008871
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Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres.
Chen, Wentao; Šmajs, David; Hu, Yongfei; Ke, Wujian; Pospíšilová, Petra; Hawley, Kelly L; Caimano, Melissa J; Radolf, Justin D; Sena, Arlene; Tucker, Joseph D; Yang, Bin; Juliano, Jonathan J; Zheng, Heping; Parr, Jonathan B The Journal of Infectious Diseases (in press) 2020 Jul;
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The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.
Caimano, Melissa J; Groshong, Ashley M; Belperron, Alexia; Mao, Jialing; Hawley, Kelly L; Luthra, Amit; Graham, Danielle E; Earnhart, Christopher G; Marconi, Richard T; Bockenstedt, Linda K; Blevins, Jon S; Radolf, Justin D Frontiers in microbiology 2019 Sep;101923
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Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.
Alhamdi JR, Peng T, Al-Naggar IM, Hawley KL, Spiller KL, and Kuhn LT. Biomaterials 2018 Jul;
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Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.
Kumar, Sanjiv; Caimano, Melissa J; Anand, Arvind; Dey, Abhishek; Hawley, Kelly L; LeDoyt, Morgan E; La Vake, Carson J; Cruz, Adriana R; Ramirez, Lady G; Pašteková, Lenka; Bezsonova, Irina; Šmajs, David; Salazar, Juan C; Radolf, Justin D mBio 2018 Jun;9(3):
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Inflammation and immune evasion coexist in Treponema pallidum-infected skin.
Trujillo, Rodolfo; Cervantes, Jorge; Hawley, Kelly L; Cruz, Adriana R; Babapoor, Sankhiros; Murphy, Michael; Dadras, Soheil S; Salazar, Juan C JAAD case reports 2018 Jun;4(5):462-464
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IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.
Hawley, Kelly L; Cruz, Adriana R; Benjamin, Sarah J; La Vake, Carson J; Cervantes, Jorge L; LeDoyt, Morgan; Ramirez, Lady G; Mandich, Daniza; Fiel-Gan, Mary; Caimano, Melissa J; Radolf, Justin D; Salazar, Juan C Frontiers in immunology 2017 Jan;81227
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FcεRI cross-linking reduces cord blood dendritic cell responsiveness to lipopolysaccharides.
Paveglio, Sara; Bennett, Erin; Hawley, Kelly L; Matson, Adam P The Journal of allergy and clinical immunology 2016 Dec;1391992-1994.e3
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A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.
Luthra, Amit; Anand, Arvind; Hawley, Kelly L; LeDoyt, Morgan; La Vake, Carson J; Caimano, Melissa J; Cruz, Adriana R; Salazar, Juan C; Radolf, Justin D Journal of bacteriology 2015 Mar;197(11):1906-20
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Serum C3 Enhances Complement Receptor 3-Mediated Phagocytosis of Borrelia burgdorferi.
Hawley, Kelly L; Olson, Chris M; Carreras-González, Ana; Navasa, Nicolás; Anguita, Juan International journal of biological sciences 2015 Jan;11(11):1269-71
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Phagosomal TLR signaling upon Borrelia burgdorferi infection.
Cervantes, Jorge L; Hawley, Kelly L; Benjamin, Sarah J; Weinerman, Bennett; Luu, Stephanie M; Salazar, Juan C Frontiers in cellular and infection microbiology 2014 Jan;455
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CD14 targets complement receptor 3 to lipid rafts during phagocytosis of Borrelia burgdorferi.
Hawley, Kelly L; Martín-Ruiz, Itziar; Iglesias-Pedraz, Juan M; Berwin, Brent; Anguita, Juan International journal of biological sciences 2013 Jan;9(8):803-10
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Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection.
Hawley, Kelly; Navasa, Nicolás; Olson, Chris M; Bates, Tonya C; Garg, Renu; Hedrick, Michael N; Conze, Dietrich; Rincón, Mercedes; Anguita, Juan The Journal of infectious diseases 2012 Jul;206(2):283-91
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CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
Hawley, Kelly L; Olson, Chris M; Iglesias-Pedraz, Juan M; Navasa, Nicolás; Cervantes, Jorge L; Caimano, Melissa J; Izadi, Hooman; Ingalls, Robin R; Pal, Utpal; Salazar, Juan C; Radolf, Justin D; Anguita, Juan Proceedings of the National Academy of Sciences of the United States of America 2012 Jan;109(4):1228-32
