|
Rajesh V. Lalla, DDS, PhDProfessor (with tenure)Associate Dean for Research School of Dental Medicine
|
Dr. Rajesh V. Lalla is a tenured Professor at the University of Connecticut School of Dental Medicine. He is a clinician and scholar who conducts clinical research on oral complications of cancer therapy. Dr. Lalla is a Diplomate of the American Board of Oral Medicine and a Fellow of the International College of Dentists. He has had NIH funding for his research for over 20 years. Dr. Lalla has held several leadership and executive positions at the local, national, and international levels. He currently serves as Associate Dean for Research in the School of Dental Medicine, and as Director of the Dental Clinical Research Center. He also serves on several institutional committees and is a past Chair of the Institutional Review Board, which oversees the conduct of clinical research. He is a Past President of the Multinational Association of Supportive Care in Cancer (MASCC), an international multidisciplinary professional organization of healthcare professionals from over 70 countries. Dr. Lalla has published 115 peer-reviewed scientific articles, which have been viewed online over 35,000 times and cited over 7500 times in the peer-reviewed literature, with an h-index of 50. This places him among the top 2% of scientists worldwide, based on the frequency of his work being cited. He is asked to speak on oral complications of cancer therapy at the national and international levels. He has reviewed articles written by others for over 25 scientific journals and served as a grant reviewer for several US and international funding agencies. Dr. Lalla also serves as a consultant for industry on various topics including oral mucositis and other oral complications of cancer therapy, and clinical trial design and outcomes. He is the recipient of several national and international awards including the IADR Innovation in Oral Care Award, the ADA/AADR Evidence-based Dentistry Accomplished Faculty Award, the MASCC Distinguished Service Award, and the ISOO Distinguished Service Award (links below).
Lalla Recognized for Excellence in Evidence-Based Dentistry
Lalla Recognized with Top Honor from International Cancer Society
Dr Rajesh Lalla Recognized with International Distinguished Service Award
Journal Articles
-
Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.
Oral diseases 2024 Jul;
-
Reduced mouth opening in patients with head and neck cancer treated with radiation therapy: an analysis of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad).
Oral surgery, oral medicine, oral pathology and oral radiology 2024 Mar;137(3):264-273
-
Dental Caries Postradiotherapy in Head and Neck Cancer.
JDR clinical and translational research 2023 Jul;8(3):234-243
-
Oral health-related quality of life after radiation therapy for head and neck cancer: the OraRad study.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2023 Apr;31(5):286
-
Survey of experiences and barriers to dental care post-head and neck cancer in OraRad study participants.
Oral surgery, oral medicine, oral pathology and oral radiology 2023 Apr;135(4):501-509
-
Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries.
Oral surgery, oral medicine, oral pathology and oral radiology 2022 May;133(5):539-546
-
The impact of head and neck radiotherapy on salivary flow and quality of life: Results of the ORARAD study.
Oral oncology 2022 Feb;127105783
-
Oncologists' Perspective on Dental Care Around the Treatment of Head and Neck Cancer: A Pattern of Practice Survey.
JCO oncology practice 2021 Jul;OP2000913
-
An integrated E-Tube cap for sample preparation, isothermal amplification and label-free electrochemical detection of DNA.
Biosensors & bioelectronics 2021 May;186113306
-
Now we are 30: 10 more years of MASCC.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2021 Apr;29(4):1713-1718
-
Enhanced drug loading of in situ forming gels for oral mucositis pain control.
International journal of pharmaceutics 2021 Feb;595120225
-
Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy.
Head & neck 2020 Sep;
-
Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay.
Nature communications 2020 Sep;11(1):4711
-
Identification of single nucleotide pleomorphisms associated with periodontal disease in head and neck cancer irradiation patients by exome sequencing.
Oral surgery, oral medicine, oral pathology and oral radiology 2020 Jul;130(1):32-42.e4
-
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy.
Nutrients 2020 Jun;12(6):
-
Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020 May;28(5):2473-2484
-
Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020 May;28(5):2485-2498
-
Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines - part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020 May;28(5):2457-2472
-
Mucoadhesive in situ forming gel for oral mucositis pain control.
International journal of pharmaceutics 2020 Apr;580119238
-
Efficacy and safety of Dentoxol® in the prevention of radiation-induced oral mucositis in head and neck cancer patients (ESDOM): a randomized, multicenter, double-blind, placebo-controlled, phase II trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020 Apr;
-
Evidence-Based Management of Oral Mucositis.
JCO oncology practice 2020 Mar;16(3):111-112
-
Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Dec;
-
Gingivitis and plaque scores among residents of low-income senior housing.
Gerodontology 2019 Nov;
-
Randomized phase 2 trial of a novel clonidine mucoadhesive buccal tablet for the amelioration of oral mucositis in patients treated with concomitant chemo-radiotherapy for head and neck cancer.
International journal of radiation oncology, biology, physics 2019 Oct;
-
Oral Mucosal Injury Caused by Targeted Cancer Therapies.
Journal of the National Cancer Institute. Monographs 2019 Aug;2019(53):
-
Oral Mucositis Due to High-Dose Chemotherapy and/or Head and Neck Radiation Therapy.
Journal of the National Cancer Institute. Monographs 2019 Aug;2019(53):
-
Development of the MASCC/ISOO clinical practice guidelines for mucositis: an overview of the methods.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
Evaluation of an Experiential and Self-Learning Approach to Teaching Evidence-Based Decision Making to Dental Students.
Journal of dental education 2019 Jul;
-
Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines-part 1: vitamins, minerals, and nutritional supplements.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
The pathogenesis of mucositis: updated perspectives and emerging targets.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019 Jul;
-
Recurrent oral ulceration: Etiology, classification, management, and diagnostic algorithm.
Periodontology 2000 2019 Jun;80(1):49-60
-
Caries-associated oral microbiome in head and neck cancer radiation patients: a longitudinal study.
Journal of oral microbiology 2019 Jan;11(1):1586421
-
Osteonecrosis of the jaw related to non-antiresorptive medications: a systematic review.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2018 Oct;27383-394
-
Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer.
Oral surgery, oral medicine, oral pathology and oral radiology 2018 Jan;125286-294
-
Oral complications at 6 months after radiation therapy for head and neck cancer.
Oral diseases 2017 Jul;231134-1143
-
Clinical registry of dental outcomes in head and neck cancer patients (OraRad): rationale, methods, and recruitment considerations.
BMC oral health 2017 Feb;17(1):59
-
Pilot Study on the Efficacy of Combined Intraoral and Extraoral Low-Level Laser Therapy for Prevention of Oral Mucositis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation.
Photomedicine and laser surgery 2015 Nov;33(11):540-6
-
Ultrasensitive microfluidic array for serum pro-inflammatory cytokines and C-reactive protein to assess oral mucositis risk in cancer patients.
Analytical and bioanalytical chemistry 2015 Jul;407(23):7239-43
-
Dental surgery in anticoagulated patients--stop the interruption.
Oral surgery, oral medicine, oral pathology and oral radiology 2015 Feb;119(2):136-57
-
Alleviating mucositis: are we on track for a novel therapeutic?
Expert review of gastroenterology & hepatology 2014 Oct;9(2):127-8
-
Antifungal medications or disinfectants for denture stomatitis.
Evidence-based dentistry 2014 Jun;15(2):61-2
-
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Cancer 2014 May;120(10):1453-61
-
Chemotherapy or radiation-induced oral mucositis.
Dental clinics of North America 2014 Apr;58(2):341-9
-
The MASCC/ISOO mucositis guidelines: dissemination and clinical impact.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013 Aug;21(11):3161-3
-
Emerging evidence on the pathobiology of mucositis.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013 Jul;21(7):2075-83
-
Validation of anamnestic diagnostic criteria for recurrent aphthous stomatitis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2013 Apr;42(4):290-4
-
Retrospective study of microorganisms associated with vascular access infections in hemodialysis patients.
Oral surgery, oral medicine, oral pathology and oral radiology 2013 Jan;115(1):56-61
-
Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013 Jan;21(1):327-32
-
The MASCC/ISOO Mucositis Guidelines Update: introduction to the first set of articles.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013 Jan;21(1):301-2
-
A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2012 Aug;20(8):1797-804
-
Association between interactive voice response adherence and subject retention in a randomized controlled trial.
Contemporary clinical trials 2012 Jul;33(4):589-92
-
Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial.
Journal of the American Dental Association (1939) 2012 Apr;143(4):370-6
-
Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2012 Feb;41(2):149-52
-
Urban legends: recurrent aphthous stomatitis.
Oral diseases 2011 Nov;17(8):755-70
-
Supportive care treatment guidelines: value, limitations, and opportunities.
Seminars in oncology 2011 Jun;38(3):367-73
-
Miconazole mucoadhesive tablet for oropharyngeal candidiasis.
Expert review of anti-infective therapy 2011 Jan;9(1):13-7
-
A systematic review of oral fungal infections in patients receiving cancer therapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2010 Aug;18(8):985-92
-
Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2010 May;39(5):420-3
-
Electronic versus paper diaries: a pilot study of concordance and adherence in head and neck cancer patients receiving radiation therapy.
Head & neck oncology 2010 Jan;2(29):29
-
Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2010 Jan;18(1):95-103
-
Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2009 Nov;17(11):1409-15
-
Management of dental patients taking common hemostasis-altering medications.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2007 Mar;103 Suppl(SUPPL.):S45.e1-11
-
Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery 2003 Aug;129(8):882-8
-
Association of fibrin and interleukin 8 in human oral squamous cell carcinoma.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2003 Apr;95(4):452-7
-
Identification of a region of the fibrin molecule involved in upregulation of interleukin-8 expression from human oral squamous cell carcinoma cells.
Archives of oral biology 2003 Apr;48(4):263-71
-
Dental management considerations for the patient with diabetes mellitus.
Journal of the American Dental Association (1939) 2001 Oct;132(10):1425-32
-
Fibrin induces IL-8 expression from human oral squamous cell carcinoma cells.
Oral oncology 2001 Apr;37(3):234-42
Editorials
-
Anticoagulants are dental friendly.
Oral surgery, oral medicine, oral pathology and oral radiology 2018 Feb;125(2):103-106
Erratums
-
Correction to: Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and Clinical Practice Guidelines - Part 1: vitamins, minerals and nutritional supplements.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2021 Mar;
Reviews
-
Dental Treatment Planning for the Patient with Oral Cancer.
Dental clinics of North America 2018 Jan;62(1):121-130
-
Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.
Cancer medicine 2017 Oct;62918-2931
-
Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.
Critical reviews in oncology/hematology 2016 Apr;100147-66
-
Oral mucosal injury in oncology patients: perspectives on maturation of a field.
Oral diseases 2015 Mar;21(2):133-41
-
Oral mucositis: The new paradigms.
Current Opinion in Oncology 2010 Jan;22(4):318-322
-
Management of oral mucositis in patients who have cancer.
Dental clinics of North America 2008 Jan;52(1):61-77, viii
-
Anti-inflammatory agents in the management of alimentary mucositis.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2006 Jun;14(6):558-65
-
Treatment of mucositis, including new medications.
Cancer Journal 2006 Jan;12(5):348-354
-
Velafermin (CuraGen).
Current opinion in investigational drugs (London, England : 2000) 2005 Nov;6(11):1179-85
-
Oral mucositis.
Dental clinics of North America 2005 Jan;49(1):167-84, ix