Photo of Ulrike W. Klueh, Ph.D.

Ulrike W. Klueh, Ph.D.

Adjunct Assistant Professor of Surgery
Academic Office Location:
Surgery
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3955
Phone: 860-679-2859
Fax: 860-679-2936
Education
DegreeInstitutionMajor
R.N.University Clinic of Wuerzburg, School of NursingNursing
B.S.Fachhochschule Giessen-Friedberg (University for Applied Science)Biotechnology
M.S.University of ConnecticutChemical Engineering
Ph.D.University of ConnecticutBiomedical Engineering

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipUniversity of ConnecticutVisiting Research Scholar Internship: Department of Molecular and Cell Biology Title: “Purification of a Depolymerase from Fusarium moniliforme using HPLC” (Thesis research as required for Biotechnology degree, Fachhochschule Giessen-Friedberg)
FellowshipUniversity of ConnecticutVisiting Research Scholar Fellowship: Fermentation and Separation Laboratory, Thesis Title: “Purification of a Depolymerase from Fusarium moniliforme using HPLC” (Thesis research as required for Biotechnology degree, Fachhochschule Giessen-Friedberg)
FellowshipUniversity of Connecticut School of MedicineCenter for Molecular Tissue Engineering

Awards
Name of Award/HonorAwarding Organization
Junior Faculty Award, “Uses of Stem Cells to Enhance Glucose Sensor Function in Vivo"American Diabetes Association
Invited to Speak at the Pre-meeting Workshop Entitled, “Workshop B – Advances in Continuous Glucose Monitoring”, Bethesda, MarylandTenth Diabetes Technology Meeting
Student Award for Outstanding Research in the Doctoral Degree Category. Award presented at the Society for Biomaterials Meeting in Reno, Nevada, April 30 – May 3, 2003.Society for Biomaterials
Excellence in Teaching AwardFarmington High School
Student Award for Outstanding Research in the Masters Science Degree Category. Award Presented at the Society for Biomaterials Meeting in Minneapolis, MN.Society for Biomaterials
Dorothy and Earl S. Hoffman Travel Scholarship. AVS 47th International Symposium Held in Boston, Massachusetts.American Vacuum Society
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
National Institute of Health, Small Business (SBIR to Develop New or Improved Closed Loop Automated Technologies for Diabetes Therapy and Monitoring): National Institute of Diabetes and Digestive and Kidney Diseases) [ZDK1 GRB-2 (M4) 1]; study section, ad hoc reviewerStudy Sectionad hoc reviewerExternalNational20152016
Lead Guest Editor for a Special Issue for the Journal of Diabetes ResearchProfessional/Scientific JournalLead Guest EditorExternalInternational20152016
NIH, Bioengineering, Technology and Surgical Sciences (BTSS)Study Sectionad hoc reviewerExternalNational2014
NIH, Small Business (Artificial Pancreas SBIR): National Institute of Diabetes and Digestive and Kidney Diseases [ZDK1 GRB-2 (03)]Study Sectionad hoc reviewerExternalNational2014
National Institute of Health, Bioengineering, Technology and Surgical Sciences (BTSS) study section, ad hoc reviewerStudy Sectionad hoc reviewerExternalNational20142016
NIH Workshop on Innovation Towards an Artificial Pancreas, NIH campus, Bethesda, MDWorkshop/ConferencePanel member ExternalNational2013
Journal of Diabetes Science and Technology symposium on “Physiology of Interstitial Fluid (ISF)”Workshop/ConferenceInvited Co-Editor ExternalNational20102011
American Diabetes Association, Connecticut LeadershipAdvisory CommitteeBoard MemberExternalNational20092011
Diabetes UK (The British Diabetic Association), London, UKAdvisory CommitteeGrant reviewer ExternalInternational2007
Diabetes CareProfessional/Scientific JournalReviewerExternalNational
BiomaterialsProfessional/Scientific JournalReviewerExternalNational
Diabetes Science & TechnologyProfessional/Scientific JournalReviewerExternalNational
Diabetes Technology & TherapeuticProfessional/Scientific JournalReviewerExternalNational
Tissue EngineeringProfessional/Scientific JournalReviewerExternalNational
NanomedicineProfessional/Scientific JournalReviewerExternalNational
Biotechnology ProgressProfessional/Scientific JournalReviewerExternalNational
SensorsProfessional/Scientific JournalReviewerExternalNational
Acta BiomaterialiaProfessional/Scientific JournalReviewerExternalNational

Research Interests
Use of molecular tissue engineering for enhancing biocompatibility of implantable devices and their products including:

Redesign transdermal glucose sensors to extend the functional lifespan in vivo.
Development of new generations of totally implantable glucose sensors, utilizing ASIC and RF telemetry.
Developing new strategies and devices to extend insulin and infusion sets.
Development of closed loop technology for clinical management of patients with diabetes.
Development of novel composite meshes for hernia repair.

Journal Articles

Abstracts

  • Central Role of Macrophages in Controlling Long Term Continuous Glucose Monitoring in Vivo
    U Klueh, Y. Qiao and DL Kreutzer BMES Hartford Connecticut 2011 Oct;
  • Mast Cells, Macrophages and Continuous Glucose Monitoring in Vivo
    U Klueh, M. Kaur, Y. Qiao and DL Kreutzer Diabetes Techonology Society, 9th Scientific Meeting, San Francisco, CA 2009 Nov;
  • Activation of Human Mononuclear Cells by Porcine Biologic Meshes in Vitro
    S. Orenstein MD, Y. Qiao MD, M. Kaur BS, U. Klueh PhD, Don Kreutzer, Yuri Novitsky 16th Annual NESS Surgical Resident and Fellow Research Presentation Day (New England Surgical Society). Boston, MA 2009 May;
  • Activation of human monocytes by human biologic meshes in vitro.
    S. Orenstein, M. Kaur, U. Klueh PhD, D. Kreutzer, Y. Novitsky Association for Academic Surgery Society of University Surgeons. Academic Surgical Congress, Fort Myers, FL 2009 Feb;
  • Activation of human monocytes by human biologic meshes in vitro.
    S. Orenstein, M. Kaur, U. Klueh, D. Kreutzer, Y. Novitsky CTACSPA (Connecticut Chapter of the American College of Surgeons Professional Association). Waterbury, CT 2008 Oct;
  • Polypeptide Multilayer Nanocoatings for Cell Culture and Implant Devices
    DeRome ME, N. Palath, K. Dave, JS Rudra, S. Bhad, U Klueh, DL Kreutzer, DT Haynie Nanomedicine: Nanotechnology, Biology and Medicine 2007 Dec;3(4):353-354
  • Development and Validation of a Murine Model of Implantable Glucose Sensor in the Type I (Juvenile) Diabetic Mouse.
    Platt K, E. Hubert, DL Kreutzer, U. Klueh Medi2005 BEACON, Hartford Connecticut 2005 Oct;
  • Role of Inflammation in Glucose Sensor Function in Vivo.
    Kaur M, D. Montrose, D. Kreutzer, U. Klueh Medi2005 BEACON, Hartford Connecticut October 2005 2005 Oct;
  • Use of Vascular Endothelial Cell Growth Factor Gene Transfer to Enhance Biosensor Function in Vivo.
    Klueh U, D. Dorsky, D. L. Kreutzer Transactions 2003 Society for Biomaterials. 2003 Jan;
  • Uses Of Collagen Related Peptides and Bacterial Related Peptides To Bind And Orient Fibronectin On Surfaces.
    Klueh U, S. Goralnick, J. D. Bryers, D. L. Kreutzer Transactions 2001 Society for Biomaterials. 2001 Jan;
  • Use of Bacterial Adhesion Related and Collagen Related Peptides to Bind and Orient Fibronectin on Surfaces.
    Klueh U, S. Goralnick, J. D. Bryers, D. L. Kreutzer American Vacuum Society. 47th International Symposium 2000 Oct;
  • Characterization of Ligand (Fibronectin) Orientation Once Tethered to Surfaces by Self-Assembled Monolayers.
    Klueh U, J. D. Bryers, D. L. Kreutzer UWEB Summer Symposium 2000. Seattle, Washington. 2000 Jan;
  • Efficacy of Silver-Coated Dacron Fabric to Reduce Colonization by Staphylococcus epidermidis Bacteria in Static Batch and Flowing Fluid Conditions.
    Klueh U, Wagner V, Kelly S, Johnson A, Bryers JD Sixth World Biomaterials Congress Transactions. 2000 Society for Biomaterials. 2000 Jan;
  • Efficacy of Silver-Coated Dacron to Reduce Colonization by Staphylococcus epidermidis Bacteria: Use of a Continuous System.
    Wagner V, Klueh U, Kelly S, Johnson A, Bryers JD Sixth World Biomaterials Congress Transactions. 2000 Society for Biomaterials. 2000 Jan;

Conference Papers

Other

  • Cannulas, Collars for Implantable Devices, and Corresponding Systems and Methods
    Co-Inventors: Klueh U, Kreutzer DL No. US-2014-0262879-A1 2015 Dec;
  • Sensors, Sensor Systems and Methods
    Co-Inventors: Klueh U, Kreutzer DL No. US-2014-0275904-A1 2015 Dec;
  • Artificial Tissue Systems and Uses Thereof (Co-Inventors: Klueh U, Dorsky DI, Kreutzer, DL); Application No.: 13/787188; Filing Date: 03.06.2013; Approved October 7, 2015
    Co-Inventors: Klueh U, Dorsky DI, Kreutzer, DL Application No.: 13/787188 2015 Oct;
  • Sensors, Cannulas, Collars and Coated Surgical Mesh, and Corresponding Systems and Methods (Co-Inventors: Klueh and Kreutzer); Patent Application No. PCT/US2014/025738 (Country: Patent Cooperation Treaty) Application Date: 03.14.2014
    Inventors: Klueh and Kreutzer Patent Application No. PCT/US2014/025738 2015 Feb;
  • Coated Surgical Mesh, and Corresponding Systems and Methods
    Co-Inventors: Klueh U, Kreutzer DL No. US-2014-0275905-A1 2015 Jan;
  • Sensors, Cannulas, Collars and Coated Surgical Mesh, and Corresponding Systems and Methods; Patent Application No. US-20150257865; Filing Date: 09.12.2014
    Ulrike Klueh and Donald Kreutzer Application No. US-20150257865 2015 Jan;
  • Uses of Artificial Tissues Containing Genetically Engineered Cells and Cell Support Systems to Enhance the Function of Implanted Materials and Devices
    Co-Inventors: Klueh U, Dorsky DI, Kreutzer DL Publication No.: WO/2005/046445 2015 Jan;
  • Uses of Artificial Tissues Containing Genetically Engineered Cells and Cell Support Systems to Enhance the Function of Implanted Materials and Devices (Co-Inventors: Klueh, Dorsky, Kreutzer); Canadian Application No.: 2,544,726
    Co-Inventors: Klueh, Dorsky, Kreutzer Canadian Patent Application No.: 2,544,726
  • Uses of Artificial Tissues Containing Genetically Engineered Cells and Cell Support Systems to Enhance the Function of Implanted Materials and Devices (Co-Inventors: Klueh, Dorsky, Kreutzer); International Application Date: 05.11.2004; European Application No.: 04816945.2
    Co-Inventors: Klueh, Dorsky, Kreutzer European Patent Application No.: 04816945.2
Title or AbstractTypeSponsor/EventDate/YearLocation
Inflammation, continuous glucose monitoring and diabetes managementLectureWayne State University, Detroit, MI2015
Inflammation, Macrophages and CGM TalkConnecticut Children Medical Center2013Hartford, CT
“Bridging” to the Cure for DiabetesTalkFood and Drug Administration 2012Silver Spring, MD
Critical Role of Macrophage Chemokines in Controlling Continuous Glucose Monitoring (CGM) in Vivo.TalkDiabetes Techonology Society, 12th Scientific Meeting2012Bethesda, MD
The Role of Macrophages in Continuous Glucose Monitoring. TalkThe 5th International Conference on Advanced Technologies & Treatments for 2012Barcelona, Spain
Role of Interleukin 1 / Interleukin 1 Receptor Antagonist in Long-Term Continuous Glucose Monitoring in Vivo. Talk11th Annual Diabetes Technology Meeting, Burlingame, California2011
Role of Interleukin 1 / Interleukin 1 Receptor Antagonist in Long-Term Continuous Glucose Monitoring in Vivo. Talk11th Annual Diabetes Technology Meeting2011Burlingame, California
Central Role of Macrophages in Controlling Long Term Continuous Glucose Monitoring in Vivo.TalkBMES 2011Hartford Connecticut
Identifying and overcoming tissue responses that compromise implantable glucose sensor function and continuous glucose monitoring (CGM). TalkBD Medical2011Boston
Insulin Induced Tissue Reaction Associated with Insulin PumpsTalkBD Technologies2010Research Triangle Park, North Carolina
Continuous Glucose Monitoring Beyond 7 days.TalkBD Technologies2010Research Triangle Park, NC
“Workshop B – Advances in Continuous Glucose Monitoring"TalkTenth Diabetes Technology Meeting2010Bethesda, Maryland
Mast Cells, Macrophages and Continuous Glucose Monitoring in VivoTalkDiabetes Techonology Society2009San Francisco, California
Key Role of Mast Cells in Controlling Glucose Sensor Function in VivoTalkAmerican Diabetes Association2009New Orleans, Louisiana
Activation of Human Mononuclear Cells by Porcine Biologic Meshes in VitroTalkNew England Surgical Society2009Boston, Massachusetts
Activation of Human Monocytes by Human Biologic Meshes In VitroTalkAssociation for Academic Surgery Society of University Surgeons2009Fort Myers, Florida
The Artificial Pancreas: Hope and HurtlesTalkAmerican Diabetes Association2009Middletown, Connecticut
Activation of Human Monocytes by Human Biologic Meshes In VitroTalkCTACSPA2008Waterbury, Connecticut
Uses of Stem Cells to Enhance Glucose Sensor Function in VivoTalkAmerican Diabetes Association2008Middletown, Connecticut
Investigations into the Causes of Post Insertion Variability (PIV) Observed in vivo with the Abbott Navigator Glucose SensorTalkAbbott Diabetes Care2007Alameda, California
Mouse Model of Implantable Glucose SensorTalkBRM Biomedical Research Models, Inc.2007Worcester, Massachusetts
Continuous Blood Glucose Monitoring in Normal and Diabetic Mice using Implantable Glucose SensorsTalkJackson Laboratories2006Bar Harbor, Maine
Glucose Sensor Function in Vitro and in VivoTalkAbbott-TheraSense Inc.2005Oakland, California
Evaluation of Tissue Responses and Glucose Sensor Function in Vivo Utilizing a Murine ModelTalkAbbott-TheraSense Inc.2005Oakland, California
Enhancing Implantable Sensor Function in Vivo Using Gene Transfer and Bio-Hydrogel SystemsTalkDexcom Inc.2004San Diego, California
Implantable Sensors from a Tissues ViewpointTalkAbbott Laboratories2004Chicago, Illinois
Uses of Local Gene Transfer to Enhance Sensor Function in VivoPlenary LectureUniversity of Washington Engineered Biomaterials Symposium 2004Seattle, Washington
Use of Mouse Model for Wireless-Telemetry for Implantable Glucose SensorsTalkDigital Angels2003Riverside, California
Use of Mouse Model for Wireless-Telemetry for Implantable Glucose SensorsTalkDigital Angels2003Riverside, California
Use of Gene Transfer and Wireless-Telemetry for Implantable Glucose SensorsTalkDigital Angels2003Riverside, California
Molecular Tissue Engineering and Implantable SensorsTalkAdvanced Digital Solutions2003Palm Beach, Florida
Use of Ex Ova Chick Embryo Model for Evaluation of Tissue Response Modifiers in vivoTalkBoston Scientific2003Boston, Massachusetts
Use of Vascular Endothelial Cell Growth Factor Gene Transfer To Enhance Biosensor Function In VivoTalkBoston Scientific2003Boston, Massachusetts
The Ex Ova Chick Embryo Model and its Uses in Biomaterials EvaluationTalkBoston Scientific2001Boston, Massachusetts