The Miura lab studies alternative RNA isoforms, including long 3’UTR mRNA isoforms, alternatively spliced mRNA isoforms, and circRNAs. We are interested in the molecular functions of these RNAs in neurons, and how different steps of RNA biogenesis are coordinated. We use gene editing approaches such as CRISPR-Cas to manipulate RNAs of interest in Drosophila and mammalian cell culture systems, and then study how loss of these RNAs impact gene regulation. A particular interest is the in the connectivity of alternatively spliced exons to alternative 3’UTRs within individual mRNAs, and we use long read RNA-sequencing to study this.

We are looking for trainees and technicians that would like to work with mammalian cultured cells (mES, hES, and derived neurons), CRISPR gene editing, and RNA-sequencing to answer questions in RNA biology.

UConn Graduate students in the Biomedical Science Ph.D. Program have the opportunity to rotate in the lab. Contact Dr. Miura for more information. We are part of the Genetics and Developmental Biology Area of Concentration.

For specific technician and postdoc opportunities, please contact Dr. Miura.

Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025

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