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Carl Malchoff, M.D., Ph.D.Professor of Medicine
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- Education & Training
- Teaching
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.S. | Cornell University | Biological Sciences |
| M.D., Ph.D. | University of Rochester School of Medicine and Dentistry | Medicine and Biochemistry |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Internship | University of Virginia Medical Center | Internal Medicine |
| Residency | University of Virginia Medical Center | Internal Medicine |
| Fellowship | University of Virginia Medical Center | Endocrinology and Metabolism |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Invited Lecture New Guidelines for Surgery for Asymptomatic Primary Hyperparathyroidism, | Second Annual New England Endocrine Tumor Symposium at Yale |
| 2012-2013 Best Doctors | US News and World Report |
| 2012-2013 Best Doctors | US News and World Report |
| Honoree of the Raynbow Diabetes Foundation for Contributions to Diabetes Care and Research | Raynbow Diabetes Foundation |
| Invited Lecture, Familial Nonmedullary Thyroid Carcinoma | American Thyroid Association |
| Invited Lecture, Adrenal Insufficiency: The Annual Meeting of the Endocrine Nurses Society | Endocrine Nurses Society |
| Invited Lecture, Diagnosis of Adrenal Insufficiency: The Endocrine Society 85th Annual Meeting | Endocrine Society 85th Annual Meeting |
| Included in Best Doctors in America Database | |
| Invited Lecture, Molecular Genetics of Familial Papillary Thyroid Carcinoma | Endocrine Society Annual Meeting |
| Invited Lecture, Glucocorticoid Use and Withdrawal,Continuing Education Program | Endocrine Society |
| Invited Lecture, Familial Papillary Thyroid Carcinoma | Satellite Meeting of the American Society of Human Genetics |
| Invited Lecture, Adrenal Insufficiency, Continuing Education Update | Endocrine Society |
| Leader, Meet the Professor Session - Adrenal Insufficiency | Endocrine Society Annual Meeting |
| Moderator, Adrenal Session | Endocrine Society Annual Meeting |
| Invited Lecture, Glucocorticoid Resistance | Endocrine Society, Continuing Education Update |
| Moderator, Adrenal Disorders | Endocrine Society Annual Meeting |
| Invited "State-of-the-Art" Lecture on Generalized Inherited Glucocorticoid Resistance | 20th Annual International Aldosterone Conference |
| Invited Lecture, Generalize Inherited Glucocorticoid Resistance | Endocrine Society Annual Meeting |
| Moderator, Adrenal Gland Slide Presentation Session | Endocrine Society Annual Meeting |
| John Horsley Memorial Award | University of Virgina Health Sciences Center |
| Primary Opponent to Claes-Hakan Bergh, at His Ph.D. Thesis Defense | University of Gothenburg |
| American Cancer Society Postdoctoral Fellowship | American Cancer Society |
| Young Investigator Award | American Diabetes Association |
| Juvenile Diabetes Foundation Postdoctoral Fellowship | Juvenile Diabetes Foundation |
Lecture to second year medical students in endocrinology and metabolism course.
Clinical teaching of residents and endocrinology fellows in endocrinology.
Clinical teaching of residents and endocrinology fellows in endocrinology.
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Senior Appointments and Promotions Committee | Advisory Committee | member | UConn Health | University | 2016 | |
| Compensation Committee at University of Connecticut Health Center (for compensation grievances) | Other | UConn Health | University | 2006 | 2012 | |
| UConn Health Diabetes Education Program | Education Committee | Medical Director | UConn Health | University | 2005 | |
| Faculty Review Board | Advisory Committee | Member | UConn Health | National | 2005 | 2008 |
| Scientific Advisory Committee, General Clinical Research Center | Advisory Committee | Alternate | UConn Health | University | 2003 | |
| Scientific Review Committee for Institutional Review Board | Advisory Committee | Member | UConn Health | University | 2003 | |
| Endocrine Neoplasia Program | Education Committee | Head | UConn Health | National | 2001 | |
| American Association of Clinical Endocrinologists | Professional/Scientific Organization | member | External | National | 2000 | |
| Connecticut Endocrine Society | Professional/Scientific Organization | President | External | State | 1994 | 1996 |
| The Endocrine Society | Professional/Scientific Organization | Member | External | National | ||
| American Thyroid Association | Professional/Scientific Organization | Member | External | National | ||
| American College of Physicians | Professional/Scientific Organization | Member | External | National | ||
| American Diabetes Association | Professional/Scientific Organization | Member | External | National | ||
| American Association of Clinical Endocrinologists | Professional/Scientific Organization | Member | External | National | ||
| Hartford County Medical Association | Professional/Scientific Organization | Member | External | Regional |
Dr. Malchoff has a general interest in the molecular pathogenesis of tumors of the thyroid, adrenal, and pituitary gland. Specific research interests include familial papillary thyroid carcinoma, autoimmunity in thyroid cancer, and primary aldosteronism. He has published over 45 peer-reviewed manuscripts and over 35 invited reviews.
Summer research rotations are available in the molecular pathogenesis of endocrine neoplasms.
Clinical research rotations are available in primary aldosteronism.
Clinical research rotations are available in primary aldosteronism.
Journal Articles
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A Retrospective Evaluation of the Diagnostic Performance of an Interdependent Pairwise microRNA Expression Analysis with a Mutation Panel in Indeterminate Thyroid Nodules.
Thyroid : official journal of the American Thyroid Association 2022 Aug;
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3-D Ultrasound and Thyroid Cancer Diagnosis: A Prospective Study.
Ultrasound in medicine & biology 2021 May;47(5):1299-1309
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Inherited Risk Factors for Nonmedullary Thyroid Carcinoma.
The Journal of clinical endocrinology and metabolism 2021 Mar;
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Empiric Determination of the Daily Glucocorticoid Replacement Dose in Adrenal Insufficiency.
Journal of the Endocrine Society 2020 Nov;4(11):bvaa145
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Analytical and clinical validation of pairwise microRNA expression analysis to identify medullary thyroid cancer in thyroid fine-needle aspiration samples.
Cancer cytopathology 2020 Oct;
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Adrenal vein sampling with and without cosyntropin stimulation for detection of surgically remediable aldosteronism.
Endocrinology, Diabetes & Metabolism 2019 Apr;2(2):e00066
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Molecular and phenotypic evaluation of a novel germline TMEM127 mutation with an uncommon clinical presentation.
Endocrine-related cancer 2018 Sep;25(9):X3
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Shear wave elastography and Afirma™ gene expression classifier in thyroid nodules with indeterminate cytology: a comparison study.
Endocrine 2018 Mar;59(3):573-584
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Evaluation of a novel germline TMEM127 mutation in an uncommon presentation.
Endocrine-related cancer 2017 Aug;24L79-L82
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AN INDIVIDUALIZED APPROACH TO THE EVALUATION AND MANAGEMENT OF PRIMARY ALDOSTERONISM.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2017 Mar;23680-689
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Shear wave elastography and parathyroid adenoma: A new tool for diagnosing parathyroid adenomas.
European journal of radiology 2016 Sep;85(9):1586-93
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Shear Wave Elastography and Cervical Lymph Nodes: Predicting Malignancy.
Ultrasound in medicine & biology 2016 Mar;421273-81
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Thyroid Nodules and Shear Wave Elastography: A New Tool in Thyroid Cancer Detection.
Ultrasound in medicine & biology 2015 Aug;41(11):2855-65
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Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.
The Journal of clinical endocrinology and metabolism 2015 May;100(5):E710-9
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Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(13):4062-7
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Thyroid hormones and functional outcomes after ischemic stroke.
Thyroid research 2015 Jan;89
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Association of Hashimoto's thyroiditis with thyroid cancer.
Endocrine-related cancer 2014 Sep;21(6):845-52
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Is familial nonmedullary thyroid carcinoma more aggressive than sporadic nonmedullary thyroid carcinoma?
Thyroid : official journal of the American Thyroid Association 2014 Feb;24(4):782-3
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Intracerebral hemorrhage with hypothyroidism.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2013 Sep;22(8):e602-9
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Performance of elastography for the evaluation of thyroid nodules: a prospective study.
Thyroid : official journal of the American Thyroid Association 2013 Jun;23(6):734-40
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Three-dimensional ultrasound images and fine-needle aspiration biopsy of a thyroid nodule.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2011 Jul;17(4):659-61
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Autoimmune thyroid disease: a risk factor for thyroid cancer.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2011 Mar;17(2):201-9
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Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2010 May;109(5):739-43
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Number of aberrant crypt foci associated with adiposity and IGF1 bioavailability.
Cancer causes & control : CCC 2009 Jul;20(5):653-61
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The Diagnosis of Neurorendocrine Tumor a Clinical, Laboratory Imaging Perspective
Clinical Nuclear Medicine 2009 Jan;34(2):259
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A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds.
The Journal of clinical endocrinology and metabolism 2006 May;91(5):1943-9
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Invasiveness as a barrier to self-monitoring of blood glucose in diabetes.
Diabetes technology & therapeutics 2005 Aug;7(4):612-9
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Radioguided tumorectomy in the management of parathyroid adenomas.
Archives of surgery (Chicago, Ill. : 1960) 2003 Jul;138(7):716-20
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A novel noninvasive blood glucose monitor.
Diabetes care 2002 Dec;25(12):2268-75
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Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.
Molecular endocrinology (Baltimore, Md.) 2002 Dec;16(12):2746-53
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Laparoscopic resection of large adrenal tumors.
Annals of surgical oncology 2002 Jun;9(5):480-5
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Unilateral adrenal hyperplasia causing primary aldosteronism: limitations of I-131 norcholesterol scanning.
American journal of hypertension 2002 May;15(5):459-64
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Treatable lower motor neuron disease due to vitamin D deficiency and secondary hyperparathyroidism.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2000 Sep;1(4):283-6
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Familial papillary thyroid carcinoma is genetically distinct from familial adenomatous polyposis coli.
Thyroid : official journal of the American Thyroid Association 1999 Mar;9(3):247-52
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Familial nonmedullary thyroid carcinoma.
Seminars in surgical oncology 1999 Jan;16(1):16-8
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A cluster of cases of subacute and silent thyroiditis in the northern Connecticut, Greater Hartford area.
Connecticut medicine 1998 Jul;62(7):395-7
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Concurrence of Graves' disease and dysplastic cerebral blood vessels of the moyamoya variety.
Thyroid : official journal of the American Thyroid Association 1997 Aug;7(4):625-9
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Bilateral laparoscopic adrenalectomy for adrenocorticotropic dependent Cushing's syndrome.
The Journal of urology 1997 Jan;157(1):16-8
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Chiasmal herniation as a complication of bromocriptine therapy.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 1996 Dec;16(4):252-7
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Preferential localization of regional metastases from gastroenteropancreatic endocrine tumors with somatostatin-receptor scintigraphy.
Archives of surgery (Chicago, Ill. : 1960) 1996 Dec;131(12):1338-42
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Bronchogenic carcinoma presenting as a pseudopregnancy.
Chest 1995 Feb;107(2):567-9
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Dexamethasone therapy for isosexual precocious pseudopuberty caused by generalized glucocorticoid resistance.
The Journal of clinical endocrinology and metabolism 1994 Dec;79(6):1632-6
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Somatostatin receptor scintigraphy: its value in tumor localization in patients with Cushing's syndrome caused by ectopic corticotropin or corticotropin-releasing hormone secretion.
The American journal of medicine 1994 Apr;96(4):305-12
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Glucocorticoid resistance.
Current therapy in endocrinology and metabolism 1994 Jan;5167-71
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A mutation of the glucocorticoid receptor in primary cortisol resistance.
The Journal of clinical investigation 1993 May;91(5):1918-25
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Diurnal blood pressure variability in mineralocorticoid excess syndrome.
American journal of hypertension 1992 Jun;5(6 Pt 1):414-8
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Primary cortisol resistance presenting as isosexual precocity.
The Journal of clinical endocrinology and metabolism 1990 Feb;70(2):503-7
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A glucocorticoid receptor mutation in a subject with primary cortisol resistance.
Transactions of the Association of American Physicians 1990 Jan;10353-63
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Adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia: an unusual cause of Cushing's syndrome.
The Journal of clinical endocrinology and metabolism 1989 Apr;68(4):855-60
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Eruptive abdominal pain. Chylomicronemia.
Chest 1987 Oct;92(4):747-8
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Persistent Metastatic Thyroid Carcinoma.
Journal of medical ultrasound 28(2):111-113
Book Chapters
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Oncogenes and Tumor Suppressor Genes in Thyroid Nodules and Thyroid Cancer
UPToDate 2019 Aug;
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Oncogenes and Tumor Suppressor Genes in Thyroid Nodules and Thyroid Cancer
UpToDate 2019 Aug;
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Oncogenes and Tumor Suppressor Genes in Thyroid Nodules and Thyroid Cancer - update of previous chapter
UpToDate 2019 Aug;10
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Glucocorticoid Receptors, Their Mechanisms of Actin , and Glucocorticoid Resistance
Endocrinology: Adult and Pediatric 2016 Jan;1717-1726
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Glucocorticoid Receptors, Mechanisms of Action and Glucocorticoid Resistance
Endocrinology Adult and Pediatric: The Adrenal Gland, 6th Edition 2010 Jan;1820-1830
Abstracts
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Hematologic abnormalities in patients exposed to monthly triple-dose gadolinium for a year.
American College of Radiology Annual Meeting. Washington, DC. 2019 May;
Case Reports
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Isolated DHEAS production by an adrenal neoplasm: Clinical, biochemical and pathologic characteristics.
Urology case reports 2020 Jul;31101148
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Precision Medicine with 3D Ultrasound.
VideoEndocrinology 2020 Jan;7(3):
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Diagnosis of Parathyroid Adenomas with New Ultrasound Imaging Modalities
VideoEndocrinology (American Thyroid Association and Mary Ann Liebert, Inc publishers) 2019 Nov;
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Diagnosis of Parathyroid Adenomas with New Ultrasound Imaging Modalities.
VideoEndocrinology 2019 Jan;6(4):
Editorials
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Editorial: Carney complex--clarity and complexity.
The Journal of clinical endocrinology and metabolism 2000 Nov;85(11):4010-2
Notes
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An unusual presentation of McCune-Albright syndrome confirmed by an activating mutation of the Gs alpha-subunit from a bone lesion.
The Journal of clinical endocrinology and metabolism 1994 Mar;78(3):803-6
Other
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Diagnosis of Thyroid Nodule with New Ultrasound Imaging Modalities.
VideoEndocrinology 2019 Jan;7(1):
Reviews
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Differentiated Thyroid Cancer
Orphanet 2014 Jan;
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Familial nonmedullary thyroid carcinoma.
Cancer control : journal of the Moffitt Cancer Center 2006 Apr;13(2):106-10
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Clinical syndromes of glucocorticoid resistance and hypersensitivity
Current Opinion in Endocrinology and Diabetes 2006 Jan;13(3):242-247
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Glucocorticoid resistance and hypersensitivity.
Endocrinology and metabolism clinics of North America 2005 Jun;34(2):315-26, viii
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Familial papillary thyroid carcinoma.
Cancer treatment and research 2004 Jan;122381-7
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The genetics of hereditary nonmedullary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2002 Jun;87(6):2455-9
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Adrenal insufficiency.
Current therapy in endocrinology and metabolism 1997 Jan;6142-7
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Adrenocorticotropic hormone-independent adrenal hyperplasia
Endocrinologist 1996 Jan;6(2):79-85
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The Sipple syndrome: From clinical description to genetic analysis in the index family
Endocrinologist 1996 Jan;6(6):427-430
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Diagnosis and classification of diabetes mellitus.
Connecticut medicine 1991 Nov;55(11):625-9
Short Surveys
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Glucocorticoid resistance in humans
Trends in Endocrinology and Metabolism 1995 Jan;6(3):89-95
Websites
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Adrenal Insufficiency
American College of Physicians, Smart Medicine Website, PIER Module 2011 Jan;
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Oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer
UpToDate 2011 Jan;
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Oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer
UpToDate 2009 Jan;
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Immunotherapy Use in Adrenocortical Carcinoma with Encouraging Results – A Case Report. | Poster | The Endocrine Society | 2020 | SanFrancisco |
| Empiric Determination of Daily Glucocorticoid Replacement Doses in Adrenal Insufficiency, | Poster | Endocrine Society | 2019 | New Orleans |
| Isolated DHEA-S Production by an Adrenal Neoplasm; Clinical, Biochemical, and Pathologic Findings | Poster | Endocrine Society, Annual Meeting | 2019 | |
| Anaplastic thyroid carcinoma with metastases involving soft tissues of the upper and lower extremities | Poster | The Endocrine 95th Society Annual Meeting Program | 2013 | San Francisco, CA |
| Long-term outcome following adrenalectomoy of primary hperaldosteronism caused by unilateral adrenal hyperplasia. | Poster | The Endocrine Society 94th Annual Meeting Program | 2012 | Houston, TX |
| A new syndromic association: pituitary adenomas, paragangliomas and pheochromocytomas | Lecture | The Endocrine Society 94th Annual Meeting | 2012 | Houston, TX |
| Unusually aggressive paraganglioma phenotype in a kindred with a 57dlG SDHD mutation | Poster | The Endocrine Society 94th Annual Meeting | 2012 | Houston, TX |
| Unusually aggressive paraganglioma phenotype in a kindred with a 57delG SDHD mutation | Poster | The Endocrine Society 94th Annual Meeting Program | 2012 | Houston, TX |
| In primary aldosteronism an adrenal macroadenoma on CT scan does not reliably predict surgically remediable hyperaldosteronism | Poster | The Endocrine Society Annual Meeting | 2011 | Boston, MA |
| Adrenal Venous Sampling Criteria for Surgically Remediable Primary Hyperaldosteronism, | Poster | The Endocrine Society Annual Meeting | 2010 | San Diego |