Mayu Inaba, M.D., Ph.D.Assistant Professor, Department of Cell Biology
- Education & Training
- Research Opportunities
- Lab Rotations
|M.D.||Ehime University School of Medicine||Medicine|
|Ph.D.||Graduate School of Kyushu University||Pathological Medicine|
|Postdoctoral||University of Tokyo||JSPS postdoctoral research fellow|
|Postdoctoral||University of Michigan||HHMI Research Specialist I|
|Name of Award/Honor||Awarding Organization|
|R35 Outstanding Investigator Award, The National Institute of General Medical Sciences||NIH, NIGMS|
|DeLill Nasser Travel Award for Professional Development in Genetics||Genetics Society of America|
|Travel Award for 52nd Annual Meeting of the American Society for Cell Biology||American Society for Cell Biology|
|Research Fellowship 2003 - 2006||Japan Society for the Promotion of Science for Young Scientists|
MEDS-6449-Foundations of Biomedical Science II (Cell cycle)
MEDS-6497-Graduate Seminar: Cell Biology Journal Club
MEDS-5418-Stem Cells and Regenerative Biology-SECF40-1208
MEDS-5369-Advanced Genetics and Molecular Biology-SECF40-1223
MEDS-5309-Molecular Basis of Disease
Our long term goal is to understand the regulatory mechanisms of asymmetric stem cell division.
Asymmetric stem cell division is a mechanism that balances stem cell self-renewal and differentiation through the production of one stem cell and one differentiating cell. It is a simple way of maintaining the stem cell population without increasing it and is thus thought to be a vital mechanism for tissue homeostasis and tumor suppression. My research goal is to elucidate the molecular mechanism how differently fated two daughter cells are made after only one cell division. My lab primarily uses Drosophila gonads in which we can monitor asymmetric division in vivo. Owning to the simple anatomy and abundant imaging tools, this system allow us to discover previously unrecognized regulatory mechanisms and thus contribute to develop a new therapeutic approach for cancers and degenerative diseases.
Accepting Lab Rotation Students: The Drosophila germline stem cell system is an excellent model to monitor stem cell behavior while they are still located in the niche. We use a combination of approaches including CRISPR genome engineering, genetics, and quantitative and whole-mount live imaging to understand adult stem cell regulation. Results from our research are relevant to human physiology and diseases, as many of the molecules that control Drosophila stem cell system are conserved in humans.
- Understanding the flexibility of niche-stem cell interaction: Tissue stem cells are under dynamic state that is largely governed by their microenvironment, or the niche, which facilitates plasticity and adaptability of stem cells to changing conditions. The aim of 1st rotation project is to investigate dynamics of cell signaling and downstream pathway activation in Drosophila germline stem cells, while they are adapting to various physiological and pathological conditions, including dietary changes, abnormalities in nervous system, methabolic disorders and aging.
- Visualizing chromosome interaction and gene expression change in stem cell systems: Dysregulation in stem-cell gene transcriptional program leads to abberent tissue homeostasis, and then human diseases such as cancer. Growing number of evidences suggest that diversification of regulatory elements is a major source of phenotypic polymorphism among population. These DNA elements interact not only with transcription factors and other regulatory proteins, but also with other DNA elements. Our recent study identified that interhomolog interaction of stem cell gene locus is uniquely regulated and is essential for prompt downregulation of the transcript. While biological importance of interchromosomal interaction is becoming increasingly clear in recent years, very little is known about the mechanism in the control of gene expression. The 2nd rotation project is to establish the tools for monitoring homolog interaction and gene expression simutaniously, by using MS2/MCP, PP7/PCP based visualization and quantification of nascent transcripts.
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|ERATO International Symposium Kurumizaka Chromatin Atlas (Poster: Mayu Inaba)||Poster||ERATO/Tokyo University||2023||Online|
|NIH/NICHD Seminar (Talk: Mayu Inaba)||Talk||NIH/NICHD||2023||Bethesda, Maryland|
|Frontiers in Biology, Stanford University (Talk: Mayu Inaba)||Talk||Stanford University||2023||Palo Alto, San Francisco|
|Johns Hopkins University, Department of Biology Seminar Series (Talk: Mayu Inaba)||Talk||JHU||2022||Online|
|FASEB 2022, The TGF-ß Superfamily Conference: Signaling in Development and Disease (Talk: Mayu Inaba)||Talk||FASEB||2022||Malahide, Ireland|
|Developmental Biology Seminar Series, Gurdon Institute, University of Cambridge (Talk: Mayu Inaba)||Talk||Gurdon Institute, University of Cambridge||2021||Online|
|Queens College Biology Colloquium, Queens College, CUNY (Talk: Mayu Inaba)||Talk||Queens College, CUNY, NY||2019||NY, United States|
|The Fifth International Oocyte Meeting (Talk: Mayu Inaba)||Talk||The Fifth International Oocyte Meeting||2019||Nice, France|
|2019 Gordon Research Conference on Fertilization and Activation of Development (Talk: Mayu Inaba)||Talk||Gordon Research Conference||2019||NH, United States|
|Cold Spring Harbor Meeting, Germ Cells, Cold Spring Harbor Laboratory (Talk: Mayu Inaba)||Talk||Cold Spring Harbor Laboratory||2018||NY, United States|
|The 15th Stem Cell Research Symposium (Talk: Mayu Inaba)||Talk||2017||Tokyo, Japan|
|Keio University, Department of Microbiology and Immunology (Talk: Mayu Inaba)||Talk||2017||Tokyo, Japan|
|Northeast Society for Developmental Biology Regional Meeting at MBL (Talk: Mayu Inaba)||Talk||Northeast Society for Developmental Biology||2017||MA, United States|
|International Society for Stem Cell Research, Annual Meeting (Talk: Mayu Inaba)||Talk||ISSCR||2016||San Francisco, CA, United States|
|56th Annual Drosophila Research Conference, “Cell Biology & Signal Transduction” (Talk: Mayu Inaba)||Talk||GSA||2015||Chicago, IL, United States|
|Annual Meeting, The American Society for Cell Biology, “Positioning the Microtubule Organizing Center: A Matter of Life or Death?” (Talk: Mayu Inaba)||Talk||ASCB||2014||Philadelphia, PA, United States|
|52nd Annual Meeting, The American Society for Cell Biology, Mini symposium, Cell Polarity (Talk: Mayu Inaba)||Talk||ASCB||2012||San Francisco, CA, United States|