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Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions.
Hensel, Jessica A; Nicholas, Sarah-Anne E; Kimble, Amy L; Nagpal, Arjun S; Omar, Omar M F; Tyburski, Jordan D; Jellison, Evan R; Ménoret, Antoine; Ozawa, Manabu; Rodriguez-Oquendo, Annabelle; Vella, Anthony T; Murphy, Patrick A Proceedings of the National Academy of Sciences of the United States of America 2022 Jul;119(30):e2122227119
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A method for rapid flow-cytometric isolation of endothelial nuclei and RNA from archived frozen brain tissue.
Kimble, Amy L; Silva, Jordan; Omar, Omar M; Murphy, Melissa; Hensel, Jessica A; Nicholas, Sarah-Anne E; Jellison, Evan R; Reese, Bo; Murphy, Patrick A Laboratory investigation; a journal of technical methods and pathology 2021 Nov;
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Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen.
Hensel, Jessica A; Heineman, Brent D; Kimble, Amy L; Jellison, Evan R; Reese, Bo; Murphy, Patrick A Scientific reports 2021 Oct;11(1):19835
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Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow.
Murphy, Patrick A; Jailkhani, Noor; Nicholas, Sarah-Anne; Del Rosario, Amanda M; Balsbaugh, Jeremy L; Begum, Shahinoor; Kimble, Amy; Hynes, Richard O Arteriosclerosis, thrombosis, and vascular biology 2021 Jan;41(1):e18-e32
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Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.
Xu, Maria Mei; Ménoret, Antoine; Nicholas, Sarah-Anne E; Günther, Sebastian; Sundberg, Eric J; Zhou, Beiyan; Rodriguez, Annabelle; Murphy, Patrick A; Vella, Anthony T American journal of physiology. Heart and circulatory physiology 2019 Apr;
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Activated T effector seeds: Cultivating atherosclerotic plaque through alternative activation.
Xu, Maria Mei; Murphy, Patrick A; Vella, Anthony T American journal of physiology. Heart and circulatory physiology 2019 Mar;
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Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation.
Al-Yafeai, Zaki; Yurdagul, Arif; Peretik, Jonette M; Alfaidi, Mabruka; Murphy, Patrick A; Orr, A Wayne Arteriosclerosis, thrombosis, and vascular biology 2018 Nov;38(11):2601-2614
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Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.
Murphy, Patrick A; Butty, Vincent L; Boutz, Paul L; Begum, Shahinoor; Kimble, Amy L; Sharp, Phillip A; Burge, Christopher B; Hynes, Richard O eLife 2018 Jan;7
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Mouse Models of Cerebral Arteriovenous Malformation.
Nielsen, Corinne M; Huang, Lawrence; Murphy, Patrick A; Lawton, Michael T; Wang, Rong A Stroke; a journal of cerebral circulation 2016 Jan;47(1):293-300
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Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.
Murphy, Patrick A; Begum, Shahinoor; Hynes, Richard O PloS one 2015 Jan;10(3):e0120872
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Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.
Murphy, Patrick A; Kim, Tyson N; Huang, Lawrence; Nielsen, Corinne M; Lawton, Michael T; Adams, Ralf H; Schaffer, Chris B; Wang, Rong A Proceedings of the National Academy of Sciences of the United States of America 2014 Dec;111(50):18007-12
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Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall.
Murphy, Patrick A; Hynes, Richard O Arteriosclerosis, thrombosis, and vascular biology 2014 Sep;34(9):2042-50
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Notch4 normalization reduces blood vessel size in arteriovenous malformations.
Murphy, Patrick A; Kim, Tyson N; Lu, Gloria; Bollen, Andrew W; Schaffer, Chris B; Wang, Rong A Science translational medicine 2012 Jan;4(117):117ra8
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Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.
Murphy, Patrick A; Lu, Gloria; Shiah, Steven; Bollen, Andrew W; Wang, Rong A Laboratory investigation; a journal of technical methods and pathology 2009 Sep;89(9):971-82
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Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.
Murphy, Patrick A; Lam, Michael T Y; Wu, Xiaoqing; Kim, Tyson N; Vartanian, Shant M; Bollen, Andrew W; Carlson, Timothy R; Wang, Rong A Proceedings of the National Academy of Sciences of the United States of America 2008 Aug;105(31):10901-6
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Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions
Jessica A Hensel, Sarah-Anne E Nicholas, Evan R Jellison, Amy L Kimble, Antoine Menoret, Manabu Ozawa, Annabelle Rodriguez-Oquendo, Anthony T Vella, Patrick A Murphy