Photo of Changchun  Liu, Ph.D.

Changchun Liu, Ph.D.

Associate Professor of Biomedical Engineering
Academic Office Location:
Biomedical Engineering
UConn Health
263 Farmington Avenue
Farmington, CT 06030

Smart Medical Devices and Systems (SMDS) Laboratory

Paradigm shifts in biomedical fields often arise from breakthroughs and innovations in tools and measurement methods. Our laboratory is interested in applying interdisciplinary approaches to develop new medical devices and systems to solve current challenges in biomedicine, such as disease diagnostics, medical therapeutics, mobile health, as well as personalized medicine. Our research philosophy is “Interdisciplinary Integration and Innovation.” We have widely collaborated with a variety of scientists (clinician, microbiologist, and epidemiologist) and engineers (biomedical, mechanical, electronic, and material) globally (e.g., UK, Botswana, and China). We have developed a number of medical devices and systems for disease detection and diagnostics (i.e., HIV virus, Zika virus, cervical cancer screening).

B.S.Yunnan UniversityApplied Chemistry
M.S.Yunnan UniversityOrganic Chemistry
Ph.D.Institute of Electronics Chinese Academy of SciencesPhysical Electronics

Name of Award/HonorAwarding Organization
W.W. Smith Charitable Trust Award
Penn One Health AwardUniversity of Pennsylvania
NIH Career Development Award (K25)
NSF Fellowship for Summer Institute on Cancer Nanotechnology

Our laboratory works at the interface of biomedicine, chemistry, biology and engineering (e.g., biomedical, electrical, mechanical, computer). On the one hand, we study fundamental problems in microfluidics, nanotechnology, analytical chemistry and clinical medicine. On the other hand, we are interested in using these findings to address current challenges in biomedicine, such as disease diagnostics, medical therapeutics, and personalized medicine. Our current research focuses include:

Microfluidic Technologies for Global Health
Rapid and sensitive diagnostics of infectious disease at the point-of-care (POC) is critical for prompt and appropriate therapeutic intervention. Microfluidic technology not only allows the miniaturization of traditional biochemical assays, but also reduces cost, sample amount and testing time. We combine microfluidics with nucleic acid detection technology (e.g., isothermal amplification) to develop simple, low-cost and easy-to-use molecular diagnostic platform for infectious disease detection (e.g., HIV, ZIKV) (Liu, et al., Scientific reports, 2014, 4, 7335)

Salivary Diagnostics
Saliva (oral fluid) is considered as a mirror of the body. Saliva shares many of the same biomarkers (e.g., viruses, bacterial, nucleic acids, proteins) found in blood. Unlike blood, however, saliva has many advantages as a diagnostic biofluid including non-invasive, easy, and rapid to collect. We are interested in investigating new micro/nano technologies to enable non-invasive salivary diagnostics (e.g., oral cancer screening) (e.g., Song et al., Analytical chemistry, 2016, 88 (14), 7289-7294).

Smart Connected Diagnostic System
In the context of mobile Health (mHealth) and personalized medicine, the integration of inexpensive POC diagnostics technology with the ubiquitous smartphone will create a new paradigm shift for cost-effective, mobile, personalized, health monitoring. We investigate smart connected diagnostic systems that take advantage of smartphone/internet technology to develop next generation health care solutions (e.g., Internet of Diagnostic Things) (Song et al., Analytical chemistry, 2018, 90(7):4823-4831).

Wearable Biosensors and Novel Biosensing Research
Biosensors have become an important tool for detection of chemical and biological components for clinical, food and environmental monitoring. We are interested in studying novel biosensing mechanism (e.g., optical, electrochemical, nanomaterial) and wearable (implantable) bio/chemical sensing technologies for health monitoring and biomedical remote sensing.

People are the engine and driving force of innovations in our research lab. We always seek highly talented researchers from different backgrounds and trainings (e.g., biomedical science, clinical chemistry/microbiology, microfluidics, 3D printing, electrochemistry, and microfabrication) with demonstrated expertise, and ability in working in a diverse, interdisciplinary environment. We have an immediate opening for postdoctoral fellows and Ph.D. students. If you are interested in applying or would like more information, please contact Changchun Liu at

Accepting students for Lab Rotations: Spring '19, Fall '19, and Spring '20

Journal Articles