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Brian J. Kelley, M.D., Ph.D.Assistant Professor of Neurosurgery
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Brian Kelley joined UConn Health Neurosurgery in a dual role as a neurosurgeon and neurointensivist after fellowship training in Neurocritical Care at the University of Pennsylvania. Dr. Kelley is a surgeon-scientist, recently transitioning to his own independent laboratory where he studies mechanisms of diffuse axonal injury and alterations of the blood-meningeal barrier using an experimental model of traumatic brain injury. He holds a K08 Career Development Award from NIH/NINDS and a foundation grant from the University of Connecticut Brain and Cognitive Science Institute.
Dr. Kelley’s clinical interests are in neurotrauma and related neurocritical care with surgical techniques to address primary neurologic injuries and intensive care unit expertise to treat secondary mechanisms of injury. He also has pediatric training, which affords him unique insights into issues related to hydrocephalus and mechanisms of cerebrospinal fluid diversion. Additionally, he performs muscle and nerve biopsies.
Dr. Kelley’s research interests focus on basic science techniques to investigate pathologic mechanisms of diffuse axonal injury, a significant component of traumatic brain injury and concussion. Similarly, he studies post-traumatic vascular and inflammatory mechanisms at the blood-meningeal barrier, one of three sites responsible for regulating substrates between the brain and the surrounding environment.
| Degree | Institution | Major |
|---|---|---|
| B.S. | University of Virginia | Biochemistry |
| B.A. | University of Virginia | Biology |
| M.D. | Medical College of Virginia/Virginia Commonwealth University | Medicine |
| Ph.D. | Medical College of Virginia/Virginia Commonwealth University | Anatomy and Neurobiology |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Residency | Yale-New Haven Hospital | Neurosurgery |
| Fellowship | Children's Hospital of Philadelphia | Pediatric Neurosurgery |
| Fellowship | University of Pennsylvania School of Medicine | Neurocritical Care |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Joint Section in Pediatrics Research Support Award | American Assoc. of Neurological Surgeons/Congress of Neurological Surgery |
| Department of Surgery Clayton Award | Texas Children's Hospital |
| Depuy Synthes Neurotrauma Educational Grant | |
| Depuy Synthes Spine Educational Grant | |
| William F. Collins Neurosurgery Resident Research Award | |
| Codman Fellowship in Neurotrauma and Critical Care | American Assoc. of Neurological Surgeons/Congress of Neurological Surgery |
| Resident Traveling Fellowship in Pediatric Neurosurgery | Boston Children's Hospital |
Dr. Kelley’s clinical interests are in neurotrauma and related neurocritical care with surgical techniques to address primary neurologic injuries and intensive care unit expertise to treat secondary mechanisms of injury. He also has pediatric training, which affords him unique insights into issues related to hydrocephalus and mechanisms of cerebrospinal fluid diversion. Additionally, he performs muscle and nerve biopsies.
UConn School of Medicine Neurosurgery Elective
UConn AANS and Undergraduate Student Chapters
Weekly Didactic Sessions with Residents and PAs
Dr. Kelley’s research interests focus on basic science techniques to investigate pathologic mechanisms of diffuse axonal injury, a significant component of traumatic brain injury and concussion. Similarly, he studies post-traumatic vascular and inflammatory mechanisms at the blood-meningeal barrier, one of three sites responsible for regulating substrates between the brain and the surrounding environment.
Journal Articles
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Traumatic brain injury recapitulates developmental changes of axons.
Progress in neurobiology 2022 Oct;217102332
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Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [11C]AFM.
Molecular imaging and biology 2022 Aug;24(4):560-569
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Temporary occipital fixation in young children with severe cervical-thoracic spinal deformity.
Neurosurgical focus 2017 Oct;43(4):E11
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Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery.
Journal of neurotrauma 2014 Aug;31(15):1362-73
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Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion.
Journal of neuropathology and experimental neurology 2009 Mar;68(3):241-9
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Neuroinflammatory responses after experimental diffuse traumatic brain injury.
Journal of neuropathology and experimental neurology 2007 Nov;66(11):989-1001
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Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death.
Journal of neuropathology and experimental neurology 2007 Mar;66(3):218-29
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Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration.
Experimental neurology 2006 Apr;198(2):350-60
Book Chapters
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Early Onset Scoliosis and Congenital Spinal Anomalies
Orthopedic Knowledge Update – Series 5 2017 Jan;
Case Reports
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Craniopharyngioma arising in a Rathke's cleft cyst: case report.
Journal of neurosurgery. Pediatrics 2015 Mar;15(3):250-4
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Two-level thoracic pedicle subtraction osteotomy for progressive post-laminectomy kyphotic deformity following resection of an unusual thoracolumbar intradural extramedullary tumor.
Journal of neurosurgery. Pediatrics 2012 Oct;10(4):334-9
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Primary central nervous system vasculitis presenting as spinal subdural hematoma.
World neurosurgery 2012 Jul;78(1-2):192.E5-8
Reviews
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The current state-of-the-art of spinal cord imaging: applications.
NeuroImage 2014 Jan;841082-93
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The current state-of-the-art of spinal cord imaging: methods.
NeuroImage 2014 Jan;841070-81