Ivo Kalajzic, MD, PhDProfessor, Center for Regenerative Medicine and Skeletal DevelopmentCenter for Regenerative Medicine and Skeletal Development Professor, Department of Genetics and Genome Sciences
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Degree | Institution | Major |
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MD | Zagreb University School of Medicine | Medicine |
PhD | Split University School of Medicine | Basic Medical Sciences - Genetics |
Awards
Name of Award/Honor | Awarding Organization |
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Career Enhancement Award | American Society of Bone and Mineral Research |
Harold Frost Young Investigator Award | American Society of Bone and Mineral Research |
Young Investigator Award, Annual Meeting | American Society of Bone and Mineral Research |
Fellowship Award | Children Brittle Bone Foundation |
John Haddad Young Investigator Award | American Society of Bone and Mineral Research |
Outstanding Presentation Award, Washington, DC | East Coast Connective Tissue Society Meeting |
Michael Geisman Fellowship Award | Osteogenesis Imperfecta Foundation |
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
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Orthopedic Research Society | Professional/Scientific Organization | Member | External | National | 2012 | |
American Society of Bone and Mineral Research | Professional/Scientific Organization | Member | External | National | 2006 | |
International Chinese Hard Tissue Society | Professional/Scientific Organization | Member | External | International | 2006 |
“Growth factor based enhancement of bone repair”
Our project will define the signaling mechanisms by which PDGF regulate BMP induced osteogenesis using in vitro and in vivo models. Understanding how these two critical factors for interact can pave the way for more targeted therapies in future. In addition, we will evaluate the efficacy of combining these two clinically approved growth factors, BMP2 and PDGF, with the aim of improving healing, and reducing BMP2 dosage to prevent complications and reduce cost.
“Notch signaling and bone fracture healing”
The effects of Notch signaling modulation will be evaluated In vivo using stage specific Notch gain- and loss-of-function models during fracture healing. We postulate that inhibition of Notch will provide evidence for potential future application to accelerate or improve fracture healing. Our results will provide a better understanding of the role of Notch signaling during fracture healing and will evaluate the potential for therapeutic modulation of the healing process.
“Transplantation of Mesenchymal Stem Cells as therapy for Osteogenesis Imperfecta”,
This purpose of this project is to test the efficacy of direct intrabone transplantation of mesenchymal stem cells as a therapeutic approach for osteogenesis imperfecta.
Not Accepting Lab Rotation Students at this time
Journal Articles
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Signaling pathways associated with Lgr6 to regulate osteogenesis.
Bone 2024 Oct;187117207
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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.
Bone reports 2024 Sep;22101795
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Endothelial to mesenchymal Notch signaling regulates skeletal repair.
JCI insight 2024 May;
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Hematopoietic and stromal DMP1-Cre labeled cells form a unique niche in the bone marrow.
Scientific reports 2023 Dec;13(1):22403
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Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment.
Bioactive materials 2023 Jul;2542-60
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Lineage tracing of RGS5-CreER labeled cells in long bones during homeostasis and injury.
Stem cells (Dayton, Ohio) 2023 Mar;
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Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
Bone 2023 Jan;169116681
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PDGF inhibits BMP2-induced bone healing.
NPJ Regenerative medicine 2023 Jan;8(1):3
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AcanCreER lacks specificity to chondrocytes and targets periosteal progenitors in the fractured callus.
Bone 2023 Jan;166116599
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CD51 labels periosteal injury-responsive osteoprogenitors.
Frontiers in physiology 2023 Jan;141231352
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Inhibition of CGRP signaling impairs fracture healing in mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Oct;
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Vitamin C epigenetically controls osteogenesis and bone mineralization.
Nature communications 2022 Oct;13(1):5883
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Natural Polymer-Based Micronanostructured Scaffolds for Bone Tissue Engineering.
Methods in molecular biology (Clifton, N.J.) 2022 Jan;2394669-691
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
Scientific reports 2021 May;11(1):10736
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Heterogeneity of murine periosteum progenitors involved in fracture healing.
eLife 2021 Feb;10
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Tmem100- and Acta2-Lineage Cells Contribute to Implant Osseointegration in a Mouse Model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 Feb;
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Divergent effects of peripheral and global neuropeptide Y deletion.
Journal of musculoskeletal & neuronal interactions 2020 Dec;20(4):579-590
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Diabetes impairs periosteal progenitor regenerative potential.
Bone 2020 Nov;115764
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What do we know about bone morphogenetic proteins and osteochondroprogenitors in inflammatory conditions?
Bone 2020 Aug;137115403
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
BioRxiv 2020 Jun;
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Origin and Lineage Plasticity of Endogenous Lacrimal Gland Epithelial Stem/Progenitor Cells.
iScience 2020 Jun;23(6):101230
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Modulation of Notch1 signaling regulates bone fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Mar;
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Perivascular osteoprogenitors are associated with transcortical channels of long bones.
Stem cells (Dayton, Ohio) 2020 Feb;
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Osteoclasts Derive Predominantly from Bone Marrow-Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair.
Journal of immunology (Baltimore, Md. : 1950) 2020 Jan;
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Engraftment of skeletal progenitor cells by bone directed transplantation improves osteogenesis imperfecta murine bone phenotype.
Stem cells (Dayton, Ohio) 2019 Dec;
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CTRP3 regulates endochondral ossification and bone remodeling during fracture healing
Journal of Orthopaedic Research 2019 Dec;
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αSMA Osteoprogenitor Cells Contribute to the Increase in Osteoblast Numbers in Response to Mechanical Loading.
Calcified tissue international 2019 Oct;
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Human amniotic fluid stem cells attract osteoprogenitor cells in bone healing.
Journal of cellular physiology 2019 Oct;
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A New Osteocytic Cell Line, Raising New Questions and Opportunities.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Jun;
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PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells.
JBMR plus 2019 May;3(5):e10127
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Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2019 Jan;29654-67
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A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing.
PloS one 2019 Jan;14(10):e0223846
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Skeletal phenotype of the neuropeptide Y knockout mouse.
Neuropeptides 2018 Nov;7378-88
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Responses to spaceflight of mouse mandibular bone and teeth.
Archives of oral biology 2018 Jun;93163-176
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FGF2 Enhances Odontoblast Differentiation by αSMA+ Progenitors In Vivo.
Journal of dental research 2018 Apr;971170-1177
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The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair.
Frontiers in immunology 2018 Jan;9417
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Micro-Nanostructures of Cellulose-Collagen for Critical Sized Bone Defect Healing.
Macromolecular bioscience 2017 Nov;18
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Mineral trioxide aggregate improves healing response of periodontal tissue to injury in mice.
Journal of periodontal research 2017 Jul;521058-1067
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Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine.
Bone 2017 Jun;1031-11
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FGF Signaling Prevents the Terminal Differentiation of Odontoblasts.
Journal of dental research 2017 Feb;96663-670
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αSMA-Expressing Perivascular Cells Represent Dental Pulp Progenitors In Vivo.
Journal of dental research 2016 Nov;96323-330
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Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury.
Nature communications 2016 Oct;713073
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Instructive Role of the Microenvironment in Preventing Renal Fibrosis.
Stem cells translational medicine 2016 Oct;
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Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood.
Stem cells (Dayton, Ohio) 2016 Aug;342930-2942
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Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing.
Connective tissue research 2016 May;57507-515
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Osteogenic potential of alpha smooth muscle actin expressing muscle resident progenitor cells.
Bone 2015 Dec;8469-77
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Enhanced Dentinogenesis of Pulp Progenitors by Early Exposure to FGF2.
Journal of dental research 2015 Aug;94(11):1582-90
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Gene-expression analysis of cementoblasts and osteoblasts.
Journal of periodontal research 2015 Jul;51304-12
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Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation.
Bone 2015 Jul;8153-9
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Mammary stem cells have myoepithelial cell properties.
Nature cell biology 2014 Aug;16(10):942-50, 1-7
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Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts.
Blood 2014 Aug;124(18):2834-46
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Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.
PloS one 2014 Jan;9(1):e86757
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Local transplantation is an effective method for cell delivery in the osteogenesis imperfecta murine model.
International orthopaedics 2014 Jan;38(9):1955-62
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Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Nov;29(5):1283-94
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Utilization of transgenic models in the evaluation of osteogenic differentiation of embryonic stem cells.
Connective tissue research 2013 Aug;54(4-5):296-304
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In vivo identification of periodontal progenitor cells.
Journal of dental research 2013 Aug;92(8):709-15
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In vitro and in vivo approaches to study osteocyte biology.
Bone 2013 Jun;54(2):296-306
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Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Mar;28(3):618-26
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Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts.
PloS one 2013 Jan;8(9):e75204
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Bone-specific overexpression of NPY modulates osteogenesis.
Journal of musculoskeletal & neuronal interactions 2012 Dec;12(4):209-18
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In vivo fate mapping identifies mesenchymal progenitor cells.
Stem cells (Dayton, Ohio) 2012 Feb;30(2):187-96
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Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Nov;26(11):2634-46
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Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation.
Connective tissue research 2011 Oct;52(5):401-7
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Isolation of murine bone marrow derived mesenchymal stem cells using Twist2 Cre transgenic mice.
Bone 2010 Nov;47(5):916-25
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Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes.
Bone 2010 Jun;46(6):1486-97
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Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine.
The American journal of pathology 2010 May;176(5):2405-13
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Defining a visual marker of osteoprogenitor cells within the periodontium.
Journal of periodontal research 2010 Feb;45(1):60-70
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Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity.
Journal of cellular biochemistry 2009 Oct;108(3):621-30
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Identification of differentially expressed genes between osteoblasts and osteocytes.
Bone 2009 Oct;45(4):682-92
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A rapid, nonradioactive in situ hybridization technique for use on cryosectioned adult mouse bone.
Calcified tissue international 2008 Sep;83(3):212-21
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Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population.
Bone 2008 Sep;43(3):501-10
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Expression and function of Dlx genes in the osteoblast lineage.
Developmental biology 2008 Apr;316(2):458-70
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Pericyte/myofibroblast phenotype of osteoprogenitor cell.
Journal of musculoskeletal & neuronal interactions 2007 Jan;7(4):320-2
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Second harmonic generation imaging microscopy studies of osteogenesis imperfecta.
Journal of biomedical optics 2007 Jan;12(5):051805
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In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice.
Biochemical and biophysical research communications 2006 Jan;339(2):490-8
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Expression profile of osteoblast lineage at defined stages of differentiation.
The Journal of biological chemistry 2005 Jul;280(26):24618-26
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Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo.
The Journal of biological chemistry 2005 May;280(21):20680-90
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Alteration of newly induced endochondral bone formation in adult mice without tumour necrosis factor receptor 1.
Clinical and experimental immunology 2005 Feb;139(2):236-44
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In vitro and in vivo study on osteocyte-specific mechanical signaling pathways.
Journal of musculoskeletal & neuronal interactions 2004 Dec;4(4):386-7
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Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.
Bone 2004 Jul;35(1):74-82
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Non-functional Fas ligand increases the formation of cartilage early in the endochondral bone induction by rhBMP-2.
Life sciences 2003 Nov;74(1):13-28
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Ascorbic acid is a requirement for the morphogenesis of the human filarial parasite Brugia malayi.
The Journal of parasitology 2003 Aug;89(4):868-70
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Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin.
Journal of cellular biochemistry 2003 Apr;88(6):1168-76
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Osteoblastic response to the defective matrix in the osteogenesis imperfecta murine (oim) mouse.
Endocrinology 2002 May;143(5):1594-601
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Col1a1-GFP transgene expression in developing incisors.
Connective tissue research 2002 Jan;43(2-3):216-9
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Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Jan;17(1):15-25
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Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001 Dec;16(12):2222-31
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Human bone marrow stromal cells are efficiently transduced by vesicular stomatitis virus-pseudotyped retrovectors without affecting subsequent osteoblastic differentiation.
Bone 2001 Oct;29(4):331-5
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Osteogenesis imperfecta at the beginning of bone and joint decade.
Croatian medical journal 2001 Aug;42(4):393-415
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Col1a1-driven transgenic markers of osteoblast lineage progression.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001 Jul;16(7):1228-36
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Use of VSV-G pseudotyped retroviral vectors to target murine osteoprogenitor cells.
Virology 2001 May;284(1):37-45
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Bone-directed expression of Col1a1 promoter-driven self-inactivating retroviral vector in bone marrow cells and transgenic mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2001 Apr;3(4):543-50
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Role of B lymphocytes in new bone formation.
Laboratory investigation; a journal of technical methods and pathology 2000 Nov;80(11):1761-74
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[Dynamic aggregation of thrombocytes in acute myocardial infarct].
Lijec?nic?ki vjesnik 1996 Sep;118(9):198-201
Conference Papers
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A systems biology approach to the identification and analysis of transcriptional regulatory networks in osteocytes.
BMC bioinformatics 2009 Jan;10 Suppl 9(SUPPL. 9):S5
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PBC: A software framework facilitating pattern-based clustering for microarray data analysis
Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 2009 Jan;30-36
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Time lapse imaging techniques for comparison of mineralization dynamics in primary murine osteoblasts and the late osteoblast/early osteocyte-like cell line MLO-A5.
Cells, tissues, organs 2009 Jan;189(1-4):6-11
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Osteonectin-null mutation compromises osteoblast formation, maturation, and survival.
Endocrinology 2003 Jun;144(6):2588-96
Editorials
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Animal models for musculoskeletal research.
Bone 2023 Aug;173116813
Reviews
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Increased chemotaxis and activity of circulatory myeloid progenitor cells may contribute to enhanced osteoclastogenesis and bone loss in C57BL/6 mouse model of collagen-induced arthritis.
Clinical and experimental immunology 2016 Sep;186321-335
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Visual reporters for study of the osteoblast lineage.
Bone 2016 Sep;92189-195