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Kevin Lo, Ph.D.Associate ProfessorDepartment of Medicine, Endocrinology Department of Biomedical Engineering Institute of Materials Science (IMS) Assistant Director Connecticut Convergence Institute for Translation in Regenerative Engineering
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Education
Post-Graduate Training
| Degree | Institution | Major |
|---|---|---|
| B.Sc. | Hong Kong University of Science and Technology | Biochemistry |
| M.Phil. | Hong Kong University of Science and Technology | Biochemistry |
| Ph.D. | Hong Kong University of Science and Technology | Biochemistry |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Fellowship | University of Connecticut Health Center | Supervisor: Dr. Cato T. Laurencin, Department of Orthopaedic Surgery |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Orthopeadic Research and Education Foundation (OREF) | Advisory Committee | Reviewer | External | National | 2023 | |
| NICHD/Development Biology Study Section | Study Section | Panelist | External | National | 2023 | 2023 |
| CDMRP | Study Section | Panelist | External | National | 2023 | 2023 |
| NSF/EFRI Panel | Study Section | Panelist | External | National | 2022 | 2022 |
| Biomedicines | Editorial Board | Editorial Board member | External | International | 2022 | |
| NIH Small Business Grants | Study Section | Panelist | External | National | 2022 | |
| Frontiers in Bioengineering and Biotechnology | Professional/Scientific Journal | Associate Editor | External | International | 2021 | |
| CDMRP | Advisory Committee | Peer review panel | External | National | 2021 | 2021 |
| NIH Small Business Grants | Study Section | Peer review panel | External | National | 2021 | 2021 |
| Swiss National Science Foundation | Research Committee | Peer Reviewer | External | International | 2020 | 2020 |
| PLoS ONE | Editorial Board | Associate Editor | External | International | 2019 | |
| ASSAY and Drug Development Technologies | Editorial Board | Board Member | External | International | 2019 | |
| F1000 Research | Editorial Board | Referee | External | International | 2019 | |
| Society for Biomaterials | Professional/Scientific Organization | Biomaterials Forum Reporter | External | International | 2019 | |
| Israeli Ministry of Science and Technology | Advisory Committee | Peer Reviewer | External | International | 2019 | 2019 |
| Aetna Health Cafe Series | Community Service | Organizer | External | Regional | 2018 | |
| Society for Biomaterials | Professional/Scientific Organization | Publication Committee | External | International | 2018 | |
| Connecticut Convergence Institute for Translation in Regenerative Engineering | Professional/Scientific Organization | Assistant Director of Education | UConn Health | Local | 2018 | |
| New Investigator grants, Orthopeadic Research and Education Foundation (OREF) | Advisory Committee | Peer Reviewer | External | National | 2018 | 2020 |
| Advanced Regenerative Manufacturing Institute (ARMI)/BioFab USA | Advisory Committee | Working Group Member | External | National | 2017 | |
| Research Experience Mentoring (REM) summer research program funded by NSF | Education Committee | Program Lead | External | Regional | 2017 | |
| Regenerative Engineering Society of AIChE | Professional/Scientific Organization | Board Member | External | International | 2016 | |
| Kavli Science Café Series | Community Service | Organizer | External | Regional | 2016 | |
| Regenerative Engineering and Translational Medicine | Professional/Scientific Journal | Assistant Managing Editor | External | International | 2016 | |
| Core Interest Group (CIG) of CICATS | Research Committee | Coordinator | UConn Health | Regional | 2016 | 2018 |
| Connecticut Institute for Clinical and Translational Science (CICATS) | Investigator Advocate | UConn Health | Regional | 2014 | 2018 | |
| Advances in Regenerative Biology | Editorial Board | Board Member | External | International | 2014 | 2018 |
| J. of Racial and Ethnic Health Disparities | Professional/Scientific Journal | Deputy Editor | External | International | 2013 | |
| Current Pharmaceutical Design | Professional/Scientific Journal | Guest Editor | External | International | 2013 | 2013 |
| University of Connecticut Stem Cell Institute (USCI) | Other | Investigator | UConn Health | Local | 2013 | 2016 |
| Institute for Regenerative Engineering | Other | Assistant Professor | UConn Health | Local | 2012 | 2018 |
| Society for Biomaterials | Professional/Scientific Organization | Member | External | International | 2009 | |
| The American Society for Cell Biology | Professional/Scientific Organization | Member | External | International | 2004 | 2008 |
| Cells, Journal of Tissue Engineering and Regenerative Medicine Annals of Biomedical Engineering, Trends in Biotechnology, Journal of Biomaterials and Tissue Engineering, Current Pharmaceutical Design, Journal of Biomaterials Science: Polymer Edition, International Journal of Molecular Sciences, Current Medicinal Chemistry, Cell Health and Cytoskeleton | Professional/Scientific Journal | Reviewer | External | International | ||
| Biotechnology and Bioengineering, Current Drug Delivery, Regenerative Engineering and Translational Medicine; J. Control Release; Biomaterial Science; Materials Chemistry and Physics; Acta Biomaterialia; Drug Delivery; ACS Applied Materials & Interfaces; International Journal of Pharmaceutics; Current Pharmaceutical Biotechnology, J. of Racial and Ethnic Health Disparities | Professional/Scientific Journal | Reviewer | External | International |
Project 1: Small Molecule based Musculoskeletal Tissue Engineering The utilization of small molecules for engineering musculoskeletal tissues has been largely overlooked. We envision that this trend is very likely to be reversed as advanced screening technologies have recently generated a large number of novel regenerative small molecule compounds, and advanced tissue engineering scaffolds continue to provide promise for controllable drug delivery to target tissues. We have chosen skeletal tissue as a test bed of small molecule-based regenerative engineering because of the challenge of treating skeletal diseases and injury clinically.
Project 2: Targeted Nanoscale Drug Delivery Vehicle for Bone Diseases.
Project 3: Intracellular drug delivery system utilizing cytoplasmic dynein motor protein.
Accepting new students.
Journal Articles
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Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds.
PloS one 2024 Jan;19(2):e0299579
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Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment.
Nature communications 2023 Oct;14(1):6257
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Regenerative engineering of long bones using the small molecule forskolin.
Proceedings of the National Academy of Sciences of the United States of America 2023 May;120(22):e2219756120
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Effects on bone regeneration of single-dose treatment with osteogenic small molecules.
Drug discovery today 2022 Feb;
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Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits.
Science translational medicine 2022 Jan;14(627):eabi7282
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Emergence of the Stem Cell Secretome in Regenerative Engineering.
Trends in biotechnology 2020 Dec;38(12):1373-1384
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Biodegradable nanofiber bone-tissue scaffold as remotely-controlled and self-powering electrical stimulator
Nano Energy 2020 Oct;76105028
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Health Café Series: a Potential Platform to Reduce Health Disparities.
Journal of racial and ethnic health disparities 2020 Aug;7(4):592-594
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Repositioning Tacrolimus: Evaluation of the Effect of Short-Term Tacrolimus Treatment on Osteoprogenitor Cells and Primary Cells for Bone Regenerative Engineering.
Assay and drug development technologies 2019 Jan;
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Bone Regenerative Engineering Using a Protein Kinase A-Specific Cyclic AMP Analogue Administered for Short Term
Regenerative Engineering and Translational Medicine 2018 Jul;4(4):206-215
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Injectable nanocomposite analgesic delivery system for musculoskeletal pain management.
Acta biomaterialia 2018 May;74280-290
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Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue.
Journal of nanoscience and nanotechnology 2018 Apr;18(4):2310-2317
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The roles of ions on bone regeneration.
Drug discovery today 2018 Feb;23879-890
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Biodegradable Piezoelectric Force Sensor.
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan;115909-914
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Engineered Bone Tissue with Naturally-Derived Small Molecules.
Current pharmaceutical design 2017 May;233585-3594
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Osteotropic Nanoscale Drug Delivery System via a Single Aspartic Acid as the Bone-targeting Moiety
J. Nanosci Nanotechnol 2016 Sep;in press
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Osteotropic Nanoscale Drug Delivery Systems Based On Small Molecule Bone-Targeting Moieties
Nanomedicine: Nanotechnology, Biology and Medicine 2016 Aug;Epub Alead of Print
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Pain management via local anesthetics and responsive hydrogels.
Therapeutic delivery 2015 Feb;6(2):165-76
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Electrospinning Polymers for Tissue Regeneration
Prog Polym Sci 2014 Dec;461-24
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Regulation of bone regeneration with approved small molecule compounds
Advances In Regenerative Biology 2014 Sep;125276
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Poly aspartic acid peptide-linked PLGA based nanoscale particles: potential for bone-targeting drug delivery applications.
International journal of pharmaceutics 2014 Sep;475(1-2):547-57
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Simple signaling molecules for inductive bone regenerative engineering.
PloS one 2014 Jul;9(7):e101627
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Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.
Nanomedicine : nanotechnology, biology, and medicine 2014 Jun;10(8):1691-9
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Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84.
Journal of neuroscience research 2014 May;92(9):1143-54
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Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications.
Drug discovery today 2014 Feb;19(6):794-800
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Small-molecule based musculoskeletal regenerative engineering.
Trends in biotechnology 2014 Feb;32(2):74-81
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Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.
Advanced healthcare materials 2013 Dec;3(6):843-7
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One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation.
Journal of tissue engineering and regenerative medicine 2013 Nov;10867-875
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Short-term administration of small molecule phenamil induced a protracted osteogenic effect on osteoblast-like MC3T3-E1 cells.
Journal of tissue engineering and regenerative medicine 2013 Jul;10518-26
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Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Oct;32(44):15495-510
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Studies of bone morphogenetic protein-based surgical repair.
Advanced drug delivery reviews 2012 Sep;64(12):1277-91
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Evaluating the feasibility of utilizing the small molecule phenamil as a novel biofactor for bone regenerative engineering.
Journal of tissue engineering and regenerative medicine 2012 Jul;8(9):728-36
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The role of small molecules in musculoskeletal regeneration.
Regenerative medicine 2012 Jul;7(4):535-49
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The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization.
Journal of tissue engineering and regenerative medicine 2012 Jan;6(1):40-8
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Activation of cyclic amp/protein kinase: a signaling pathway enhances osteoblast cell adhesion on biomaterials for regenerative engineering.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011 Apr;29(4):602-8
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Current Patents on Osteoinductive Molecules for Bone Tissue Engineering.
Recent Patents on Biomed. Eng. 2011 Jan;4168-84
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Novel polymer-ceramics for bone repair and regeneration
Recent Patents on Biomedical Engineering 2011 Jan;4(3):168-184
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Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex.
The Journal of biological chemistry 2007 Dec;282(51):36871-8
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Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells.
Journal of neuroscience research 2007 Sep;85(12):2640-7
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The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.
The Journal of biological chemistry 2007 Apr;282(15):11205-12
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Methods to study the interactions of the dynein light chains and intermediate chains.
Methods in molecular biology (Clifton, N.J.) 2007 Jan;39285-95
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Identification of a novel region of the cytoplasmic Dynein intermediate chain important for dimerization in the absence of the light chains.
The Journal of biological chemistry 2006 Apr;281(14):9552-9
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The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation.
The Journal of biological chemistry 2005 Mar;280(9):8172-9
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Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly.
The Journal of biological chemistry 2003 Oct;278(42):41491-9
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Purification and Characterization of ALG2: A Novel Apoptosis-linked Calcium Binding Protein.
Methods Mol. Biol. 2002 Jan;172235-42.
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The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.
The Journal of biological chemistry 2001 Apr;276(17):14059-66
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Apoptosis-linked gene product ALG-2 is a new member of the calpain small subunit subfamily of Ca2+-binding proteins.
Biochemistry 1999 Jun;38(23):7498-508
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Molecular Mechanisms Underlying the Short-Term Intervention of Forskolin Mediated Bone Regeneration
Regen Eng Transl Med. in press
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Molecular Mechanisms Underlying the Short-Term Intervention of Forskolin Mediated Bone Regeneration
Regen Eng Transl Med.
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Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds.
PLoS ONE
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Small molecule-mediated regenerative engineering for craniofacial and dentoalveolar bone
Front. Bioeng. Biotechnol. in press
Book Chapters
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Cytoplasmic Dynein Function Defined by Subunit Composition.
Chapter 15
Dyneins: Structure, Biology and Disease 2012 Jan;423-436
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Biomimetric Matrices for Integrin-mediated Cell Adhesion
Biologically-Responsive Hybrid Biomaterials: A Reference for Material Scientists and Bioengineers 247-284
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Calcium Phosphate based Ceramics for Biomedical Application. Biodegradable polymers in clinical use and clinical development.
Chapter 14 495-517
Editorials
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Bone morphogenetic proteins for bone regeneration and their alternatives.
Curr Pharm Des 19(19):3353
Reviews
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The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine.
Biomedicines 2023 Sep;11(9):
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Small molecule-mediated regenerative engineering for craniofacial and dentoalveolar bone.
Frontiers in bioengineering and biotechnology 2022 Jan;101003936
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Harnessing cAMP signaling in musculoskeletal regenerative engineering.
Drug discovery today 2017 Jul;22(7):1027-1044
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Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties.
Nanomedicine : nanotechnology, biology, and medicine 2016 Aug;1337-47
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Small molecule-based treatment approaches for long bone fractures | Lecture | 2023 | University of Alberta | |
| Harnessing small signaling molecules in musculoskeletal regenerative engineering: A Convergence Approach | Talk | Department of Mechanical Engineering, UConn | 2020 | Storrs CT |
| Regenerative Engineering: The roles of Small Molecule | Lecture | University of Hartford | 2020 | West Hartford, CT |
| Convergence and Regenerative Engineering | Talk | The Aetna Foundation | 2019 | YWCA Hartford |
| Cytoplasmic Dynein Associated Peptide-linked Nanoparticles for Non-viral Vector Applications | Poster | World Biomaterials Congress | 2016 | Montreal, Canada |
| Inductive Small Molecule Regeneration: Convergence of Pharmaceutical Sciences and Biomedical Engineering. | Lecture | Wallace H. Coulter Foundation Lecture Series. | 2015 | Florida International University, Miami, FL, |
| Osteotropic Nanoscale Drug Delivery System via a Single Aspartic Acid as the Bone-targeting Moiety | Poster | BMES | 2015 | Tampa, FL |
| Development of Poly-aspartic Acid Peptide Linked PLGA-based Nanoparticles for Bone Targeting | Plenary Lecture | BMES | 2014 | TX |
| Engineered Bone Tissue Through Short-term Administration of an Osteogenic Small Molecule | Poster | BMES | 2014 | TX |
| Inductive Small Molecule Regeneration: Convergence of Pharmaceutical Sciences and Regenerative Engineering | Lecture | University of Houston | 2014 | Houston, TX |