John Travis Hinson, M.D.Assistant Professor of Cardiology and Genetics
Dr. Travis Hinson is the second joint faculty appointment with The Jackson Laboratory for Genomic Medicine. He brings his expertise in cardiovascular genetics from Brigham and Women’s Hospital. Dr. Hinson’s study of the genetics of heart muscle diseases includes the bioengineering of heart cells derived from pluripotent stem cells. He also treats patients with inherited forms of cardiovascular diseases.
|M.D.||Havard Medical School||Medicine|
|Residency||Massachusetts General Hospital||Internal Medicine|
|Fellowship||Brigham and Women's Hospital||Cardiovascular Medicine|
My laboratory utilizes genomic approaches to interrogate mechanisms of inherited cardiovascular disorders especially those that lead to heart failure. We are particularly interested in developing single cell and cardiac microtissue assays derived from disease-specific, human induced pluripotent stem cells (iPScs) in combination with in vivo mouse models. My lab’s current research focus is directed toward: 1) defining the role of AMPactivated protein kinase in physiologic and pathologic forms of cardiac remodeling; 2) engineering cardiac microtissues to study the most common forms of familial hypertrophic and dilated cardiomyopathies due to sarcomere mutations; and 3) to develop assays for high-throughput functional genomic screens to predict pathogenicity of genetic variation in cardiomyopathy genes. These studies capitalize on the laboratory’s expertise in human genetics, stem cell biology, tissue engineering and computational methods.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
Adult mouse fibroblasts retain organ-specific transcriptomic identity.
eLife 2022 Mar;11
Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells.
Development (Cambridge, England) 2022 Feb;
Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics.
Circulation research 2022 Jan;130(2):273-287
Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions.
Circulation 2021 Dec;
Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2.
Cell reports 2021 Aug;36(6):109512
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Cell reports 2021 May;35(5):109088
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis.
JACC. Basic to translational science 2021 Feb;
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis.
Molecular cell 2020 Nov;80(4):648-665.e9
Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants.
Circulation 2020 Oct;
From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model.
Circulation research 2020 Jan;126(3):347-349
Single-cell analysis of human cardiomyocyte polyploidization reveals that sarcomere assembly regulates endocycling through CCNB1 inhibition.
Under Review 2019 Oct;
Sarcomere-Directed Calcium Reporters in Cardiomyocytes.
Circulation research 2019 Apr;124(8):1151-1153
A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations.
Stem cell reports 2018 Dec;1271-83
Telomere shortening is a hallmark of genetic cardiomyopathies.
Proceedings of the National Academy of Sciences of the United States of America 2018 Sep;115(37):9276-9281
Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.
Developmental cell 2018 Jan;44(1):87-96.e5
Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.
Cell reports 2016 Dec;17(12):3292-3304
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Science (New York, N.Y.) 2015 Aug;349(6251):982-6
Induced pluripotent stem cell modeling of complex genetic diseases.
Drug discovery today. Disease models 2012 Jan;9(4):e147-e152
Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
American journal of physiology. Heart and circulatory physiology 2008 Apr;294(4):H1939-47
Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome.
The New England journal of medicine 2007 Feb;356(8):809-19
Gene delivery to pig coronary arteries from stents carrying antibody-tethered adenovirus.
Human gene therapy 2002 Feb;13(3):443-54
Bisphosphonate derivatized polyurethanes resist calcification.
Biomaterials 2001 Oct;22(19):2683-93
High reactivity of alkyl sulfides towards epoxides under conditions of collagen fixation--a convenient approach to 2-amino-4-butyrolactones.
Biomaterials 2001 Sep;22(18):2501-6
Localized adenovirus gene delivery using antiviral IgG complexation.
Gene therapy 2001 May;8(9):659-67
Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts.
Journal of biomedical materials research 1999 Oct;47(1):65-70
Coronary sinus pacing for the management of right ventricular and atrial infarction with isolated right ventricular pulsus alternans.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 2013 Jan;40(4):497-9
Family Screening in DCM: Can Genetics and Baseline Clinical Data Assist Prognostication and Surveillance Planning?
JACC. Heart failure 2022 Nov;10(11):804-806
Molecular genetic mechanisms of dilated cardiomyopathy.
Current opinion in genetics & development 2022 Jul;76101959
The Cardiac Sarcomere and Cell Cycle.
Current cardiology reports 2022 Apr;
The NIH Somatic Cell Genome Editing program.
Nature 2021 Apr;592(7853):195-204