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Mayu Inaba-Oguro, MD, PhDAssociate Professor, Department of Cell BiologyCo-Director, Cell Biology Area of Concentration-Biomedical Science Ph.D. program
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- Education & Training
- Teaching
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| MD | Ehime University School of Medicine | Medicine |
| PhD | Graduate School of Kyushu University | Pathological Medicine |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Tokyo | JSPS postdoctoral research fellow |
| Postdoctoral | University of Michigan | HHMI Research Specialist I |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| R35 Outstanding Investigator Award, The National Institute of General Medical Sciences | NIH, NIGMS |
| DeLill Nasser Travel Award for Professional Development in Genetics | Genetics Society of America |
| Travel Award for 52nd Annual Meeting of the American Society for Cell Biology | American Society for Cell Biology |
| Research Fellowship 2003 - 2006 | Japan Society for the Promotion of Science for Young Scientists |
- MEDS-6449-Foundations of Biomedical Science II (Cell cycle)
- MEDS-5309-Molecular Basis of Disease
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| NIGMS MIRA Study Section | Study Section | Panelist | External | National | 2025 | |
| NSF MCB Study section | Study Section | Panelist | External | National | 2025 | |
| Director, Cell Biology PhD program | Education Committee | UConn Health | University | 2024 |
Our research aims to elucidate how cells alter their fates between normal or disease conditions. Building on our long-standing interest in the molecular mechanisms that control gene expression and cell fate, our laboratory has recently expanded its research to investigate how genome architecture and nuclear RNA contribute to the gene regulatory networks. Transposable elements (TEs) are major drivers of genome evolution, yet how they persist under selective pressure and become integrated into host gene regulatory networks remains poorly understood. Our laboratory investigates the expression of TEs in the germline, where their activity can generate heritable variation. We unexpectedly found that multiple TE RNAs that localize to distinct nuclear domains corresponding to the "lampbrush chromosomes" formed by giant Y-linked fertility genes. Disruption of a key splicing factor results in a widespread loss of TE transcripts, confirming that many TEs are transcribed as part of introns within cellular genes. Importantly, single-molecule FISH targeting distinct TE families, combined with the probes targetting fertility genes, enables direct visualization of nascent TE transcripts on lampbrush chromosomes with remarkable spatial resolution, providing a unique opportunity to investigate the structural basis of active gene expression.
Using TE tools, we are currently investigating the gene regulatory mechanisms during Drosophila spermatogenesis. Our work will further tackle the mechanism in which continual remodeling of gene structure occuring among closely related Drosophila species, and provide a mechanism for the evolution of germline gene expression and reproductive diversification and speciation.
Accepting Lab Rotation Students: Fall Block 2026, Spring 1 and 2 Block 2027
Rotation programs will be related to one of ongoing projects.
Journal Articles
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Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche.
Communications biology 2026 Apr;
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Protocol to evaluate a lineage marking system in the Drosophila testis.
STAR protocols 2026 Apr;7(2):104479
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Stem cells resume asymmetric division upon niche re-entry through reactivating the centrosome orientation checkpoint.
Communications biology 2026 Mar;
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The functional organization of chromosome territories in single nuclei during zygotic genome activation.
Scientific reports 2026 Jan;
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Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells.
bioRxiv : the preprint server for biology 2025 Oct;
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Detection of dedifferentiated stem cells in the Drosophila testis.
iScience 2025 Oct;28(10):113564
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Oligopaint FISH in Drosophila Testes.
Methods in molecular biology (Clifton, N.J.) 2025 Apr;
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Phyloproteomics Reveals Conserved Patterns of Axonemal Dynein Methylation Across the Motile Ciliated Eukaryotes.
Molecular biology of the cell 2025 Feb;mbcE25020055
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Soma-to-germline BMP signal is essential for Drosophila spermiogenesis.
Developmental biology 2025 Jan;517140-147
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Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation.
Nature communications 2024 Feb;15(1):1166
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Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.
Nature communications 2022 Jul;13(1):3981
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Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary.
PloS one 2022 Jan;17(11):e0276704
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Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division.
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar;118(13):e2006786118
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Self-limiting stem-cell niche signaling through degradation of a stem-cell receptor.
PLoS biology 2020 Dec;18(12):e3001003
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Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development.
G3 (Bethesda, Md.) 2016 Dec;6(12):3849-3857
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Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division.
eLife 2016 Nov;5
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Nanotubes mediate niche-stem-cell signalling in the Drosophila testis.
Nature 2015 Jul;523(7560):329-32
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The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline.
eLife 2015 Mar;4
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Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary.
PloS one 2014 Jan;9(3):e90267
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Lineage tracing quantification reveals symmetric stem cell division in Drosophila male germline stem cells.
Cellular and molecular bioengineering 2013 Dec;6(4):441-448
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Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells.
Molecular biology of the cell 2012 Apr;23(8):1524-32
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String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.
Development (Cambridge, England) 2011 Dec;138(23):5079-86
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E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells.
PloS one 2010 Aug;5(8):e12473
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Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006 Jan;176(1):380-9
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Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
The Journal of experimental medicine 2005 Jul;202(1):169-79
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Physical and functional interactions between STAP-2/BKS and STAT5.
The Journal of biological chemistry 2005 Mar;280(9):8188-96
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Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.
Biochemical and biophysical research communications 2003 Jul;306(3):767-73
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STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.
The Journal of biological chemistry 2003 Mar;278(13):11182-9
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Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation.
Biochemical and biophysical research communications 2003 Feb;301(4):899-906
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CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation.
Journal of biochemistry 2003 Jan;133(1):109-13
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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.
The Journal of biological chemistry 2001 Apr;276(16):12530-8
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Identification of a stimulus-dependent DNase I hypersensitive site between the Ialpha and Calpha exons during immunoglobulin heavy chain class switch recombination.
FEBS letters 2000 Feb;467(2-3):268-72
Book Chapters
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Enrichment of Undifferentiated Germline and Somatic Cells from Drosophila Testes.
Methods in molecular biology (Clifton, N.J.) 2023 Jan;127-138
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Ultrastructural Analysis of Cell-Cell Interactions in Drosophila Ovary.
Methods in molecular biology (Clifton, N.J.) 2021 Jan;234679-90
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Evaluation of the Asymmetric Division of Drosophila Male Germline Stem Cells.
Methods in molecular biology (Clifton, N.J.) 2017 Jan;49-62
Editorials
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Editorial.
Seminars in cell & developmental biology 2022 Sep;12961-62
Other
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Dedifferentiating germ cells regain stem-cell specific polarity checkpoint prior to niche reentry.
bioRxiv : the preprint server for biology 2023 Apr;
Reviews
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Plasticity and stringency: rethinking stem cell division modes.
Biochemical Society transactions 2026 Feb;54(2):
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Removal of cellular protrusions.
Seminars in cell & developmental biology,129:126-134. 2022 Mar;
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Modulation of Cell-Cell Interactions in Drosophila Oocyte Development.
Cells 2020 Jan;9(2):
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Specialized Intercellular Communications via Cytonemes and Nanotubes.
Annual review of cell and developmental biology 2018 Aug;3459-84
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Keeping stem cells under control: New insights into the mechanisms that limit niche-stem cell signaling within the reproductive system.
Molecular reproduction and development 2016 Aug;83(8):675-83
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Signaling by Cellular Protrusions: Keeping the Conversation Private.
Trends in cell biology 2016 Jul;26(7):526-34
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Asymmetric stem cell division: precision for robustness.
Cell stem cell 2012 Oct;11(4):461-9
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| 67th Annual Drosophila Research Conference (Poster: Sophia Bizink) | Poster | GSA | 2026 | Chicago |
| 67th Annual Drosophila Research Conference (Poster: Stella DiPippo) | Poster | GSA | 2026 | Chicago |
| UNLV life science seminar (Talk: Mayu Inaba) | Talk | University of Nevada, Las Vegas | 2026 | Las Vegas |
| The 14th International BMP Conference (Talk: Mayu Inaba) | Talk | 2025 | University of Pennsylvania | |
| University of Michigan, CDB Seminar (Talk: Mayu Inaba) | Talk | University of Michigan | 2025 | Ann Arbor, MI |
| The 14th International BMP Conference (Poster: Samaneh Poursaeid) | Poster | 2025 | University of Pennsylvania | |
| The 76th Annual Meeting of the Japan Society for Cell Biology | Talk | Japan Society for Cell Biology | 2024 | Tsukuba, Japan |
| Emerging mechanism of asymmetric stem cell division | Talk | 2024 Cell Polarity Signaling Gordon Research Conference | 2024 | NH, United States |
| Dedifferentiation of Fly Germline Stem Cells by Burak Bener | Poster | CSHL Germ Cell Meeting | 2024 | CSHL NY |
| Role of Brinker in dedifferentiation of germline stem cells by Samaneh Poursaeid | Poster | CSHL Germ Cell Meeting | 2024 | CSHL NY |
| Mitochondrial quality control in Drosophila spermatocytes by Emma Kristine Beard | Poster | 2024 | CSHL Germ Cell Meeting | |
| Characterization of stage-specific expression and localization of a non-LTR retrotransposon, Juan, in Drosophila spermatocytes (Poster: Emma Kristine Beard: UConn undergraduate student) | Poster | American Society for Cell Biology meeting | 2023 | Boston |
| Long-term live imaging to monitor dedifferentiation in the Drosophila testicular niche (Poster: Muhanmmed Burak Bener: PhD student) | Poster | American Society for Cell Biology meeting | 2023 | Boston |
| Roles of Insulin receptor (InR) and an adaptor protein Lnk indedifferentiation of Drosophila male germline stem cells (Poster: Autumn Twillie: UConn undergraduate student) | Poster | ASCB 2023 Annual Meeting | 2023 | Boston |
| Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation (Poster: Mayu Inaba) | Poster | ASCB 2023 Annual Meeting | 2023 | Boston |
| The Role of Diffusible Niche Ligand in Fine-Tuning Expression of bag of marbles in the Drosophila Testis (Poster: Samaneh Poursaeid: Post-doc) | Poster | ASCB | 2023 | Boston |
| Mobius strips in cells (Poster: Rakshan Chadha: UConn Undergraduate student, and Mayu Inaba) | Poster | ASCB | 2023 | Boston |
| NIH/NICHD Seminar (Talk: Mayu Inaba) | Talk | NIH/NICHD | 2023 | Bethesda, Maryland |
| Frontiers in Biology, Stanford University (Talk: Mayu Inaba) | Talk | Stanford University | 2023 | Palo Alto, San Francisco |
| Johns Hopkins University, Department of Biology Seminar Series (Talk: Mayu Inaba) | Talk | JHU | 2022 | Online |
| ISSCR 2022 Annual Meeting (Poster: Matthew Antel) | Poster | ISSCR | 2022 | San Francisco |
| 63rd Annual Drosophila Research ConferencePoster (Muhammed Burak Bener) | Poster | GSA | 2022 | San Diego |
| FASEB 2022, The TGF-ß Superfamily Conference: Signaling in Development and Disease (Talk: Mayu Inaba) | Talk | FASEB | 2022 | Malahide, Ireland |
| 63rd Annual Drosophila Research Conference (Poster: Matthew Antel) | Poster | GSA | 2022 | San Diego |
| Developmental Biology Seminar Series, Gurdon Institute, University of Cambridge (Talk: Mayu Inaba) | Talk | Gurdon Institute, University of Cambridge | 2021 | Online |
| ASCB-EMBO 2020 Meeting (Poster: Muhanmmed Burak Bener) Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division | Poster | ASCB | 2020 | Online |
| Queens College Biology Colloquium, Queens College, CUNY (Talk: Mayu Inaba) | Talk | Queens College, CUNY, NY | 2019 | NY, United States |
| The Fifth International Oocyte Meeting (Talk: Mayu Inaba) | Talk | The Fifth International Oocyte Meeting | 2019 | Nice, France |
| 2019 Gordon Research Conference on Fertilization and Activation of Development (Talk: Mayu Inaba) | Talk | Gordon Research Conference | 2019 | NH, United States |
| Cold Spring Harbor Meeting, Germ Cells, Cold Spring Harbor Laboratory (Talk: Mayu Inaba) | Talk | Cold Spring Harbor Laboratory | 2018 | NY, United States |
| The 15th Stem Cell Research Symposium (Talk: Mayu Inaba) | Talk | 2017 | Tokyo, Japan | |
| Keio University, Department of Microbiology and Immunology (Talk: Mayu Inaba) | Talk | 2017 | Tokyo, Japan | |
| Northeast Society for Developmental Biology Regional Meeting at MBL (Talk: Mayu Inaba) | Talk | Northeast Society for Developmental Biology | 2017 | MA, United States |
| International Society for Stem Cell Research, Annual Meeting (Talk: Mayu Inaba) | Talk | ISSCR | 2016 | San Francisco, CA, United States |
| 56th Annual Drosophila Research Conference, “Cell Biology & Signal Transduction” (Talk: Mayu Inaba) | Talk | GSA | 2015 | Chicago, IL, United States |
| Annual Meeting, The American Society for Cell Biology, “Positioning the Microtubule Organizing Center: A Matter of Life or Death?” (Talk: Mayu Inaba) | Talk | ASCB | 2014 | Philadelphia, PA, United States |
| 52nd Annual Meeting, The American Society for Cell Biology, Mini symposium, Cell Polarity (Talk: Mayu Inaba) | Talk | ASCB | 2012 | San Francisco, CA, United States |