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Kai Li, PhDAssistant Professor of Immunology
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| Degree | Institution | Major |
|---|---|---|
| BS | Harbin Institute of Technology | Biochemistry |
| MS | Chinese Academy of Sciences | BIochemistry |
| PhD | Technical University of Munich | Immunology |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | Cedars-Sinai Medical Center | Immunology |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| TUM Graduate School Scholarship | Technical University of Munich |
| Student Award of Merit | Chinese Academy of Sciences |
| National Scholarship | Harbin Institute of Technology |
Research Areas: Innate Immunity, Immune Recognition, Phagocytosis, Proximity Labeling, Host-Microbe Interaction
Immune recognition is the process by which the immune system distinguishes self from non-self or aberrant self entities. Our lab has previously developed PhagoPL , an innovative proteomic platform for studying the composition of phagosomes (Li et al., Nature 2024). Future work of our lab will focus on the progressive expansion and refinement of this technique, alongside the integration of other cutting-edge tools, to uncover the mechanisms of innate immune recognition in infection, autoimmunity, and tumorigenesis.
We are looking for students and postdocs that are interested in studying immune recognition, innate immunity or host-microbe interaction.
Students in PhD or MD-PhD program at UConn Health are welcome to rotate in our lab. Please email me (kali@uchc.edu) directly.
Our lab is seeking postdoctoral researchers that have received training in relevant fields (e.g., immunology, biochemistry, microbiology etc.). Please email me (kali@uchc.edu) with “Postdoc application: + YOUR NAME” as the subject line and include your CV (including contacts of 3 references) and a cover letter describing your doctoral research, your research interests and your career goals. Review of applications will begin immediately and continue until the position is filled.
Currently Accepting PhD and MD-PHD Lab Rotation Students
Journal Articles
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Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor.
Nature 2024 Jun;630(8017):736-743
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Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson's disease.
Communications biology 2024 May;7(1):570
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Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation.
Cell reports 2022 Mar;38(13):110567
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The uric acid crystal receptor Clec12A potentiates type I interferon responses.
Proceedings of the National Academy of Sciences of the United States of America 2019 Sep;116(37):18544-18549
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In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis.
Oncogenesis 2016 Dec;5(12):e278
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α-Galactosylceramide potently augments M2e-induced protective immunity against highly pathogenic H5N1 avian influenza virus infection in mice.
Vaccine 2011 Oct;29(44):7711-7
Reviews
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C-Type Lectin Receptors in Phagocytosis.
Current topics in microbiology and immunology 2020 Jan;4291-18
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Snapshots of Immune Recognition: Exploring Phagosome Proteome with a New Approach | Talk | 2024 | MD Anderson Cancer Center | |
| Analysis of phagosome diversity reveals PD-L1 as a receptor for fungi | Talk | Malaniak award for excellence in postdoctoral research | 2023 | US |
| Poster: Damage recognizing C-type lectin receptor Clec12A positively regulates type-I interferon response | Poster | Keystone Symposia Conference on Cell Death, Inflammation and Adaptation to Tissue | 2018 | US |
| Damage recognizing C-type lectin receptor Clec12A positively regulates type I interferon response | Poster | TUM annual faculty meeting | 2017 | Germany |
| The function of Clec12A during virus infection | Talk | Symposium on Immunity and Infection | 2016 | Germany |
| Novel Adjuvant in M2e-Based Broad-Spectrum Influenza Vaccine | Talk | Asia-Pacific Conference on Wildlife-borne Diseases | 2011 | China |