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Chia-Ling Kuo, Ph.D.Senior Biostatistician, Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Center on Aging, Associate Professor, Public Health Sciences
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I hold a PhD in biostatistics with special emphasis and expertise in statistical genetics and genetic epidemiology. During my postdoctoral training at the National Institute of Environmental Health Sciences, my research was focused on design and analysis of large-scale genetic association studies. My research interest is primarily in genetic epidemiology of aging. I have a track record of publications and NIH-funded grants as the Principal Investigator (see below).
R21AG060018 (PI: Kuo) 09/01/2018-06/30/2021
NIH/NIA
Understanding the Role of ApoE2 in Longevity and Age-Related Diseases and Conditions Using 500,000 UK Biobank Participants
Role: Principal Investigator
R21AG060018-02S1 (PI: Kuo) 09/01/2020-06/30/2021
NIH/NIA COVID-19 supplement grant
Genetic susceptibility of ApoE to delirium and dementia in COVID-19 confirmed cases
Role: Principal Investigator
R21NR018963-01A1 (PI: Kuo) 09/02/2020-07/31/2022
NIH/NINR
Identifying potentially modifiable exposures to improve telomere health and disease outcomes
Role: Principal Investigator
3R21NR018963-01A1S1 (PI: Kuo) 07/01/2021-06/30/2022
NIH/NINR
Prognostic value of telomere length for Alzheimer's disease and related measures in the UK Biobank chohort
Role: Principal Investigator
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.B.A. | National Chengchi University | Statistics |
| M.S. | National Taiwan University | Biostatistics, Statistical Genetics |
| Ph.D. | University of Pittsburgh | Biostatistics, Statistical Genetics |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | National Institute of Environmental Health Sciences (NIEHS) | Research Fellow |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Accredited Professional Statistician (2014-present) | American Statistical Association |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Journal of Applied Gerontology | Editorial Board | Statistical Advisor | External | International | 2022 | 2023 |
| Journal of Racial and Ethnic Health Disparities | Editorial Board | Statistical Reviewer | External | International | 2017 | 2022 |
Journal Articles
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Evaluation of interproximal reduction in individual teeth, and full arch assessment in clear aligner therapy: digital planning versus 3D model analysis after reduction.
Progress in orthodontics 2022 Mar;23(1):9
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Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men.
British Journal of Clinical Pharmacology 2022 Jan;
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GCM2 Variants in Familial and Multiglandular Primary Hyperparathyroidism.
The Journal of Clinical Endocrinology and Metabolism 2021 Dec;
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Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study.
BMJ open 2021 Dec;11(12):e053905
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Long-term effects of conventional and miniscrew-assisted rapid palatal expansion on root resorption.
American Journal of Orthodontics and Dentofacial Orthopedics 2021 Dec;161(3):e235-e249
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Antidiabetic Effects of the Senolytic Agent Dasatinib.
Mayo Clinic Proceedings 2021 Oct;96(12):3021-3029
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The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research.
PLoS genetics 2021 Sep;17(9):e1009783
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Examining the Development of Operative Autonomy in Vascular Surgery Training and When Trainees and Program Directors Agree and Disagree.
Annals of vascular surgery Surgery 2021 Jul;74(1):1-10
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Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19
Front Aging 2021 Jul;
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Joint Corticosteroid Injection Associated With Higher Physical Therapy Compliance in Knee Osteoarthritis.
Cureus 2021 Jul;13(7):e16403
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APOE e4 genotypes increase risk of delirium during COVID-19 related hospitalizations: evidence from a large United Kingdom cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Jun;
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Patients' perceptions of orthodontic treatment experiences during COVID-19: a cross-sectional study.
Progress in orthodontics 2021 Jun;22(1):17
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Genetic associations for two biological age measures point to distinct aging phenotypes.
Aging cell 2021 May;e13376
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Esophageal dysmotility and lung disease in patients with systemic sclerosis: is there a possible association or correlation? A retrospective chart review.
Rheumatology International 2021 May;
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Aging changes in bladder HCN are associated with increasing heterogeneity of adrenergic/mucosal influence on detrusor control in the mouse.
The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Mar;
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Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants.
The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Mar;
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The Influence of Age and Facial Expression (Eye Open/Closed) On Maxillary Dental and Gingival Display.
Journal of prosthodontics : official journal of the American College of Prosthodontists 2021 Feb;
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The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies.
Progress in orthodontics 2021 Feb;22(1):5
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
Nature Communications. 2021 Jan;12(1):654
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Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
Journal of Alzheimer's disease : JAD 2021 Jan;79(3):1203-1211
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Smoking cessation and counseling: A mixed methods study of pediatricians and parents.
PloS one 2021 Jan;16(2):e0246231
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Long-term effects of mini-screw-assisted rapid palatal expansion on airway.
The Angle orthodontist 2020 Dec;
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Effect of positional errors on the accuracy of cervical vertebrae maturation assessment using CBCT and lateral cephalograms.
Journal of the World federation of orthodontists 2020 Dec;9(4):146-154
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Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.
JAMA 2020 Nov;324(20):2048-2057
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Evaluation of open bite closure using clear aligners: a retrospective study.
Progress in orthodontics 2020 Aug;21(1):23
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Utility of Smartphone Telemedical Consultations for Peritonsillar Abscess Diagnosis and Triage.
JAMA otolaryngology-- head & neck surgery 2020 Aug;
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Quantifying tinnitus suppression in cochlear implantation using tinnitus interval-limited tracking.
The Laryngoscope 2020 Aug;130(8):2047-2052
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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Jul;
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Biomarkers of orthodontic tooth movement with fixed appliances and vibration appliance therapy: a pilot study.
European journal of orthodontics 2020 Jun;
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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.
Aging 2020 Jun;12
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Opioid Use and Rate of Nicotine Metabolism among Pregnant Smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2020 May;22(6):1046-1050
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Comparison of external apical root resorption with clear aligners and pre-adjusted edgewise appliances in non-extraction cases: a systematic review and meta-analysis.
European journal of orthodontics 2020 Feb;
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Influence of type of radiograph and levels of experience and training on reproducibility of the cervical vertebral maturation method.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2020 Feb;157(2):228-239
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GRK2 enforces androgen receptor dependence in the prostate and prostate tumors.
Oncogene 2020 Jan;
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A 16-Year Study on Incidence and Progression of Diseased Sphenoethmoidal (Onodi) Cell.
BioMed research international 2020 Jan;20202410415
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An analysis of anterior mandibular anatomy by using cone beam computed tomography: A study of 225 mandibular images.
The Journal of prosthetic dentistry 2019 Oct;
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Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
Aging Cell. 2019 Aug;e13017
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Relationship between Radiographic Misfit and Clinical Outcomes in Immediately Loaded Complete-Arch Fixed Implant-Supported Prostheses in Edentulous Patients.
Journal of prosthodontics : official journal of the American College of Prosthodontists 2019 Aug;
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The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Aug;
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Cornstarch Requirements of the Adult Glycogen Storage Disease Ia Population: A Retrospective Review.
Journal of inherited metabolic disease 2019 Aug;
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A school nurse-led asthma program reduces absences: Evaluation of Easy Breathing for Schools.
Academic pediatrics 2019 Jul;
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Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Jul;
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Hair cortisol, perceived stress, and social support in mother-child dyads living in an urban neighborhood.
Stress (Amsterdam, Netherlands) 2019 Apr;1-8
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Sarcopenia and variation in the Human Leukocyte Antigen complex.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;
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Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.
The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Feb;74(3):337-342
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Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.
BMJ (Clinical research ed.) 2019 Jan;364k5222
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Analysis of activating GCM2 sequence variants in sporadic parathyroid adenomas
J Clin Endocrinol Metab 2019 Jan;1041948-52
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Evaluation of a guideline directed medical therapy titration program in patients with heart failure with reduced ejection fraction.
International journal of cardiology. Heart & vasculature 2018 Nov;221-5
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Training for Failure: A Simulation Program for Emergency Medicine Residents to Improve Communication Skills in Service Recovery.
AEM education and training 2018 Oct;2(4):277-287
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Outcomes of an early childhood obesity prevention program in a low-income community: a pilot, randomized trial.
Pediatric obesity 2018 Aug;13677-685
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Bone Regenerative Engineering Using a Protein Kinase A-Specific Cyclic AMP Analogue Administered for Short Term
Regenerative Engineering and Translational Medicine 2018 Jul;4(4):206-215
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Endoscopic Features of Mucous Cap Polyps: A Way to Predict Serrated Polyps.
Clinical endoscopy 2018 Apr;51368-374
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Opioid Prescribing Patterns among Otolaryngologists.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2018 Feb;158854-859
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Which orthodontic appliance is best for oral hygiene? A randomized clinical trial.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2018 Feb;153(2):175-183
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Biodegradable Piezoelectric Force Sensor.
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan;115909-914
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Unconditional or Conditional Logistic Regression Model for Age-Matched Case-Control Data?
Frontiers in public health 2018 Jan;657
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Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging 2017 Dec;9(12):2504-2520
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Modified Z-palatoplasty with one-layer closure in one-stage multilevel surgery for severe obstructive sleep apnea.
Auris, nasus, larynx 2017 Oct;45791-795
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Racial/Ethnic Disparities in Morbidity and Mortality for Preterm Neonates Admitted to a Tertiary Neonatal Intensive Care Unit.
Journal of racial and ethnic health disparities 2017 Oct;5867-874
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The more you test, the more you find: The smallest P-values become increasingly enriched with real findings as more tests are conducted.
Genetic epidemiology 2017 Sep;41726-743
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Does the Difference in Fascial Closure Technique Affect Post-Operative Pain?
Journal of minimally invasive gynecology 2017 Jul;241190-1194
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Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population - Part 3: Unblinded and Discriminatory Subjective Analysis.
Journal of prosthodontics : official journal of the American College of Prosthodontists 2017 May;2722-28
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Correlates of Electronic Cigarettes Use Before and During Pregnancy.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 May;19(5):585-590
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Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
PloS one 2017 Jan;12(9):e0185083
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Ranking question designs and analysis methods
Journal of Medical Statistics and Informatics 2016 May;6(4):
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Cost Implications for Subsequent Perinatal Outcomes After IVF Stratified by Number of Embryos Transferred: A Five Year Analysis of Vermont Data.
Applied health economics and health policy 2016 Mar;14387-95
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Prospective cohort pilot study of 2-visit CAD/CAM monolithic complete dentures and implant-retained overdentures: Clinical and patient-centered outcomes.
The Journal of prosthetic dentistry 2016 Jan;115578-586.e1
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Evaluation of the donor cell contribution in rhBMP-2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice.
Journal of biomedical materials research. Part A 2015 Dec;104928-41
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Neck recurrence and mortality in esthesioneuroblastoma: Implications for management of the N0 neck.
The Laryngoscope 2015 Nov;1261373-9
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Assessing the Probability that a Finding Is Genuine for Large-Scale Genetic Association Studies.
PloS one 2015 Jan;10(5):e0124107
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The ranking probability approach and its usage in design and analysis of large-scale studies.
PloS one 2013 Jan;8(12):e83079
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Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.
Human mutation 2011 Dec;32(12):1407-16
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Novel rank-based approaches for discovery and replication in genome-wide association studies.
Genetics 2011 Sep;189(1):329-40
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Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.
American journal of epidemiology 2011 Jun;173(12):1357-64
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What's the best statistic for a simple test of genetic association in a case-control study?
Genetic epidemiology 2010 Apr;34(3):246-53
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Robust score statistics for QTL linkage analysis.
American journal of human genetics 2008 Mar;82(3):567-82
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Aging changes in bladder HCN are associated with increasing heterogeneity of adrenergic/mucosal influence on detrusor control in the mouse
Book Chapters
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Normal and non-normal data simulations for the evaluation of
two-sample location tests
Monte Carlo Simulation-Based Statistical Modeling 2017 Feb;
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Discovering multilocus associations with complex pain phenotypes
Genetics of Human Pain Perception: Basic to Translational Science 2013 Nov;
Letters
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Response to Comment on "ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank" by Kuo et al.
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Aug;
Reviews
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Clinical Factors Affecting the Accuracy of Guided Implant Surgery-A Systematic Review and Meta-analysis.
The journal of evidence-based dental practice 2018 Mar;18(1):28-40
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Prevention of complications in glycogen storage disease type Ia with optimization of metabolic control.
Pediatric diabetes 2017 Jun;18327-331