Photo of Peter F. Maye, PhD

Peter F. Maye, PhD

Associate Professor, Center for Regenerative Medicine and Skeletal Development
Academic Office Location:
Center for Regenerative Medicine and Skeletal Development
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3705
Phone: 860-679-7347
Fax: 860-679-2910
Email: pmaye@uchc.edu
Website(s):

Skeletal Biology and Regeneration Graduate Program

My lab investigates how different genes and cell types contribute to the regulation of skeletal tissues. Advances in omics approaches and applications to mine datasets are rapidly changing the landscape of biology. Current efforts in my lab are focused on applying spatial transcriptomics and the archiving of skeletal phenotyping datasets to develop a deeper understanding of the cell types and molecular mechanisms that impact the skeleton.

Spatial Transcriptomics of Skeletal Tissues:  Spatial transcriptomics is a technique that allows the detection of RNA molecules on a scale that previously was not possible, but now provides remarkable insight into the cellular composition of tissues and when integrated with other omics datasets, an ability to understand the communication the goes on between neighboring cells. My research utilizes spatial transcriptomic approaches to understand the biology of skeletal tissues. Currently, as part of the Human Biomolecular Atlas Program, we are actively involved in the spatial transcriptomic mapping of human articular cartilage.


Development of a Rodent Skeletal Phenotyping Database:  While significant limitations exist in the skeletal phenotyping of human patients, rodents remain the animal model of choice to study skeletal biology and model human skeletal diseases, where extensive phenotyping is routinely performed. Because the experimental animals are genetically homogeneous, the data captured is quantitative and, when coupled with experimental metadata, provides valuable insight into the mechanistic regulation of bone tissue. The magnitude of experimental questions being tested in rodent animal models to determine a skeletal phenotype is highly relevant to human disease, making for a rich data source that that if properly archived and shared can be exploited to understand mechanisms of skeletal regulation for rodents and humans. Shockingly, no central resource exists to obtain skeletal phenotyping data and much of the published work is largely forgotten.  We are actively working on a repository to archive and share skeletal phenotyping data with the global research community.


 


 


  


 


 


  

Accepting Lab Rotation Students: Fall Block 2024, Spring 2 Block 2025

Journal Articles

Title or AbstractTypeSponsor/EventDate/YearLocation
Murine Animal Models to Interrogate the Function and Commitment of Skeletal ProgenitorsTalkNew England Musculoskeletal Institute Research Day2016Farmington, CT
Understanding the Coordinated Development of Bone Tissue and the Bone MarrowLectureUniversity of Hartford2016West Hartford, CT
Cherubism and Transforming Growth Factor Beta SignalingTalkDental Dean's Lecture Series2016Farmington, CT
Development of Genetic Models to Study Cartilage BiologyTalkNew England Musculoskeletal Institute Research Day2014Farmington, CT
Genetic Approaches to Study Adult Bone Marrow Skeletal ProgenitorsTalkConnecticut Science Festival Stem Cell Panelist2014Farmington, CT
Mouse Transgenesis: Approaches to Genetically Engineer MiceLectureUniversity of Hartford2014West Hartford, CT
Fate Mapping with Osterix Cre Mice Reveals the Origin and Contribution of Bone Marrow Mesenchymal Stem CellsTalkAmerican Society for Bone and Mineral Research Meeting2012Minneapolis, MN
Differentiating Embryonic Stem Cells Down the Axial Skeletal LineageLectureCentral Connecticut State University2012New Britain, CT
Differentiating Embryonic Stem Cells Down the Axial Skeletal LineageTalkStem Cells and Regenerative Biology Symposium, UCONN Health2011Farmington, CT
New Fluorescent Protein Reporter Animal Models to Study Skeletal BiologyPosterASBMR2010Toronto, Canada
The Application of Transgenic Reporter Mice to Study Skeletal Cell TypesTalkDental Dean's Seminar Series2010Farmington, CT
Characterizing the Osteogenic Potential of Mesenchymal Stem Cells and Their Immediate Cellular DerivativesPosterAmerican Society for Bone and Mineral Research2009Denver, CO
The Next Generation of Fluorescent Protein Reporter Animal Models to Mark Skeletal Cell TypesTalkRegenerative Engineering Workshop2009Farmington, CT
Dermo1 Lineage Tracing Identifies Early Osteoprogenitor Cells in Adult Murine Bone Marrow Mesenchymal Stem Cell CulturesPosterASBMR2008Montreal, Canada
Engineering Mice with Multiple BAC Fluorescent Protein Reporter Gene ElementsPosterAmerican Society for Bone and Mineral Research2008Montreal, Canada
Engineering Mice with Multiple Reporter Gene ElementsTalkNew England Musculoskeletal Institute Research Day2008Farmington, CT
Engineering Mice with Multiple BAC Fluorescent Protein Reporter Gene ElementsPosterEndocrine Society /Endocrine Fellows Forum2007Honolulu, Hawaii
A Bacterial Recombination Strategy to Generate Linked Multiple Gene Reporter ConstructsPosterIADR2007New Orleans, LA
A Bacterial Recombination Strategy to Link Multiple Gene Reporter ConstructsPosterStemConn2007Hartford, CT
Characterization of LRP5 Mutant Osteoblast Cultures using Collagen 1a1 GFP Reporter MicePosterASBMR2006Philadelphia, PA
Haploinsufficiency of Beta-Catenin Results in Reduced Bone MassPosterASBMR2005Nashville, Tennessee