Photo of Patrick A. Murphy, PhD

Patrick A. Murphy, PhD

Associate Professor
Academic Office Location:
Center for Vascular Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Website(s):

Murphy Lab

Center for Vascular Biology
Education
DegreeInstitutionMajor
PhDUniversity of California, San FranciscoBiomedical Sciences
BS, BAHamilton CollegeBiology and English

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralMassachusetts Institute of TechnologyRichard Hynes Lab

Awards
Name of Award/HonorAwarding Organization
Invited Speaker to North American Vascular Biology MeetingNorth American Vascular Biology Organization
North American Vascular Biology Meeting - Roundtable Discussion of Cell-Matrix Interactions in Vascular RemodelingNorth American Vascular Biology Meeting
North American Vascular Biology Meeting Co-chair - Session Vascular Matrix Biology and Bioengineering Nano talksNorth American Vascular Biology Meeting
Paul Dudley White International Scholar AwardAmerican Heart Association
Finalist for the Irvine H. Page Junior Faculty Research AwardAmerican Heart Association
Lab of the monthNorth American Vascular Biology Organization (NAVBO)
National Institutes of Health Pathway to Independence Award (R00)National Institutes of Health - NHLBI
National Institutes of Health Pathway to Independence Award (K99)National Institutes of Health - NHLBI
Postdoctoral FellowshipAmerican Heart Association
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)National Institutes of Health - NHLBI
Predoctoral FellowshipAmerican Heart Association
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
ImmunoCardiovascular MeetingProfessional/Scientific OrganizationOrganizerUConn HealthLocal2021

Disturbed blood flow patterns can lead to chronic inflammatory conditions in the arterial wall, a precipitating event in cardiovascular components of heart attack and stroke.  The Murphy lab is dissecting the interactions between recruited immune cells and the arterial wall using inducible genetic models combined with intravital imaging, and in vitro co-culture models under varying flow regimes. We are endothelial-centric and focused on changes in alternative splicing and the sub-endothelial extracellular matrix induced by innate immune cell recruitment, which our data suggests play an important role in the progression of arterial inflammation. A deeper understanding of how the endothelium interacts with recruited immune cells will reveal ways to intervene with the processes underlying the growth and rupture of aneurysms and atherosclerotic plaques.


Accepting Lab Rotation Students: Spring 2 Block 2025

Journal Articles

Title or AbstractTypeSponsor/EventDate/YearLocation
Tarred with the Same Brush: InCITE Single-Cell Analysis of the Nuclear Proteome in the Endothelium of Alzheimer's Disease and ALS-FTD Reveals Common TDP-43/TARDBP Molecular Mechanisms of DysfunctionTalk2024University of California, San Franscisco
InCITE-Seq Analysis Links Disruption of Core Blood Brain Barrier Pathways in Neurodegeneration to the Nuclear Depletion of TDP-43 in Endothelial CellsTalkNorth American Vascular Biology Organization2024NAVBO Monterey, CA
An unexpected role for the TDP-43 RNA-binding protein linked to ALS/FTD in endothelial activation and recoveryTalkNorth American Vascular Biology Organization2024NAVBO Monterey, CA
Analysis of the Ribosomal Translatome in Atherosclerotic Lesions Identifies a Novel Endothelial Immune Checkpoint Regulated by Elavl1/HuRPosterPost transcriptional Gene Regulation Gordon2024Post-Transcriptional GRC, Portland ME
Single-allele TDP-43G348C Mutation Leads to Endothelial Dysfunction and Blood-Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal DementiaTalkBarriers of the CNS Gordon Research2024Barriers of the CNS GRC, New London, NH
Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow ConditionsPosterNorth American Vascular Biology Meeting2021Virtual
A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain TissuePosterNorth American Vascular Biology Meeting2021Virtual
Alternative Splicing in the Endothelium: Post-transcriptional Regulation in Arterial InflammationTalkAlbany Medical College2018Albany, NY
Alternative Splicing in the Endothelium: Post-transcriptional Regulation in Arterial InflammationTalkHarvard2018Boston, MA
Dangerous Current: Genetic Dissection of Alternative Splicing Mechanisms in Flow-induced Arterial InflammationTalkUniversity of California, San Francisco2017San Francisco, CA
A Splice in Time: Alternative Splicing Regulation and Functions in Flow-induced Arterial InflammationTalkCenter for Excellence in Vascular Biology at Brigham and Women's Hospital2015Boston, MA
A Splice Odyssey :  Alternative RNA Splicing Regulates Arterial Response to Innate Immune Cell Recruitment under Altered FlowTalkBoston Angiogenesis Meeting2015Boston, MA
Endothelial Regulation of the Arterial Subendothelial Matrix by Disturbed Flow: A Quantitative Transcriptomic and Proteomic CharacterizationTalkNorth American Vascular Biology Organization : Matrix Biology2015Hyannis, MA
A Splice Odyssey: an epic drama of alternative splicing in vascular inflammationTalkMassachusetts Institute of Technology2015Cambridge, MA
Macrophages induce an alternative splicing program in arterial endothelium exposed to disturbed flowTalkNorth American Vascular Biology Organization : Vascular Inflammation2014Monterey, CA
Alternative splicing of fibronectin protects against dissecting aneurysmTalkNorth American Vascular Biology Organization : Matrix Biology2013Hyannis, MA
Alternative splicing in the vascular response to pathological shear stressPosterNAVBO : International Vascular Biology Meeting2012Wiesbaden, GER
Notch reversibly converts veins to arteries and regulates arteriovenous hierarchy in miceTalkCold Spring Harbor : Blood Brain Barrier2010Cold Spring Harbor, NY
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the diseaseTalkNorth American Vascular Biology Organization : Genetics and Genomics2009Hyannis, MA
Endothelial expression of constitutively activated Notch4 promotes Brain Arterio-Venous Malformations (BAVM) and characteristics of stroke in miceTalkGordon Research Conference : Angiogenesis and Microcirculation2007Newport, RI