Photo of Yuanhao James  Li, Ph.D.

Yuanhao James Li, Ph.D.

Professor, Genetics and Genome Sciences
Academic Office Location:
Genetics and Genome Sciences
UConn Health
400 Farmington Avenue
Farmington, CT 06030-6403
Phone: 860-679-3836
Fax: 860-679-8345
Email: jali@uchc.edu
Website(s):

Genetics and Developmental Biology Graduate Program

Neuroscience Graduate Program

James Li Lab

Education
DegreeInstitutionMajor
B.S.Zhongshan UniversityBiochemistry
Ph.D.University of TexasMolecular Genetics

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralHHMI in Skirball Institute of Biomolecular Medicine, New York University School of MedicinePostdoctoral Fellow in the Developmental Genetics Program

Awards
Name of Award/HonorAwarding Organization
Individual National Research Service Award
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Search Committee for Neuroscience Endowed Chair positionAdvisory CommitteeMemberUConn HealthInternational20192019
Search Committee for new faculty of the Department of Genetics and Genome SciencesAdvisory CommitteeMemberUConn HealthInternational20192020
National Institute of Child Health and Human Development, Developmental Biology Subcommittee (CHHD-C)Study SectionRegular memberExternalNational20162020
NIH Study Sections, Developmental Brain Disorders (DBD)Study SectionAd Hoc memberExternalNational20142015
UCHC Biomedical Sciences graduate admissions committeeEducation CommitteeMemberUConn HealthUniversity20132016
Animal Services Advisory Committee of UCHCAdvisory CommitteeMemberUConn HealthUniversity2007
UCHC Biomedical Sciences Graduate Admissions CommitteeAdvisory CommitteeMemberUConn HealthUniversity20052007
Society for Developmental BiologyProfessional/Scientific OrganizationMemberExternalNational
Society for NeuroscienceProfessional/Scientific OrganizationMemberExternalNational

The cerebellum is best known for its function in motor coordination. However, emerging and compelling evidence indicates that the cerebellum is also involved in higher cognitive function. Accordingly, abnormalities in cerebellar development and function have been linked to a wide variety of mental diseases, such as autism spectrum disorder, schizophrenia, and language impairment. We investigate how different cerebellar cell types are generated from naïve neural stem cells and how cerebellar neurons and glia are organized into functional networks. These questions are fundamentally important to understand the causes of cerebellum-related diseases and develop therapeutic strategies to improve the quality of life of affected individuals.


The cerebellum contains relatively few cell types, which are arranged in layers uniformly throughout the cerebellar cortex. In the developing cerebellum, different cell types arise following a strict spatial-temporal order. Therefore, the cerebellum provides an excellent model to study the molecular mechanisms that control the cellular diversity and assembly of neural circuits. We use single-cell genomics to reconstruct the developmental trajectories of different cerebellar cell types and identify potential regulators for key developmental events in the development of the cerebellum. We use mouse genetics to interrogate how perturbations of the genetic network affect cerebellar development.

Accepting Lab Rotation Students: Summer 2021, Fall 2021, and Spring 2022


We also have openings for postdoctoral research associates!


 

Journal Articles

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Bergmann Glia Development, Genesis and DifferentiationTalkThe 8th International Symposium of the Society for Research on the Cerebell2017Winnipeg, Manitoba , Canada
Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellumPanel Discussion2014Ventura, CA
Analysis of the development of the mouse inner ear using Gbx2 as a guide.PosterSociety for Neuroscience Annual Meeting2008Washington, DC
Cassette Exchange”: a Cre-loxP mediated recombination method for efficient generation of stable transgenic human embryonic stem cell lines.PosterAnnual Connecticut Stem Cell Technology Symposium2008Farmington, CT
Gbx2-dependent program regulates axon guidance of the thalamocortical projections. PosterGordon Conference on Neural Development2008Newport, RI
Gbx2 and Fgf8 are sequentially required for formation of the mid-hindbrain compartment boundary.PosterSociety For Developmental Biology, 67st Annual Meeting2008Philadelphia, PA
Gbx2-dependent program regulates axon guidance of the thalamocortical projections.PosterNortheast Regional Developmental Biology Meeting2007Northeast, USA
Fgf8 function is orchestrated by different Fgf8 splice variants.PosterGordon Conference on Fibroblast, Growth Factors In Development & Disease2006Ventura, CA
Fgf8 function is orchestrated by different Fgf8 splice variants.PosterDevelopment Biology, Gordon Research Conferences2005New Hampshire
Expressing Gbx2 in rhombomere 4 in Gbx2 mutants rescues rhombomere 3 and causes deletion of the posterior midbrain.PosterDevelopment Biology, Gordon Research Conferences2003New Hampshire
Temporal requirements for Gbx2 in cerebellar development. PosterSociety For Developmental Biology, 61st Annual Meeting2002New Hampshire
Genetic analysis of Otx2 and Gbx2 function in mid-hindbrain development.Poster2001 Development Biology, Gordon Research Conferences2001New Hampshire