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Masako Nakanishi, Ph.D.Assistant Professor-in-Residence
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Our laboratory is interested in pathogenesis of gastrointestinal inflammation and cancer, mouse tumor models, role of lipid metabolism, microbiome, nutritional intervention. My primary interests have been focused on examining the role of bioactive lipid signaling in colon carcinogenesis using both genetically engineered mouse models and cell culture systems.
Education
Post-Graduate Training
| Degree | Institution | Major |
|---|---|---|
| B.S. | Shippensburg University | Biotechnology |
| Ph.D. | University of Connecticut Health Center | Biomedical Science |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Connecticut Health Center | Postdoctoral Fellow |
My research focuses on pathogenesis of gastrointestinal inflammation and cancer, mouse tumor models, the role of lipid metabolism, microbiome, nutritional intervention.
I have several research projects available that focus on chemoprevention of Colorectal Cancer (CRC) and inflammatory bowel diseases (IBDs).
Not Accepting Lab Rotation Students at this time
Journal Articles
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Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice.
Journal of Cancer Prevention 2021 Dec;26(4):304-308
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Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation.
The American journal of pathology 2020 Feb;
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Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster.
Cancer prevention research (Philadelphia, Pa.) 2019 Dec;
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Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration.
Nutrients 2019 May;11(5):
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Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound.
Molecular cancer research : MCR 2018 Sep;16(9):1361-1372
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Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria-Stimulated Immunity.
Journal of immunology (Baltimore, Md. : 1950) 2018 Apr;2003729-3738
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Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis.
Frontiers in nutrition 2018 Jan;537
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A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice.
Carcinogenesis 2017 Dec;39429-438
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Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.
PloS one 2017 Jan;12(9):e0184455
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Effects of walnut consumption on colon carcinogenesis and microbial community structure.
Cancer prevention research (Philadelphia, Pa.) 2016 May;9692-703
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Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas.
Cancer prevention research (Philadelphia, Pa.) 2015 Apr;8(5):387-99
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Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
Carcinogenesis 2015 Jan;36(4):478-86
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The role of PGE2 in intestinal inflammation and tumorigenesis.
Prostaglandins & other lipid mediators 2014 Oct;116-11726-36
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Suppression of colon carcinogenesis by targeting Notch signaling.
Carcinogenesis 2013 Jun;34(10):2415-23
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Differential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells.
Molecular carcinogenesis 2012 Dec;53 Suppl 1E11-22
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Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
Cancer prevention research (Philadelphia, Pa.) 2011 Aug;4(8):1198-208
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cPLA2 is protective against COX inhibitor-induced intestinal damage.
Toxicological sciences : an official journal of the Society of Toxicology 2010 Sep;117(1):122-32
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Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention.
Proteomics. Clinical applications 2007 Dec;1(12):1660-6
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Deoxycholic acid promotes the growth of colonic aberrant crypt foci.
Molecular carcinogenesis 2007 Jan;46(1):60-70
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Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis.
Cancer research 2005 Apr;65(7):2636-43
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Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Mar;11(6):2265-71
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Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells.
Carcinogenesis 2004 Nov;25(11):2239-46
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Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer.
Cancer research 2004 Sep;64(18):6394-401
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Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.
Oncogene 2004 May;23(21):3813-21
Conference Papers
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Gene deletion of mPGES-1 results in a significant reduction in tumor stage and burden in the BBN mouse model of bladder cancer. Highly Rated Abstract, Top 2%
2010 Jan;51596-597
Reviews
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Multifaceted roles of PGE2 in inflammation and cancer.
Seminars in immunopathology 2013 Mar;35(2):123-37
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mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".
Biochimie 2010 Jun;92(6):660-4
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Roles of cPLA2alpha and arachidonic acid in cancer.
Biochimica et biophysica acta 2006 Nov;1761(11):1335-43