Sun-Kyeong Lee, Ph.D.Associate Professor of Medicine, UConn Center on Aging
|Ph.D.||University of Connecticut||Physiology|
|Postdoctoral||University of Connecticut Health Center||Bone Biology|
|Name of Award/Honor||Awarding Organization|
|Accepted for NIA Summer Institute on Aging Research|
|Mazess Research Grant Award||National Osteoporosis Foundation|
|Annual Judge Award for outstanding Presentation||The New England Endocrinology Conference|
|Doctoral Dissertation Fellowship Award|
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|American Society for Bone and Mineral Research||Professional/Scientific Organization||Member||External||National||1999|
|Member-in-Training, American Society for Bone and Mineral Research||Professional/Scientific Organization||Member||External||National||1991||1998|
|American Society for Integrative and Comparative Biology||Professional/Scientific Organization||Member||External||National||1987||1996|
|Korean Entomological Society||Professional/Scientific Organization||Member||External||National||1982||1985|
|Korean Zoological Society||Professional/Scientific Organization||Member||External||National||1982||1985|
1. Understanding the role of macrophage migration inhibitory factor (MIF) in osteoclastogenesis. MIF plays an important role in systemic as well as local inflammatory and immune responses. However, the precise role of MIF in the regulation of normal and abnormal bone metabolism has not been fully defined. Specific studies ongoing in my lab include the examination if MIF acts through a putative receptor CD74 and coreceptor (CD44) in osteoclastogenesis and the role of MIF in osteoclast fusion process using MIF knockout, CD74 knockout and CD44 knockout mouse models. We are particularly interested in the role of MIF in osteoclast precursor population and differentiation including fusion process of multinucleated osteoclastogenesis.
2. Role of interleukin-7 (IL-7) in bone. IL-7 is a cytokine to be involved in the regulation of hematopoiesis, which primarily acts on the lymphoid cell (B and T lymphocytes) compartment of the immune system. We are examining the local effect of IL-7 in osteoclastogenesis as well as bone mass using targeted overexpression of IL-7 in osteoblasts. In addition using IL-7 knockout mouse model, we are developing the role of T or B cells in bone marrow compartment in osteoclastogenesis and how alteration in bone mass occurs in response to local IL-7 overexpression in IL-7 KO mice. We are also interested in examining the possible role of IL-7 in osteoblastogenesis in these mouse models.
3. Role of CD97 in osteoclastogenesis. CD97 is a member of the epidermal growth factor (EGF) seven-span transmembrane (7TM) subfamily of adhesion G protein-coupled receptors (GPCRs). Different from other membrane proteins of these subfamilies, CD97 possesses several EGF-like domains at the large N-terminal extracellular domain suggesting a potential function associated with adhesion. However, the presence of seven transmembrane domains with homology to GPCRs leads to the speculation that may also acts as cell surface receptor to transduce signals across the cell membrane. In mice CD97 is detected in most myeloid cells and variable portions of lymphocytes including T and B cells, and NK cells. Despite all data regarding the expression of CD97 in human and mice, the precise role of CD97 in the regulation of normal and abnormal bone metabolism has not been fully defined. We are interested in the possible role of CD97 and its interaction with its known ligand, CD55 in osteoclastogenesis.
Not accepting lab rotation students at this time